The biological function of clusterin (CLU, also known as ApoJ,
SGP2, TRPM2, CLI) has been puzzling researchers since its discovery
and characterization in the early 1980s. Approaches such as
cloning, expression and functional characterization of the
different protein products generated by the CLU gene have now
produced a critical mass of information of tremendous biological
importance that are teaching us an important lesson in molecular
biology of gene expression regulation. This volume brings together
the contributions of top researchers in the field, providing an
overview and synthesis of the latest thought and findings relating
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