The second edition of this successful book provides further and in-depth insight into theoretical models dealing with Internet addiction, as well as includes new therapeutical approaches. The editors also broach the emerging topic of smartphone addiction. This book combines a scholarly introduction with state-of-the-art research in the characterization of Internet addiction. It is intended for a broad audience including scientists, students and practitioners. The first part of the book contains an introduction to Internet addiction and their pathogenesis. The second part of the book is dedicated to an in-depth review of neuroscientific findings which cover studies using a variety of biological techniques including brain imaging and molecular genetics. The third part of the book focuses on therapeutic interventions for Internet addiction. The fourth part of the present book is an extension to the first edition and deals with a new emerging potential disorder related to Internet addiction - smartphone addiction. Moreover, in this second edition of the book new content has been added. Among others, the reader will find an overview of theoretical models dealing with Internet addiction, results from twin studies in the context of Internet addiction and additional insights into therapeutic approaches to Internet addiction.

This ground breaking title presents the many different neurologic syndromes and vastly expanding data in the brain sciences from an evolutionary, or neuro-archeological, perspective, as well as a clinical one. The neuro-archeological perspective offers a more thorough picture of the field - providing hindsight that leads to great insight and foresight. It thus provides the reader with the core foundational aspects of many perplexing neurologic syndromes. Authored by a noted authority in cognitive neurology and including ample tables, diagrams and images, the book covers the full range of behavioral neurological, psychological and neuropsychiatric syndromes, as well as their underlying disease states, relevant neuropsychological tests and contemporary neuroimaging, both structural and functional. The evolutionary approach offers a comprehensive, novel, and completely updated overview of each topic. An invaluable title unlike any other in the field, Cognitive, Conative and Behavioral Neurology: An Evolutionary Perspective is a landmark resource and will be of great interest to neurologists, psychiatrists, neuroscientists, and trainees in all fields.

This issue of Critical Care Clinics focuses on Neurocritical Care and covers topics such as: The Evolution of Neurocritical Care, Update in management of acute ischemic stroke, Intracerebral hemorrhage, Subarachnoid treatment, Intracranial pressure monitoring and management of intracranial hypertension, Status Epilepticus, Brain Resuscitation and Prognosis after Cardiac Arrest, Neuromuscular complications of Critical Illness, Adverse Neurological Effects of Commonly Used ICU medications, and Brain death and management of a potential organ donor.

The diagnosis of autism spectrum disorder (ASD) has evolved greatly since Asperger's day. And as our clinical understanding of this spectrum of disorders has grown, so has recognition of the connections between anxiety disorders and ASD a welcome development, but also a source of confusion for many in the field.

The "Handbook of Autism and Anxiety" brings together leading experts to explain this comorbidity, the diagnostic similarities and differences between the two disorders and the extent to which treatment for each can be coordinated for optimum results. Focusing on repetitive behaviors, social difficulties and fears as core components of anxiety disorders as well as ASD, contributors discuss specific symptoms in depth to aid in diagnosis. Assessment and treatment issues relevant to the autism-anxiety connection are considered in clinical and school contexts. And an especially timely conclusion details how key changes in the "DSM-5 "affect the diagnosis and conceptualization of each disorder.

Key topics addressed in the "Handbook "include: Phenotypic variability in ASD: clinical considerations.Etiologic factors and transdiagnostic processes.Social worries and difficulties: autism and/or social anxiety disorder?Implementing group CBT interventions for youth with ASD and anxiety in clinical practice.Autism and anxiety in school settings."DSM"-"5" and autism spectrum disorder.

The "Handbook of Autism and Anxiety" is an essential resource for researchers, clinicians/professionals and graduate students in child and school psychology, psychiatry, social work, education, clinical counseling and behavioral therapy."

Pain is the most common reason people seek medical help. The treatment of chronic pain is a major unmet clinical need and its impact on health, well-being, society and the economy is immense. Pain is an integrative, whole-systems (patho)physiological phenomenon and behavioural neuroscience plays a key role in advancing our understanding of pain. This volume brings together a series of authoritative chapters written by leading experts in preclinical and clinical aspects of pain neurobiology. Behavioural approaches to the study of persistent or chronic pain in animal models or humans are at the core of the volume, but the anatomical, physiological, neurochemical and molecular mechanisms that underpin behavioural alterations are also emphasized.

This book demystifies, deconstructs, and simultaneously humanizes the field of estrogen-mediated neuroprotection following TBI, making the subject approachable to both researchers and advanced students. Bringing together leading researchers and practitioners to explain the basis for their work, methods, and their results, chapters explore what is known about the role of estrogens following damage to the brain. With topics covering induction of estrogen response, consequences of estrogen action, and mechanisms underlying estrogen mediated neuroprotection, Estrogen Effects on Traumatic Brain Injury is of great importance to teachers, researchers, and clinicians interested in the role that estrogens play following traumatic brain injury.

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents.

This is a comprehensive guide to the science, diagnosis and treatment of craniopharyngiomas, rare brain tumors that grow near the pituitary gland. Even though these tumors are generally benign, due to the location, prognosis was often bleak. New diagnostic, imaging and surgical techniques, including endoscopic endonasal cranial base surgery, now enable successful neurosurgical intervention. With a better prognosis, patients require multidisciplinary management from neurology, otolaryngology, radiation oncology, endocrinology, and neuropathology. This reference will provide a resource for these specialists requiring a comprehensive overview of this rare form of tumor.

*The only comprehensive guide to the science, diagnosis and treatment of craniopharyngiomas

*Includes multidisciplinary management from neurology, otolaryngology, radiation oncology, endocrinology, and neuropathology

*Detailed coverage of the impacts of new diagnostic, imaging and neurosurgical techniques including endoscopic endonasal cranial base surgery

With an annual rate of more than 12 million global diagnoses and 7.6 million deaths, the societal and economic burden of cancer cannot be overstated. Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. This series fills that gap, serving as the first two part reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types - lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age and gender related trends are also discussed, as is the use of biomarkers for early detection.

* The only comprehensive reference detailing the link between primary cancers and brain metastases

* Aids the target audience in determining the incidence of brain metastases in patients with a primary cancer

* Provided education about the potential use of biomarkers for early detection, diagnosis and prevention of the spread of primary cancer to the brain

* Documents temporal and gender-related trends in brain metastases from other cancers

* Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available

This issue of the Neurologic Clinics is dedicated to the cerebellum and includes articles on its functional neuroanatomy and different cerebellar pathologies. Among the various reviews contained in this issue, there are two particularly unique articles devoted to the role of the cerebellum in human cognition and psychiatric diseases. Other topics include: the Cerebellum and Sleep; Toxic-Metabolic, Nutritional, and Medicinal-Induced Disorders of Cerebellum; Multiple Sclerosis and the Cerebellum; and Infections of the Cerebellum, among others.

This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.

Lipid Structure, Domains, and Proteins: Molecular Mechanisms of Ethanol and Anesthetic Actions (C.D. Stubbs, E. Rubin). Membrane Cholesterol and Ethanol (W.G. Wood et al.). The Effects of Ethanol on Polyunsaturated Fatty Acid Composition (N. Salem, Jr., G. Ward). Receptors and Ion Channels: Sensitivity of NMDA Receptors to Acute and in Utero Ethanol Exposure (S.W. Leslie, M.S. Weaver). Molecular Mechanisms of Alcohol Neurotoxicity (F.T. Crews et al.). Second Messenger Systems and Kinases: Nucleoside Transport and EthanolInduced Heterologous Desensitization (A. Gordon et al.). Ethanol and Phospholipid Dependent Signal Transduction (J.B. Hoek et al.). Gene Expression: Regulation of Neuronal Gene Transcription by Ethanol (M.F. Miles et al.). Effect of Acute and Chronic Administration of Ethanol on cfos Expression in Brain (F. Le et al.). 19 additional articles. Index.

The daily life impact of movement disorders on people affected ranges from the inconvenient to major quality of life issues, depending upon the disorder and its progression. Topics in this issue of Neurologic Clinics address: Pathogenic Nechanisms of Neurodegeneration in Parkinson's Disease; Treatment Strategies in Early and Advanced Parkinson's Disease; Atypical Parkinsonism; Medical and Surgical Treatment of Tremors; Diagnosis and Treatment of Dystonia; Huntington's Disease: Pathogenesis and Treatment; Tics and Tourette Syndrome; Paroxysmal Movement Disorders; Drug-induced Movement Disorders; Wilson Disease and other Neurodegenerations with Metal Accumulations; Psychogenic Movement Disorders; Ataxia; Gait Disorders; and Movement Disorders in Systemic Diseases. Videos are planned for the majority of the presentations and each article presents an Overview, Imaging, Pathology, and Diagnostic Dilemmas. The editor of this issue of Neurologic Clinics, Dr. Joseph Jankovic, is well known as expert in the pathophysiology, diganosis, and management of movement disorders - he has served as president of the international Movement Disorder Society and is recipient of numerous research awards related to these disorders. Dr Jankovic has involved world renown experts as authors in this publication.

This text highlights the endogenous regenerative potential of the central nervous system in neonates and juveniles and discusses possible ways it might be manipulated for medical purposes. The first section provides a descriptive summary of the salient steps of human brain development with a discussion of comparisons with other mammalian brains. It also provides a historical perspective on our understanding of ongoing brain development throughout the lifespan and serve to introduce the concept of brain plasticity following injury. The second part is devoted to the endogenous reparative potential of the brain, including its limitations, and articles focusing on defined pathologies (e.g. anoxia/hypoxia, epilepsy, traumatic brain injury and stress) in animal models and in humans pinpoint eventual ways these pathologies might be manipulated. The third and final focuses on the "dark side" of stem cells for brain repair or of the manipulation of spontaneous adaptive events after injury (e.g. genomic instability, sensitization to cancerous transformation and defective neural networks).

I wrote this book urged by the overwhelming desire that arises towards the end of life to recapitulate the past. My goal was to summarize my experience of practicing science at the end of the 20th and early 21st centuries in Argentina, a country located far away from the world's leading scientific centers. In the book, I summarize the intricacies of the pineal gland ("the stone of madness") as historical, mystical and medical entity and its entry in contemporary medicine with the description of melatonin. I also reflect on how being associated with an unexplored subject at the beginning of his scientific career impacts the life of a scientist throughout their entire life. Today we know that in humans pineal melatonin is released every day late in the evening, and there is evidence that it is the trigger for the sleep process. But the most exciting aspect of melatonin is that it is a substance that is present in all living creatures, from unicellular organisms to plants and higher mammals, a fact that evinces its importance for life. Further, the neuroprotective action of melatonin promises to be crucial for the control of neurodegenerative diseases we face as a pandemic in this century. The discoverer of melatonin, Aaron Lerner, based its name on melano, the Greek word for black, because of its effect on the pigment cells of the skin. As in "La vie en rose", the immortal Edith Piaf song written in 1946, my lifelong work with melatonin could well be called "Ma vie en noir".

Of those which deal with sex and love addiction, this work is alone in that it examines adolescents as a specific population. The number of case histories presented in the text are a prominent feature. The work should be of interest to clinicians and clients both. The book addresses the case of adolescent sex and love addicts as was done with adolescent chemical dependents 20 years ago.

The 'epi-(Greek for 'over', 'above')genome', with its rich cache of highly regulated, structural modifications-including DNA methylation, histone modifications and histone variants-defines the moldings and three-dimensional structures of the genomic material inside the cell nucleus and serves, literally, as a molecular bridge linking the environment to the genetic materials in our brain cells. Due to technological and scientific advances in the field, the field of neuroepigenetics is currently one of the hottest topics in the basic and clinical neurosciences. The volume captures some of this vibrant and exciting new research, and conveys to the reader an up-to-date discussion on the role of epigenetics across the lifespan of the human brain in health and disease.

This book is a comprehensive overview of the clinical and scientific aspects of Autism from the leading experts in the field. The clinical section covers everything from epidemiological features to epigenetic regulation to behavioral therapies and much in between. The basic science section presents the latest knowledge on the underlying causes of the disorder including the role of various neurotransmitters, neurexins and neuroligins, reelin, and other proteins. Chapters also explore the cognition and motor control in autism and the connection between oxidative stress and mitochondrial dysfunction and autism. The thorough description of these underlying causes may help researchers and clinicians find more effective treatments and therapies for the 1 in 68 American children who have been diagnosed with Autism.

This book offers a compilation of papers on the role of melanin-concentrating hormone (MCH) in sleep, sleep disorders and neuroendocrine functions. Leading experts in sleep medicine, psychiatry and neuroendocrinology provide a broad perspective on the field, from the anatomical structure and physiology of the MCH system to the connection with other systems influencing sleep and diseases like anxiety and depression. The potential of MCHR-1 antagonists as anxiolytic/antidepressant drugs is also reviewed. The book will represent an interdisciplinary guide for sleep disorder specialists, sleep researchers, psychiatrists, neurologists, psychologists, and behavioral sleep medicine specialists.

This book presents a unique exploration of common myths about autism by examining these myths through the perspectives of autistic individuals. Examining the history of attitudes and beliefs about autism and autistic people, this book highlights the ways that these beliefs are continuing to impact autistic individuals and their families, and offers insights as to how viewing these myths from an autistic perspective can facilitate the transformation of these myths into a more positive direction. From 'savant syndrome' to the conception that people with autism lack empathy, each chapter examines a different social myth - tracing its origins, highlighting the implications it has had for autistic individuals and their families, debunking misconceptions and reconstructing the myth with recommendations for current and future practice. By offering an alternative view of autistic individuals as competent and capable of constructing their own futures, this book offers researchers, practitioners, individuals and families a deeper, more accurate, more comprehensive understanding of prevalent views about the abilities of autistic individuals as well as practical ways to re-shape these into more proactive and supportive practices.