A comprehensive, state-of-the-art review of our current
understanding of the molecular and structural biology of 5-HT
receptors and their potential use for drug discovery. The authors
describe the anatomical, cellular, and subcellular distribution of
5-HT receptors and demonstrate a powerful approach to elucidating
their physiological role using knockout mice in which the 5-HT
receptors were deleted. They also review our understanding of the
physiological role(s) of 5-HT receptors based mainly on studies
performed in genetically engineered mice. Highlights include
discussions of the behavioral phenotypes of 5-HT receptor knockout
animals, the molecular biology and pharmacology of 5-HT receptors,
and insights into the complexity of 5-HT receptor signal
transduction.
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