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Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbookreference exists on the market that provides researchers with more in-depth, high-levelinformation on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole.
This reference is the first of its kind to fill this need. It
pulls together the relevant articles on the topic from the
10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and
serves as an affordable and immediate resource for scientists,
postdocs, graduate students with an interest beyond the basic
textbook materials on the subject.
This fully revised 2e provides the only unified synthesis of
available information concerning the mechanisms of higher-order
memory formation. It spans the range from learning theory, to human
and animal behavioral learning models, to cellular physiology and
biochemistry. It is unique in its incorporation of chapters on
memory disorders, tying in these clinically important syndromes
with the basic science of synaptic plasticity and memory
mechanisms. It also covers cutting-edge approaches such as the use
of genetically engineered animals in studies of memory and memory
diseases. Written in an engaging and easily readable style and
extensively illustrated with many new, full-color figures to help
explain key concepts, this book demystifies the complexities of
memory and deepens the reader s understanding.
An understanding of mechanisms underlying seizure disorders depends
critically on the insights provided by model systems. In particular
with the development of cellular, molecular, and genetic
investigative tools, there has been an explosion of basic epilepsy
research. Models of Seizures and Epilepsy brings together, for the
first time in 30 years, an overview of the most widely-used models
of seizures and epilepsy. Chapters cover a broad range of
experimental approaches (from in vitro to whole animal
preparations), a variety of epileptiform phenomenology (including
burst discharges and seizures), and suggestions for model
characterization and validation, such as electrographic,
morphologic, pharmacologic, and behavioral features. Experts in the
field provide not only technical reviews of these models but also
conceptual critiques - commenting on the strengths and limitations
of these models, their relationship to clinical phenomenology, and
their value in developing a better understanding and treatments.
Models of Seizures and Epilepsy is a valuable, practical reference
for investigators who are searching for the most appropriate
laboratory models for addressing key questions in the field. It
also provides an important background for physicians, fellows, and
students, offering insight into the potential for advances in
A single volume of 31 articles, Mechanisms of Hormone Actions on
Behavior is an authoritative selection of relevant chapters from
the Hormones Brain and Behavior 2e MRW, the most comprehensive
source of neuroendocrinological information assembled to date (AP
Stress is a universal phenomenon that impacts adversely on most
people. This volume provides a readily accessible compendium that
explains the phenomenon of stress, the neural, endocrine and
molecular mechanisms involved, the clinical effects, and the impact
on individuals and society. Clinical attention focuses on disorders
of the stress control system (e.g. Cushing s Syndrome: Addison s
Disease) and the adverse impact of stress on human physicaland
mental health . Detailed reviews address disorders such as PTSD,
anxiety, major depression, psychoses and related disorders such as
combat fatigue and burnout. The work covers interactions between
stress and neurodegenerative disorders, such as Alzheimer s disease
and Parkinson s disease, as well as stress-immune-inflammatory
interactions in relation to cancer and autoimmune and viral
diseases. Emphasis is alsoplaced on the role of stress in obesity,
hypertension, diabetes type II and other features of the metabolic
syndrome which has now reached epidemic proportions in the USA and
Richly illustrated with over 200 figures, 75 in color
Priced affordably, this compendium of articles appeals to the end user interested in stress research who would not otherwise purchase the larger Encyclopedia of Stress
Articles carefully selected by one of the world s most preeminent stress researchers and contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge "
A single volume of 41 articles, Hormone/Behavior Relations of
Clinical Importance is an authoritative selection of relevant
chapters from the Hormones Brain and Behavior 2e MRW, the most
comprehensive source of neuroendocrinological information assembled
to date (AP July 2009).
As MRI research becomes more detailed and specialized, it becomes essential to have detailed atlases that also explain individual variability, but other atlases do not provide this detail and leave users without illustration of, or guidance regarding how to deal with the variability they inevitably encounter in research and practice.This bookserves as the first cortex atlas to address this growing need, appealing to clinicians, researchers and graduate students in neuroscience, neurology, neurosurgery and radiology.
The atlas provides nearly 200 photographs of 3D reconstructions
of human brains in a standard series of coronal, sagittal, and
horizontal sections. It illustrates in detail and labels 95% of the
cortex sulci and gyri, and images are presented in the MNI
stereotaxic space. In addition to the standard brain and its
sections are numerous examples of brains that exhibit patterns of
deviating sulci and gyri. Examples of these variants are presented
next to the standard illustration, accompanied by brief commentary
aimed at helping users identify these variants and use them in
their own work
* Nearly 200 photographic plates of the cortex in standard series of coronal, sagittal, and horizontal sections, presented in MNI stereotaxic coordinates
* Illustrates in detail and labels all of the cortex sulci and gyri, providing more detail than any other MRI atlas
*Provides commentary and practical guidance on the variability in the patterns of sulci and gyri, aiding readers in dealing with variability they encounter in research and practice"
This volume provides a comprehensive look into the innovative methods used to explore the visual system. From the way the brain processes vision, an imperative part of the human experience, to the role eye movement plays in a range of questions concerning visual perception, memory, attention, free will, and even topological diagnoses, this in-depth handbook gives neurologists, ophthalmologists, and neuro-ophthalmologists an invaluable tool to help them better understand the visual system.
Disorders of the retinal and cerebral cortex, and those that affect control of eye and lid movements are thoroughly discussed, along with groundbreaking visual rehabilitative methods, and chapters on individual parts of the visual system. Practitioners will find a useful resource that lays out fundamental concepts, while seamlessly summarizing clinical and laboratory methods for neuro-ophthalmological evaluation.
The material is perfect for early-stage physicians or long
practicing specialists who wish to learn the latest developments in
This book is a short and simple pedagogical guide to the diagnosis and management of epilepsy. After the headache, epilepsy is the second most common neurological disorder, and this book clarifies the many courses of action to take in treating patients with epilepsy. The book simplifies the classification, testing, and treatment of epilepsy, addresses important psychosocial issues and the efficacy of pharmaceutical and other interventions, and also includes an account of modern concepts of the aetiology of the disease. The Comprehensive Evaluation and Treatment of Epilepsy: A Practical Guide is an important reference work for all medical schools, hospitals, clinics and primary care centers. Features: * CONTAINS ESSENTIALS ON: * Initial management of patients with seizures * Psychosocial aspects of epilepsy * Neuropsychologic problems associated with epilepsy * Psychiatric disorders * Diagnosis and treatment of status epilepticus * Nonepileptic seizures * Ambulatory EEG monitoring * Epilepsy surgery * Endocrine aspects of partial seizures * Epilepsy in the elderly
This is the fully revised and updated second edition of the very
sucessful introductory textbook on cognitive neuroscience. Written
by two leading experts in the field, thisbook takes a unique
thematic approach to introduce concepts of cognitive neurosciences,
guiding students along a clear path to understand the latest
findings whether or not they have a background in neuroscience. New
to this edition are "Frontiers in Cognitive Neuroscience" text
boxes; each one focuses on a leading researcher and their topic of
expertise. There is a new chapter on Genes and Molecules of
Cognition, and all other chapters have been thoroughly revised,
based on the most recent discoveries.
Rapid adoption and course preparation: A wide array of instructor support materials are available online including PowerPoint lecture slides, a test bank with answers, and eFlashcords on key concepts for each chapter. A textbook with an easy-to-understand thematic approach: in a way that is clear for students from a variety of academic backgrounds, the text introduces concepts such as working memory, selective attention, and social cognition.A step-by-step guide for introducing students to brain anatomy: color graphics have been carefully selected to illustrate all points and the research explained. Beautifully clear artist's drawings are used to 'build a brain' from top to bottom, simplifying the layout of the brain.
An easy-to-read, complete introduction to mind-brain science: all chapters begin from mind-brain functions and build a coherent picture of their brain basis. A single, widely accepted functional framework is used to capture the major phenomena. Learning Aids include a student support site with study guides and exercises, a new Mini-Atlas of the Brain and a full Glossary of technical terms and their definitions.Richly illustrated with hundreds of carefully selected color graphics to enhance understanding. "
Neuroendocrinology, the discipline concerned with how the
nervous system controls hormonal secretion and how hormones control
the brain, is pivotal to physiology and medicine.
Neuroendocrinology has disclosed and underpins fundamental
physiological, molecular biological and genetic principles such as
the regulation of gene transcription and translation, the
mechanisms of chemical neurotransmission and intracellular and
systemic feedback control systems. Reproduction, growth, stress,
aggression, metabolism, birth, feeding and drinking and blood
pressure are some of the bodily functions that are triggered and/or
controlled by neuroendocrine systems. In turn, neuroendocrine
dysfunction due to genetic or other deficits can lead, for example,
to infertility, impotence, precocious or delayed puberty, defective
or excessive growth, obesity and anorexia, Cushing s Syndrome,
hypertension or thyroid disorders. These as well as neuroendocrine
tumors are some of the themes covered in the 36 chapters of the
Handbook. Drafted by internationally acknowledged experts in the
field, the Handbook chapters feature detailed up-to-date
bibliographies as well as "how do we know?" call out sections that
highlight the experimental or technical foundations for major
concepts, principles, or methodological advances in each area.
Aimed at senior undergraduate and graduate students, post-doctoral
fellows and faculty in neuroscience, medicine, endocrinology,
psychiatry, psychology and cognate disciplines, the "Handbook of
Neuroendocrinology" satisfies an unmet need that will prove useful
at the laboratory bench as well as in the office.
Neurological Rehabilitation is the latest volume in the definitive
Handbook of Clinical Neurology series. It is the first time that
this increasing important subject has been included in the series
and this reflects the growing interest and quality of scientific
data on topics around neural recovery and the practical
applications of new research. The volume will appeal to clinicians
from both neurological and rehabilitation backgrounds and contains
topics of interest to all members of the multidisciplinary clinical
team as well as the neuroscience community. The volume is divided
into five key sections. The first is a summary of current research
on neural repair, recovery and plasticity. The authors have kept
the topics readable for a non-scientific audience and focused on
the aspects of basic neuroscience that should be most relevant to
clinical practice. The next section covers the basic principles of
neurorehabilitation, including excellent chapters on learning and
skill acquisition, outcome measurement and functional neuroimaging.
The key clinical section comes next and includes updates and
reviews on the management of the main neurological disabling
physical problems, such as spasticity, pain, sexual functioning and
dysphagia. Cognitive, emotional and behavioural problems are just
as important and are covered in the next section, with excellent
chapters, for example, on memory and management of executive
dysfunction. The final part draws the sections on symptom
management together by discussing the individual diseases that are
most commonly seen in neurorehabilitation and providing an overview
of the management of the disability associated with those
disorders. The volume is a definitive review of current
neurorehabilitation practice and will be valuable to a wide range
of clinicians and scientists working in this rapidly developing
The book is a history of the McKnight Endowment Fund for
Neuroscience and an assessment of its effectiveness in advancing
neuroscience. The book discusses the Fund's early and steady
commitment to basic science as well as it's tradition of leveraging
relatively modest dollars to make a big difference in careers and
the field overall.
This second volume follows on from Part I by reviewing the
variety of animal models of PD current available (from drosophila
to rodents to non-human primate species) and their specific
contributions to PD research. This is followed by comprehensive
coverage of functional neuroimaging studies that explore different
pathophysiological questions and evaluate treatment outcome in PD
patients. Different areas of experimental therapeutics and
outstanding challenges to PD treatment are presented in a
concluding group of articles.
Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist.
This volume of Progress in Brain Research provides a synthetic source of information about state-of-the-art research that has important implications for the evolution of the brain and cognition in primates, including humans. This topic requires input from a variety of fields that are developing at an unprecedented pace: genetics, developmental neurobiology, comparative and functional neuroanatomy (at gross and microanatomical levels), quantitative neurobiology related to scaling factors that constrain brain organization and evolution, primate palaeontology (including paleoneurology), paleo-anthropology, comparative psychology, and behavioural evolutionary biology.
Written by internationally-renowned scientists, this timely
volume will be of wide interest to students, scholars, science
journalists, and a variety of experts who are interested in keeping
track of the discoveries that are rapidly emerging about the
evolution of the brain and cognition.
Written by internationally renowned scientists, this timely volume will be of wide interest to students, scholars, science journalists, and a variety of experts who are interested in keeping track of the discoveries that are rapidly emerging about the evolution of the brain and cognition.
A single volume of 85 articles, the Handbook of the Neurobiology of
Aging is an authoritative selection of relevant chapters from the
Encyclopedia of Neuroscience, the most comprehensive source of
neuroscience information assembled to date (AP Oct 2008).
Neurobiology of Addiction is conceived as a current survey and
synthesis of the most important findings in our understanding of
the neurobiological mechanisms of addiction over the past 50 years.
The book includes a scholarly introduction, thorough descriptions
of animal models of addiction, and separate chapters on the
neurobiological mechanisms of addiction for psychostimulants,
opioids, alcohol, nicotine and cannabinoids. Key information is
provided about the history, sources, and pharmacokinetics and
psychopathology of addiction of each drug class, as well as the
behavioral and neurobiological mechanism of action for each drug
class at the molecular, cellular and neurocircuitry level of
analysis. A chapter on neuroimaging and drug addiction provides a
synthesis of exciting new data from neuroimaging in human addicts -
a unique perspective unavailable from animal studies. The final
chapters explore theories of addiction at the neurobiological and
neuroadaptational level both from a historical and integrative
Volume 30 examines the prominent role of calcium as an intracellular second messenger. Leading investigators review a wide variety of studies on how calcium enters and moves through cells, how it interacts with its many binding proteins, and how calcium and its intracellular receptor, calmodulin, control vital cellular processes. Coverage includes a detailed analysis of the mechanisms by which calcium bound to calmodulin regulates contractile proteins in smooth muscle cells. Close attention is given to the roles of calcium and calmodulin-dependent protein kinases and phosphatases in synaptic signal transduction, protein synthesis, gene expression, programmed cell death, activation of T-lymphocytes, and control of cell division cycles. Other chapters discuss studies using genetically manipulable nonmammalian organisms to further proble the functions of calcium and calmodulin.
Theoretical Mechanics of Biological Neural Networks develops an engineering science for the description of neuroclectric signalling of biological neural networks in terms of the underlying neurobiological mechanisms. The primary theoretical contribution of the book is to show how to describe the co-ordinated electrical activity of arbitrarily complex neural networks in terms of a single governing principle ' for each significant component in the same way that Newton's formulation of classical mechanics allows one to express force-motion relationships for arbitrarily complex mechanical systems in terms of one fundamental principle of motion for each constituent element.;Practically, the book shows how to generate mathematical and computational representations Of' the co-ordinated electrical activity of neural networks, ranging from individual neurons to composite systems of interconnected networks. Complete listings of several general purpose computer programs embodying the theory are included in the book.
Neuromodulation is an emerging field that explores the use of electrical, chemical, and mechanical interventions to heal neurological deficits. Suchneurostimulation has already shown great promise with disorders and diseases such as chronic pain, epilepsy, and Parkinson s disease. This is the first concise reference covering all of the basic principles of neuromodulation in a single affordable volume for neuro-residents, fellows, and basic clinical practitioners, edited by two prominent clinical experts in the field.
This volume emphasizes essential observations from all of the
important clinical phases involved in any neuromodulation:
targeting, intraoperative assessment, programming, complications,
and complication avoidance. There are commonalities to all
neuromodulation procedures that must be brought to the forefront to
form a cohesive presentation of neuromodulation, and such emphasis
will give readers a more solid grounding in the fundamentals needed
to embrace this field as a cohesive clinical entity.
Hardbound. This volume is devoted to Sample Surveys, which is the most widely used method in statistical practice. It covers many theoretical and practical aspects of social and biological investigations, and is a valuable guide for those involved in designing sample surveys.
This issue of Progress in Brain Research is split over 2 volumes,
bringing together cutting-edge research on Functional Neural
Transplantation. The 2 volumes review current knowledge and
understanding, provide a starting point for researchers and
practitioners entering the field, and build a platform for further
research and discovery.
This book presents the anatomical systems that take part in the
scientific and clinical study of emotional functions and
neuropsychiatric disorders. It discusses the limbic system-the
cortical and subcortical structures in the human brain involved in
emotion, motivation, and emotional association with memory-at
length and how this is no longer a useful guide to the study of
psychiatric disorders. The book provides an understanding of brain
anatomy, with an emphasis on the new anatomical framework which has
emerged during the last quarter century. The goal is to help the
reader develop an understanding of the gross anatomical
organization of the human forebrain.
Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
This volume is a collection of articles covering "Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders. "Topics covered include molecular profiling of direct and indirect striatal medium spiny neurons, the role of epigenetics in development and function of basal ganglia and transgenic animal models for Parkinson's disease.
Treatment of patients with a brain tumor remains one of the most
challenging and difficult areas of modern oncology. Recent advances
in the molecular biology of these neoplasms have improved our
understanding of the malignant phenotype and have lead to the
development of novel forms of chemotherapy, including "targeted"
agents. The Handbook of Brain Tumor Chemotherapy reviews the
state-of-the-art of chemotherapy development and clinical treatment
of patients with this devastating disease.
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