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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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G Protein Methods and Protocols - Role of G Proteins in Psychiatric and Neurological Disorders (Hardcover, 1997 ed.)
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G Protein Methods and Protocols - Role of G Proteins in Psychiatric and Neurological Disorders (Hardcover, 1997 ed.)
Series: Neuromethods, 31
Expected to ship within 18 - 22 working days
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The G proteins are a family of structurally homologous, plasma
membrane-associated guanine-nucleotide-binding proteins. These
proteins play an integral role in the tra- duction of extracellular
signals through second messenger systems. As such, G proteins
affect a wide variety of intra cellular biochemical reactions by
regulating the concent- tion of second messengers in cells. G
proteins are heterotrimeric, consisting of a, p, and y polypeptide
chains, with G protein specificity largely det- mined by the
a-subunit, Molecular cloning of G protein s- units has revealed 23
distinct a-subunits, encoded by 17 different genes. Based on
functional measures, G proteins are generally classified into three
major categories: the G, family, which is stimulatory for adenylyl
cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase;
and the G, f- ily, which stimulates phospholipases (Birnbaumer and
Birnbaumer, 1995). Alternatively, on the basis of sequence
homology, G proteins can be subdivided into four cate- ries: G,,
G,, G,, and G12.
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