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This volume presents recent empirical advances using neuroscience techniques to investigate how culture influences neural processes underlying a wide range of human abilities, from perception and scene processing to memory and social cognition. It also highlights the theoretical and methodological issues with conducting cultural neuroscience research. Section I provides diverse theoretical perspectives on how culture and biology interact are represented. Sections II VI is to demonstrate how cultural values, beliefs, practices and experience affect neural systems underlying a wide range of human behavior from perception and cognition to emotion, social cognition and decision-making. The final section presents arguments for integrating the study of culture and the human brain by providing an explicit articulation of how the study of culture can inform the study of the brain and vice versa.
It is well recognized that there is an intimate and reciprocal
interaction between epilepsy and sleep. The book, Epilepsy and
Sleep is a ground-breaking, comprehensive source for exploring this
correlation and is especially timely because of the considerable
growth in the understanding of the physiology underlying both sleep
and epilepsy. An insightful reference, it presents many of the
complex physiologic mechanisms underlying epilepsy--sleep
interaction and highlights sleeping disorder symptoms that may be
related to epilepsy.
This book is a short and simple pedagogical guide to the diagnosis and management of epilepsy. After the headache, epilepsy is the second most common neurological disorder, and this book clarifies the many courses of action to take in treating patients with epilepsy. The book simplifies the classification, testing, and treatment of epilepsy, addresses important psychosocial issues and the efficacy of pharmaceutical and other interventions, and also includes an account of modern concepts of the aetiology of the disease. The Comprehensive Evaluation and Treatment of Epilepsy: A Practical Guide is an important reference work for all medical schools, hospitals, clinics and primary care centers. Features: * CONTAINS ESSENTIALS ON: * Initial management of patients with seizures * Psychosocial aspects of epilepsy * Neuropsychologic problems associated with epilepsy * Psychiatric disorders * Diagnosis and treatment of status epilepticus * Nonepileptic seizures * Ambulatory EEG monitoring * Epilepsy surgery * Endocrine aspects of partial seizures * Epilepsy in the elderly
Hormones and Signaling focuses on the mechanism of gene regulation
at the cellular level. It also covers the way hormones act to
modulate gene regulation and animal development.
This volume encompasses a variety of topics pertaining to patients with altered levels of consciousness, including valuable differences between disorders. Neurologists, researchers, and clinicians will find a comprehensive accounting of the distinctions between disorders that cause these altered states. Beginning with basic concepts of consciousness and neurobiology, this handbook progresses into more targeted and complex areas of discussion, including important technological advancements that have occurred in neuroimaging.
Neurologists who are frequently called upon for prognostication
and to guide management of patients with these disorders will find
invaluable information, including chapters discussing comatose
states in children and pregnant women, encephalopathic patients,
nutrition disorders, and vegetative and minimally conscious states.
In addition, chapters devoted to philosophical backgrounds and
ethical implications involving patients with impaired
consciousness, are thoroughly presented.
Parkinson s disease is the second most prevalent neurodegenerative
disease and is characterized by the irreversible loss of dopamine
neurons. Despite its high prevalence in society and many decades of
research, the origin of the pathogenesis and the molecular
determinants involved in the disorder has remained elusive.
Confounding this issue is the lack of experimental models that
completely recapitulate the disease state. The identification of a
number of genes thought to play a role in the cell death, and
development of both toxin and genetic models to explore the
function of the genes both in unaffected and diseased cells are now
providing new insights into the molecular basis of the
neurodegeneration, as well as therapeutic approaches. In this
reference, we will describe the advances and the advantages that
various invertebrates, cell culture, rodents, and mammals provide
in the identification of the molecular components and mechanisms
involved in the cell death, and outline the opportunities that
these systems provide in drug discovery.
One of the most pressing questions in neuroscience, psychology
and economics today is how does the brain generate preferences and
make choices? With a unique interdisciplinary approach, this volume
is among the first to explore the cognitive and neural mechanisms
mediating the generation of the preferences that guide choice. From
preferences determining mundane purchases, to social preferences
influencing mating choice, through to moral decisions, the authors
adopt diverse approaches to answer the question. Chapters explore
the instability of preferences and thecommon neural processes that
occur across preferences. Edited by one of the world s most
renowned cognitive neuroscientists, each chapter is authored by an
expert in the field, with a host of international
Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
With recent advancements in new knowledge, it has become evident that psychostimulants and related drugs of abuse are influencing our central nervous system (CNS) remarkably and could alter their function for a longtime. This volume is the first to focus on substance abuse induced brain pathology in the widest sense as it covers alterations in neuronal, glial and endothelial cell functions under the influence of acute or chronic usage of substance abuse.
In the last ten years the neuroscience of language has matured as a
field. Ten years ago, neuroimaging was just being explored for
neurolinguistic questions, whereas today it constitutes a routine
component. At the same time there have been significant
developments in linguistic and psychological theory that speak to
the neuroscience of language. This book consolidates those advances
into a single reference.
This volume provides a broad overview of important new advances in
the field of Neuropharmacology. In 20 chapters, a selection of
international contributors discuss topics including endocannabinoid
function, pain, stress, astrocytes etc, and new possibilities for
treatments of neurological diseases with neuropharmacological
The effects of global warming on human health factors with special
regards to our brain function are still not well understood. There
is an urgent need to expand our knowledge on the effects of hot
environment on our brain functions in healthy and in diseased
populations. It is still unclear whether infectious events,
traumatic injuries, metabolic diseases, carcinogenic events,
cardiovascular and respiratory functions will be adversely affected
by the rise in global temperature or whether environmental
pollutants, such as nanoparticles entered into our body system will
produce more damage at high ambient temperatures. This book aims to
answer these questions based on recent research carried out by top
experts in the field from the USA (11 chapters), Europe (8)
chapters), the Middle East (3 chapters), Asia (2 chapters) and
Epilepsy is a neurological disorder that affects millions of
patients worldwide and arises from the concurrent action of
multiple pathophysiological processes. The power of mathematical
analysis and computational modeling is increasingly utilized in
basic and clinical epilepsy research to better understand the
relative importance of the multi-faceted, seizure-related changes
taking place in the brain during an epileptic seizure. This
groundbreaking book is designed to synthesize the current ideas and
future directions of the emerging discipline of computational
epilepsy research. Chapters address relevant basic questions (e.g.,
neuronal gain control) as well as long-standing, critically
important clinical challenges (e.g., seizure prediction). The book
should be of high interest to a wide range of readers, including
undergraduate and graduate students, postdoctoral fellows and
faculty working in the fields of basic or clinical neuroscience,
epilepsy research, computational modeling and bioengineering.
This volume provides a vital and comprehensive resource on stroke, including research, diagnosis, prevention, and treatment modalities. Practitioners in these fields will find invaluable information in this handbook, from basic mechanisms of the disease, to enhanced diagnostic and therapeutic capabilities for patient care.
With the field of cerebrovascular disorders, including stroke, making rapid advancements, clinicians will find illuminating and insightful chapters on the pathophysiological basis of this disorder.
Advances in our understanding of the biochemical background of
strokes, coupled with an examination of breakthroughs in
epidemiology, genetics, neuroimaging, interventional radiology,
surgery, and even clinical psychology are also explored, giving
researchers and clinicians a profoundly altered way to approach
stroke research, diagnosis, and patient treatment and care.
This fully revised 2e provides the only unified synthesis of
available information concerning the mechanisms of higher-order
memory formation. It spans the range from learning theory, to human
and animal behavioral learning models, to cellular physiology and
biochemistry. It is unique in its incorporation of chapters on
memory disorders, tying in these clinically important syndromes
with the basic science of synaptic plasticity and memory
mechanisms. It also covers cutting-edge approaches such as the use
of genetically engineered animals in studies of memory and memory
diseases. Written in an engaging and easily readable style and
extensively illustrated with many new, full-color figures to help
explain key concepts, this book demystifies the complexities of
memory and deepens the reader s understanding.
Hardbound. This volume covers an area of statistics dealing with complex problems in the production of goods and services, maintenance and repair, and management and operations. The opening chapter is by W. Edwards Deming, pioneer in statistical quality control, who was involved in the quality control movement in Japan and helped the country in its rapid industrial development. He gives a program to keep a country in an ascending path of industrial development.Areas covered in the further 23 chapters of the work include: - reliability of hardware and process control software;- the concepts and theory of reliability and the statistical inference problems arising therein;- the aspects of Quality Control of manufactured goods.
A single volume of 41 articles, Hormone/Behavior Relations of
Clinical Importance is an authoritative selection of relevant
chapters from the Hormones Brain and Behavior 2e MRW, the most
comprehensive source of neuroendocrinological information assembled
to date (AP July 2009).
Hardbound. This volume of the Handbook is concerned particularly with the frequency side, or spectrum, approach to time series analysis. This approach involves essential use of sinusoids and bands of (angular) frequency, with Fourier transforms playing an important role. A principal activity is thinking of systems, their inputs, outputs, and behavior in sinusoidal terms. In many cases, the frequency side approach turns out to be simpler with respect to computational, mathematical, and statistical aspects. In the frequency approach, an assumption of stationarity is commonly made. However, the essential roles played by the techniques of complex demodulation and seasonal adjustment show that stationarity is far from being a necessary condition. Assumptions of Gaussianity and linearity are also commonly made and yet, as a variety of the papers illustrate, these assumptions are not necessary. This volume complements Handbook of Statistics 5: Time Series in the
The efficient delivery of cellular constituents to their proper
location is of fundamental importance for all cells and is of
particular interest to neuroscientists, because of the unique
functions and complex architecture of neurons. Protein Trafficking
in Neurons examines mechanisms of protein trafficking and the role
of trafficking in neuronal functioning from development to
plasticity to disease. The book is divided into seven sections that
review mechanisms of protein transport, the role of protein
trafficking in synapse formation, exo- and endocytosis, transport
of receptors, trafficking of ion channels and transporters,
comparison of trafficking mechanisms in neuronal vs. non-neuronal
cell types, and the relationship between trafficking and neuronal
diseases such as Alzheimer's, Huntington's and Prion Diseases.
Treatment of patients with a brain tumor remains one of the most
challenging and difficult areas of modern oncology. Recent advances
in the molecular biology of these neoplasms have improved our
understanding of the malignant phenotype and have lead to the
development of novel forms of chemotherapy, including "targeted"
agents. The Handbook of Brain Tumor Chemotherapy reviews the
state-of-the-art of chemotherapy development and clinical treatment
of patients with this devastating disease.
Neuromodulation is an emerging field that explores the use of electrical, chemical, and mechanical interventions to heal neurological deficits. Suchneurostimulation has already shown great promise with disorders and diseases such as chronic pain, epilepsy, and Parkinson s disease. This is the first concise reference covering all of the basic principles of neuromodulation in a single affordable volume for neuro-residents, fellows, and basic clinical practitioners, edited by two prominent clinical experts in the field.
This volume emphasizes essential observations from all of the
important clinical phases involved in any neuromodulation:
targeting, intraoperative assessment, programming, complications,
and complication avoidance. There are commonalities to all
neuromodulation procedures that must be brought to the forefront to
form a cohesive presentation of neuromodulation, and such emphasis
will give readers a more solid grounding in the fundamentals needed
to embrace this field as a cohesive clinical entity.
This selection of articles from the "Encyclopedia of the Eye"
provides a comprehensive overview of immunological features,
diseases and inflammation of the eye and its support structures and
organs. Rather than taking an immunological focus that is strictly
suitable for clinicians, the volume offers a considerable basic
science background and addresses a broad range of topics - the
immune system of the eye, its various disorders, mechanisms of
inflammation of the eye and visual system, treatment, wound healing
mechanisms, stem cells, and more.
*The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of ocular immunology
*Chapters are carefully selected from the Encyclopedia of the Eye by the world's leading vision researchers
*The best researchers in the field provide their conclusions in the context of the latest experimental results
The serotonin 5-HT6 receptor represents a novel pharmacological
target whose impact on physiopathology of CNS functions remains
undetermined. Some receptor antagonists have been synthesized and
they show a modulatory role in learning and memory processes and
food intake. The pharmacology of 5-HT6 receptor agonists is still
under evaluation. However, both 5-HT6 antagonists and agonists seem
to exert potential antidepressant activity. Recently, a second
messenger system has been discovered. 5-HT6 receptor function is
becoming more and more intriguing. Thus, the aim of the present
book is to try to clarify the pharmacology of 5-HT6
written by expert researchers covers all published literature to date in the field of 5-HT6 receptors
The Limits of Dream focuses on what we currently know of the human
central nervous system (CNS), examining the basic sciences of
neurochemisty, neuroanatomy, and CNS electrophysiology as these
sciences apply to dream, then reaching beyond basic science to
examine the cognitive science of dreaming including the processes
of memory, the perceptual interface, and visual imagery. Building
on what is known of intrapersonal CNS processing, the book steps
outside the physical body to explore artificially created dreams
and their use in filmmaking, art and story, as well as the role of
dreaming in creative process and creative madness. The limits of
our scientific knowledge of dream frame this window that can be
used to explore the border between body and mind. What is known
scientifically of the cognitive process of dreaming will lead the
neuroscientist, the student of cognitive science, and the general
reader down different paths than expected into an exploration of
the fuzzy and complex horizon between mind and brain.
Over the past 25 years the amount of data pertaining to the
GABAergic function in the basal ganglia has increased dramatically.
GABA and the Basal Ganglia - From Molecules to Systems is a
comprehensive review of the current state-of-the-art of knowledge
about the neuroanatomy, neuropharmacology and neurophysiology of
the basal ganglia, focusing on its GABAergic microcircuitry. It
serves as a complete reference to the body of knowledge about the
basal ganglia, its constituent neurons, and their interconnections.
This volume is designed to serve as a convenient all-in-one review
and reference for experienced basal ganglia researchers as well as
an introduction to the functional organization of the basal ganglia
and its GABAergic circuitry for students and researchers new to the
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