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Toll-like Receptors: Roles in Infection and Neuropathology (Hardcover, 2009 ed.)
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Toll-like Receptors: Roles in Infection and Neuropathology (Hardcover, 2009 ed.)
Series: Current Topics in Microbiology and Immunology, 336
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Mammalian Toll-like receptors (TLRs) were first identified in 1997
based on their homology with Drosophila Toll, which mediates innate
immunity in the fly. In recent years, the number of studies
describing TLR expression and function in the nervous system has
been increasing steadily and expanding beyond their traditional
roles in infectious diseases to neurodegenerative disorders and
injury. Interest in the field serves as the impetus for this volume
in the Current Topics in Microbiology and Immunology series
entitled "Toll-like receptors: Roles in Infection and
Neuropathology." The first five chapters highlight more traditional
roles for TLRs in infectious diseases of the CNS. The second half
of the volume discusses recently emerging roles for TLRs in
non-infectious neurodegenerative diseases and the challenges faced
in these models with identifying endogenous ligands. Several
conceptual theories are introduced in various chapters that deal
with the dual nature of TLR engagement and whether these signals
favor neuroprotective versus neurodegenerative outcomes. This
volume should be informative for both experts as well as newcomers
to the field of TLRs in the nervous system based on its coverage of
basic TLR biology as well as specialization to discuss specific
diseases of the nervous system where TLR function has been
implicated. A must read for researchers interested in the dual role
of these receptors in neuroinfection and neurodegeneration.
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