A single volume of 31 articles, Mechanisms of Hormone Actions on Behavior is an authoritative selection of relevant chapters from the Hormones Brain and Behavior 2e MRW, the most comprehensive source of neuroendocrinological information assembled to date (AP June 2009).
The study of hormones as they impact the brain and, subsequently, behavior is a central topic in neuroscience, endocrinology and psychiatry. This volume offers an overview of neuroendocrinological topics, approaching the subject from the perspective of the mechanisms which control hormone actions on behavior. Female, male and stress hormones are discussed at the cellular, behavioral and developmental level, and sexual differentiation of the development of hormone-dependent neuronal systems, neuropeptides/neuromodulators, and steroid-inducedneuroplasticity are addressed. There is simply no other current single-volume reference with such comprehensive coverage and depth.
Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 175 figures (over 50 in color). A collection of articles reviewing our fundamental knowledge of the mechanisms of neuroendocrinology, the book provides an essential, affordable reference for researchers, clinicians and graduate students in the area.
- The most comprehensive single-volume source of up-to-date data on the mechanisms behind neuroendocrinology, with review articles covering x, y z
- Chapters synthesize information otherwise dispersed across a number of journal articles and book chapters, thus saving researchers the time consuming process of finding and integrating this information themselves
- Offering outstanding scholarship, each chapter is written by an expert in the topic area and approximately 35% of chapters are written by international contributors
- Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions
- Heavily illustrated with 175 figures, approximately 54 in color
- Presents material in most visually useful form for the reader

This volume investigates the implications of how our brain directs our movements on decision making. An extensive body of knowledge in chapters from international experts is presented as well as integrative group reports discussing new directions for future research.
The understanding of how people make decisions is of central interest to experts working in fields such as psychology, economics, movement science, cognitive neuroscience, neuroinformatics, robotics, and sport science. For the first time the current volume provides a multidisciplinary overview of how action and cognition are integrated in the planning of and decisions about action.
* Offers intense, focused, and genuine interdisciplinary perspective
* Conveys state-of-the-art and outlines future research directions on the hot topic of mind and motion (or embodied cognition)
* Includes contributions from psychologists, neuroscientists, movement scientists, economists, and others

A single volume of 85 articles, the Handbook of the Neurobiology of Aging is an authoritative selection of relevant chapters from the Encyclopedia of Neuroscience, the most comprehensive source of neuroscience information assembled to date (AP Oct 2008).
The study of neural aging is a central topic in neuroscience, neuropsychology and gerontology. Some well-known age-related neurological diseases include Parkinson's and Alzheimer's, but even more common are problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging become more common and conditions associated with aging need more attention by doctors and researchers.
This book offers an overview of topics related to neurobiological impairments which are related to the aging brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer's, dementia, Down syndrome, Parkinson's, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth.
Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 100 color figures. A collection of articles reviewing our fundamental knowledge of neural aging, the book provides an essential, affordable reference for scientists in all areas of Neuroscience, Neuropsychology and Gerontology.
* The most comprehensive source of up-to-date data on the neurobiology of aging, review articles cover: normal, sensory and cognitive aging; neuroendocrine, structural and molecular factors; and fully address both patholgy and intervention
* Chapters represent an authoritative selection of relevant material from the most comprehensive source of information about neuroscience ever assembled, (Encyclopedia of Neuroscience), synthesizing information otherwise
dispersed across a number of journal articles and book chapters, and saving researchers the time consuming process of finding and integrating this information themselves
* Offering outstanding scholarship, each chapter is written by an expert in the topic area and over 20% of chapters feature international contributors, (representing 11 countries)
* Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions
* Fully explores various pathologies associated with the aging brain (Alzheimer's, dementia, Parkinson's, memory disorders, stroke, Down's syndrome, etc.)
* Coverage of disorders and key interventions makes the volume relevant to clinicians as well as researchers
* Heavily illustrated with over 100 color figures

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
Key Features
*Provides solid scientific basis to our understanding of the associations between the brain and the immune system the importance of these connections
* Presents coherent development from cellular and molecular neuroimmune communication to social and health considerations, including psychological intervention
* Addresses the theory that there is a neurobiology of the immune system

This volume provides a vital and comprehensive resource on stroke, including research, diagnosis, prevention, and treatment modalities. Practitioners in these fields will find invaluable information in this handbook, from basic mechanisms of the disease, to enhanced diagnostic and therapeutic capabilities for patient care.

With the field of cerebrovascular disorders, including stroke, making rapid advancements, clinicians will find illuminating and insightful chapters on the pathophysiological basis of this disorder.

Advances in our understanding of the biochemical background of strokes, coupled with an examination of breakthroughs in epidemiology, genetics, neuroimaging, interventional radiology, surgery, and even clinical psychology are also explored, giving researchers and clinicians a profoundly altered way to approach stroke research, diagnosis, and patient treatment and care.
* A comprehensive resource on stroke, prevention techniques, diagnosis, and treatment modalities
* Illuminating and insightful information on the pathophysiological basis of stroke
* A thorough examination of the rapid advancements made in the field of cerebrovascular disorders and their applications to stroke

This volume provides a comprehensive exploration of stroke, from basic mechanisms of disease to enhanced diagnostic and therapeutic capabilities. The ongoing efforts within the neurological community are also highlighted, bringing a better understanding of the pathophysiological basis of this disorder.

Clinicians will find invaluable information that can be used to enhance the lives of an aging global population. Covered topics include the functional anatomy of the brain itself, as well as advancements in the understanding of the biochemical background of strokes.

Related fields and their dramatic impact on stroke research are also included, with findings in the fields of epidemiology, genetics, neuroimaging, and interventional radiology thoroughly explored. In addition, great attention is paid to therapeutic avenues, including investigation, prevention, and patient management.
* A comprehensive resource for information on diagnostic advancements, prevention, and treatment of strokes
* A clinical perspective on the ways related fields such as epidemiology, genetics, and neuroimaging, amongst others, are impacting new research in this disorder
* A foundation that will enable researchers to pursue new clinical investigations

Episodic memory is the name of the kind of memory that records personal experiences instead of the mere remembering of impersonal facts and rules. This type of memory is extremely sensitive to ageing and disease so an understanding of the mechanisms of episodic memory might lead to the development of therapies suited to improve memory in some patient populations. Episodic memory is unique in that it includes an aspect of self-awareness and helps us to remember who we are in terms of what we did and what we have been passed through and what we should do in the future.
This book brings together a renowned team of contributors from the fields of cognitive psychology, neuropsychology and behavioural and molecular neuroscience. It provides a detailed and comprehensive overview of recent developments in understanding human episodic memory and animal episodic-like memory in terms of concepts, methods, mechanisms, neurobiology and pathology. The work presented within this book will have a profound effect on the direction that future research in this topic will take.
- The first and most current comprehensive handbook on what we know about episodic memory, the memory of events, time, place, and emotion, and a key feature of awareness and consciousness
- Articles summarize our understanding of the mechanisms of episodic memory as well as surveying the neurobiology of epsidodic memory in patients, animal studies and functional imaging work
- Includes 34 heavily illustrated chapters in two sections by the leading scientists in the field

Parkinson s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery.
* Comprehensive and critical assessment of the utility of various model systems to identify the molecular components and pathways involved in Parkinson s disease
* Describes the power of toxin and genetic models to identify novel therapeutic targets and compounds that can be used in PD
* Current overviews of current status of PD research and discovery from bench-to-bedside
* Provides novel insights and views on where the future of PD research may lead
* Provides a powerful teaching tool and template to explore the utility of model systems to identify molecular pathways, molecular targets, and therapeutics that are applicable to a variety of neurological diseases"

This volume provides concise and comprehensive information on neuromuscular disorders, including rapid advancements in the understanding of the neurobiology of neuromuscular transmission. In addition, clinicians will find timely discussions on the various forms of these disorders that have been discovered due to increased study within the field.

New observations into the immunopathogenesis of myasthenia gravis, and the molecular mechanisms underlying the links between activity and patterns of gene expression, particularly in muscle, are also explored, along with novel information on the understanding of the pathophysiology of the heterogeneous group of peripheral nerve hyperexcitability syndromes.

Each of these valuable insights, and their accompanying explanations, provides a framework on which new therapeutic strategies can be built to aid in the enhancement and restoration of normal function in neuromuscular junction disorders.
* New insights into the study of neuromuscular junction disorders, including rapid advancements in the field
* Comprehensive information on the neuromuscular junction, and a detailed examination of myasthenia gravis and other disorders
* A new framework upon which to build therapeutic strategies that will enhance the restoration of normal function in neuromuscular disorders

The Limits of Dream focuses on what we currently know of the human central nervous system (CNS), examining the basic sciences of neurochemisty, neuroanatomy, and CNS electrophysiology as these sciences apply to dream, then reaching beyond basic science to examine the cognitive science of dreaming including the processes of memory, the perceptual interface, and visual imagery. Building on what is known of intrapersonal CNS processing, the book steps outside the physical body to explore artificially created dreams and their use in filmmaking, art and story, as well as the role of dreaming in creative process and creative madness. The limits of our scientific knowledge of dream frame this window that can be used to explore the border between body and mind. What is known scientifically of the cognitive process of dreaming will lead the neuroscientist, the student of cognitive science, and the general reader down different paths than expected into an exploration of the fuzzy and complex horizon between mind and brain.
* The clearest presentation of research and philosophy currently available relating to the mind/brain interface
* Discusses the cognitive processes of dreaming utilized in film and artificial intelligence
* Describes the functioning of dream in the creative process"

This book details how "Alzheimer Disease" went from being an obscure neurologic diagnosis to a household word. The words of those responsible for this revolution are the heart of this book. Dr. Robert Katzman and Dr. Katherine Bick, leaders in Alzheimer research and policy making, interview the people responsible for this awakening of public consciousness about Alzheimer
Disease from 1960 to 1980. They speak with the scientists, public health officials, government regulators, and concerned relatives and activists responsible for taking this neurodegenerative disease out of the "back wards" through the halls of Congress, and on to the front page. The reader will learn how the explosive increase in research funding and public awareness came about, how physicians and psychiatrists established diagnostic criteria, how drugs were developed that offer hope for sufferers, and how the Alzheimer's Association was born.
* Written in the words of those responsible for the widespread recognition of this neurodegenerative disease
* The authors are recognised as leaders in Alzheimer research and policy making

Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). The book should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering.
* Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures
* Contributors are top experts at the forefront of computational epilepsy research
* Chapter contents are highly relevant to both basic and clinical epilepsy researchers

This text introduces underlying principles of the endocrine regulation of behavior in animals and humans. Every chapter begins by stating a principle, followed by specific examples of hormone actions derived from scientific experiments and clinical observations, and concludes with a few challenging unanswered questions. The reference source Hormones, Brain & Behavior identified this field as rapidly expanding within neurobiology and endocrinology. Now, this well-illustrated and referenced text will serve students from undergraduate school to medical school as they learn this new discipline.
* Uniform presentation of material across all chapter, with each chapter addressing a key principle, illustrated by basic experimental and clinical examples
* Includes user-friendly features such as boxed figures with extended captions and references, numerous clinical notes, and a comprehensive list of abbreviations
* Illustrations highlight both the clinical and basic science information

This book presents the anatomical systems that take part in the scientific and clinical study of emotional functions and neuropsychiatric disorders. It discusses the limbic system-the cortical and subcortical structures in the human brain involved in emotion, motivation, and emotional association with memory-at length and how this is no longer a useful guide to the study of psychiatric disorders. The book provides an understanding of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century. The goal is to help the reader develop an understanding of the gross anatomical organization of the human forebrain.
The book also includes an enlightening DVD describing the basic surface anatomy of the cerebral hemispheres, coronal and horizontal sections, and blunt dissection of the forebrain with special attention to clinical-anatomical correlations of interest to psychiatrists.
* A re-evaluation of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century
* A compellingly expanded conceptualization of Broca's famous limbic lobe
* Clinical and basic science boxes highlighting specific concepts, structures, or neuronal circuits from a clinical perspective
* DVD illustrating dissection of the human brain by one of the world's masters

This volume provides a comprehensive understanding of HIV/AIDS and neuro-AIDS, including a history of the disease, and an explanation of many of the conditions that can arise in afflicted patients, including opportunistic infections, central nervous system tumors, spinal cord disorders, myopathies and progressive encephalopathy, amongst others.

Clinicians will gain a greater understanding of the complex mechanisms of the disease. Beginning with a basic introduction to HIV infections and Neuro-AIDS, practitioners will find useful data on advances in molecular biology, neuroepidemiology, neuroimaging, neuropathology, neuropharmacology, as well as information on the development of therapeutic strategies appropriate for the disorder, including groundbreaking retroviral therapies.

In addition, the socioeconomic and political constraints that hinder treatment and disease management in developing parts of the world are presented.
* A comprehensive understanding of HIV/AIDS and neuro-AIDS, and the progression of the scientific community s understanding of the disease
* Detailed information on fields such as neuroepidemiology, neuropathology, neuropharmacology, and neuroimaging and their contributions to HIV/AIDS research
* Subject specific chapters on conditions associated with HIV/AIDS, including opportunistic infections, central nervous system tumors, and myopathies, amongst others"

This book examines the role that dopamine plays in schizophrenia, examining its role in not only the symptoms of the disease but also in its treatment. It also reviews all neurotransmitters that have been implicated in schizophrenia, exploring the genetic data, clinical data implicating the transmitter, and the preclinical data exploring how a transmitter may interact with dopamine and contribute to the dopaminergic phenotype observed in the illness. This book will serve as an educational tool for instructors, a guide for clinicians, and be of interest to researchers. It is a good reference for researchers specialized in one particular area and interested in learning about other areas of pathology in schizophrenia and how they may all feed into each other. The book concludes with an overall integrative model assembling as many of these elements as possible.

Currently, few drugs are available for the effective treatment of neurodegenerative diseases and neurodevelopmental disorders. Recent advances in neuroscience research offer hope that future strategies for treating these brain disorders will include neurogenesis and neuroenhancement as therapeutic endpoints. This volume reviews cutting-edge findings related to the pharmacological aspects of neurogenesis and neuroprotection. A broad range of topics are covered from basic lab bench research to drug discovery efforts and important clinical issues. This collection of reviews is a perfect way to become acquainted with these exciting new fields in the space of a single volume. Chapters are written with a general audience in mind, but with enough high-level discussion to appeal to specialists and experts as well. The authors have done an excellent job of challenging current paradigms and pushing the boundaries of exploration in keeping with the pioneering spirit that gave rise to these emerging areas of research. Consequently, this will be an indispensable resource for many years to come.
* Provides state-of-the-art reviews spanning significant emerging fields
* Discusses future directions and questions for future studies
* Includes informative illustrations
*

Comprised of two separate volumes, Neuroimaging provides a state-of-the-art review of a broad range of neuroimaging techniques applied to both clinical and research settings. The breadth of the methods covered is matched by the depth of description of the theoretical background. Part B covers the application of neuroimaging in both research and clinical settings for the study of anxiety disorders, dementia, depression, schizophrenia, functional somatic syndromes, stroke, and multiple sclerosis using a range of neuroimaging modalities including CT, PET, SPECT, DTI, structural MRI and fMRI. One chapter is devoted to the study of brain development using structural MRI, and one chapter to the study of pediatric neurobehavioral disorders using fMRI. One of the most exciting recent applications of neuroimaging to the area of genetics is covered, and with the theory and application of neuroreceptor imaging in psychiatry, forms the final two chapters.
The two parts of Neuroimaging complement each other providing in-depth information on a broad range of routine and cutting edge techniques that is not available in any other text. This book is superbly written and beautifully illustrated by contributors working at the top of their chosen specialty.
* Presents recent applications of neuroimaging to the area of genetics
* Discusses the study of brain development using structural MRI
* Includes chapters on the theory and application of neuroreceptor imaging in psychiatry

Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts - a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective.
The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature.
- Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction
- Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work
- Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching

Theoretical Mechanics of Biological Neural Networks develops an engineering science for the description of neuroclectric signalling of biological neural networks in terms of the underlying neurobiological mechanisms. The primary theoretical contribution of the book is to show how to describe the co-ordinated electrical activity of arbitrarily complex neural networks in terms of a single governing principle ' for each significant component in the same way that Newton's formulation of classical mechanics allows one to express force-motion relationships for arbitrarily complex mechanical systems in terms of one fundamental principle of motion for each constituent element.;Practically, the book shows how to generate mathematical and computational representations Of' the co-ordinated electrical activity of neural networks, ranging from individual neurons to composite systems of interconnected networks. Complete listings of several general purpose computer programs embodying the theory are included in the book.

The Handbook of Statistics, a series of self-contained reference books. Each volume is devoted to a particular topic in statistics. Every chapter is written by prominent workers in the area to which the volume is devoted. The series is addressed to the entire community of statisticians and scientists in various disciplines who use statistical methodology in their work. At the same time, special emphasis is placed on applications-oriented techniques, with the applied statistician in mind as the primary audience.

This volume presents a state of the art exposition of topics in the field of industrial statistics. It serves as an invaluable reference for the researchers in industrial statistics/industrial engineering and an up to date source of information for practicing statisticians/industrial engineers. A variety of topics in the areas of industrial process monitoring, industrial experimentation, industrial modelling and data analysis are covered and are authored by leading researchers or practitioners in the particular specialized topic. Targeting the audiences of researchers in academia as well as practitioners and consultants in industry, the book provides comprehensive accounts of the relevant topics. In addition, whenever applicable ample data analytic illustrations are provided with the help of real world data.

Aiming to provide the reader with a general overview of the mathematical and numerical techniques used for the simulation of matter at the microscopic scale, this book lays the emphasis on the numerics, but modelling aspects are also addressed. The contributors come from different scientific communities: physics, theoretical chemistry, mathematical analysis, stochastic analysis, numerical analysis, and the text should be suitable for graduate students in mathematics, sciences and engineering and technology.

Investigation of the functional architecture of the human brain using modern noninvasive imaging techniques is a rapidly expanding area of research. A proper knowledge of methodology is needed to appreciate the burgeoning literature in the field. This timely publication provides an excellent catalogue of the main techniques.
The authors offer an invaluable analysis of mapping strategies and techniques, providing everything from the foundations to the major pitfalls and practical applications of the modern techniques used in neuroimaging. Contains over 1000 full color pages with more than 200 color figures.
Spanning the methodological gamut from the molecular level to the whole brain while discussing anatomy, physiology, and pathology, as well as their integration, Brain Mapping: The Methods, 2e, brings the reader a comprehensive, well-illustrated and entirely readable description of the methods for brain mapping. Drs. Toga and Mazziotta provide everything from the foundations to the major pitfalls and practical applications of the technique by assembling an impressive group of experts, all widely known in their field, who contribute an outstanding set of chapters.

Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments.
Key Features
* Organized by function, making it easy to find and understand the material
* Addresses impairments both associated with diseases and not associated with diseases
* Written by leading researchers in the field
* Most comprehensive source of information on the neurobiology of aging

Febrile Seizures is written by the most active researchers and clinicians in epilepsy research today. This book presents the latest developments in this field as well as the current state of knowledge in the following:
* New imaging tools and emerging data, visualizing effects of febrile seizures on the brain
* New genetic methodologies
* The use of animal models to permit scientific analysis of the electrophysiology and molecular biology of the seizure.

Key Features
* First book on febrile seizures in over 20 years
* Broad spectrum of approaches, from genetic and epidemiological to bench research using animal models and in vitro single-cell patch-clamp methods
* Comprehensive update of the topic, written by world leaders in the field
* Novel and newly discovered information based on up-to the minute methods
* Engaging style, accessible to the clinician, researcher, and educated parent