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Mechanisms of Circadian Systems in Animals and Their Clinical Relevance (Hardcover, 2015 ed.)
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Mechanisms of Circadian Systems in Animals and Their Clinical Relevance (Hardcover, 2015 ed.)
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Well known experts in the field of Chronobiology from around the
world, provide an integrative view of the state of the art of
circadian biology. At present, genetic and epigenetic interaction
of regulatory pathways among circadian oscillators, metabolic
networks, cellular differentiation and neuronal communication are
subject of intense scrutiny. The book is organized in three
sections: The first includes selected examples of the circadian
systems of crustaceans, insects, fish, birds and mammals. The
second is a detailed view of the physiological mechanisms
underlying the circadian clocks in mammals. Finally, in the third
section some examples of the relevance of circadian biology and
circadian misalignment to health and disease are provided including
nutrition and metabolism, obesity, cancer, cardiovascular and
pulmonary diseases, Huntington and affective diseases. This section
concludes with a brief review on gene therapy and its potential use
as a therapeutic tool to correct "clock genes" pathologies. This
book is aimed at all those interested in contemporary aspects of
physiology, biochemistry and molecular biology applied to the study
and characterization of timing systems.. It could be used as an
initial approach to this field, but it also provides updated
information for those already familiar with the fascinating field
of Chronobiology.
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