G Protein Methods and Protocols - Role of G Proteins in Psychiatric and Neurological Disorders (Hardcover, 1997 ed.)

The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G,, G,, G,, and G12.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Neuromethods, 31
Release date:	July 1997
First published:	1997
Editors:	Ram K. Mishra • Glen B. Baker • Alan A. Boulton
Dimensions:	235 x 155 x 28mm (L x W x T)
Format:	Hardcover
Pages:	433
Edition:	1997 ed.
ISBN-13:	978-0-89603-490-7
Categories:	Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology Books > Medicine > Other branches of medicine > Psychiatry Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
LSN:	0-89603-490-9
Barcode:	9780896034907

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