A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

How should neuroscience, psychology and behavioral genetics impact legal responsibility practices? Recent findings from these fields are sometimes claimed to threaten the moral foundations of legal responsibility practices by revealing that determinism, or something like it, is true. On this account legal responsibility practices should be abolished because there is no room for such outmoded fictions as responsibility in an enlightened and scientifically-informed approach to the regulation of society. However, the chapters in this volume reject this claim and its related agenda of radical legal reform. Embracing instead a broadly compatibilist approach - one according to which responsibility hinges on psychological features of agents not on metaphysical features of the universe - this volume's authors demonstrate that the behavioral and mind sciences may impact legal responsibility practices in a range of different ways, for instance: by providing fresh insight into the nature of normal and pathological human agency, by offering updated medical and legal criteria for forensic practitioners as well as powerful new diagnostic and intervention tools and techniques with which to appraise and to alter minds, and by raising novel regulatory challenges. Science and law have been locked in a philosophical dialogue on the nature of human agency ever since the 13th century when a mental element was added to the criteria for legal responsibility. The rich story told by the 14 essays in this volume testifies that far from ending this philosophical dialogue, neuroscience, psychology and behavioral genetics have the potential to further enrich and extend this dialogue.

In this issue of Neurologic Clinics, guest editors Drs. Doris Kung and Everton A. Edmondson bring their considerable expertise to Outpatient Neurology. Top experts in the field cover key topics such as neck pain; how to read neurophysiology reports for the non-neurophysiologist; trigeminal neuralgia; epilepsy: choosing the best AED for your patient; insomnia: differential diagnosis and treatment options; dementia: management of psychiatric symptoms; and more. Contains 15 relevant, practice-oriented topics including back pain; MS/CNS demyelinating disorders: diagnosis, initial treatment, and prognosis; chronic migraine; post-concussion syndrome; diabetic neuropathies: mononeuritis multiplex, plexopathy, and distal symmetric polyneuropathy; and more. Provides in-depth clinical reviews on outpatient neurology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

A "beautiful and astonishing" (Walter Isaacson, # 1 New York Times bestselling author of The Code Breaker) narrative that examines the many ways to be fully human, told by the first young adult with autism to attend Oxford University as a Rhodes Scholar. As a child, Jory Fleming was wracked by uncontrollable tantrums, had no tolerance for people, and couldn't manage the outside world. Slightly more than a decade later, he was bound for England, selected to attend one of the world's premier universities. How to Be Human is a "profound, thought-provoking" (Barry M. Pizant, PhD, author of Uniquely Human) exploration of life amid a world constructed for neurotypical brains when yours is not. But the miracle of this book is that instead of dwelling on Jory's limitations, those who inhabit the neurotypical world will begin to better understand their own: they will contemplate what language cannot say, how linear thinking leads to dead ends, and how nefarious emotions can be, particularly when, in Jory's words, they are "weaponized." Through a series of deep, personal conversations with writer Lyric Winik, Jory makes a compelling case for logical empathy based on rational thought, asks why we tolerate friends who see us as a means to an end, and explains why he believes personality is a choice. Most movingly, he discusses how, after many hardships, he maintains a deep, abiding faith: "With people, I don't understand what goes in and what comes out, and how to relate," he says. "But I can always reconnect with my relationship with my Creator." Join Jory and Lyric as they examine what it means to be human and ultimately how each of us might become a better one. Jory asks us to consider: Who has value? What is a disability? And how do we correct the imbalances we see in the world? How to Be Human shows us the ways a beautifully different mind can express the very best of our shared humanity.

The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G,, G,, G,, and G12.

Since the appearance of the John O'Keefe and Lynn Nadel book in which they proposed that the hippocampus provides an abstract, internal representation of the animal's environment, considerable conceptual progress in the area of navigational information processing has been achieved. The purpose of the current work is to consolidate recent data and conceptual insights related to navigational insight processing in a format useful to both practitioners and advanced students in neuroscience.

Kernicterus (bilirubin encephalopathy) is a highly interesting example of metabolic encephalopathy. It fills all the characteristics of a metabolic encephalopathy in that it can develop rapidly, produces signature signs and symptoms, and is amenable to successful treatment. In the absence of treatment kernicterus can produce devastating sequelae and death. The present volume will examine the biochemistry and physiology of bilirubin as well as its hepatic metabolism and renal excretion. Chapters will elaborate bodily disposition of bilirubin and its neuropathology. Both early treatments and current therapy will be discussed in detail. Phototherapy will be presented, and its efficacy and influence on incidence thoroughly examined.

This volume includes paradigms, model systems, and techniques for the study of dysfunctions in the nervous system. The advantages and disadvantages of the approaches presented are critically discussed.
Key Features
* Neural injury
* Developmental cell death
* Disease processes and aging

This book is devoted to the study of the functional architecture of the visual cortex. Its geometrical structure is the differential geometry of the connectivity between neural cells. This connectivity is building and shaping the hidden brain structures underlying visual perception. The story of the problem runs over the last 30 years, since the discovery of Hubel and Wiesel of the modular structure of the primary visual cortex, and slowly cams towards a theoretical understanding of the experimental data on what we now know as functional architecture of the primary visual cortex.
Experimental data comes from several domains: neurophysiology, phenomenology of perception and neurocognitive imaging. Imaging techniques like functional MRI and diffusion tensor MRI allow to deepen the study of cortical structures.Due to this variety of experimental data, neuromathematematics deals with modellingboth cortical structures and perceptual spaces.
From the mathematical point of view, neuromathematical call for new instruments of pure mathematics: sub-Riemannian geometry models horizontal connectivity, harmonic analysis in non commutative groups allows to understand pinwheels structure, as well as non-linear dimensionality reduction is at the base of many neural morphologies and possibly of the emergence ofperceptual units. Butat the center of theneurogeometry is the problem of harmonizing contemporary mathematical instruments with neurophysiological findings and phenomenological experiments in an unitary science of vision.
The contributions to this book come from the very founders of the discipline."

I. Introduction: General Issues in Developmental Disorders.- 1 State of the World's Children: Developmental-Behavioral Disorders in a Global Context.- 1. Introduction.- 2. Children in History.- 3. Children Today.- 4. Recent Nutrition Data.- 5. Children Tomorrow.- 6. Conclusions.- References.- 2 PL 99-457: A New Challenge and Responsibility for Physicians.- 1. Introduction.- 2. Physician Involvement.- 2.1. Identification.- 2.2. Medical Evaluation.- 2.3. Communication with the IFSP Team.- 2.4. Family Support.- 2.5. Participation in the IFSP Process.- 2.6. Advocacy.- 3. Barriers to Physician Involvement.- 4. Overcoming Barriers.- Selected Readings.- 3 An Ethical Issue in Developmental Pediatrics: Analysis and Discussion of a Case History.- Case History-S. L., a Newborn with Partial Trisomy-13.- Reference.- Selected Readings: Ethical-Legal Issues.- 4 A Physician's Primer of Developmental and Psychologic Test Instruments.- 1. Introduction.- 2. Possible Developmental Delay.- 2.1. Developmental (Cognitive/Motor) Delay.- 2.2. Language Delay.- 2.3. Behavioral/Adaptive Delays.- 3. Cases Involving Suspected Developmental Delay.- 4. Difficulties in School Performance.- 4.1. Intelligence.- 4.2. Academic Achievement.- 4.3. Perceptual/Visual Motor.- 4.4. Attention/Concentration.- 4.5. Behavioral.- 5. Cases Involving Suspected School Problems.- 6. Conclusions.- References.- II. Developmental Disorders.- 5 Neonatal Brain Care: Does Early Developmental Intervention Work?.- 1. Introduction.- 2. Supplemental Stimulation.- 3. Protection at All Costs.- 4. Contingency-Based and Developmentally-Based Interventions.- 5. Summary.- References.- 6 Early Identification of Cerebral Palsy.- 1. Introduction.- 2. Types of Cerebral Palsy.- 3. Early Clinical Signs of Cerebral Palsy.- 3.1. Amiel-Tison et al. (1977).- 3.2. Ellenberg and Nelson (1981).- 3.3. Harris (1987).- 3.4. Research Conclusions.- 4. Summary.- References.- 7 Movement Disorders and Paroxysmal Behaviors in Children and Adolescents.- 1. Introduction.- 2. Disorders Characterized by Alteration in the State of Consciousness and Abnormal Movements.- 2.1. Seizure Disorders.- 2.2. Pseudoseizures.- 3. Disorders Characterized Primarily by an Alteration in Consciousness.- 3.1. Syncope Due to Inadequate Cerebral.- 3.2. Postural Hypotension.- 3.3. Steal Syndromes.- 3.4. Cardiac Arrhythmias.- 3.5. Breath Holding Spells.- 3.6. Syncope Due to Hypoxia or Hypoglycemia.- 4. Disorders Characterized Primarily by Abnormal Movements.- 4.1. Disorders Characterized by Hyperkinesia.- 4.2. Disorders Characterized Primarily by Abnormalities of Posture and Tone.- 4.3. Disorders Characterized Primarily by Akinesia.- 5. Other Paroxysmal Disorders.- 5.1. Rett Syndrome.- 5.2. Mannerisms.- References.- 8 Epilepsy: Implications for Intelligence, Learning, and Behavior.- 1. Introduction.- 2. Epilepsy and Intelligence.- 3. Epilepsy and Learning Difficulties.- 4. Epilepsy and Childhood Emotional and Behavioral Disorders.- 4.1. Anticonvulsants and Behavior Disorders.- 4.2. Temporal Lobe Epilepsy and Psychiatric Disorders.- 5. Summary.- References.- 9 Learning Disabilities: "The Good News/The Bad News".- 1. Introduction.- 2. Toward a Definition.- 3. Significant Discrepancy.- 4. Research.- 5. The Future.- References.- 10 Lessons I've Learned from Learning Disabilities.- 1. Introduction.- 2. Overlooked Learning Disability.- 2.1. Emotional Disturbance and Underachievement.- 2.2. Headaches and Fatigue.- 3. Miscellaneous Lessons I Have Learned.- 3.1. "Abnormal Depth Perception" in a Clumsy Child.- 3.2. Involuntary Movements with Accompanying Behavioral Upset.- 3.3. Refusal to Speak in an Anxious Child.- 3.4. Cerebral Palsy with Accompanying Depression.- 3.5. Newly Acquired Perceptual Disorder in an Intelligent Child.- 3.6. Situational Depression with a Well-Controlled Seizure Disorder.- 3.7. Acute Psychosis with Temporal Lobe Epilepsy.- 3.8. Declining School Performance and the Misdiagnosis of Seizures.- 3.9. Adolescent Stroke with Com...

This volume is designed to serve as a reference source containing both historical and recent references with a special focus on the existing gaps of knowledge regarding EEG deviations in psychiatricpopulations. Every chapter begins by outlining the clinical issues, then reviews available literature and concludes by highlighting a) currently supportable findings, and b) open research questions. In some chapters the author makes suggestions regarding the research design that will most likely lead to generating data that can move the field towards resolving unresolved issues."

Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret. The breakdown part of protein turnover in vivo, particularly in nervous tissue, was such a subject in the past - it was difficult to measure and difficult to explore the mechanisms involved. For factors that influence protein metabolism, it was thought that protein content, function, and distribution are controlled only by the synthetic mechanisms that can supply the needed specificity and response to stimuli. The role of breakdown was thought to be only a general metabolic digestion, elimination of excess polypeptides. We now know that the role of breakdown is much more complex: it has multiple functions, it is coupled to turnover, and it can affect protein composition, function, and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions: it serves to activate and inactivate enzymes, modulate membrane function, alter receptor channel properties, affect transcription and cell cycle, form active peptides, and much more. The hydrolysis of peptide bonds often involves multiple steps, many enzymes, and cycles (such as ubiquination), and often requires the activity of enzyme complexes. Their activation, modification, and inactivation can thus play an important role in biological functions, with numerous families of proteases participating. The specific role of each remains to be elucidated.

Drug addiction remains one of the most important public health problems in western societies and is a rising concern for developing nations. Over the past 3 decades, experimental research on the neurobiology and psychology of drug addiction has generated a torrent of exciting data, from the molecular up to the behavioral levels. As a result, a new and pressing challenge for addiction research is to formulate a synthetic theoretical framework that goes well beyond mere scientific eclectism to deepen our understanding of drug addiction and to foster our capacity to prevent and to cure drug addiction. Intrigued by the apparent irrational behavior of drug addicts, researchers from a wide range of scientific disciplines have formulated a plethora of theoretical schemes over the years to understand addiction. However, most of these theories and models are qualitative in nature and are formulated using terms that are often ill-defined. As a result, the empirical validity of these models has been difficult to test rigorously, which has served to generate more controversy than clarity. In this context, as in other scientific fields, mathematical and computational modeling should contribute to the development of more testable and rigorous models of addiction.

This book provides a comprehensive overview of the latest research in the role of non-neuronal cells - astrocytes, oligodendrocytes, endothelial cells, pericytes, microglia, and other immune cells in ischemic brain injury and long-term recovery. In these cases, neurodegeneration and brain repair are controlled in a sophisticated system, incorporating interactions between different cell types and cellular systems. Also explored are the therapeutic strategies that target non-neuronal responses after stroke and their translational potentials.

At least one in seven people are thought to be neurodivergent. So what exactly is neurodiversity? What does 'executive functioning' mean? What are 'spiky profiles'? In this simple guide, expert speaker and trainer Daniel Aherne provides a clear introduction to neurodiversity and the four most common neurodivergent identities of autism, ADHD, dyslexia and dyspraxia. Using an analogy of a cactus needing a desert to grow in, he emphasises the importance of getting the environment right for neurodivergent people, rather than expecting them to adapt to the neurotypical world. Daniel, who himself has ADHD, also explains how neurodivergent people often have great strengths alongside areas of difficulty, and writes about the interplay between diagnoses, as well as unpacking tricky concepts such as working memory, sensory processing, communication differences and more. Busting common misconceptions and setting out simple tips and guidance for supporting the neurodivergent people around you, whether among your family, friends or at your school, college or workplace - or if you yourself are ND and want to improve the understanding of others - this essential guide will help us all celebrate neurodiversity and foster more inclusive communities.

The main message of this monograph is that the appearance of the mammalian brain with the ability to acquire drives ensured the development of social life, and eventually led to the evolution of the human society. This most sophisticated form of organized life on earth is still in the trial and error phase of its development. It seeks to outgrow the myth-directed era of its history and come to its final state, the ration-directed human society.

In this volume contemporary methods designed to provide insights into, mathematical structure for, and predictive inferences about neuroendocrine control mechanisms are presented.
Key Features
* Collates an array of contemporary techniques for analysis of neuroendocrine data
* Discusses current problems in and solutions to neurohormone pulse analysis
* Identifies relevant software available

How does the brain code and process incoming information, how does it recog nize a certain object, how does a certain Gestalt come into our awareness? One of the key issues to conscious realization of an object, of a Gestalt is the attention de voted to the corresponding sensory input which evokes the neural pattern underly ing the Gestalt. This requires that the attention be devoted to one set of objects at a time. However, the attention may be switched quickly between different objects or ongoing input processes. It is to be expected that such mechanisms are reflected in the neural dynamics: Neurons or neuronal assemblies which pertain to one object may fire, possibly in rapid bursts at a time. Such firing bursts may enhance the synaptic strength in the corresponding cell assembly and thereby form the substrate of short-term memory. However, we may well become aware of two different objects at a time. How can we avoid that the firing patterns which may relate to say a certain type of move ment (columns in V5) or to a color (V 4) of one object do not become mixed with those of another object? Such a blend may only happen if the presentation times be come very short (below 20-30 ms). One possibility is that neurons pertaining to one cell assembly fire syn chronously. Then different cell assemblies firing at different rates may code different information."

Clinical Neurology of Aging, Third Edition continues the tradition of the First (1984) and Second (1994) editions with 60 chapters written by the world's elite clinicians from neurology, geriatrics and research on all aspects of geriatric neurology. Aging does not automatically imply decline. Many older people find joy in their friendships and their willingness to look at the world with a calmer view than they may have had in youth. This clinically focused book is designed to help clinicians help older persons maintain that joy. Now divided into 9 comprehensive sections, the Third Edition contains subjects ranging from geriatric assessment to pain management and palliative care. Specific sections include: Introduction to Geriatric Neurology; Neurological Assessment in Aging; Cognitive Disorders in Aging; Motor Disorders in Aging; Neuropsychiatric Illness in Aging; Sensory Disturbance in Aging; Peripheral Neurology of Aging; Disease States in Elderly; and Neurological Therapeutics. With a deft touch, the editors - Drs. Martin Albert and Janice Knoefel - have incorporated the geriatric care perspective and a quality-oriented approach to health care throughout the volume. The result: the definitive reference, useful for all clinicians caring for older people and informative to those who set policies that affect research and clinical practice.

The therapeutic era for MS has begun, and many new, potentially effective treatments are now available. MRI offers a range of techniques which are more reliable and sensitive than any other available approach in detecting brain and spinal cord abnormalities, monitoring their evolution, and providing in vivo information about heterogenous pathological substrates of the MS lesions. Readers will find this volume a valuable summary of the state-of- the art, as well as a useful reference text from which to plan future clinical trials in MS.

This book breaks new ground by offering neuroscientific insights into post-traumatic stress disorder (PTSD). PTSD has emerged as the model mental disorder for studying the effect of the environment on human biological systems, especially the brain. The authors - who range from skilled basic scientists to experienced diagnosticians and therapists - are leaders in the recent surge of biological investigation into this distressing and disabling condition.