The role of the immune response in both the pathology of liver
disease and in the modulation ofliver injury has been the subject
of intense research. This book aims to present the current
understanding of the involvement of the immune response in liver
disease. The first chapters examine the role of the immune response
in viral infections of the liver. These viruses cause hepatitis of
varying severity and it is thought that many of the mechanisms
responsible for liver cell injury are immunologically mediated. In
addition three of these viruses, hepatitic B, C, and D, are
associated with persistent infection and chronic liver disease. The
role of the immune response in viral persistence is discussed.
Further chapters are devoted to the three major autoimmune liver
diseases which are thought to be the result of loss of tolerance to
autologous liver tissue. There has been much recent research on
cellular immune responses in these diseases but knowledge of the
immunological processes which lead to the breakdown of tolerance
and the mechanisms of tissue damage are limited. Other research has
concentrated on the identification of the antigens which are the
targets of this immune response. Linkage disequilibrium between MHC
alleles and autoimmune diseases has suggested a role for
immunogenetic factors.
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