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Books > Medicine > Clinical & internal medicine > Geriatric medicine
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Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease (Hardcover, 1st ed. 2016)
Loot Price: R6,002
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Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease (Hardcover, 1st ed. 2016)
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This volume brings together various theories of how aberrations in
mitochondrial function and morphology contribute to
neurodegeneration in idiopathic and familial forms of Parkinson's
disease. Moreover, it comprehensively reviews the current search
for therapies, and proposes how molecules are involved in specific
functions as attractive therapeutic targets. It is expected to
facilitate critical thought and discussion about the fundamental
aspects of neurodegeneration in Parkinson's disease and foster the
development of therapeutic strategies among researchers and
graduate students. Theories of idiopathic Parkinson's etiology
support roles for chronic inflammation and exposure to heavy metals
or pesticides. Interestingly, as this project proposes, a case can
be made that abnormalities in mitochondrial morphology and function
are at the core of each of these theories. In fact, the most common
approach to the generation of animal and cell-culture models of
idiopathic Parkinson's disease involves exposure to mitochondrial
toxins. Even more compelling is the fact that most familial
patients harbor genetic mutations that cause disruptions in normal
mitochondrial morphology and function. While there remains to be no
effective treatment for Parkinson's disease, efforts to postpone,
prevent and "cure" onset mitochondrial aberrations and
neurodegeneration associated with Parkinson's disease in various
models are encouraging. While only about ten percent of Parkinson's
patients inherit disease-causing mutations, discovering common
mechanisms by which familial forms of Parkinson's disease manifest
will likely shed light on the pathophysiology of the more common
idiopathic form and provide insight to the general process of
neurodegeneration, thus revealing therapeutic targets that will
become more and more accessible as technology improves.
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