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This volume provides a comprehensive exploration of stroke, from basic mechanisms of disease to enhanced diagnostic and therapeutic capabilities. The ongoing efforts within the neurological community are also highlighted, bringing a better understanding of the pathophysiological basis of this disorder.
Clinicians will find invaluable information that can be used to enhance the lives of an aging global population. Covered topics include the functional anatomy of the brain itself, as well as advancements in the understanding of the biochemical background of strokes.
Related fields and their dramatic impact on stroke research are
also included, with findings in the fields of epidemiology,
genetics, neuroimaging, and interventional radiology thoroughly
explored. In addition, great attention is paid to therapeutic
avenues, including investigation, prevention, and patient
The importance of chloride ions in cell physiology has not been
fully recognized until recently, in spite of the fact that chloride
(Cl-), together with bicarbonate, is the most abundant free anion
in animal cells, and performs or determines fundamental biological
functions in all tissues. For many years it was thought that Cl-
was distributed in thermodynamic equilibrium across the plasma
membrane of most cells. Research carried out during the last couple
of decades has led to a dramatic change in this simplistic view. We
now know that most animal cells, neurons included, exhibit a
non-equilibrium distribution of Cl- across their plasma membranes.
Over the last 10 to 15 years, with the growth of molecular biology
and the advent of new optical methods, an enormous amount of
exciting new information has become available on the molecular
structure and function of Cl- channels and carriers. In nerve
cells, Cl- channels and carriers play key functional roles in GABA-
and glycine-mediated synaptic inhibition, neuronal growth and
development, extracellular potassium scavenging,
sensory-transduction, neurotransmitter uptake and cell volume
control. Disruption of Cl- homeostasis in neurons underlies
pathological conditions such as epilepsy, deafness, imbalance,
brain edema and ischemia, pain and neurogenic inflammation. This
book is about how chloride ions are regulated and how they cross
the plasma membrane of neurons. It spans from molecular structure
and function of carriers and channels involved in Cl- transport to
their role in various diseases.
Neuromodulation is an emerging field that explores the use of electrical, chemical, and mechanical interventions to heal neurological deficits. Suchneurostimulation has already shown great promise with disorders and diseases such as chronic pain, epilepsy, and Parkinson s disease. This is the first concise reference covering all of the basic principles of neuromodulation in a single affordable volume for neuro-residents, fellows, and basic clinical practitioners, edited by two prominent clinical experts in the field.
This volume emphasizes essential observations from all of the
important clinical phases involved in any neuromodulation:
targeting, intraoperative assessment, programming, complications,
and complication avoidance. There are commonalities to all
neuromodulation procedures that must be brought to the forefront to
form a cohesive presentation of neuromodulation, and such emphasis
will give readers a more solid grounding in the fundamentals needed
to embrace this field as a cohesive clinical entity.
Epilepsy, Part I, "Basic Principles and Diagnosis," Volume 107,
in the"Handbook of Clinical Neurology"series offers a comprehensive
review of our knowledge of the field today, including epidemiology,
basic mechanisms, animal models, and topics of increasing interest
such as the role of inflammation in epilepsy. It provides a
comprehensive approach to description of the clinical,
electrographic and imaging aspects of the epilepsies, with a clear
outline of contemporary classification and the role of modern
diagnostic techniques, as well as neuropsychological and
psychiatric aspects of epilepsy. Chapters are authored by
internationally respected neurologists with varied perspectives
insuring depth to the content. "Epilepsy, Part II," "Treatment, "
Volume 108, continues coverage of epilepsy with a focus on
treatment. The volumes will be a very important resource for basic
scientists, clinical investigators, and all health professionals
treating patients with epilepsy.
Neuroscience LabFax is a comprehensive collection of the most
up-to-date methods and data available in neuroscience, addressing
issues from the molecular and biophysical to the cellular and
systems level of analysis. Complemented by excellent diagrams, the
information is clearly presented and easily accessible.
Neuroscience LabFax has a broad-based interdisciplinary focus,
integrating methods and data from cellular and molecular
neuroscience, biophysics and behavior. This volume covers
electrophysical recording, neuronal cell culture, preparation of
tissues for microscopy or analysis, and molecular biology and
neurobiology techniques. Written by experts in the field, this text
is essential for neuroscientists from all subdisciplines, for those
new to the field as well as experienced researchers.
Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the
major excitatory neurotransmitter, and the serotonergic system is
one of the best studied and understood transmitter systems. It is
crucially involved in the organization of virtually all behaviours
and in the regulation of emotion and mood. Alterations in the
serotonergic system, induced by e.g. learning or pathological
processes, underlie behavioural plasticity and changes in mood,
which can finally results in abnormal behaviour and psychiatric
conditions. Not surprisingly, the serotonergic system and its
functional components appear to be targets for a multitude of
pharmacological treatments - examples of very successful drugs
targeting the serotoninergic system include Prozac and Zoloft.
This book provides a comprehensive description of how human sensory
systems function, with comparisons of the five senses and detailed
descriptions of the functions of each of them. In addition to
describing anatomy and function, the book also provides insight as
to how sensory information is processed in the brain to provide the
basis for communication and for our perception of our surroundings.
Hardbound. In this volume prominent workers in the field discuss various time series methods in the time domain. The topics included are autoregressive-moving average models, control, estimation, identification, model selection, non-linear time series, non-stationary time series, prediction, robustness, sampling designs, signal attenuation, and speech recognition. This volume complements Handbook of Statistics 3: Time Series in the Frequency Domain.
One of the most pressing questions in neuroscience, psychology
and economics today is how does the brain generate preferences and
make choices? With a unique interdisciplinary approach, this volume
is among the first to explore the cognitive and neural mechanisms
mediating the generation of the preferences that guide choice. From
preferences determining mundane purchases, to social preferences
influencing mating choice, through to moral decisions, the authors
adopt diverse approaches to answer the question. Chapters explore
the instability of preferences and thecommon neural processes that
occur across preferences. Edited by one of the world s most
renowned cognitive neuroscientists, each chapter is authored by an
expert in the field, with a host of international
Febrile Seizures is written by the most active researchers and
clinicians in epilepsy research today. This book presents the
latest developments in this field as well as the current state of
knowledge in the following:
The Limits of Dream focuses on what we currently know of the human
central nervous system (CNS), examining the basic sciences of
neurochemisty, neuroanatomy, and CNS electrophysiology as these
sciences apply to dream, then reaching beyond basic science to
examine the cognitive science of dreaming including the processes
of memory, the perceptual interface, and visual imagery. Building
on what is known of intrapersonal CNS processing, the book steps
outside the physical body to explore artificially created dreams
and their use in filmmaking, art and story, as well as the role of
dreaming in creative process and creative madness. The limits of
our scientific knowledge of dream frame this window that can be
used to explore the border between body and mind. What is known
scientifically of the cognitive process of dreaming will lead the
neuroscientist, the student of cognitive science, and the general
reader down different paths than expected into an exploration of
the fuzzy and complex horizon between mind and brain.
This book describes human hereditary ion channel diseases of
voltage- and ligand-gated ion channels covering the diverse fields
of medicine myology, neurology, cardiology, and nephrology
requiring a wide and interdisciplinary readership. Interesting
parallels in pathogenetic mechanisms of disease are especially
emphasized to interest even highly specialized readers in entities
outside of their fields. Each author has written an objective
overview of his or her particular subject in a way that should
allow the reader within a short period of time to obtain a
comprehensive picture of the present state of art.
Comprised of two separate volumes, Neuroimaging provides a
state-of-the-art review of a broad range of neuroimaging techniques
applied to both clinical and research settings. The breadth of the
methods covered is matched by the depth of description of the
theoretical background. Part B covers the application of
neuroimaging in both research and clinical settings for the study
of anxiety disorders, dementia, depression, schizophrenia,
functional somatic syndromes, stroke, and multiple sclerosis using
a range of neuroimaging modalities including CT, PET, SPECT, DTI,
structural MRI and fMRI. One chapter is devoted to the study of
brain development using structural MRI, and one chapter to the
study of pediatric neurobehavioral disorders using fMRI. One of the
most exciting recent applications of neuroimaging to the area of
genetics is covered, and with the theory and application of
neuroreceptor imaging in psychiatry, forms the final two chapters.
With recent advances of modern medicine more people reach the "elderly age" around the globe and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians' and neuroscientists' interest to carry out more research projects into pathogenesis of this devastating group of diseases.
This volume of "Progess in Brain Research" follows on from the 32nd International Symposium of the Groupe de recherche sur le systeme nerveux central (GRSNC), May 2010, and aims to provide an overview of the various neural mechanisms that contribute to learning new motor and sensory skills, and to adapting to changed circumstances, including the use of devices and implants to substitute for lost sensory or motor abilities (brain machine interfaces). The focus is on recent developments covering five major themes: Mechanisms to improve motor performanceNeuro-rehabilitation of motor functionMechanisms to enhance sensory perceptionCross modal interationc for enhancing sensorimotor performanceAssistive technologies to enhance sensorimotor performance
This volume focuses on the translation of scientific knowledge
into applications and strategies that can help restore lost
function following injury or disease including assistive
neuroprosthetic technologies to enhance sensorimotor performance
Theoretical Mechanics of Biological Neural Networks develops an engineering science for the description of neuroclectric signalling of biological neural networks in terms of the underlying neurobiological mechanisms. The primary theoretical contribution of the book is to show how to describe the co-ordinated electrical activity of arbitrarily complex neural networks in terms of a single governing principle ' for each significant component in the same way that Newton's formulation of classical mechanics allows one to express force-motion relationships for arbitrarily complex mechanical systems in terms of one fundamental principle of motion for each constituent element.;Practically, the book shows how to generate mathematical and computational representations Of' the co-ordinated electrical activity of neural networks, ranging from individual neurons to composite systems of interconnected networks. Complete listings of several general purpose computer programs embodying the theory are included in the book.
Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
With recent advancements in new knowledge, it has become evident that psychostimulants and related drugs of abuse are influencing our central nervous system (CNS) remarkably and could alter their function for a longtime. This volume is the first to focus on substance abuse induced brain pathology in the widest sense as it covers alterations in neuronal, glial and endothelial cell functions under the influence of acute or chronic usage of substance abuse.
The previous two editions of the "Human Nervous System "have
been the standard reference for the anatomy of the central and
peripheral nervous system of the human. The work has attracted
nearly 2,000 citations, demonstrating that it has a major influence
in the field of neuroscience. The 3e is a complete and updated
revision, with newchapters covering genes and anatomy, gene
expression studies, and glia cells. The book continues to be an
excellent companion to the "Atlas of the Human Brain," and a common
nomenclature throughout the book is enforced. Physiological data,
functional concepts, and correlates to the neuroanatomy of the
major model systems (rat and mouse) as well as brain function round
out the new edition.
Neuroendocrinology, the discipline concerned with how the
nervous system controls hormonal secretion and how hormones control
the brain, is pivotal to physiology and medicine.
Neuroendocrinology has disclosed and underpins fundamental
physiological, molecular biological and genetic principles such as
the regulation of gene transcription and translation, the
mechanisms of chemical neurotransmission and intracellular and
systemic feedback control systems. Reproduction, growth, stress,
aggression, metabolism, birth, feeding and drinking and blood
pressure are some of the bodily functions that are triggered and/or
controlled by neuroendocrine systems. In turn, neuroendocrine
dysfunction due to genetic or other deficits can lead, for example,
to infertility, impotence, precocious or delayed puberty, defective
or excessive growth, obesity and anorexia, Cushing s Syndrome,
hypertension or thyroid disorders. These as well as neuroendocrine
tumors are some of the themes covered in the 36 chapters of the
Handbook. Drafted by internationally acknowledged experts in the
field, the Handbook chapters feature detailed up-to-date
bibliographies as well as "how do we know?" call out sections that
highlight the experimental or technical foundations for major
concepts, principles, or methodological advances in each area.
Aimed at senior undergraduate and graduate students, post-doctoral
fellows and faculty in neuroscience, medicine, endocrinology,
psychiatry, psychology and cognate disciplines, the "Handbook of
Neuroendocrinology" satisfies an unmet need that will prove useful
at the laboratory bench as well as in the office.
Episodic memory is the name of the kind of memory that records
personal experiences instead of the mere remembering of impersonal
facts and rules. This type of memory is extremely sensitive to
ageing and disease so an understanding of the mechanisms of
episodic memory might lead to the development of therapies suited
to improve memory in some patient populations. Episodic memory is
unique in that it includes an aspect of self-awareness and helps us
to remember who we are in terms of what we did and what we have
been passed through and what we should do in the future.
This volume provides a broad overview of important new advances in
the field of Neuropharmacology. In 20 chapters, a selection of
international contributors discuss topics including endocannabinoid
function, pain, stress, astrocytes etc, and new possibilities for
treatments of neurological diseases with neuropharmacological
This volume provides a comprehensive understanding of HIV/AIDS and neuro-AIDS, including a history of the disease, and an explanation of many of the conditions that can arise in afflicted patients, including opportunistic infections, central nervous system tumors, spinal cord disorders, myopathies and progressive encephalopathy, amongst others.
Clinicians will gain a greater understanding of the complex mechanisms of the disease. Beginning with a basic introduction to HIV infections and Neuro-AIDS, practitioners will find useful data on advances in molecular biology, neuroepidemiology, neuroimaging, neuropathology, neuropharmacology, as well as information on the development of therapeutic strategies appropriate for the disorder, including groundbreaking retroviral therapies.
In addition, the socioeconomic and political constraints that
hinder treatment and disease management in developing parts of the
world are presented.
Leading authors review the state-of-the-art in their field of
investigation, and provide their views and perspectives for future
With data from the United States and Europe, Jon Miller and Linda
Kimmel examine the public's understanding of and attitude toward
biotechnology and biomedicine while they present methods of
introducing cutting edge science to the
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