Complement has long been regarded as a pivotal effector arm of
the innate immune response, eliciting important immunoregulatory
functions in the context of inflammation and also serving as a
vital link between the innate and adaptive immune response. In the
post-genomic era, our knowledge of the innate immune system is
enriched by findings that point to novel functions that do not
strictly correlate with immunological defense and surveillance,
immune modulation or Inflammation. Several studies indicate that
complement proteins exert functions that are either more complex
than previously thought, or go well beyond the innate immune
character of the system. The advent of high-throughput platforms
for genome and proteome-wide profiling, together with the enormous
amount of raw genetic information that has accumulated in the
databases, have stirred new expectations in biomedical research.
They have led complementologists to revisit established biological
systems, such as the complement system, from a global and
integrative perspective. Complement research is now faced with the
challenge of trying to integrate isolated biochemical pathways into
complex gene and protein regulatory circuits.
In this respect, scientists from around the world convened at
the Fourth Aegean Conferences Workshop on Complement Associated
Diseases, Animal Models, and Therapeutics (June 10-15, 2007), to
discuss recent advances in this fast evolving field. This volume
represents a collection of topics on the "novel" functions of
complement, patho-physiology, protein structures, design of
complement inhibitors, and complement assays discussed during the
conference.
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