Brain Control of Wakefulness and Sleeping explores the history of efforts to understand the nature of waking and sleeping states from a biological point of view. This research represents the synthesis of the work of two individuals who have devoted their careers to investigating the mysterious states of the mind. This landmark book will interest the beginner scientist/researcher as well as the sleep clinician, with chapters on subjects including Neuronal Control of REM Sleep, Motor Systems and the Role of Active Forebrain, and Humoral Systems in Sleep Control. The authors explore the behavioral and physiological events of waking and sleep, analyzing the current realities and the future possibilities of unifying basic studies on anatomy and cellular psychology.

A fascinating account by one of the world's leading neurologists of the profound influence of William Burroughs on his medical career. Lees relates how Burroughs, author of Naked Lunch and troubled drug addict, inspired him to discover a ground-breaking treatment for Parkinson's Disease. Lees journeys to the Amazonian rainforest in search of cures for Parkinson's Disease, and through self-experimentation seeks to find the answers his patients crave. He enters a powerful plea for the return of imagination to medical research.

Use of psychotropic drugs has come to dominate clinical practice in psychiatry worldwide-perhaps owing largely to perceived simplicity, ease of use, and apparent efficiency, as well as apparent cost-effectiveness of such treatments. Nevertheless, medicinal treatments for patients with psychiatric disorders are but one component of comprehensive clinical care of complex human problems. Extensively updated since its second edition in 1985, "Chemotherapy in Psychiatry," "Third Edition, " again addresses basic aspects of modern psychopharmacology and clinical applications of drugs used in the treatment of major psychiatric disorders, with major emphasis on psychotic, bipolar, and depressive disorders. The presentation covers descriptions of the main classes of psychotropic drugs, selected information concerning their known action mechanisms and metabolic disposition, and their clinical applications for acute illnesses and to prevent recurrences and long-term morbidity. Also covered are limitations and adverse effects of each type of agent, with emphasis on the fact that all psychotropic medicines have adverse effects that range from annoying to potentially lethal." Chemotherapy in Psychiatry, Third Edition, " outlines the need to balance benefits and risks at the level of individual persons. Authoritative, and an important contribution to the literature, "Chemotherapy in Psychiatry, Third Edition" is an invaluable resource for physicians, scientists, trainees, and policymakers. "

Dr Jennifer Bute is in considerable demand as a speaker, and has been the subject of a number of features in the press and the electronic media. She is comfortable with being interviewed.

The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7-9 years, and the "success" rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement.

This volume provides a comprehensive overview of the methodology, physiology, and contemporary and novel applications of cerebrovascular reactivity (CVR) measurements. The chapters in this book cover topics such as an introduction of the neurophysiology, neuroimaging, and clinical methods for CVR measurement; the use of CVR methods in the study of aging, cerebrovascular dysfunction, dementia, and brain tumors; and recommendations for measurement protocols and future applications in clinical translation. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation. Thorough and comprehensive, Cerebrovascular Reactivity: Methodological Advances and Clinical Applications is a valuable tool that provides researchers in neuroscience and neurology with the latest resources on the measurement, interpretation, and application of CVR measurement.

Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis. "Animal Models of Brain Tumors" brings together developments and discoveries in in vivo experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism. Written for the popular "Neuromethods "series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results.

Authoritative and cutting-edge, "Animal Models of Brain Tumors" provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments."

This detailed book examines the main methods to study mammalian monoamine oxidases (MAOs), ranging from cell biology to computational chemistry. Beginning with techniques on how to obtain pure samples of MAO A and MAO B, the volume continues by covering assays and techniques used to measure MAO enzymatic activity and perform inhibition studies, methods to address cellular localization and function of MAOs, either in cell lines or in animal models, as well as computational methods applied to rational drug design approaches that are used to develop new MAO inhibitors. Written for the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Monoamine Oxidase: Methods and Protocols serves as a vital resource for scientists who are interested in studying MAOs and other similar amine oxidase enzymes.

Serendipitous discovery has played an important role m the identification of physiological mechanisms in central and peri- eral neurotransmission. In many cases, the subsequent followup of these discoveries has been substantially aided by previouslyiden- fied natural substances that interfered with these mechanisms. The site of neuromuscular blockade produced by curare extracts, for example, was shown in the 1850s by Claude Bernard, and Sir Henry H. Dale m 1906 discovered the reversal of the pressor effects of adrenal extracts by ergot alkaloids. These findings were the first clues that led eventually to the definition of mcotinic cholinergic receptors and the present classification of adrenergic receptors. In the 1950s many discoveries, including the identification of the catecholamines and 5-hydroxytryptamine in the central n- vous system, followed by the development of specific sensitive biochemical and histochemical methods and the introduction of modern psychotropic drugs led to our increased understanding of chemical transmission and the formulation of theories that attempt to explain the causes of some mental disorders. The finding that hydroxylated derivatives of noradrenaline and- hydroxytryptamine are readily taken up by catecholaminergic or serotonergic neurons, and that this is followed by poisoning and death of the cell, encouraged the use of these compounds for the mapping of central and peripheral catecholamine or- hydroxytryptamine systems, and the mvestigation of the re- vance of these pathways to receptor regulation or behavioral - sponses.

The Springer Handbook of Auditory Research presents a series of synthetic reviews of fundamental topics dealing with auditory systems. Each volume is independent and authoritative; taken as a set, this series will be the definitive resource in the field. This volume contains a coherent collection of synthetic reviews on the vestibular system: the component of our auditory and nervous systems that is responsible for our sense of balance. This volume will be of interest to neuroscientists and otolaryngologists involved in studying the vestibular and auditory senses.

Neurodevelopmental disorders encompass a group of conditions that can typically manifest during early childhood. These include intellectual disabilities, communication disorders, autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), specific learning disorder (SLD), and motor disorders. Early identification and assessment can be a valuable tool in determining diagnosis, prognosis, functional abilities, and formulating clinical intervention for both children and adults with neurodevelopmental disorders. Emerging Trends in the Diagnosis and Intervention of Neurodevelopmental Disorders is an essential reference source that discusses and disseminates contributions covering recent trends in diagnosis, assessment, and intervention techniques. Featuring research on topics such as clinical linguistics, neural connectivity, and animal-assisted therapy, this book is ideally designed for speech pathologists, social workers, occupational therapists, psychologists, psychiatrists, neurologists, pediatricians, researchers, clinicians, and academicians seeking coverage on neural and developmental disorder identification and strategies for clinician support and therapies.

The "Encyclopedia of the Neurological Sciences, Second Edition" develops from the first edition, covering all areas of neurological sciences through over 1000 entries focused on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. The contributing authors represent all aspects of neurology from many viewpoints and disciplines to provide a complete overview of the field. Entries are designed to be understandable without detailed background knowledge in the subject matter, and cross-referencing and suggested further reading lead the reader from a basic knowledge of the subject to more advanced understanding.

The easy-to-use 'encyclopedic-dictionary' format of the "Encyclopedia of the Neurological Sciences, Second Edition" features alphabetic entries, extensive cross-referencing, and a thorough index for quick reference. The wealth of information provided by these four volumes makes this reference work a trusted source of valuable information for a wide range of researchers, from undergraduate students to academic researchers.
Provides comprehensive coverage of the field of neurological science in over 1,000 entries in 4 volumes "Encyclopedic-dictionary" format provides for concise, readable entries and easy searching Presents complete, up-to-date information on 32 separate areas of neurology Entries are supplemented with extensive cross-referencing, useful references to primary research articles, and an extensive index

Depression ranks as a leading mental health problem among Hispanic immigrants and their US-born children. And a wide array of issues - starting with the widespread stereotype of the "illegal immigrant" - makes the Latino experience of this condition differ from that of any other group. Depression in Latinos consolidates the conceptual, diagnostic, and clinical knowledge based on this salient topic, providing coverage from prevalence to prevention, from efficient screening to effective interventions. In this concise yet comprehensive volume, leading clinicians, researchers, and academics offer extensive research and clinical findings, literature reviews (e.g., an in-depth chapter on the Mexican American Prevalence and Services Survey), and insights gathered from first-hand experience in clinical practice. Perceptive information is offered on the most urgent and complex issues on depression in this diverse and dynamic population, including: (1) The impact language, culture, and societal factors have on depression and its diagnosis. (2) The most relevant assessment instruments. (3) How depression manifests among Latino children, youth, and seniors as well as in Latinas. (4) The relationship between depression and substance abuse. (5) The most effective evidence-based treatment methods. (6) The efficacy of interventions for depression at the community level. Depression in Latinos is vital reading for clinicians, counseling and school psychologists, psychiatrists, clinical social workers, and public health professionals interested in providing their Hispanic clients with the most effective treatment possible. In addition, its coverage of the broader issues of access to care makes this volume essential reading for mental health administrators, volunteer/outreach agencies, and policymakers.

For centuries the great minds of medical science puzzled over the importance of the cerebrospinal fluid. As far back as Hippocrates, it was thought that this "phlegm" that flooded the intracranial contents had pathological significance. However, not until the late 1800s, when Quincke introduced and popularized lumbar puncture, did physicians take an interest in the study of this fluid in relation to clinical illness. Since then a variety of techniques for obtaining cerebrospinal fluid from various sites have developed, and the relationship of cerebrospinal fluid to a variety of disease processes has received considerable study. In this volume, we have attempted to assemble reviews of some of these important developments during the past century. Chapter 1 contains a historical review of key investigations that helped shape our concepts of cerebrospinal fluid from the earliest recorded description by the author of the Edwin Smith Surgical Papyrus in the seventeenth century B. C. to contemporaries such as Kabat, Glusman, and Knaub, who introduced quantitative determinations of cerebrospinal fluid gamma globulin levels. In Chapter 2 there is a description of our current understanding of the anatomical compartment for the cerebrospinal fluid and the physiology of its formation, circulation, and absorption. Dr. Richard Leech in Chapter 3 contributes a comprehensive description of the disorders associated with excessive quanti ties of cerebrospinal fluid-commonly referred to as hydrocephalus. A variety of techniques for properly collecting and evaluating cerebrospinal fluid are detailed in Chapter 4.

In this book, experts in the field discuss the latest research in developmental neuroendocrinology. Given that the hypothalamus is the center of neuroendocrine activity, the reader will learn about the molecular specification of hypothalamic cells, developmental modulators and epigenetic factors influencing hypothalamic development, and the development of neuroendocrine circuits. Each chapter provides a concise review of the current and future perspectives in developmental neuroendocrinology. Important insights into state-of-the-art techniques applied to functional circuit tracking, lineage tracing of hypothalamic cells, and the identification of genes altered through epigenetic mechanisms are also provided. Given its scope, the book will appeal to all students and researchers who are eager to understand the processes involved in hypothalamus development and the establishment of neuroendocrine circuits. This is the ninth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series* that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. *Volumes 1-7 published by Wiley.

This book discusses the contemporary medico-social, psychological, legal, and therapeutic concerns related to people affected by dementia as a patient or as a caregiver. It provides global emerging responses to dementia. It highlights different dimensions of dementia in terms of issues, concerns, policies, and strategies all around the globe. The contributing authors present issues from cross-cultural education visible in dementia studies and discuss the power of music, art therapy, artistic collaborations, and many innovative practices in dealing with dementia. Written by international specialists from various disciplines, the chapters include challenges and emerging issues related to the role of family caregivers, the concern with vulnerability to elder abuse and neglect, and the role of technology in dementia care. The book provides a diverse perspective to dementia care not covered in such a broad way by any other books on the topic. This book is intended for academics from a wide range of fields such as sociology, geriatrics, community medicine, public health, clinical psychology, social work all of which, collectively, bear on the problem and the solutions for better dementia care.

This book focuses on current applications of glial cells in neural regeneration, especially in spinal cord repair. It introduces the application of a few types of glial cells including oligodendrocyte, astrocyte, Schwann cells, and stem cell derived glial cells in neural regeneration. The latest glial cell research with biomaterials, gene modification, and electrical signals is also summarized. This is an ideal book for undergraduate and research students in tissue engineering, neurobiology, and regenerative medicine as well as researchers in the field.

Now in its third edition, Stronger After Stroke puts the power of recovery in the reader's hands by providing simple-to-follow instructions for reaching the highest possible level of recovery. The book's neuroplastic recovery model stresses repetition of task-specific practice, proper scheduling of practice, setting goals, and measuring progress to achieve optimal results. Researcher Peter G Levine breaks down the science and gives survivors evidence-based tools to retrain the brain and take charge of recovery. In easy-to-read sections, Stronger After Stroke introduces readers to leading-edge stroke recovery information while simplifying the process to attain specific benchmarks. Also included is a sample recovery schedule, a helpful glossary of frequently used stroke recovery terms, and a list of resources for readers to research emerging stroke recovery options. The new Third Edition of Stronger After Stroke features: Complete update of all chapters to reflect new knowledge about maximizing recovery The latest research insights applied to individual recovery programs Steps to cope with challenges at each stage of recovery and achieve success DIY strategies to save time and money New chapters on using electrical stimulation, reducing post-stroke pain, and understanding spasticity

This volume contains up-to-date contributions written by leading experts in the role played by various microorganisms in psychiatric and neurological illness. The initial chapters present an evolutionary framework for the impact of microorganisms on behavior. This is followed by historical and epidemiological perspectives of the role of viruses in psychiatric illness. Subsequent chapters focus on different classes of microorganisms and psychiatric illnesses and emphasize diverse research approaches ranging from preclinical models to therapeutic interventions.

Over the past thirty years, with improvements in optics, electronics, and computer technology, great strides have been made in the quantitative analysis of the visual system. A number of books on eye movement research have been written that have dealt with specific aspects of either eye movement control. However, none of these books provide a comprehensive overview of multiple aspects of the visual system. Moreover, few of these books contain modeling and detailed quantitative analyses of the visual system. Further, since the major books are almost ten years old, there is a need for an update to include the most recent research findings. It is with these considerations in mind that we have carefully compiled this updated, comprehensive, and quantitative model-based edited book on various components of the visual system. Some of the best vision scientists in the world in their respective fields have contributed to chapters in this book. They have expertise in a wide variety of fields, including bioengineering, basic and clinical visual science, medicine, neurophysiology, optometry, and psychology. Their combined efforts have resulted in a high quality book that covers modeling and quantitative analysis of optical, neurosensory, oculomotor, perceptual and clinical systems. It includes only those techniques and models that have such fundamentally strong physiological, control system, and perceptual bases that they will serve as foundations for models and analysis techniques in the future. The book is aimed first towards seniors and beginning graduate students in biomedical engineering, neurophysiology, optometry, and psychology, who will gain a broad understanding of quantitative analysisof the visual system. In addition, it has sufficient depth in each area to be useful as an updated reference and tutorial for graduate and post-doctoral students, as well as general vision scientists.

There is an increasing demand for high-standard fetal and infant neuropathology examinations. Novel imaging techniques, development of new diagnostic methods and advances in genetics have stimulated the interest in gaining additional knowledge on developmental, perinatal and neonatal neuropathology. Approaching the subject from a practical standpoint, diagnostic templates for reports are provided in this essential guide to aid clinicians with different areas of expertise. Each chapter will includes numerous high-quality images, accompanied by explanatory legends from the authors' own experiences. Covering autopsy and tissue processing techniques, the authors discuss a range of disorders such as neural tube defects, brain tumours, storage disorders and many others. This book provides access to an online version on Cambridge Core, which can be accessed via the code printed on the inside of the cover. Compiling the latest advances in fetal and infant diagnostics and care, this book is a highly valuable educational resource.

The book explores the lived reality of parenting and caring for children with autism in contemporary urban India. It is based on a qualitative, ethnographic study of families of children with autism as they negotiate the tricky terrain of identifying their child s disability, obtaining a diagnosis, accessing appropriate services and their on-going efforts to come to terms with and make sense of their child s unique subjectivity and mode of being. It examines the gendered dimensions of coping and care-giving and the differential responses of mothers and fathers, siblings and grandparents and the extended family network to this complex and often extremely challenging condition. The book tackles head on the sombre question, What will happen to the child after the parents are gone ? It also critically examines the role of the state, civil society and legal and institutional frameworks in place in India and undertakes a case study of Action for Autism ; a Delhi-based NGO set up by parents of children with autism. This book also draws upon the author s own engagement with her child' s disability and thus lends an authenticity born out of lived experience and in-depth understanding. It is a valuable addition to the literature in the sociology of the family and disability studies.

WHAT IF A GOOD NIGHT’S SLEEP WAS ALL YOU NEEDED TO TRANSFORM YOUR LIFE BEYOND YOUR WILDEST DREAMS? SLEEP TO HEAL IS HERE TO HEAL AND INSPIRE.Are you tired of waking up tired? You are not alone. We may have become super-productive in our fast-paced, always-connected, 24/7  society, but in exchange we lost something precious: our harmonious connection to sleep, a natural biological function integral to our overall health, wellness, and well-being. The new and unraveling science of sleep tells us that sleep impacts everything from anxiety and creativity to productivity and longevity. We also now know it’s an essential pillar of health—perhaps even more important than nutrition and exercise.  Dr. Abhinav Singh is a physician with a keen interest in preventive medicine, and he firmly believes that better sleep equals better health. No matter your age, this book will help you revolutionize your patterns on a daily basis and support you on a renewed journey toward better sleep, better health, and ultimately a better life—not just for tonight but for a lifetime. No matter your goal—better sleep, losing weight, or simply feeling more patient around loved ones—it is never too late for a sleep reboot. Based on scientific research and 15 years of clinical experience from a double board-certified sleep physician who has taught the art of sleep to more than 7,000 patients, SLEEP TO HEAL will forever reshape the way you think about sleep, and give you the strategies and tools you need to transform your life from the inside out—one peaceful night at a time. REFRESH, RESTORE, AND REVITALIZE YOUR LIFE TODAY!