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The Limits of Dream focuses on what we currently know of the human
central nervous system (CNS), examining the basic sciences of
neurochemisty, neuroanatomy, and CNS electrophysiology as these
sciences apply to dream, then reaching beyond basic science to
examine the cognitive science of dreaming including the processes
of memory, the perceptual interface, and visual imagery. Building
on what is known of intrapersonal CNS processing, the book steps
outside the physical body to explore artificially created dreams
and their use in filmmaking, art and story, as well as the role of
dreaming in creative process and creative madness. The limits of
our scientific knowledge of dream frame this window that can be
used to explore the border between body and mind. What is known
scientifically of the cognitive process of dreaming will lead the
neuroscientist, the student of cognitive science, and the general
reader down different paths than expected into an exploration of
the fuzzy and complex horizon between mind and brain.
Over the past 25 years the amount of data pertaining to the
GABAergic function in the basal ganglia has increased dramatically.
GABA and the Basal Ganglia - From Molecules to Systems is a
comprehensive review of the current state-of-the-art of knowledge
about the neuroanatomy, neuropharmacology and neurophysiology of
the basal ganglia, focusing on its GABAergic microcircuitry. It
serves as a complete reference to the body of knowledge about the
basal ganglia, its constituent neurons, and their interconnections.
This volume is designed to serve as a convenient all-in-one review
and reference for experienced basal ganglia researchers as well as
an introduction to the functional organization of the basal ganglia
and its GABAergic circuitry for students and researchers new to the
This volume provides a comprehensive understanding of HIV/AIDS and neuro-AIDS, including a history of the disease, and an explanation of many of the conditions that can arise in afflicted patients, including opportunistic infections, central nervous system tumors, spinal cord disorders, myopathies and progressive encephalopathy, amongst others.
Clinicians will gain a greater understanding of the complex mechanisms of the disease. Beginning with a basic introduction to HIV infections and Neuro-AIDS, practitioners will find useful data on advances in molecular biology, neuroepidemiology, neuroimaging, neuropathology, neuropharmacology, as well as information on the development of therapeutic strategies appropriate for the disorder, including groundbreaking retroviral therapies.
In addition, the socioeconomic and political constraints that
hinder treatment and disease management in developing parts of the
world are presented.
This book describes human hereditary ion channel diseases of
voltage- and ligand-gated ion channels covering the diverse fields
of medicine myology, neurology, cardiology, and nephrology
requiring a wide and interdisciplinary readership. Interesting
parallels in pathogenetic mechanisms of disease are especially
emphasized to interest even highly specialized readers in entities
outside of their fields. Each author has written an objective
overview of his or her particular subject in a way that should
allow the reader within a short period of time to obtain a
comprehensive picture of the present state of art.
Stress is a universal phenomenon that impacts adversely on most
people. This volume provides a readily accessible compendium that
explains the phenomenon of stress, the neural, endocrine and
molecular mechanisms involved, the clinical effects, and the impact
on individuals and society. Clinical attention focuses on disorders
of the stress control system (e.g. Cushing s Syndrome: Addison s
Disease) and the adverse impact of stress on human physicaland
mental health . Detailed reviews address disorders such as PTSD,
anxiety, major depression, psychoses and related disorders such as
combat fatigue and burnout. The work covers interactions between
stress and neurodegenerative disorders, such as Alzheimer s disease
and Parkinson s disease, as well as stress-immune-inflammatory
interactions in relation to cancer and autoimmune and viral
diseases. Emphasis is alsoplaced on the role of stress in obesity,
hypertension, diabetes type II and other features of the metabolic
syndrome which has now reached epidemic proportions in the USA and
Richly illustrated with over 200 figures, 75 in color
Priced affordably, this compendium of articles appeals to the end user interested in stress research who would not otherwise purchase the larger Encyclopedia of Stress
Articles carefully selected by one of the world s most preeminent stress researchers and contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge "
The purpose of this book is to review the basic science and
clinical findings concerning maternal substance abuse and the
developing nervous system of unborn children. The short-term but
vitally significant repercussions of such exposure on biological
development, with particular reference to the nervous system, are
discussed. The book also discusses the profound influence of
maternal substance abuse on behavior in adulthood, which is caused
by subtle changes in the chemistry or structure of the developing
nervous system. The subject will not only be of interest to
clinical and basic science researchers and teachers in the field of
maternal substance abuse, but also to individuals in psychology,
social work, cellular and molecular biolgoy, embryology,
neuroscience, pharmacology, and in clinical professions such as
pediatrics, neonatology, and obstetrics. The breadth of topics
covered includes alcohol, cocaine, opiates, nicotine,
benzodiazepines, marijuana, and the role of stress and hormones.
Emphasis is placed on the relationship of the effects of substance
abuse on neurotrophic factors and receptors.
This volume investigates the implications of how our brain directs
our movements on decision making. An extensive body of knowledge in
chapters from international experts is presented as well as
integrative group reports discussing new directions for future
Neuroendocrinology, the discipline concerned with how the
nervous system controls hormonal secretion and how hormones control
the brain, is pivotal to physiology and medicine.
Neuroendocrinology has disclosed and underpins fundamental
physiological, molecular biological and genetic principles such as
the regulation of gene transcription and translation, the
mechanisms of chemical neurotransmission and intracellular and
systemic feedback control systems. Reproduction, growth, stress,
aggression, metabolism, birth, feeding and drinking and blood
pressure are some of the bodily functions that are triggered and/or
controlled by neuroendocrine systems. In turn, neuroendocrine
dysfunction due to genetic or other deficits can lead, for example,
to infertility, impotence, precocious or delayed puberty, defective
or excessive growth, obesity and anorexia, Cushing s Syndrome,
hypertension or thyroid disorders. These as well as neuroendocrine
tumors are some of the themes covered in the 36 chapters of the
Handbook. Drafted by internationally acknowledged experts in the
field, the Handbook chapters feature detailed up-to-date
bibliographies as well as "how do we know?" call out sections that
highlight the experimental or technical foundations for major
concepts, principles, or methodological advances in each area.
Aimed at senior undergraduate and graduate students, post-doctoral
fellows and faculty in neuroscience, medicine, endocrinology,
psychiatry, psychology and cognate disciplines, the "Handbook of
Neuroendocrinology" satisfies an unmet need that will prove useful
at the laboratory bench as well as in the office.
Epilepsy is one of the most common neurological disorders, and
original observations in the field are often the key to diagnosis
and successful treatment. Physicians new to the field as well as
seasoned practitioners will benefit from more than one hundred case
vignettes that explore the universe of epilepsy as it presents in
daily practice. Some of these cases challenge long-held views about
epilepsy and others bring the reader to the limits of our
understanding of epilepsy, both in clinical and basic science. To
improve the interface of clinical and basic science in epilepsy,
basic scientists comment on the potential mechanisms underlying
clinical observations, and clinicians assess the potential impact
of recent results of experiments in the laboratory. This book
highlights the importance that original observations have in
inspiring both new treatments and continued research.
Neuroendocrinology is a discipline which originated about 50 years ago as a branch of Endocrinology and that is now strictly linked to neuroscience.
Volumes 181 and 182 of Progress in Brain Researchprovide a rapid view of the major points presently discussed at biological and clinical levels.
The chapters have been written by top scientists who are directly involved in basic or clinical research and who use the most sophisticated biotechnological techniques.
The volumes cover of the role of genetics in many
endocrine-related events, like neuroendocrinological diseases and
endocrine depenedent cancers (prostate, breast, etc, ). Interesting
information is also provided on possibile treatments of
neurodegenerative brain diseases (e.g., Alzheimer and similar
The best researchers in the field provide their conclusions in the context of the latest experimental results
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
Of great value for researchers and experts, but also for students as a background reference"
The analysis of the protein content of the Cerebrospinal Fluid
(CSF) is a central tool in the diagnosis of a number of diseases,
including Multiple Sclerosis and Encephalitis. This book is a
complete revision of the first edition published 16 years ago and
reflects the advances in the field in that period. Containing the
most comprehensive reference list available today with over 1300
references cross-indexed according to topics, it also includes many
classical works that cannot be easily found through the public
literature database (like PubMed). This book covers new areas of
research such as the use of the analysis of protein content in the
CSF to guide the prognosis of patients with severe head injury
and/or stroke (currently being tested using technology which can be
applied at the bedside to yield results within 15 minutes).
A single volume of 31 articles, Mechanisms of Hormone Actions on
Behavior is an authoritative selection of relevant chapters from
the Hormones Brain and Behavior 2e MRW, the most comprehensive
source of neuroendocrinological information assembled to date (AP
Natural product chemistry covers a fascinating area of organic chemistry and its study has enriched organic chemistry in a myriad of different ways. In recent years the thrust has been in three major directions: advances in stereoselective synthesis of bioactive natural products, developments in structure elucidation of complex natural products through the applications of multidimensional NMR and mass spectroscopy, and the integration of bioassay procedures with the isolation processes leading to the isolation of active principles from the extracts. The present volume reflects these developments, and the growing emphasis on bioactive natural products, chemical constituents of echinoderms, diterpenoids from Rabdosia and Eremophila sp., structural studies on saponins, marine sesquiterpene quinones and antimicrobial activity of amphibian venoms. The reviews on bioactive metabolites of Phomophis, cardenolide detection by ELISA, xenocoumacins and bioactive dihydroisocoumarins, CD studies of carbohydrate-molybdate complexes, oncogene function inhibitors from microbial secondary metabolites and Gelsemium and Lupin alkaloids present frontier developments in several areas of natural product chemistry. It is hoped that the present volume, which contains articles by eminent authorities in each field, will be received with the same enthusiasm as the previous volumes of this series.
This issue of "Progress in Brain Research" is split over 2 volumes,
bringing together cutting-edge research on functional neural
transplantation. The 2 volumes review current knowledge and
understanding, provide a starting point for researchers and
practitioners entering the field, and build a platform for further
research and discovery.
The book is a history of the McKnight Endowment Fund for
Neuroscience and an assessment of its effectiveness in advancing
neuroscience. The book discusses the Fund's early and steady
commitment to basic science as well as it's tradition of leveraging
relatively modest dollars to make a big difference in careers and
the field overall.
Volume 33 reviews the current understanding of ion channel
regulation by signal transduction pathways. Ion channels are no
longer viewed simply as the voltage-gated resistors of
biophysicists or the ligand-gated receptors of biochemists. They
have been transformed during the past 20 years into signaling
proteins that regulate every aspect of cell physiology. In addition
to the voltage-gated channels, which provide the ionic currents to
generate and spread neuronal activity, and the calcium ions to
trigger synaptic transmission, hormonal secretion, and muscle
contraction, new gene families of ion channel proteins regulate
cell migration, cell cycle progression, apoptosis, and gene
transcription, as well as electrical excitability. Even the genome
of the lowly roundworm Caenorhabditis elegans encodes almost 100
distinct genes for potassium-selective channels alone. Most of
these new channel proteins are insensitive to membrane potential,
yet in humans, mutations in these genes disrupt development and
increase individual susceptibility to debilitating and lethal
Published since 1959, International Review of Neurobiology is a
well-known series appealing to neuroscientists, clinicians,
psychologists, physiologists, and pharmacologists. Led by an
internationally renowned editorial board, this important serial
publishes both eclectic volumes made up of timely reviews and
thematic volumes that focus on recent progress in a specific area
of neurobiology research. This volume reviews existing theories and
current research surrounding the movement disorder
Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
International Review of Neurobiology is a well-respected series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a cumulative subject index of volumes 26-50.
This volume provides a comprehensive look into the innovative methods used to explore the visual system. From the way the brain processes vision, an imperative part of the human experience, to the role eye movement plays in a range of questions concerning visual perception, memory, attention, free will, and even topological diagnoses, this in-depth handbook gives neurologists, ophthalmologists, and neuro-ophthalmologists an invaluable tool to help them better understand the visual system.
Disorders of the retinal and cerebral cortex, and those that affect control of eye and lid movements are thoroughly discussed, along with groundbreaking visual rehabilitative methods, and chapters on individual parts of the visual system. Practitioners will find a useful resource that lays out fundamental concepts, while seamlessly summarizing clinical and laboratory methods for neuro-ophthalmological evaluation.
The material is perfect for early-stage physicians or long
practicing specialists who wish to learn the latest developments in
This volume focuses on the interplay of mind and motion - the bidirectional link between thought and action. In particular, it investigates the implications that this coupling has for decision making. How do we anticipate the consequences of choices and how is the brain able to represent these choice options and their potential consequences? How are different options evaluated and how is a preferred option selected and implemented? This volume addresses these questions not only through an extensive body of knowledge consisting of individual chapters by international experts, but also through integrative group reports that pave a runway into the future. The understanding of how people make decisions is of common interest to experts working in fields such as psychology, economics, movement science, cognitive neuroscience, neuroinformatics, robotics, and sport science. So far, however, it has mainly been advanced in isolation within distinct research disciplines; in contrast, this book results from a deliberate assembly of multidisciplinary teams. It offers intense, focused, and genuine interdisciplinary perspective. It conveys state-of-the-art and outlines future research directions on the hot topic of Mind and Motion (or embodied cognition). It includes contributions from psychologists, neuroscientists, movement scientists, economists, and others.
Since the late 90 s, a renewed interest in the neurobiology of sleep has provided new advancements in the understanding of basic sleep science and the clinical aspects of sleep disorders, with particular interest given to the role of genetics.
From laboratory techniques and therapies, groundbreaking research in sleep-wakefulness, new models of rapid eye movement (REM) sleep mechanisms, to bright light therapy for circadian rhythm sleep disorders, this handbook will provide clinicians and researchers with a state-of-the-art reference that summarizes the clinical features and management of the many neurological manifestations of sleep disorders.
Practitioners will find invaluable research, information, and
laboratory techniques on such topics as sleep-wake-dependent genes,
the role of sleep duration in mortality and morbidity, and
advancements in the understanding of the neurobiology of sleep
disorders, including narcolepsy-cataplexy, restless legs syndrome,
REM behavior disorders, fatal familiar insomnia, sleep apnea and
heart failure, and nocturnal paroxysmal dystonia, amongst others.
In addition, significant advancements in therapies and drug
protocols are presented.
This text synthesizes current information on defined neurotrophic factors (emphasizing their localization and molecular/cellular function in the central nervous system), provides current reviews and offers a conceptual framework for understanding the spectrum of actions of neurotropic factors. It also reviews the members of the major growth factor families, including the neurotrophins, the epidermal growth factor and the fibroblast growth factors.;Other topics and issues that are covered include multifaceted approaches to the study of growth factor effects on specific and defined neuronal groups; the actions of neurotrophic factors on first, second and third messenger systems and their convergence into primary response genes; synergistic effects and interactions between neurotrophic factors; and the growth promoting effects of neurotransmitters, neuronal activity and interactions with extra cellular matrix.; The book's key features include an up-to-date synthesis of concepts on neurotrophic factors in the nervous system; discussion of molecular, cellular and neuroanatomical concepts of the neurotrophic factor function; chapters on primary, secondary and tertiary messenger systems; a
Handbook of Clinical Neurology: Neuro-Oncology, Part II provides an overview of the most recent developments in the field of neuro-oncology, including new diagnostic imaging techniques, along with immunology, molecular biology, and clinical aspects of different types of tumors. It also considers management and new therapeutic strategies for tumors, such as gene therapy, radiation therapy, and molecularly targeted treatments. Divided into five sections encompassing 33 chapters, the book begins with a description of specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. It then discusses tumors at special sites, from brainstem tumors to peripheral nerve tumors, tumors of the meninges, and optic, hypothalamic, and thalamic tumors. It also explains the neurological complications of systemic cancer and the adverse effects of some treatments. Clinicians and neuroscientists, as well as researchers who read this book, will gain a better understanding of the clinical features and management of the neurological manifestations of tumors.
This volume of "Progess in Brain Research" follows on from the 32nd International Symposium of the Groupe de recherche sur le systeme nerveux central (GRSNC), May 2010, and aims to provide an overview of the various neural mechanisms that contribute to learning new motor and sensory skills, and to adapting to changed circumstances, including the use of devices and implants to substitute for lost sensory or motor abilities (brain machine interfaces). The focus is on recent developments covering five major themes: Mechanisms to improve motor performanceNeuro-rehabilitation of motor functionMechanisms to enhance sensory perceptionCross modal interationc for enhancing sensorimotor performanceAssistive technologies to enhance sensorimotor performance
This volume focuses on the translation of scientific knowledge
into applications and strategies that can help restore lost
function following injury or disease including assistive
neuroprosthetic technologies to enhance sensorimotor performance
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