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Books > Academic & Education > Professional & Technical > Neuroscience

Developmental Neurobiology (Hardcover): Greg Lemke Developmental Neurobiology (Hardcover)
Greg Lemke
R3,969 Discovery Miles 39 690 Special order

Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbookreference exists on the market that provides researchers with more in-depth, high-levelinformation on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole.

This reference is the first of its kind to fill this need. It pulls together the relevant articles on the topic from the 10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and serves as an affordable and immediate resource for scientists, postdocs, graduate students with an interest beyond the basic textbook materials on the subject.
The first and only comprehensive, single-volume reference for developmental neuroscience that goes beyond the basic textbook informationThe 93 chapters cover topics ranging from cell fate determination, path finding, synapse generation, neural stem cells, to neurodegeneration and regeneration, carefully selected from the "Encyclopedia of Neuroscience" by one of the great developmental neuroscientists, Greg LemkeThe best researchers in the field provide their conclusions in the context of the latest experimental results"

Mechanisms of Memory (Hardcover, 2nd edition): J. David Sweatt Mechanisms of Memory (Hardcover, 2nd edition)
J. David Sweatt
R2,366 Discovery Miles 23 660 Special order

This fully revised 2e provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader s understanding.
More than 25% new content, particularly expanding the scope to include new findings in translational research. Unique in its depth of coverage of molecular and cellular mechanisms Extensive cross-referencing to Comprehensive Learning and Memory Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples
"

Models of Seizures and Epilepsy (Hardcover, New): Asla Pitkanen, Philip A. Schwartzkroin, Solomon L. Moshe Models of Seizures and Epilepsy (Hardcover, New)
Asla Pitkanen, Philip A. Schwartzkroin, Solomon L. Moshe
R4,883 Discovery Miles 48 830 Special order

An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research.
. The first comprehensive description of animal models of epilepsy since the early 1970's
. Comprehensive analysis of "What the models model" to guide the selection of each model, and what specific questions it will answer
. Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research
. World expert opinions on the clinical relevance of each model"

Molecular Mechanisms of Hormone Actions on Behavior (Hardcover, New): Anne M. Etgen, Donald W. Pfaff Molecular Mechanisms of Hormone Actions on Behavior (Hardcover, New)
Anne M. Etgen, Donald W. Pfaff
R4,869 Discovery Miles 48 690 Special order

A single volume of 31 articles, Mechanisms of Hormone Actions on Behavior is an authoritative selection of relevant chapters from the Hormones Brain and Behavior 2e MRW, the most comprehensive source of neuroendocrinological information assembled to date (AP June 2009).
The study of hormones as they impact the brain and, subsequently, behavior is a central topic in neuroscience, endocrinology and psychiatry. This volume offers an overview of neuroendocrinological topics, approaching the subject from the perspective of the mechanisms which control hormone actions on behavior. Female, male and stress hormones are discussed at the cellular, behavioral and developmental level, and sexual differentiation of the development of hormone-dependent neuronal systems, neuropeptides/neuromodulators, and steroid-inducedneuroplasticity are addressed. There is simply no other current single-volume reference with such comprehensive coverage and depth.
Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 175 figures (over 50 in color). A collection of articles reviewing our fundamental knowledge of the mechanisms of neuroendocrinology, the book provides an essential, affordable reference for researchers, clinicians and graduate students in the area.
- The most comprehensive single-volume source of up-to-date data on the mechanisms behind neuroendocrinology, with review articles covering x, y z
- Chapters synthesize information otherwise dispersed across a number of journal articles and book chapters, thus saving researchers the time consuming process of finding and integrating this information themselves
- Offering outstanding scholarship, each chapter is written by an expert in the topic area and approximately 35% of chapters are written by international contributors
- Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions
- Heavily illustrated with 175 figures, approximately 54 in color
- Presents material in most visually useful form for the reader

Stress Science - Neuroendocrinology (Hardcover): George Fink Stress Science - Neuroendocrinology (Hardcover)
George Fink
R3,580 Discovery Miles 35 800 Special order

Stress is a universal phenomenon that impacts adversely on most people. This volume provides a readily accessible compendium that explains the phenomenon of stress, the neural, endocrine and molecular mechanisms involved, the clinical effects, and the impact on individuals and society. Clinical attention focuses on disorders of the stress control system (e.g. Cushing s Syndrome: Addison s Disease) and the adverse impact of stress on human physicaland mental health . Detailed reviews address disorders such as PTSD, anxiety, major depression, psychoses and related disorders such as combat fatigue and burnout. The work covers interactions between stress and neurodegenerative disorders, such as Alzheimer s disease and Parkinson s disease, as well as stress-immune-inflammatory interactions in relation to cancer and autoimmune and viral diseases. Emphasis is alsoplaced on the role of stress in obesity, hypertension, diabetes type II and other features of the metabolic syndrome which has now reached epidemic proportions in the USA and other countries.
Chapters offer impressive scope with topics addressing animal studies, disaster, diurnal rhythms, drug effects and treatments, cognition and emotion, physical illness, psychopathology, immunology and inflammation, lab studies and tests, and psychological / biochemical / genetic aspects

Richly illustrated with over 200 figures, 75 in color

Priced affordably, this compendium of articles appeals to the end user interested in stress research who would not otherwise purchase the larger Encyclopedia of Stress

Articles carefully selected by one of the world s most preeminent stress researchers and contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge "

Hormone/Behavior Relations of Clinical Importance - Endocrine Systems Interacting with Brain and Behavior (Hardcover, New):... Hormone/Behavior Relations of Clinical Importance - Endocrine Systems Interacting with Brain and Behavior (Hardcover, New)
Robert H. Rubin, Donald W. Pfaff
R4,880 Discovery Miles 48 800 Special order

A single volume of 41 articles, Hormone/Behavior Relations of Clinical Importance is an authoritative selection of relevant chapters from the Hormones Brain and Behavior 2e MRW, the most comprehensive source of neuroendocrinological information assembled to date (AP July 2009).
The study of hormones as they impact the brain and, subsequently, behavior is a central topic in neuroscience, endocrinology and psychiatry. This volume offers an overview of neuroendocrinological topics, approaching the subject from the perspective of hormone-brain function, hormone-behavior relations, sex differences, and the impact on various diseases/pathologies. Many basic human behavioral functions are subject to the influence of hormones - sexual orientation, the experience of pain, fertility, immunity - as are clinical conditions such as diabetes, substance abuse disorder, eating disorders, PTSD, TBI, pain, Alzheimer's, stress/anxiety, affective disorders, and more. There is considerable commercial clinical potential in the study of hormones - drug companies are currently developing a Cholecystokinin (hormonal peptide) booster to reduce appetite in those who suffer from sever obesity, and catamenial epilepsy (features seizure exacerbation in relation to the menstrual cycle) is resistant to treatment by standard antiepileptic medications, but may be hormonally controlled. These issues and more are covered, and there is simply no other current single-volume reference with such comprehensive coverage and depth.
Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 150 figures (50 in color). A collection of articles reviewing our fundamental knowledge of neuroendocrinology, the book provides an essential, affordable reference for researchers, clinicians and graduate students in the area.
- Offering outstanding scholarship, each chapter is written by an expert in the topic area and approximately 25% of chapters are written by international contributors (7 countries represented)
- Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions
- Heavily illustrated with 150 figures, approximately 50 in color, presenting the material in the most visually useful form for the reader
- Fully explores various clinical conditions associated with the hormones and the brain (PTSD, TBI, Stress & Anxiety, eating disorders, diabetes, addictive disorders, Alzheimer's, affective disorders)
- Broad coverage of disorders makes the volume relevant to clinicians as well as researchers and basic scientists

The Human Cerebral Cortex - An MRI Atlas of the Sulci and Gyri in MNI Stereotaxic Space (Hardcover): Michael Petrides The Human Cerebral Cortex - An MRI Atlas of the Sulci and Gyri in MNI Stereotaxic Space (Hardcover)
Michael Petrides
R4,139 Discovery Miles 41 390 Special order

As MRI research becomes more detailed and specialized, it becomes essential to have detailed atlases that also explain individual variability, but other atlases do not provide this detail and leave users without illustration of, or guidance regarding how to deal with the variability they inevitably encounter in research and practice.This bookserves as the first cortex atlas to address this growing need, appealing to clinicians, researchers and graduate students in neuroscience, neurology, neurosurgery and radiology.

The atlas provides nearly 200 photographs of 3D reconstructions of human brains in a standard series of coronal, sagittal, and horizontal sections. It illustrates in detail and labels 95% of the cortex sulci and gyri, and images are presented in the MNI stereotaxic space. In addition to the standard brain and its sections are numerous examples of brains that exhibit patterns of deviating sulci and gyri. Examples of these variants are presented next to the standard illustration, accompanied by brief commentary aimed at helping users identify these variants and use them in their own work

* Nearly 200 photographic plates of the cortex in standard series of coronal, sagittal, and horizontal sections, presented in MNI stereotaxic coordinates

* Illustrates in detail and labels all of the cortex sulci and gyri, providing more detail than any other MRI atlas

*Provides commentary and practical guidance on the variability in the patterns of sulci and gyri, aiding readers in dealing with variability they encounter in research and practice"

Neuro-ophthalmology, Volume 102 (Hardcover, 102nd edition): Christopher Kennard, R.John Leigh Neuro-ophthalmology, Volume 102 (Hardcover, 102nd edition)
Christopher Kennard, R.John Leigh
R5,511 Discovery Miles 55 110 Special order

This volume provides a comprehensive look into the innovative methods used to explore the visual system. From the way the brain processes vision, an imperative part of the human experience, to the role eye movement plays in a range of questions concerning visual perception, memory, attention, free will, and even topological diagnoses, this in-depth handbook gives neurologists, ophthalmologists, and neuro-ophthalmologists an invaluable tool to help them better understand the visual system.

Disorders of the retinal and cerebral cortex, and those that affect control of eye and lid movements are thoroughly discussed, along with groundbreaking visual rehabilitative methods, and chapters on individual parts of the visual system. Practitioners will find a useful resource that lays out fundamental concepts, while seamlessly summarizing clinical and laboratory methods for neuro-ophthalmological evaluation.

The material is perfect for early-stage physicians or long practicing specialists who wish to learn the latest developments in the field.
* A comprehensive resource that explores the innovative methods used to understand the visual system
* An in-depth study of how the brain processes vision, and the role certain functions such as eye movement play in visual diagnosis and memory
* Clinical and laboratory methods of evaluation that are perfect for physicians and specialists in any stage of practice

The Comprehensive Evaluation and Treatment of Epilepsy - A Practical Guide (Hardcover): Steven C Schachter, Donald L. Schomer The Comprehensive Evaluation and Treatment of Epilepsy - A Practical Guide (Hardcover)
Steven C Schachter, Donald L. Schomer
R1,455 Discovery Miles 14 550 Special order

This book is a short and simple pedagogical guide to the diagnosis and management of epilepsy. After the headache, epilepsy is the second most common neurological disorder, and this book clarifies the many courses of action to take in treating patients with epilepsy. The book simplifies the classification, testing, and treatment of epilepsy, addresses important psychosocial issues and the efficacy of pharmaceutical and other interventions, and also includes an account of modern concepts of the aetiology of the disease. The Comprehensive Evaluation and Treatment of Epilepsy: A Practical Guide is an important reference work for all medical schools, hospitals, clinics and primary care centers. Features: * CONTAINS ESSENTIALS ON: * Initial management of patients with seizures * Psychosocial aspects of epilepsy * Neuropsychologic problems associated with epilepsy * Psychiatric disorders * Diagnosis and treatment of status epilepticus * Nonepileptic seizures * Ambulatory EEG monitoring * Epilepsy surgery * Endocrine aspects of partial seizures * Epilepsy in the elderly

Cognition, Brain, and Consciousness - Introduction to Cognitive Neuroscience (Hardcover, 2nd edition): Bernard J. Baars, Nicole... Cognition, Brain, and Consciousness - Introduction to Cognitive Neuroscience (Hardcover, 2nd edition)
Bernard J. Baars, Nicole M. Gage
R2,010 Discovery Miles 20 100 Special order

This is the fully revised and updated second edition of the very sucessful introductory textbook on cognitive neuroscience. Written by two leading experts in the field, thisbook takes a unique thematic approach to introduce concepts of cognitive neurosciences, guiding students along a clear path to understand the latest findings whether or not they have a background in neuroscience. New to this edition are "Frontiers in Cognitive Neuroscience" text boxes; each one focuses on a leading researcher and their topic of expertise. There is a new chapter on Genes and Molecules of Cognition, and all other chapters have been thoroughly revised, based on the most recent discoveries.
New edition of a very successful textbookCompletely revisedto reflect new advances, and feedback from adopters and studentsIncludes a new chapter on Genes and Molecules of CognitionStudent Solutions available at http: //www.baars-gage.com/

For Teachers:

Rapid adoption and course preparation: A wide array of instructor support materials are available online including PowerPoint lecture slides, a test bank with answers, and eFlashcords on key concepts for each chapter. A textbook with an easy-to-understand thematic approach: in a way that is clear for students from a variety of academic backgrounds, the text introduces concepts such as working memory, selective attention, and social cognition.A step-by-step guide for introducing students to brain anatomy: color graphics have been carefully selected to illustrate all points and the research explained. Beautifully clear artist's drawings are used to 'build a brain' from top to bottom, simplifying the layout of the brain.

For students:

An easy-to-read, complete introduction to mind-brain science: all chapters begin from mind-brain functions and build a coherent picture of their brain basis. A single, widely accepted functional framework is used to capture the major phenomena. Learning Aids include a student support site with study guides and exercises, a new Mini-Atlas of the Brain and a full Glossary of technical terms and their definitions.Richly illustrated with hundreds of carefully selected color graphics to enhance understanding. "

Handbook of Neuroendocrinology (Hardcover): George Fink, Jon E. Levine, Donald W. Pfaff Handbook of Neuroendocrinology (Hardcover)
George Fink, Jon E. Levine, Donald W. Pfaff
R2,471 Discovery Miles 24 710 Special order

Neuroendocrinology, the discipline concerned with how the nervous system controls hormonal secretion and how hormones control the brain, is pivotal to physiology and medicine. Neuroendocrinology has disclosed and underpins fundamental physiological, molecular biological and genetic principles such as the regulation of gene transcription and translation, the mechanisms of chemical neurotransmission and intracellular and systemic feedback control systems. Reproduction, growth, stress, aggression, metabolism, birth, feeding and drinking and blood pressure are some of the bodily functions that are triggered and/or controlled by neuroendocrine systems. In turn, neuroendocrine dysfunction due to genetic or other deficits can lead, for example, to infertility, impotence, precocious or delayed puberty, defective or excessive growth, obesity and anorexia, Cushing s Syndrome, hypertension or thyroid disorders. These as well as neuroendocrine tumors are some of the themes covered in the 36 chapters of the Handbook. Drafted by internationally acknowledged experts in the field, the Handbook chapters feature detailed up-to-date bibliographies as well as "how do we know?" call out sections that highlight the experimental or technical foundations for major concepts, principles, or methodological advances in each area. Aimed at senior undergraduate and graduate students, post-doctoral fellows and faculty in neuroscience, medicine, endocrinology, psychiatry, psychology and cognate disciplines, the "Handbook of Neuroendocrinology" satisfies an unmet need that will prove useful at the laboratory bench as well as in the office.
The most comprehensive up-to-date source covering basic principles, neural regulation, hormone/brain function and behavior, and neuroendocrine pathology "How do we know?" callout sections highlight core conceptsHeavily illustrated with over 350 figures, 4-color throughout"

Neurological Rehabilitation, Volume 110 (Hardcover, New): Michael P. Barnes, David C. Good Neurological Rehabilitation, Volume 110 (Hardcover, New)
Michael P. Barnes, David C. Good
R5,450 Discovery Miles 54 500 Special order

Neurological Rehabilitation is the latest volume in the definitive Handbook of Clinical Neurology series. It is the first time that this increasing important subject has been included in the series and this reflects the growing interest and quality of scientific data on topics around neural recovery and the practical applications of new research. The volume will appeal to clinicians from both neurological and rehabilitation backgrounds and contains topics of interest to all members of the multidisciplinary clinical team as well as the neuroscience community. The volume is divided into five key sections. The first is a summary of current research on neural repair, recovery and plasticity. The authors have kept the topics readable for a non-scientific audience and focused on the aspects of basic neuroscience that should be most relevant to clinical practice. The next section covers the basic principles of neurorehabilitation, including excellent chapters on learning and skill acquisition, outcome measurement and functional neuroimaging. The key clinical section comes next and includes updates and reviews on the management of the main neurological disabling physical problems, such as spasticity, pain, sexual functioning and dysphagia. Cognitive, emotional and behavioural problems are just as important and are covered in the next section, with excellent chapters, for example, on memory and management of executive dysfunction. The final part draws the sections on symptom management together by discussing the individual diseases that are most commonly seen in neurorehabilitation and providing an overview of the management of the disability associated with those disorders. The volume is a definitive review of current neurorehabilitation practice and will be valuable to a wide range of clinicians and scientists working in this rapidly developing field.
*A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
*International list of contributors including the leading workers in the field.
*Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.

Research Funding in Neuroscience - A Profile of the McKnight Endowment Fund (Hardcover): Gabrielle Strobel Research Funding in Neuroscience - A Profile of the McKnight Endowment Fund (Hardcover)
Gabrielle Strobel; Edited by Sylvia Lindman
R1,090 Discovery Miles 10 900 Special order

The book is a history of the McKnight Endowment Fund for Neuroscience and an assessment of its effectiveness in advancing neuroscience. The book discusses the Fund's early and steady commitment to basic science as well as it's tradition of leveraging relatively modest dollars to make a big difference in careers and the field overall.
The fund exists strictly to give awards and create a community of peers through an annual conference dedicated to research. In near unison, scientists who have received awards say they were able to test a risky idea, get their career off the ground, or make a significant change in their career because of McKnight's flexible dollars.
The book consists of three parts: (1) origins--including both the funder and the scientists who shaped the program; (2) a review of the science to show how McKnight awardees have advanced the field; and (3) 10 keys to success. We also have an interview with Julius Axelrod (one of the early advisors, done shortly before his death in 2004) and stories of how awardees used their McKnight grants, plus other information.

Recent Advances in Parkinsons Disease, Volume 184 - Part II: Translational and Clinical Research (Hardcover, 184th edition):... Recent Advances in Parkinsons Disease, Volume 184 - Part II: Translational and Clinical Research (Hardcover, 184th edition)
Anders Bjorklund, Angela Cenci-Nilsson
R4,687 R4,422 Discovery Miles 44 220 Save R265 (6%) Special order

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.

Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist.

Evolution of the Primate Brain, Volume 195 - From Neuron to Behavior (Hardcover, New): Michel A. Hofman, Dean Falk Evolution of the Primate Brain, Volume 195 - From Neuron to Behavior (Hardcover, New)
Michel A. Hofman, Dean Falk
R4,986 Discovery Miles 49 860 Special order

This volume of Progress in Brain Research provides a synthetic source of information about state-of-the-art research that has important implications for the evolution of the brain and cognition in primates, including humans. This topic requires input from a variety of fields that are developing at an unprecedented pace: genetics, developmental neurobiology, comparative and functional neuroanatomy (at gross and microanatomical levels), quantitative neurobiology related to scaling factors that constrain brain organization and evolution, primate palaeontology (including paleoneurology), paleo-anthropology, comparative psychology, and behavioural evolutionary biology.

Written by internationally-renowned scientists, this timely volume will be of wide interest to students, scholars, science journalists, and a variety of experts who are interested in keeping track of the discoveries that are rapidly emerging about the evolution of the brain and cognition.

Written by internationally renowned scientists, this timely volume will be of wide interest to students, scholars, science journalists, and a variety of experts who are interested in keeping track of the discoveries that are rapidly emerging about the evolution of the brain and cognition.

Handbook of the Neuroscience of Aging (Hardcover, New): Patrick R. Hof, Charles V. Mobbs Handbook of the Neuroscience of Aging (Hardcover, New)
Patrick R. Hof, Charles V. Mobbs
R3,296 R3,123 Discovery Miles 31 230 Save R173 (5%) Special order

A single volume of 85 articles, the Handbook of the Neurobiology of Aging is an authoritative selection of relevant chapters from the Encyclopedia of Neuroscience, the most comprehensive source of neuroscience information assembled to date (AP Oct 2008).
The study of neural aging is a central topic in neuroscience, neuropsychology and gerontology. Some well-known age-related neurological diseases include Parkinson's and Alzheimer's, but even more common are problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging become more common and conditions associated with aging need more attention by doctors and researchers.
This book offers an overview of topics related to neurobiological impairments which are related to the aging brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer's, dementia, Down syndrome, Parkinson's, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth.
Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 100 color figures. A collection of articles reviewing our fundamental knowledge of neural aging, the book provides an essential, affordable reference for scientists in all areas of Neuroscience, Neuropsychology and Gerontology.
* The most comprehensive source of up-to-date data on the neurobiology of aging, review articles cover: normal, sensory and cognitive aging; neuroendocrine, structural and molecular factors; and fully address both patholgy and intervention
* Chapters represent an authoritative selection of relevant material from the most comprehensive source of information about neuroscience ever assembled, (Encyclopedia of Neuroscience), synthesizing information otherwise
dispersed across a number of journal articles and book chapters, and saving researchers the time consuming process of finding and integrating this information themselves
* Offering outstanding scholarship, each chapter is written by an expert in the topic area and over 20% of chapters feature international contributors, (representing 11 countries)
* Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions
* Fully explores various pathologies associated with the aging brain (Alzheimer's, dementia, Parkinson's, memory disorders, stroke, Down's syndrome, etc.)
* Coverage of disorders and key interventions makes the volume relevant to clinicians as well as researchers
* Heavily illustrated with over 100 color figures

Neurobiology of Addiction (Hardcover): George Koob, Michel Le Moal Neurobiology of Addiction (Hardcover)
George Koob, Michel Le Moal
R4,104 Discovery Miles 41 040 Special order

Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts - a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective.
The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature.
- Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction
- Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work
- Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching

Calcium Regulation of Cellular Function, Volume 30 (Hardcover): Paul Greengard, Angus C. Nairn, Shirish Shenolikar Calcium Regulation of Cellular Function, Volume 30 (Hardcover)
Paul Greengard, Angus C. Nairn, Shirish Shenolikar; Volume editing by Anthony R. Means
R2,118 Discovery Miles 21 180 Special order

Volume 30 examines the prominent role of calcium as an intracellular second messenger. Leading investigators review a wide variety of studies on how calcium enters and moves through cells, how it interacts with its many binding proteins, and how calcium and its intracellular receptor, calmodulin, control vital cellular processes. Coverage includes a detailed analysis of the mechanisms by which calcium bound to calmodulin regulates contractile proteins in smooth muscle cells. Close attention is given to the roles of calcium and calmodulin-dependent protein kinases and phosphatases in synaptic signal transduction, protein synthesis, gene expression, programmed cell death, activation of T-lymphocytes, and control of cell division cycles. Other chapters discuss studies using genetically manipulable nonmammalian organisms to further proble the functions of calcium and calmodulin.

Theoretical Mechanics of Biological Neural Networks (Hardcover): Ronald J. MacGregor Theoretical Mechanics of Biological Neural Networks (Hardcover)
Ronald J. MacGregor
R1,209 Discovery Miles 12 090 Special order

Theoretical Mechanics of Biological Neural Networks develops an engineering science for the description of neuroclectric signalling of biological neural networks in terms of the underlying neurobiological mechanisms. The primary theoretical contribution of the book is to show how to describe the co-ordinated electrical activity of arbitrarily complex neural networks in terms of a single governing principle ' for each significant component in the same way that Newton's formulation of classical mechanics allows one to express force-motion relationships for arbitrarily complex mechanical systems in terms of one fundamental principle of motion for each constituent element.;Practically, the book shows how to generate mathematical and computational representations Of' the co-ordinated electrical activity of neural networks, ranging from individual neurons to composite systems of interconnected networks. Complete listings of several general purpose computer programs embodying the theory are included in the book.

Essential Neuromodulation (Hardcover): Jeffrey E. Arle, Jay L. Shils Essential Neuromodulation (Hardcover)
Jeffrey E. Arle, Jay L. Shils
R3,045 Discovery Miles 30 450 Special order

Neuromodulation is an emerging field that explores the use of electrical, chemical, and mechanical interventions to heal neurological deficits. Suchneurostimulation has already shown great promise with disorders and diseases such as chronic pain, epilepsy, and Parkinson s disease. This is the first concise reference covering all of the basic principles of neuromodulation in a single affordable volume for neuro-residents, fellows, and basic clinical practitioners, edited by two prominent clinical experts in the field.

This volume emphasizes essential observations from all of the important clinical phases involved in any neuromodulation: targeting, intraoperative assessment, programming, complications, and complication avoidance. There are commonalities to all neuromodulation procedures that must be brought to the forefront to form a cohesive presentation of neuromodulation, and such emphasis will give readers a more solid grounding in the fundamentals needed to embrace this field as a cohesive clinical entity.
Chapters offer point-counterpoint commentary for varied perspectivesAppendix distills current guidelines in easy, accessible formatChapters follow story of patient care, effectively emphasizing general principles with supporting examplesOffers outstanding scholarship, with over 20% of chapters involving international contributors"

Sampling, Volume 6 (Hardcover): P.R. Krishnaiah# Sampling, Volume 6 (Hardcover)
P.R. Krishnaiah#; Volume editing by Paruchuri R. Krishnaiah, C.Radhakrishna Rao
R1,120 Discovery Miles 11 200 Special order

Hardbound. This volume is devoted to Sample Surveys, which is the most widely used method in statistical practice. It covers many theoretical and practical aspects of social and biological investigations, and is a valuable guide for those involved in designing sample surveys.

Functional Neural Transplantation III, Volume 201 - Primary and Stem Cell Therapies for Brain Repair, Part II (Hardcover, New):... Functional Neural Transplantation III, Volume 201 - Primary and Stem Cell Therapies for Brain Repair, Part II (Hardcover, New)
Stephen B. Dunnett, Anders Bjorklund
R4,409 R4,162 Discovery Miles 41 620 Save R247 (6%) Special order

This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.
Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Anatomy of Neuropsychiatry - The New Anatomy of the Basal Forebrain and Its Implications for Neuropsychiatric Illness... Anatomy of Neuropsychiatry - The New Anatomy of the Basal Forebrain and Its Implications for Neuropsychiatric Illness (Hardcover)
Lennart Heimer, Gary W. Van Hoesen, Michael R. Trimble, Daniel Scott Zahm
R1,783 Discovery Miles 17 830 Special order

This book presents the anatomical systems that take part in the scientific and clinical study of emotional functions and neuropsychiatric disorders. It discusses the limbic system-the cortical and subcortical structures in the human brain involved in emotion, motivation, and emotional association with memory-at length and how this is no longer a useful guide to the study of psychiatric disorders. The book provides an understanding of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century. The goal is to help the reader develop an understanding of the gross anatomical organization of the human forebrain.
The book also includes an enlightening DVD describing the basic surface anatomy of the cerebral hemispheres, coronal and horizontal sections, and blunt dissection of the forebrain with special attention to clinical-anatomical correlations of interest to psychiatrists.
* A re-evaluation of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century
* A compellingly expanded conceptualization of Broca's famous limbic lobe
* Clinical and basic science boxes highlighting specific concepts, structures, or neuronal circuits from a clinical perspective
* DVD illustrating dissection of the human brain by one of the world's masters

Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders, Volume 89 (Hardcover, 88th edition):... Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders, Volume 89 (Hardcover, 88th edition)
Xiao-Hong Lu
R3,887 Discovery Miles 38 870 Special order

Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

This volume is a collection of articles covering "Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders. "Topics covered include molecular profiling of direct and indirect striatal medium spiny neurons, the role of epigenetics in development and function of basal ganglia and transgenic animal models for Parkinson's disease.

Handbook of Brain Tumor Chemotherapy (Hardcover): Herbert B. Newton Handbook of Brain Tumor Chemotherapy (Hardcover)
Herbert B. Newton
R4,915 Discovery Miles 49 150 Special order

Treatment of patients with a brain tumor remains one of the most challenging and difficult areas of modern oncology. Recent advances in the molecular biology of these neoplasms have improved our understanding of the malignant phenotype and have lead to the development of novel forms of chemotherapy, including "targeted" agents. The Handbook of Brain Tumor Chemotherapy reviews the state-of-the-art of chemotherapy development and clinical treatment of patients with this devastating disease.
Handbook of Brain Tumor Chemotherapy offers a unique cutting-edge compendium of basic science and clinical information on the subject of brain tumor chemotherapy, reviewing what has been accomplished thus far and how the field will continue to evolve with the development of more specific and efficacious chemotherapeutic agents. This book represents the most complete single-volume resource available for information on the subject of brain tumor chemotherapy.
* Provides the most up to date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics, for the treatment of brain tumors
* Broadly appeals to anyone interested in the field of Neuro-Oncology and in the treatment of patients with brain tumors
* Useful to clinicians interested in a thorough overview of the use of chemotherapy in patients with a broad range of brain tumors as well as serving as a source of background information to basic scientists and pharmaceutical researchers with an interest in the molecular therapeutics of brain tumors

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