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This book is devoted to the surgical treatment of epilepsy and its consequences, and provides an extraordinary perspective on the fascinating question of the relationship between brain and mind. Contrary to the current emphasis on statistics and objectivity, this book is dedicated to understanding the whole person, the life and experiences of the individual. It reports on cutting-edge technical skills provided with a human touch. This book reflects the understanding that the temporolimbic seizure originates in tissue providing the substrate for the emotional life and memory. Finally, it emphasizes the value of clinical research - here, conducted in the course of the diagnosis and surgical treatment of epilepsy - in helping to elucidate the relationship between brain and mind.
The study of catatonia in Autism Spectrum Disorders is a novel and
controversial topic. Catatonia is a motor disorder characterized by
stereotypy, rigidity, mutism, and posturing. These motor signs are
also characteristic of autism. The interest in the relation between
autism and catatonia stems from clinical observations that autistic
and catatonic symptoms overlap, that some people with autism
develop full-blown catatonia, and that anti-catatonic treatments
bring relief in some of those patients.
The thalamus is a group of cells placed centrally in the brain that
serve a critical role in controlling how both sensory and motor
signals are passed from one part of the cerebral cortex to another.
Essentially, all information reaching the cerebral cortex and thus
consciousness is relayed through the thalamus. The role of the
thalamus in controlling the flow of information (such as visual,
auditory, and motor) to the cortex has only recently begun to be
understood. This book provides an in-depth look at the function of
the thalamus and its role as relayer of information to the cerebral
cortex. The authors explore how the thalamus controls messages that
are passed to the cortex and they introduce the novel suggestion
that the thalamus serves a critical role in controlling how
messages pass from one part of the cortex to another. Exploring the
Thalamus is a comprehensive, up-to-date reference for researchers.
It discusses problems concerning the function and structure of the
thalamus and concludes each chapter with thought-provoking
questions regarding future research.
Scientists planning experiments in medical and behavioral research
will find this handbook and dictionary an invaluable desk reference
tool. Also recommended as a textbook for students of Experimental
Design or accompanying courses in Statistics.
This book details how "Alzheimer Disease" went from being an
obscure neurologic diagnosis to a household word. The words of
those responsible for this revolution are the heart of this book.
Dr. Robert Katzman and Dr. Katherine Bick, leaders in Alzheimer
research and policy making, interview the people responsible for
this awakening of public consciousness about Alzheimer
Hardbound. Major theoretical advances were made in this area of research, and in the course of these developments order statistics has also found important applications in many diverse areas. These include life-testing and reliability, robustness studies, statistical quality control, filtering theory, signal processing, image processing, and radar target detection. Theoretical researchers working on theoretical and methodological advancements on order statistics and applied statisticians and engineers developing new and innovative applications of order statistics have been successfully brought together to create this handbook. For the convenience of readers, the subject matter has been divided into two volumes. This volume focuses on theory and methods, and volume 17 deals primarily with applications. Each volume has been divided into parts, each part specializing in one aspect of order statistics. The articles in this volume have been classified into
The Cerebellum and Cognition pulls together a preeminent group of
authors. The cerebellum has been previously considered as a highly
complex structure involved only with motor control. The cerebellum
is essential to nonmotor functions, and recent research has
revealed new medically important roles of the cerebellum and
Certain long chain polyunsaturated fatty acids (LCPUFAs) are
thought to be essential components of the nutrition of infants,
including those prematurely born, in the sense that they cannot be
synthesises by the immature organism and must therefore be supplied
in the diet. Breast milk contains these substances, but many
manufactured infant formulae do not.
Hardbound. This reference work covers the many aspects of Robust Inference. Much of what is contained in the chapters, written by leading experts in the field, has not been part of previous surveys of this area. Robust Inference has been an active area of research for the last two decades. Especially during recent years it has been extended in different directions covering a wide variety of models. This volume will be valuable for both graduate students and researchers using statistical methods.
The increasing realization among behaviorists and psychologists is
that many animals learn by observation as members of social
systems. Such settings contribute to the formation of culture. This
book combines the knowledge of two groups of scientists with
different backgrounds to establish a working consensus for future
research. The book is divided into two major sections, with
contributions by a well-known, international, and interdisciplinary
team which integrates these growing areas of inquiry.
Epidemiologic Field Methods in Psychiatry: The NIMH Epidemiologic Catchment Area Program focuses on the methodology employed in the National Institute of Mental Health (NIMH) Epidemiologic Catchment Area (ECA) Program. The selection first elaborates on the historical context, major objectives, and study design and sampling the household population. Topics include the development of the ECA program, DIS instrument, program design, general issues in sampling community resident populations, household and respondent eligibility, household and respondent selection, weighting, and variance estimation. The manuscript then examines institutional survey and the characteristics, training, and field work of interviewers. Discussions focus on the changing nature of institutions, value of the institutional component, institutions included in institutional stratum, interviewer recruitment and selection, demographic characteristic of interviewers, and field work. The publication ponders on nonresponse and nonresponse bias in the ECA surveys, data preparation, and proxy interview, as well as quality of proxy data, item nonresponse, editing and coding, data entry and data cleaning, understanding nonresponse, and assessment of evidence for nonresponse bias. The selection is a valuable source of information for psychiatrists and readers interested in the Epidemiologic Catchment Area (ECA) Program.
Epilepsy, Part II, "Treatment, " Volume 108, provides a full
description of epilepsy pathology and etiology, antiepileptic drug
treatment, the approach to surgical evaluation and alternative
procedures to be considered, in both children and adults, as well
as brain stimulation and diet treatment. Economic and psychosocial
issues such as stigma are fully covered. The special problems of
epilepsy treatment in the developing world are described. Chapters
are authored by internationally respected neurologists with varied
perspectives insuring depth to the content. "Epilepsy, Part I,"
"Basic Principles and Diagnosis," Volume 107, establishes the
scientific and practical diagnosis of epilepsy. The volumes will be
a very important resource for basic scientists, clinical
investigators, and all health professionals treating patients with
This second volume follows on from Part I by reviewing the
variety of animal models of PD current available (from drosophila
to rodents to non-human primate species) and their specific
contributions to PD research. This is followed by comprehensive
coverage of functional neuroimaging studies that explore different
pathophysiological questions and evaluate treatment outcome in PD
patients. Different areas of experimental therapeutics and
outstanding challenges to PD treatment are presented in a
concluding group of articles.
Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist.
This well-established international series examines major areas of
basic and clinical research within neuroscience, as well as
emerging and promising subfields.This volume explores
interdisciplinary research on decision making taking a neural and
Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbookreference exists on the market that provides researchers with more in-depth, high-levelinformation on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole.
This reference is the first of its kind to fill this need. It
pulls together the relevant articles on the topic from the
10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and
serves as an affordable and immediate resource for scientists,
postdocs, graduate students with an interest beyond the basic
textbook materials on the subject.
With recent advances of modern medicine more people reach the "elderly age" around the globe and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians' and neuroscientists' interest to carry out more research projects into pathogenesis of this devastating group of diseases.
In the tradition of its predecessor, the main purpose of this volume is the dissemination of statistical methodologies in the area of biological and medical sciences. The chapters are written by specialists with considerable experience in the application of statistical techniques for investigating biological issues. The volume is divided into four parts and the chapters illustrate some recent work on many issues. Most of the papers discuss the statistical principles in conjunction with specific applications. As a result biological as well as statistical readers will benefit from this exposition, and obtain the current state of knowledge in these areas. Many authors emphasize the open problems that might lead to further work on these subjects.
The book presents a basis for the interaction of the brain and nervous system with painting, music and literature, and a discussion of art from multiple facets such as anatomy, migraine, illusion and evolutionary biology. The book explores several aspects of the neurobiology of painting, including evolutionary neurobiology, sensation vs. perception, the visual brain and how the mind works, and also explores the affects of brain disorders and trauma on artist, with a concluding chapter on Frida Kahlo and the spinal cord injury that influenced her painting.
An understanding of mechanisms underlying seizure disorders depends
critically on the insights provided by model systems. In particular
with the development of cellular, molecular, and genetic
investigative tools, there has been an explosion of basic epilepsy
research. Models of Seizures and Epilepsy brings together, for the
first time in 30 years, an overview of the most widely-used models
of seizures and epilepsy. Chapters cover a broad range of
experimental approaches (from in vitro to whole animal
preparations), a variety of epileptiform phenomenology (including
burst discharges and seizures), and suggestions for model
characterization and validation, such as electrographic,
morphologic, pharmacologic, and behavioral features. Experts in the
field provide not only technical reviews of these models but also
conceptual critiques - commenting on the strengths and limitations
of these models, their relationship to clinical phenomenology, and
their value in developing a better understanding and treatments.
Models of Seizures and Epilepsy is a valuable, practical reference
for investigators who are searching for the most appropriate
laboratory models for addressing key questions in the field. It
also provides an important background for physicians, fellows, and
students, offering insight into the potential for advances in
Autonomic dysfunction is a major and poorly understood consequence
of spinal cord injury. It is a cause of very serious disability and
requires much more research. It should be a focus of treatment
strategies. This book will be of interest to anyone involved in
research and treatment of spinal cord injury since it helps to
explain the tremendously negative impact on the body caused by cord
injury that is not as obvious as paralysis and loss of sensation.
It contains a compilation of what is known about bladder,
cardiovascular, bowel and sexual dysfunction after spinal cord
injury, as it relates to the changes within the autonomic nervous
system control of these functions.
In this book, the editors bring together results from studies on
all kinds of animals to show how thinking on many behaviors as
truly cognitive processes can help us to understand the biology
involved. Taking ideas and observations from the while range of
research into animal behavior leads to unexpected and stimulating
This book presents an overview of the exciting, truly
multidisciplinary research by neuroscientists and systems engineers
in the emerging field of cognitive systems, providing a
cross-disciplinary examination of this cutting-edge area of
scientific research. This is a great example of where research in
very different disciplines touches to create a new emerging area of
research. The book illustrates some of the technical developments
that could arise from our growing understanding of how living
cognitive systems behave, and the ability to use that knowledge in
the design of artificial systems. This unique book is of
considerable interest to researchers and students in information
science, neuroscience, psychology, engineering and adjacent fields.
Hardbound. This volume is devoted to Sample Surveys, which is the most widely used method in statistical practice. It covers many theoretical and practical aspects of social and biological investigations, and is a valuable guide for those involved in designing sample surveys.
Stress is a universal phenomenon that impacts adversely on most people. Following on the heels of "Stress Science: Neuroendocrinology" and "Stress Consequences: Mental, Neuropsychological and Socioeconomic," this third derivative volume will provide a readily accessible and affordable compendium that explains the phenomenon of stress as it relates physically and mentally to war, conflict and disaster. The first section will be dedicated to study of the link between stress and various forms of conflict. Specific instances of conflict will be discussed - the Gulf wars, Korea, Hiroshima bombing, the Holocaust, 9/11, Northern Ireland, terrorism in general, torture. The second section will explore the stress impact of more general physical disasters such as airline and vehicle accidents, earthquakes, floods, and hurricanes. The final section will focus on the clinical relationship between conflict stress and various mental diseases - PTSD, suicide, disaster syndrome, etc - as well as the adverse impact of stress on human physical health in general.
Comprised of about 100 top articles selected from Elsevier s
"Encyclopedias of Stress," the volume will provide a valuable desk
reference that will put relevant articles readily at the fingertips
of all scientists who consider stress.
Chapters offer impressive and unique scope with topics addressing the relationship between stress generated by war, conflict and disaster and various physical/mental disorders Richly illustrated with over 200 figures, dozens in color Articles carefully selected by one of the world s most preeminent stress researchers and contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge"
Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
This volume is a collection of articles covering "Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders. "Topics covered include molecular profiling of direct and indirect striatal medium spiny neurons, the role of epigenetics in development and function of basal ganglia and transgenic animal models for Parkinson's disease.
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