Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the localization and amount of the damage induced by combined inflammatory, demyelinating, and neurodegenerative processes. Although a cure for MS does not currently exist, therapies can help treat MS attacks, attenuate disease activity, reduce progress of the disease, and manage symptoms. Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis, from experimental models and the human disease to the translation of this research to immunotherapeutic strategies. Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers of disease activity, pharmacogenetics, and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon-such as neuroprotective strategies, stem cells, and repair promotion-are discussed. Contributed by renowned leaders in the field, this cross-disciplinary volume is a great resource for basic scientists and clinical practitioners in neuroscience, neurology, immunology, pharmacology, and in-drug development.

This issue of Immunology and Allergy Clinics of North America, Guest Edited by Anthony Montanaro, MD, is devoted to Primary Immunodeficiency Disorders. Dr. Montanaro has assembled a group of expert authors to review the following topics: Overview of Immunodeficiency Disorder; Severe Combined Immunodeficiency Disorder; Specific Antibody Deficiencies; Common Variable Immunodeficiency; Pulmonary Manifestations of Primary Immunodeficiency Disorders; Approach to the Child with Recurrent Infections; Immunoglobulin Treatment for Primary Immunodeficiency; Bone Marrow Transplantation for Primary Immunodeficiency; and Autoimmune Manifestations of Primary Immunodeficiency.

The ways in which we can better understand cancer, HIV, and other autoimmune diseases through clinical immunology are of great interest to practitioners from the student level to the advanced PhD. Designed as an introduction for practitioners and residents, this book focuses on the clinical disease-state level of immunology. Essential Clinical Immunology" begins with the basic concepts and then details the immunological aspects of various disease states involving major organs of the body. The book explores how we can better understand disease and its treatment through clinical immunology. Looking forward, each chapter concludes with patterns for future research.

This issue of Immunology and Allergy Clinics of North America, Guest Edited by Amy D. Klion, MD and Princess U. Ogbogu, MD, is devoted to Eosinophil-Associated Disorders. Drs. Klion and Ogbogu have assembled a group of expert authors to review the following topics: Evaluation and Differential Diagnosis of Persistent Marked Eosinophilia; Spectrum of Eosinophilic End Organ Manifestations; Eosinophilia in GI disorders; Eosinophilia in Hematologic Disorders; Eosinophilia in Rheumatologic/Vascular Disorders; Eosinophilia in Pulmonary Disorders; Eosinophilia in Infectious Diseases; Eosinophilia associated with Immune Deficiency and Immune Dysregulation; Eosinophilia in Dermatologic disorders; Management of Hypereosinophilic Syndromes; and Novel Therapies for Eosinophilic Disorders.

Granulomatous disorders represent a unique group of diseases both non-infectious and infectious that require the utmost clinical pathologic correlation combined with a keen sense of inquiry for underlying systemic disease. Some of these diseases are common and some are rare; however all dermatologists need to diagnose and manage these diseases whether common or rare. This issue of Dermatology Clinics "Granulomatous Disorders of the Adult Skin" supplies the readers with a comprehensive, up to date, and evidence based review of multiple granulomatous disorders (i.e. palisdaing, epitheliod, xanthomatous, casseating, supprative, vasculitic, lymphoproliferative, foreign body). Dermatologists need to be able to differentiate the entities, evaluate patients for specific underlying systemic diseases (diabetes to cancer) and treat with a wide range of immunosuppressant to anti-infectious agents. This issue will help the dermatologist learn the most current etiopathogenesis, clinical/systemic manifestations and therapeutic modalities for these diseases. Other specialists who would find the information useful: Rheumatologists, Infectious Disease specialists, Hematologists/Oncologists, Endocrinologists, Pulmonologists, Oral-maxillary surgeons, and Pharmacists.

Lupus, a disease of the immune system, can be quite deadly, claiming the lives of thousands of patients yearly. Dr. Daniel J. Wallace is one of the world's leading authorities on this disorder, an eminent clinician who has treated over 3,000 lupus patients, the largest such practice in America. His The Lupus Book, originally published in 1995, immediately established itself as the most readable and helpful book on the disease. Now Dr. Wallace has once again completely revised The Lupus Book, incorporating a wealth of new information. This Sixth Edition discusses new drug information and newly discovered information about the pathology of the diseaseall laid out in user-friendly language that any patient could understand. In particular, Wallace discusses the first drug for lupus to be approved by the FDAbelimumab (Benlysta)as well as other drugs in clinical trials. Readers will also discover fully updated sections on the science of lupus and breakthroughs in research including: genetics, microbiome, and clinical trial methodology. And as in past editions, the book provides absolutely lucid answers to such questions as: What causes lupus? How and where is the body affected? Can a woman with lupus have a baby? And how can one manage this disease? Indeed, Dr. Wallace has distilled his extensive experience, providing the most up-to-date information on causes, prevention, cure, exercise, diet, and many other important topics. There is also a glossary of terms and an appendix of lupus resource materials compiled by Dr. Wallace. Over 1.5 million Americans have lupus. The new Sixth Edition offers these patients and their families an abundance of reliable, information that will help them manage the disease and live a happier life.

Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology. This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics. Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget's disease, the genetics of bone disease, and bone cancer metastasis.

This issue of Immunology and Allergy Clinics, devoted to Obesity and Asthma, is edited by Dr. Anurag Agrawal. Articles in this issue include: Clinical Implications of the Obese Asthma Phenotypes; Childhood Obesity and the Risk of Allergy; Metabolic Asthma: Is there a link between obesity, asthma, and diabetes?; Role of Weight Management in Obese-Asthma Control; Obesity and Airway Disease: A Bioenergetic Problem?; Nutrition, Obesity, and Asthma: Exploring Epigenetic Programming; Obesity and Asthma: The Role of Environmental Pollutants; Novel Therapeutic Strategies for Adult Obese Asthmatics; and From ADMA to Asthma.

This issue of Immunology and Allergy Clinics, edited by Dr. Pascal Demoly, is devoted to Drug Hypersensitivity.? Articles in this issue include: Drug allergy diagnosis; Principles of drug allergy management: acute drug reactions, individual preventive measures, desensitization, general preventive measures; Antibiotics allergy; Non-steroidal anti-inflammatory drugs HS; Local and general anesthetics allergy; Radiocontrast media and dyes allergy; Chemotherapeutic agents allergy; Vaccine allergy; Biological agents HS; Anti-epileptic allergy; Iron and Vitamin Allergy; Antiviral drug allergy; Additive allergy; and Unmet needs in drug allergy.

Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting - cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation-related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress . The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging.

"Molecular Biology of B Cells, Second Edition" is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production.All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes.

"Molecular Biology of B Cells, Second Edition" offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, "Molecular Biology of B Cells, Second Edition" is the definitive resource, vital for researchers across molecular biology, immunology and genetics.
Covers signaling mechanisms regulating B cell differentiationProvides information on the development of therapeutics using monoclonal antibodies and clinical application of AbContains studies on B cell tumors from various stages of B lymphocytesOffers an integrated view of all aspects of B cells to produce a normal immune response"

This volume presents standard approaches and the most recent technical advances used to study innate immune activation. Chapters detail the assessment of macrophage activation, measuring innate immune responses to bacterial viability, quantification of secreted proteins, reporter systems, protocols examining specific innate immune activation by TLRs, RLRs, cGAS, and inflammasomes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Innate Immune Activation: Methods and Protocols aims to be a useful and informative reference tool for further study into this vital field.

This second edition provides new and updated chapters useful for the study of Regulatory B cells. Organized in four sections, chapters detail basic methods for the isolation and immunophenotypical analysis of these cells, experimental approaches for the ex vivo generation/expansion of IL-10 producing B cells, molecular biology techniques for the analysis of IL-10 expression and production, and animal models mimicking pathologic settings. Written in the highly successful Methods in Molecular Biology series format, chapters include an introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Regulatory B Cells: Methods and Protocols, Second Edition aims to be useful to the scientific community and serve to clarify some unsolved aspects of Regulatory B Cells research.

Urticaria, or hives, is a skin rash characterized by red, raised bumps which are usually itchy and create a burning sensation. Urticaria can be caused by allergic and non-allergic reactions. For patients with chronic hives, this condition is usually the result of an autoimmune disorder. This issue will cover the latest diagnosis and treatment strategies for this condition at the point of care, across several patient types, such as children and pregnant women.

Guest edited by Bruce Zuraw, this issue of Immunology and Allergy Clinics covers angioedema, including topics on hereditary angioedema, prophylactic and on-demand treatmetnts, and more.

Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-constituents of the body. The fully updated third edition of "Autoantibodies" is an in-depth review of the main autoantibodies identified up to now, with particular emphasis on those that display a diagnostic or prognostic clinical value.

The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). This is an ideal reference for anyone involved in the field of autoimmune diseases.
Presents all known, important autoantibodies in a single source, focusing on the antibodies needed for autoimmune disorder diagnosisIncludes clinical applications for each autoantibody along with general informationOrganized by disease and disorder type, by autoantibody family, and completely cross-referenced

This issue of Nursing Clinics, Guest Edited by Cathy Catrambone, PhD, RN, at Rush University, focuses on Asthma. Article topics will include Assessment of Asthma, Pharmacotherapy, Asthma management, Asthma action plans, Pediatric Asthma, and Asthma and Obesity.

Guest edited by Sandra Anderson this issue of Immunology and Allergy Clinics covers all aspects of exercise-induced bronchospasm, including treatment through pharmacologic agents, patient assessments, and biomarkers.

Guest edited by Eugene Choo, this issue of Immunology and Allergy Clinics covers the latest research in diagnosing and managing asthma-like diseases. Topics covered include vocal cord dysfunction, dynamic airway collapse, RADS, GERD, sarcoidosis, and more.

There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.
Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication Drs. Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research Summarizes the latest insights into how immune escape defines an essential trait of cancer Includes numerous illustrations, including how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy and how reversing immune suppression by the tumor can cause tumor regression

This book is a critical appraisal of the data and evidence available in literature of the relative roles of the immune response to neoplastic cells. An attempt has been made to render a better understanding of the various modes of impact of the immune response against tumors in general, particularly gliomas in some of the chapters. Autoimmune response is one mode of reactivity to native component cells within the body. Neoplastic transformation, on the other hand, critically necessitated the absence of an effective immune response to the transformed tumor cells in order for the lesion to grow and metastasize. This book is aimed towards a wider readership, but its particularly for oncologists and the various clinical and academic professionals that care for patients with cancer. It is especially meant to provide a clear exposition of known facts regarding the genesis and further development of neoplasms. Examples of some of the commoner lesions are accounted for.

This issue of Immunology and Allergy Clinics provides a comprehensive review of the current state of biomarkers and their role in the asthma diagnostic and therapeutic algorithm.Since the last issue on Biomarkers, which published in 2007, significant research directly targeted at biomarker development and clinical trials with new biologics, using biomarkers such as exhaled nitric oxide, sputum and tissue eosinophilia as endpoints, has occurred.

This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery.

Advances in Cancer Research, Volume 142, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research.