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Astrocytes and Epilepsy (Hardcover)
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Astrocytes and Epilepsy (Hardcover)
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Epilepsy is a devastating group of neurological disorders
characterized by periodic and unpredictable seizure activity in the
brain. There is a critical need for new drugs and approaches given
than at least one-third of all epilepsy patients are not made free
of seizures by existing medications and become "medically
refractory". Much of epilepsy research has focused on neuronal
therapeutic targets, but current antiepileptic drugs often cause
severe cognitive, developmental, and behavioral side effects.
Recent findings indicate a critical contribution of astrocytes,
star-shaped glial cells in the brain, to neuronal and network
excitability and seizure activity. Furthermore, many important
cellular and molecular changes occur in astrocytes in epileptic
tissue in both humans and animal models of epilepsy. The goal of
Astrocytes and Epilepsy is to comprehensively review exciting
findings linking changes in astrocytes to functional changes
responsible for epilepsy for the first time in book format. These
insights into astrocyte contribution to seizure susceptibility
indicate that astrocytes may represent an important new therapeutic
target in the control of epilepsy. Astrocytes and Epilepsy includes
background explanatory text on astrocyte morphology and physiology,
epilepsy models and syndromes, and evidence from both human tissue
studies and animal models linking functional changes in astrocytes
to epilepsy. Beautifully labelled diagrams are presented and
relevant figures from the literature are reproduced to elucidate
key findings and concepts in this rapidly emerging field.
Astrocytes and Epilepsy is written for neuroscientists, epilepsy
researchers, astrocyte investigators as well as neurologists and
other specialists caring for patients with epilepsy.
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