This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.

2 3 4 5 6 7 8 9 1011 1 2 3 4111 This book provides coverage of a broad range of topics in the ?eld of neurosurgery, 5 for residents and registrars in training and for recent graduates of training programs. 6 As neurosurgical training incorporates expertise from centers worldwide, there is a 7 need to have input from specialists in neurosurgery from various countries. This text 8 is a compilation by expert authors in the USA and the UK to provide information on 9 the basic knowledge and clinical management required for optimal care of neuro- 2011 surgical patients. 1 The text is an up-to-date synopsis of the ?eld of neurosurgery from American and 2 British perspectives, which covers the most common clinical conditions encountered 3 by neurosurgeons. The chapters are organized under broad topics, including inves- 4 tigative studies, perioperative care, the role of newer techniques and the management 5 of tumors, vascular and traumatic lesions. Additional topics are then covered, includ- 6 ing pediatrics, spine and peripheral nerve lesions, as well as functional neurosurgery 7 and infections. We anticipate that trainees will ?nd this information useful for certi?- 8 cation examinations and recent graduates of neurosurgical training programs can 9 utilize this text as an update of the most important neurosurgical topics.

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book's final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer's Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson's Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.

The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international forum for the latest scientific discoveries, medical practices and care initiatives. Advanced information technologies will be discussed concerning the various research, implementation and policy, as well as European and global issues in the funding of long-term care and medico-social policies regarding elderly people. GeNeDis 2014 takes place in Corfu Greece, 10-13 April 2014. This volume focuses on the sessions from the conference on computational biology and bioinformatics.

Nicotine is almost universally believed to be the major factor that motivates smoking and impedes cessation. Authorities such as the Surgeon General of the USA and the Royal College of Physicians in the UK have declared that nicotine is as addictive as heroin and cocaine. This book is a critique of the nicotine addiction hypothesis, based on a critical review of the research literature that purports to prove that nicotine is as addictive drug. The review is based on a re-examination of more than 700 articles and books on this subject, including animal and human experimental studies, effects of nicotine replacement therapies', and many other relevant sources. This review concludes that on present evidence, there is every reason to reject the generally accepted theory that nicotine has a major role in cigarette smoking. A critical examination of the criteria for drug addiction demonstrates that none of these criteria is met by nicotine, and that it is much more likely that nicotine in fact limits rather than facilitates smoking.

Contents:
Anger Disorders: Basic Science and Practice Issues. Diagnosis of Anger Disorders. Measuring the Experience, Expression and Control of Anger. A Behaviour-Analytic View of Anger and Aggression. Cross-Cultural Perspectives on Anger. Anger and Criminality. Evaluation of Treatment Strategies for Adult Anger Disorders. Developing the Therapeutic Alliance with Angry Clients. Ideal Treatment for Adults with Anger Disorders. Ideal Treatment Package for Children and Adolescents with Anger Disorders. Conclusions and a Look to the Future.

If one envisages neuroscience as a pyramid, with the more mole- lar disciplines forming the base and the more integrative d- ciplines positioned above, then neuropsychology clearly would be near the tip. Neuropsychology seeks to find order in the ultimate product of all neural systems, namely behavior, and to relate that product to its neural substrate. Relationships between brain and behavior are sought, but reductionistic explanations are eschewed. Attempting to "explain" complex behaviors in terms of neuronal activity is no more satisfying than attempting to "explain" artificial intelligence in terms of voltages within a computer's central pr- essing unit. If one is to comprehend the functioning of either the brain or the digital computer, one must know something about not only the structure and mechanics of the device, but also the prin- ples according to which components of the device are organized and the context in which the device is operating (e.g., environm- tal inputs and stored information).

Until recent advents in neuroimaging, the brain had been inaccessible to in vivo visualization, short of neurosurgical procedures or some unfortunate traumatic exposure. It is a tribute to the early contributors to clinical neuroscience that through what, by today's standards, would be deemed extremely crude measure ments, advancements in understanding brain function were made. For example, the theories of higher cortical functions of the brain by Aleksandr Luria or Hans-Lukas Teuber in the 1950s were essentially based on military subjects who sustained traumatic head wounds during World War II. These researchers could inspect the patient and determine where penetrating entrance and exit wounds were on the head; sometimes they had skull films to identify entrance and exit fracture wounds, sometimes neurosurgical reports were available, and Luria even had the opportunity to acutely examine some patients with exposed wounds. Thus, one would take whatever information might be available and infer what regions of the brain were involved but could never actually visualize the brain. Of course, this changed dramatically with the introduction of brain imag ing in the 1970s, but it really was not until the 1990s that analysis and image display technologies finally caught up with the basic brain-imaging methods of computerized tomography (CT) and magnetic resonance imaging (MRI).

This book describes the state-of-the-art of treatment of schizophrenia and reflects its development in 22 chapters written by leading authorities in the field

A number of diseases and conditions that occur primarily in remote rural or poor urban areas of low-income countries have traditionally been neglected by the neuroscience research community. These diseases and conditions affect the nervous system directly (sometimes with lethal consequences) and/or are associated with severe neurological sequels such as epilepsy, cognitive deficits, and sleep disruption. Several diseases also have the effect of promoting poverty by leaving sufferers unable to lead economically productive lives due to cognitive and behavioral disturbances or severe stigmatization. The pathogenesis of neural dysfunction in the diseases addressed in this book and their sequels remains unclear. Neuroscience of Neglected Diseases and Conditions makes available much needed information about how these diseases affect the human nervous system as well as to promote interest in further research. Further research into neglected diseases and conditions will uncover information that sheds light on more general topics of interest to the neuroscience research community.

Principles and Practice of Clinimetrics in Epilepsy; A.R. Feinstein. Statistical Aspects of the Measurement of Clinical Care in Epilepsy; A.L. Johnson. Seizure Frequency as Treatment Effect Parameter; M.W. Lammers, H. Meinardi. Seizure Severity as Treatment Effect Parameter; C. Viteri, J.M. MartinezLage. Quatitative Approaches to Seizure Severity; J.A. Cramer, R.H. Mattson. Health Status in Epilepsy Care; A. Kazis, S. Bostantjopoulou. Drug Choice and Replacement; D.G.A. Kasteleijn-Nolst Trenite. Individualization of Antiepileptic Drug Therapy; Y.A. Hekster, et al. On the Reporting of Adverse Drug Effects; M.W. Lammers, H. Meinardi. Quatitative Assessment of Adverse Drug Effects; R.H. Mattson, J.A. Cramer. Conventional and Clinimetric Approaches to Individualization of Anitepileptic Drug Therapy; J.S. Duncan. Psychosocial Consequences of Epilepsy; J. Vermeulen, R. Canger. 9 additional articles. Index.

A panel of leading experts integrate the latest findings from basic and clinical science to create a comprehensive treatment of the processes by which the brain acts as an endocrine organ, not only to control hormonal functions, but also to maintain homeostasis and regulate behavior. The authors-recognized both as leaders in their fields and as skilled teachers-provide systematic coverage of the analytical, anatomical, functional, clinical, and pathological aspects of neuroendocrinology. Topics range from the interactions between the nervous and endocrine systems to the regulation of reproduction, development, metabolism, fluid balance, and biological rhythms. Neuroendocrinology in Physiology and Medicine offers an unprecedented marriage of clinical and basic knowledge that has been missing from classical neuroscience, endocrinology, and physiology texts. It will teach today's medical students and serve researchers as a valuable reference to this rapidly growing field.

Migraine disease affects millions. Murray, a nurse and former college professor, shows readers how to develop their own wellness plan and regain control of their lives. This book explains how to reduce the frequency and severity of migraine attacks, break the cycle of medication dependence, identify triggers and headache types, create an integrative approach by combining eastern therapies (yoga, meditation, biofeedback and reflexology) with conventional western medical approaches (physical therapy, chiropractice) to heal and eliminate migraines. Murray explains the cause of the disease, where it comes from and the difference between primary and secondary headache types, along with the impact of injuries and diseases that may occur alongside migraine disease. Emphasis is on treatment of the whole person and the role of the individual in one's health care plan. Her plan includes advice on how to identify one's triggers, plus the foods, supplements, bodywork, meditation and guided imagery techniques and lifestyle adjustments that can help reduce or eliminate migraine onset. Tables and charts provide at-a-glance reference points.

Emphasizing the clinical problems surrounding urogenital tract dysfunction, this up-to-date reference details the basic science, differential diagnosis, and treatment of a wide range of neurourological conditions.
Covering recent advances in the neurobiology of the pelvic organs, the Handbook of Neuro-Urology
reviews the neural control processes that govern pelvic organs
discusses the pathogenic mechanisms behind neurological and smooth muscle disorders that produce bladder dysfunction
describes the management of impaired bladder, bowel, and sexual function after brain damage and spinal cord injury
examines various conditions that affect the autonomic nervous system and specifically result in bladder and sexual dysfunction
investigates lower urinary tract function in the elderly
suggests practical measures to manage urinary incontinence such as the use of pads, underpants, and appliances
and more!

The impetus for the present volume was provided by a European conference held at St. Martens Latem (Belgium) in September 1994 and sponsered by the Directorate General XII (Science, Research and Development) of the European Commission. Preparation of the volume was also financially supported by the Direc- torate General. The editor, the contributors and all the participants in the conference are grateful to the European Commission for the generous help received. vii CONTRIBUTORS Hennann ACKERMANN, Department of Neurology, University of Ttibingen, 3 Hoppe- Seyler-StraBe, 72076 Tiibingen (Gennany). Henny BIJLEVELD, Philologie Germanique, Faculte de Philosophie et Lettres, Universite Libre de Bruxelles, 50 avo F. Roosevelt, 1050 Brussels (Belgium). Veronique CAPPAERT, University Hospital Ghent, 2PI Centrum voor Gehoor- en Spraakrevalidatie, 185 De Pintelaan, 9000 Gent (Belgium). Patrick COPPENS, Speech-Language-Hearing Sciences, Moorhead State University, Moorhead, MN 56563 (USA). Jeanine DELEVAL, Department of Neurology, University Hospital 'Erasme', 808 Route de Lennik, 1070 Brussels (Belgium). Christine EECKHAUT, University Hospital Ghent, 2PI Centrum voor Gehoor- en Spraakrevalidatie, 185 De Pintelaan, 9000 Gent (Belgium). Ingo HERTRICH, Department of Neurology, University of Ttibingen, 3 Hoppe-Seyler- StraBe, 72076 Ttibingen (Gennany). Margaret LEAHY, Clinical Speech and Language Studies, Trinity College, Dublin 2 (Ire- land). Yvan LEBRUN, Neurolinguistics Department, School of Medicine VUB, 103 Laar- beeklaan, 1090 Brussels (Belgium). Nadine MOREAU, Laboratoire de Neuropsycholinguistique Jacques Lordat, Departement des Sciences du Langage, Universite de Toulouse-Le Mirail, 5 allee A. Machado, 31058 Toulouse Cedex (France).

This book shows how neuromarketing works in practice. It describes how companies can use the methods and insights of neuroscience to make better decisions themselves. It brings together real-world use cases in the area of applied neuroscience, collected from the globally leading consumer neuroscience companies and their clients. The use cases come from a variety of business areas, from advertising research to store design, from finding the right name for a brand to designing a compelling website. The book reveals how clients engage in neuromarketing; the business problems they can encounter, and have encountered, solving with this new approach; and the values they generate.

This volume offers guidelines for managing the therapist-patient relationship during crisis intervention and longer-term therapy with patients who exhibit borderline symptoms. Since to do no harm is the primary goal of any therapist who encounters such a patient, an appropriate therapist-patient relationship is crucial; moreover, skillful management of this relationship can, in itself, be the most effective and safe treatment. The authors present a conceptual model, based on self psychology and interpersonal theory, for reframing the borderline symptoms and the therapist's reactions. Case examples demonstrate effective relationship management and therapeutic interventions.

Related link: Free Email Alerting

In Motor Activity and Movement Disorders thirteen state-of-the-art articles explicate forefront research methodologies for measuring and interpreting motor activity in animals, as well as their applications to preclinical and clinical research involving motor disorders. The contributors emphasize motor asymmetries, turning behavior, and dyskinetic movements. They also present a variety of quantitative approaches designed to assess specific aspects of motor activity and illustrate numerous computerized measuring techniques that permit detailed and objective approaches to quantifying motor behavior.
Motor Activity and Movement Disorders will contribute to a greater understanding of brain-behavior relationships through its focus on methodology and its application to current animal models and to human disorders.

Accumulation on glia is an active pathological element in many neurological disorders. Gliosis produces neuroinflammation through both neurotrophic and inflammatory means, but the exact mechanism through which this happens remain unclear. It is suspected that damage to neurons activates the growth of glial cells. The proposed book focuses on the interaction between neurons and glia to help elucidate the pathophysiology of neuroinflammation in neurological disorders.

The sexual abuse of children is now seen as an enormous problem; first, because there is an increasing awareness that it is more prevalent than previously thought, and second, because it gives rise to so many complex questions. How is sexual abuse to be defined? What are the effects of abuse? How can the victim be helped? How can abuse be prevented? These two comprehensive volumes cover a wide spectrum of basic and applied issues. Expert contributors -- including physicians, attorneys, psychologists, philosophers, social workers, and engineers -- address such relevant topics as epidemiology, animal models, legal reforms, feminist scholarship, child pornography, medical assessment, and diverse models of psychotherapeutic intention.

The sexual abuse of children is now seen as an enormous problem; first, because there is an increasing awareness that it is more prevalent than previously thought, and second, because it gives rise to so many complex questions. How is sexual abuse to be defined? What are the effects of abuse? How can the victim be helped? How can abuse be prevented? These two comprehensive volumes cover a wide spectrum of basic and applied issues. Expert contributors -- including physicians, attorneys, psychologists, philosophers, social workers, and engineers -- address such relevant topics as epidemiology, animal models, legal reforms, feminist scholarship, child pornography, medical assessment, and diverse models of psychotherapeutic intention.

Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.