"This is clearly the most authoritative and contemporary statement
of current knowledge yet published."
from the Foreword by H. Sarnat
Tuberous sclerosis is the prototype of a category of
malformations uniquely characterized by disturbances in cellular
differentiation and growth. It presents with a complex association
of different neurological phenotypes, including seizures, cognitive
impairments and autism. It is important not only because it is a
relatively common hereditary neurological disease with high
morbidity, but because it has implications in other pathological
processes, such as dysplasia and neoplasia, hamartoma formation and
other disturbances in morphogenic processes.
This book correlates new genetic data and basic science, covers
clinical presentation, reviews the historical background and
current diagnostic criteria, and deals with the recent advances in
neuropathology, molecular genetics and neurobiology which give a
better understanding of the pathogenesis of the disease.
Paediatricians and child neurologists will find this book
uniquely useful.
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