This book puts the critical into dementia studies. It makes a timely and novel contribution to the field, offering a provocative and thought-provoking critique of current thinking and debate on dementia. Collectively the contributions gathered together in this text make a powerful case for a more politically engaged, deconstructive and critical treatment of dementia and the systems and structures that currently govern and frame it. The book is interdisciplinary and draws together leading dementia scholars alongside dementia activists from around the world. It frames dementia as first and foremost a political category. The book advances both theoretical and methodological thinking in the field as well as sharing learning from empirical research. Outlining the limits to existing efforts to frame and theorise the condition it proposes a new critical movement for the field of dementia studies and practice. The book will be of direct interest to researchers and scholars in the field of dementia studies and wider fields of health, disability and care. It will provide a novel resource for students and practitioners in the fields of dementia, health care and social care. The book also has implications for dementia policymaking, commissioning and community development.

Neuropsychologists are frequently asked to serve as experts for court cases where judgments must be made as to the cause of, and prognosis for, brain diseases and injuries, as well as the impact of brain dysfunction on legal competencies and responsibilities. This fully-updated second edition describes the application of neuropsychology to legal issues in both the civil and criminal courts. The book emphasizes the scientific basis of neuropsychology, as well as using a scientific approach in addressing forensic questions. All of the contributors are recognized experts in their fields, and the chapters cover common forensic issues such as appropriate scientific reasoning, the assessment of malingering, productive attorney-neuropsychologist interactions, admissibility of neuropsychological evidence, and ethics. Also covered are functional neuroimaging in forensic neuropsychology and the determination of damages in personal injury litigation, including pediatric brain injury (traumatic injury and perinatal birth injury), mild, moderate, and severe traumatic brain injury in adults, neurotoxic injury, chronic pain, post-traumatic stress disorder, and assessment of medically unexplained symptoms. Civil competencies in elderly persons with dementia are addressed in a separate chapter, and two chapters deal with the assessment of competency and responsibility in criminal forensic neuropsychology. The book closes with a perspective on trends in forensic practice and research. Like the previous edition, this new volume is an invaluable resource for neuropsychologists, attorneys, neurologists, clinical psychologists, psychiatrists, and their students and trainees.

This book is dedicated to the memory of two colleagues and friends, Amico Big- nami and Hendrick Vander Los. They were both pioneers in their fields: Bignami on on- togenesis and function of neuroglia, and Van der Los on brain plasticity and neuronal circuitry. Their ideas are further pursued by the authors in this book. Some of the chapters are products of a conference dedicated to these two scientists entitled "Recent Advances in Neurobiology: Plasticity and Regeneration." The conference was organized by the Insti- tute of Developmental Neuroscience and Aging and sponsored by the Region della Valle d' Aosta. Also, several chapters are written by colleagues who knew well either Amico or Hendrick and were invited to contribute to this dedication. The book is divided in four sections. The first part covers neurons, neuroglia includ- ing microglia, their plasticity and phenotypic expression, and specific functions and inter- actions. It is now established that neuroglia are an intimate component of the neuronal environment and thought to regulate several neuronal functions. More recently microglia have become prominent as the immune cells in the CNS. This part contributes new infor- mation for these cellular interactions. The second part deals with neuronal and glial cell plasticity as it relates to regeneration and neurodegeneration, more or less an extension of Part I. In recent years the role of transplantation in regeneration has become promising.

Perspective of Neurochemistry in Neurological Disorders.- Selegiline Induces "Trophic-Like" Rescue of Dying Neurons without Mao Inhibition.- Aliphatic Propargylamines, a New Series of Potent Selective, Irreversible Non-Amphetamine-Like MAO-B Inhibitors.- Medical Treatment of Parkinson's Disease.- Neuropharmacological Effects of (-)-Stepholidine and Its Analogues on Brain Dopaminergic System.- Neurotoxicity of MPTP and Uptake of MPPT into Dopamine and Norepinephrine Neurons in Mice.- Linopirdine.- Differential Changes in Regional Brain Ganglioside and Neutral Glycosphingolipid Contents in Alzheimer's Disease.- Action of Organophosphate Anticholinesterases on the Three Conformational States of Nicotinic Receptor.- Purification and Characterization of a Novel Neurotoxin-Kappa Bungarotoxin.- Development of Antidepressant Drugs.- The Identification of Heterogeneity of 5-HT Receptors with [H]Rs-42358-197.- Advances in Clinical Research on Common Mental Disorders with Computer Controlled Electro-Acupuncture Treatment.- The Importance of Glutamate Receptors in Brain Ischemia.- Biochemical Study of the Postischemic Neuronal Damage.- Effects of Ilexonin A on Circulatory Neuroregulation.- Study on Cerebrovascular Disease of the Elderly in China.- Cellular Physiology of Epileptogenic Phenomena.- The Clinical Pharmacology of Antiepileptic Drugs.- Hemodynamic Actions of Huatuo Reconstruction Pill on Anesthetized Animals.- Treatment of Affective Disorders.- Studies of Diagnosis and Pathogenesis of Wilson's Disease.- Evidence for Presynaptic Damage in Myasthenia Gravis.

For more than 35 years the Swiss Society of Neuropathology has organiseditstraditionalInternationalWinterMeeting.Themainaimofthis venue is to bring together neuropathologists and clinicians as well as neuroscientistsinterestedindiseasemechanisms.TheXVIIIthInternational WinterMeeting washeld inMarch 2000 in St. Moritz, Switzerland. The topicofthe2000Meetingwas"NeuropathologyandGeneticsofDementia." Aprogrammeofinvitedplenarylecturesofhigheducationalvalueaswellas platform andposterpresentations given by manyparticipantscoveredthe broadspectrumofdementingdisorders.Encouragedbythehighstandardof the meeting, and probably also influenced by the advent of a new Millenniumwedecided, togetherwithKluwerAcademiclPlenumPublishers, topublishtheProceedingsofthe2000Meetinginthepresentbook. The increaseofthe agedpopulation challenges social and health care systemsinindustrializedsocieties.Maintenanceofhealthandautonomyinto oldage isakeyfactor, andtheautonomyandindependenceofoldpersons crucially depend on mental health. However, neurodegenerative disorders accompanied bydementiaaffect 5-10%ofindividualsoverthe ageof65, and for the age group between 65 and 95 the prevalence of cognitive dysfunction doubles every 5 years. With this challenge in mind, Rossor discusses the clinical syndrome of dementia which encompasses an enormousvarietyofunderlyingdisorders. Over the last few years it has become apparent that many neurodegenerative disorders are characterised by protein misfolding and aberrant polymerization and may therefore be viewed as "aggregation proteopathies." Among them a substantial subsetofdementing disorders, either with or without motor dysfunction, are characterised by abundant v VI Preface neuronaland/orglialaccumulationofhyperphosphorylatedtauprotein.The molecular parametersofthese "tauopathies" are reviewed by Delacourte. Therecentdiscoverythatmutationsofthetaugenearecausativeforfamilial formsoffrontotemporaldementiaandParkinsonism(FTDP-17)broughtthe "taupathway"and the"tauopathies"tothecentrestage.Thisextraordinary breakthroughwillbecoveredbySpillantiniandGoedert.Thereisincreasing evidence that argyrophilic grain disease is much more frequent in older patients than previously thought. Tolnay et al. are reviewing recent contributionstothepathologyofthislate-onsetdementingdisorderinwhich ofamyloidbetadeposits, isalmost taupathology, inthealmosttotalabsence exclusivelyrestricted to the limbic lobe and the amygdala. Schultzet al. report an intriguing age-related progression of neuronal and glial tau pathologyinbaboonsthusrenderingthe baboonapotentialprimatemodel forage-relatedhuman"tauopathies." Gotzetal. introducetransgenicmice expressingmutated human tau as valuable animal models for reproducing formationofneuro-andglialfibrillarylesions.

This volume is a collection of a variety of brain proteins and peptides whose structures and functions are relatively well known. Each chapter provides a succinct and up-to-date summary of a protein or peptide as well as a review of the individual's contributions to the field. The volume explores the progress that has been made in the field over the past few years and provides insight into the field today.

Because of the increasing burden of hepatitis C and fatty liver disease, there is an explosion in the prevalence of chronic liver failure and hence its complications. The onset of Hepatic Encephalopathy (HE) in these patients has a significant impact on the quality of life, morbidity and mortality. Unfortunately, the approach observed by most clinicians to this complex disorder is minimalistic. Hepatic Encephalopathy provides a comprehensive review on pathophysiology and clinically important aspects in HE. Topics in basic physiology, nitrogen metabolism, new insights into pathogenesis and brain edema are covered in great detail. The authors have made a special effort by simplifying the complex aspects of pathogenesis and diagnosis so that it can be easily understood and applied clinically. This volume also focuses on recent developments regarding diagnoses of subtle forms of HE, also known as minimal or covert HE as well as on new treatments. Hepatic Encephalopathy will be of great value to gastroenterologists, hepatologists, pathologists, medical residents, fellows, internists, and general practitioners who treat patients with hepatic encephalopathy.

Multiple Sclerosis continues to be one of the most baffling and destructive diseases of our time, disabling a multitude of people around the globe. For researchers in various disciplines who are concerned with readily locating published data that are relevant to the sociodemographic factors in the epidemiology of MS, this volume makes accessible subject topics that focus on the demographic, sociocultural, and methodological correlates of the disease. Compiler George W. Lowis has gathered four decades of published research findings into this unique and useful volume. He provides summaries of 213 projects grouped according to whether they could possibly be implicated, either positively or negatively, as determinants of MS prevalence or incidence. Summaries of 192 projects look at 11 different demographic and sociocultural correlates of MS such as diet, ethnicity, urban-rural residence, and more. An additional 21 projects focus on the methodology or case ascertainment used. The majority of sample projects were abstracted from medical literature published in journals and books since 1960. Each project has been edited and presented in such a way that the author's purpose for conducting the research is made explicit, as are the main findings and conclusion. Divided into two parts, the volume first zeroes in on the sociodemographic projects. Included in the eleven chapters of this section are the demographic factors that may be implicated in MS such as age, sex, ethnicity, occupation, place of birth or residence, and population migration. Etiological factors in the sociocultural part of the environment include such variables as the types of social relationships and patterns of living that characterize people of different sexes, ages, races, and social classes and the ideas, values, and norms possessed and used by people in matters such as diet and nutrition, sanitation, and pet ownership. The second section reviews methodologic projects from the point of view of data collection and case ascertainment techniques used. Each of the 213 projects contains five sets of research information: a discussion of the purpose and occasionally the locale of the study; data relevant to the population studied; a report on the findings of the project; a brief concluding summary; and finally, an overview of other factors positively or negatively implicated. As the only book that approaches the epidemiology of MS with this focus, this annotated bibliography will be a tool of inestimable value to researchers in the fields of medical sociology, epidemiology, social epidemiology, public health, environmental health, and medical anthropology.

Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects provides and assesses the latest research and developments surrounding the use of phytonutrients for the treatment of neurological disorders. The volume analyzes advances in phytonutrient isolation, characterization and therapeutic applications, giving particular emphasis to mechanisms and safety profiles. The book takes toxicological considerations into account, including adverse drug reactions, toxicokinetics and toxicodynamics. Sections cover bioactive compound classes and biosynthesis pathways, general considerations, including quality control, standardization, and technology, and toxicology. This title is a comprehensive work on the latest research in phytonutrients and neurological disorders that will be useful to researchers and medical practitioners.

Join Alice the Aspiesaurus in this new heart-warming picture book that teaches children the value of friendship and helping others. It gives children a positive role model by showing Alice growing in confidence and facing her fear, while also teaching children that not everyone likes to be teased. Alice the Aspiesaurus thought she was the only dinosaur who found it hard to fit in. But when new dinosaur Caitlin joins her class, Alice discovers that Caitlin is shy, too. What's more, Caitlin's birthday is coming up, and the other dinosaurs are teasing her. Unless Alice helps her, Caitlin will have no one to celebrate her birthday with. Now Alice must be brave. With the help of her friends, she arranges a surprise birthday party for Caitlin. And thanks to Alice's help, Caitlin can befriend her classmates. This fun, easy-to-read story is based on the author's personal experiences of what it's like to be different. The book's original, colourful illustrations are based on the latest dinosaur research, and will appeal to any child who loves dinosaurs.

The Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics, Part B, Volume Four reviews historical background, current nosology and guidelines. In addition, it includes an overview of pathophysiology, ranging from its genetic basis and changes in neurochemistry and electrophysiology to widespread neural circuits. Specific chapters cover The genetic basis of Gilles de la Tourette Syndrome, Genome-wide association study of Tourette Syndrome, De Novo mutations in Tourette Syndrome, Animal models for Tourette Syndrome, The neural-immune crosstalk in Tourette syndrome: from immunobiology to epistemology, Functional connectivity in the Gilles de la Tourette Syndrome, and much more.

This book, covering many key aspects of autonomic nervous system maturation, was suggested by the success of a symposium on the developing autonomic nervous system held at the Spring 1982 meeting of the Federation of American Scientists for Experi mental Biology (Federation Proceedings 1983, 42, 1609). It was obvi ous from the F ASEB symposium that there is increasing interest in the developing autonomic nervous system, particularly with respect to its role in regulating visceral function. Some additional topics that were not covered in the F ASEB symposium are also included in this book. The editor feels that the readers of this volume are, in all probability, already cognizant of the state of knowledge of the adult autonomic nervous system. Therefore, a review of classical autonomic physiology, pharmacology, and neuroanatomy is not provided. For a recent detailed discussion of the ontogeny and phylog eny of the developing nervous system, I would recommend the book published not long ago by D. Purves and J. W. Lichtman, Principles of Neural Development (Sinauer, Sunderland, MA, 1985). Another recent book, Autonomic Nerve Funtion in the Vertebrates by F. Nilsson (Springer-Verlag, New York, 1984), presents a compar ative examination of autonomic nervous system function in verte brates. For a summary of recent advances in the many aspects of catecholamines as they bear on autonomic nervous system re search, I would recommend the series of three books edited by E."

In this, the fourth and final volume in the series Human Brain Function, Goldstein and Beers outline how the different rehabilitation specialties assess brain function. Using straightforward explanations, the contributors not only cover the assessment approaches and methods used by each specialty, but uniquely expand this focus to describe evaluation and treatment planning for a variety of neurobehavioral disorders. Rehabilitation specialists and non-specialists alike will value the original scope and accessibility of this work.

This varied and impressive volume is a record of the major presentations at the NATO Advanced Research Workshop on the "Development of Sex Differences and Similarities in Behavior" held at Chateau de Bonas, Gers, France, July 14-18, 1992. Although aspects of sex differences in human and animal behavior have been recently extensively explored both academically and in popularized accounts, the present work shows that the complex interplay between the various biological, political, psychological and sociological factors that account for sex differences has always been, and will continue to be, a source of infinite fascination and confusion to humans. The book contains presentations by a powerful mixture of eminent scientists from the relevant biological and social sciences areas, any ethnocentric tendencies being tempered by the wide mix of nationalities. Current information is placed in an evolutionary and genetic context and includes material from anatomical, endocrinological and behavioral studies of animal behavior and from the human cognitive sciences. The Development of Sex Differences and Similarities in Behavior is accessible to a spectrum of readers, from university undergraduates to experienced professionals.

Nervous system development evolves from the well-orchestrated processes of neural induction, cell proliferation, differentiation, cell migration, survival, and synapse formation. Among these environmental cues, neurotrophic factors are secreted proteins that promote neurite outgrowth, neuronal cell differentiation and survival both in vivo and in vitro. Nerve growth factor (NGF) is the founding and best characterized member of the neurotrophin family of neurotrophic polypeptides. Neurotrophic Factors: Methods and Protocols presents a selection of protocols and procedures which make use of cellular, tissue, and whole animal models which can be applied to the investigation of neurotrophic factors and other agents impacting on these systems. Chapters cover a wide-range of topics such as dealing with the culture of neurons and glia from the central and peripheral nervous systems, neuron-glia co-culture models, and cell-based assays for the evaluation of neuroprotective molecules, as well as assays which can be applied to the study of agents with neuroregenerative potential. Protocols describing viral- and nanoparticle-based delivery methods to neural cells are also presented, following by chapters dealing with organotypic slice culture protocols. Lastly, several chapters are dedicated to in vivo lesion models of relevance to nervous system pathology, which can be applied to the investigation of neurotrophic factors and peptides. Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Neurotrophic Factors: Methods and Protocols seeks to serve both professionals and novices alike with its well-honed methodologies in an effort to further our knowledge of what has been described as the last frontier of science.

Evolving technologies starting with tracer studies, and more recently with genomics and proteomics, have provided novel information about the molecular properties of cerebral endothelium and astrocytes; however, further studies must be done in animal models of neurological diseases and in humans to get a clearer understanding of the pathogenesis of blood-brain barrier (BBB) breakdown in nervous system diseases. In The Blood-Brain and Other Neural Barriers: Reviews and Protocols, experts in the field present a series of cutting-edge protocols which can be used to study the barriers. Opening with detailed information on components of the neurovascular unit as well as the blood-cerebrospinal, blood-retinal, and blood-nerve barriers, the book continues with meticulous techniques to image the barriers in humans and experimental animals, followed by cutting-edge molecular techniques to study the BBB and novel models to study the barriers, and it concludes with techniques for the delivery of therapeutic agents across the BBB. Written in the highly successful Methods in Molecular Biology(TM) series format, protocol chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, The Blood-Brain and Other Neural Barriers: Reviews and Protocols will aid the research efforts of not only graduate students but also more experienced investigators and support future studies of these vital systems.

Neuroscientists found that chronic stress and cortisol can trigger long-term changes in brain structure and connectivity in individuals and emphasize the importance of reducing stressful factors in one's daily life. Early exposure to stressful events can make a person more vulnerable to anxiety and other mood disorders later in their lifetime. Those who take active steps to reduce their stress through various means such as physical activity or therapy can reduce the negative long-term effects on the brain. Chronic Stress and Its Effect on Brain Structure and Connectivity is an essential reference source that presents current information on chronic stress management, the impact of mass media coverage on the human mind, and the effects of post-traumatic stress. Featuring research on topics such as the neurophysiological basis of moods, trauma, quantum cognition, mental health, therapy, and neurobiology, this book is ideally designed for mental health professionals, neuroscientists, neurologists, psychiatrists, researchers, and therapists.

Magnetic Resonance Imaging and Epilepsy; S.D. Shorvon. The Anatomical Bases of the Epilepsies and MRI; D.R. Fish. Brain Structure in Epilepsy; F. Andermann. MR Spectroscopy in Epilepsy; H. Stefan. Mesial Temporal Lobe Structures; P. Gloor. Magnetic Resonance Imaging of Hippocampal Sclerosis; S.F. Berkovic, et al. Volumetric MRI Studies of the Hippocampus; M.J. Cook, et al. Advances in Morphometric and Volumetric Analysis in Temporal Lobe Epilepsy; C. Watson, et al. The Role of MRI Volumetric Studies in the Investigation of Patients with Intractable Epilepsy; F. Cendes, et al. The Future Role for MR Imaging in Epilepsy; P. Schuler, H. Stefan. Quantitative Relaxometry of Hippocampal Sclerosis; J.S. Duncan, et al. The Significance of T2 Changes in the Hippocampus; P. Tofts. Investigation of Effects of Vigabatrin with Magnetic Resonance Imaging and Spectroscopy In Vivo; J.S. Duncan, et al. 40 additional articles. Index.

The title of this monograph, Brain Tumor Research and Therapy, is the name of the Conference itself, which had its inaugural meeting in the United States in 1975 andhas since progressed to the international scale. In Japan, the first conference ofits kind was organized by Dr. Takao Hoshino and me and was held at Nikko in 1980, hence its name, the Nikko Conference on Brain Tumor Research and Therapy. Though it started as a small, closed meeting, the conference has grown considerably, and in 1992 it was reorganized as the Japanese Conference on Brain Tumor Research and Therapy and was opened to all neurosurgeons and neuropathologists interested in the study of brain tumor problems and who are participating in this field. The main purpose of the Conference on Brain Tumor Research and Therapy is the candid and informed discussion of the most up-to-date developments in basic re search and clinical treatment of brain tumors. The 3rd Japanese Conference on Brain Tumor Research and Therapy was held at Nasu (Tochigi Prefecture), Japan, in No vember 1994. It was a great honor to welcome many distinguished guests from over seas who kindly attended each session and made valuable contributions.

It was during a pleasant and warm (both literally and figuratively) two- week period in October, 1991 that a number of researchers, scholars and c1inicians from diverse lands gathered at the beautiful Chateau de Bonas, near Toulouse, France to discuss psychological, neuropsychological and neurolinguistic aspects of reading and writing disorders. The occasion for the serious disputations of theories, research findings and c1inical appli- cations was the Advanced Study Institute (ASI) under the auspices of the Scientific Affairs Division of the North Atlantic Treaty Organization (NATO). There was much sharing of mutual experiences, and considerable debate on some issues. There were also friendly exchanges, 'international' ping-pong, tennis matches, and bicyc1e races, and even some convivial- ity akin to that of a c1ass reunion with members telling their stories of yesterday and visions of tomorrow. All these serious scientific disputations and the friendly exchanges would not have been possible without the major assistance from NATO and other institutions and individuals. We wish to express our deep appre- ciation to Dr. L. v. da Cunha ofNATO Scientific Affairs Division, Dr. Tilo Kester and Mrs. Barbara Kester of the International Transfer of Science and Technology (ITST) for their active support and substantial assistance throughout the Advanced Study Institute; Mr. Charles Stockman and his staff of the Chateau de Bonas for looking after our stay there; Christi Martin and Xi-Wu Feng of Oklahoma State University, and the University of Saskatchewan generally for facilitating our work.