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A cutting-edge examination of what it means to be human and to have a 'self' in the face of new scientific developments in genetic editing, cloning and neural downloading. After seeing his own cells used to grow clumps of new neurons - essentially mini-brains - Philip Ball begins to examine the concepts of identity and consciousness. Delving into humanity's deep evolutionary past to look at how complex creatures like us emerged from single-celled life, he offers a new perspective on how humans think about ourselves. In an age when we are increasingly encouraged to regard the 'self' as an abstract sequence of genetic information, or as a pattern of neural activity that might be 'downloaded' to a computer, he return us to the body - to flesh and blood - and anchors a conception of personhood in this unique and ephemeral mortal coil. How to Build a Human brings us back to ourselves - but in doing so, it challenges old preconceptions and values. It asks us to rethink how we exist in the world.
The genetic history of the dog is a sensational example of the co-evolution of two species, man and wolf, to each other's mutual benefit. But how did this ancient partnership begin? To answer this question, Professor Bryan Sykes identifies tantalising clues in the recently mapped genetic makeup of both species. Sykes paints a vivid picture of the dog as an ancient and essential ally. While undoubtedly it was the mastery of fire, language and agriculture that propelled Homo sapiens from a scarce, medium-sized primate to the position we enjoy today, Sykes crucially credits a fourth element for this success: the transformation of the wolf into the multi-purpose helpmate that is the dog. Drawing upon archaeology, history and genetics, Sykes shows how humans evolved to become the dominant species on Earth, but only with the help of our canine companions.
Everything you need to know about race (but were afraid to ask). In academic journals and on internet message boards, certain scientists and thinkers are laying siege to one of the great taboos. Could it be, they ask, that racism has a rational basis in science? These ideas are no longer limited to the fringe: race-based studies of intelligence have been discussed by thinkers such as Steven Pinker, Sam Harris and Jordan Peterson. If true, it would provide an intellectual foundation for so many of the attitudes that characterise the right wing, justifying inequality and discrimination. Gavin Evans tackles the nature vs nurture debate head-on, examining the latest studies on how intelligence develops and laying out new discoveries in genetics, palaeontology, archaeology and anthropology to unearth the truth about our shared past. In doing so, Skin Deep demolishes the pernicious myth that our race is our destiny, and instead reveals what really makes us who we are.
This book describes the biomedical information of albinism to determine the disability of the genetic disorder in albinism (Chapter 1).
Secondly, it describes the international and regional frameworks of disability (Chapter 2). Thirdly, it analyses the human rights perspective of disability as related to albinism (Chapter 3). Human rights apply to all human beings regardless of disability, and focus will be on the relevant Convention on the Rights of Persons with Disabilities. Fourthly, the book demonstrates the understanding of albinism through beliefs, cultures and superstitions (Chapter 4).
The book suggests a way forward, intending to provide some suggestions and recommendations to improve the life of person with disabilities in general and albinism in particular (Chapter 5).
Finally, the role of non-governmental organisations is analysed - which is to raise awareness, boost the self-esteem of their members, advocate for their needs and possibly lobby for an inclusive society (Chapter 6).
This new updated and expanded 10th anniversary edition of The Biology of Belief will forever change how you think about your own thinking. Stunning new scientific discoveries about the biochemical effects of the brain's functioning show that all the cells of your body are affected by your thoughts. Bruce H. Lipton PhD, a renowned cell biologist, describes the precise molecular pathways through which this occurs. Using simple language, illustrations, humour and everyday examples, he demonstrates how the new science of epigenetics is revolutionizing our understanding of the link between mind and matter, and the profound effects it has on our personal lives and the collective life of our species. It has been 10 years since the publication of The Biology of Belief, Bruce Lipton's seminal book on the relationship between mind and body that changed the way we think about our lives, our health and our planet. During that time, research in this field has grown exponentially - Lipton's ground-breaking experiments have now been endorsed by more than a decade of rigorous scientific study. In this greatly expanded edition, Lipton, a former medical school professor and research scientist, explores his own experiments and those of other leading-edge scientists that have unravelled in ever greater detail how truly connected the mind, body and spirit are. It is now widely recognized that genes and DNA do not control our biology. Instead, they are controlled by signals from outside the cell, including energetic messages emanating from our thoughts. This profoundly hopeful synthesis of the latest and best research in cell biology and quantum physics puts the power to create a healthy, joyous life back in our own hands. When we transform our conscious and subconscious thoughts, we transform our lives, and in the process help humanity evolve to a new level of understanding and peace.
Vast numbers of different prokaryotic microorganisms shape the biosphere, with diverse metabolic capabilities. Determination of genome sequences for a wide range of bacteria and archaea now requires an in-depth knowledge of prokaryotic metabolic function to give biochemical, physiological and ecological meaning to the genomic information. This new edition describes up-to-date knowledge of the key metabolic processes that occur under different conditions, and the cellular processes that determine prokaryotic roles in the environment, biotechnology and human health. Essential for students of microbiology, applied microbiology, biotechnology, genomics and systems biology, this advanced textbook covers prokaryotic structure, composition, nutrient transport, biosynthesis and growth. Newly characterised metabolic pathways are included, as well as the latest understanding of metabolic regulation and stress responses. Additionally, the link between energetics, growth and survival is discussed as well as the maintenance of genetic integrity by the bacterial immune system.
Armed with extraordinary new discoveries about our genes, acclaimed science writer Matt Ridley turns his attention to the nature-versus-nurture debate in a thoughtful book about the roots of human behavior.
Ridley recounts the hundred years' war between the partisans of nature and nurture to explain how this paradoxical creature, the human being, can be simultaneously free-willed and motivated by instinct and culture. With the decoding of the human genome, we now know that genes not only predetermine the broad structure of the brain, they also absorb formative experiences, react to social cues, and even run memory. They are consequences as well as causes of the will.
Full of fascinating and bizarre cases of genetic mutation and irregularity, `Mutants' is an amazing exploration of the human form in all its beautiful and unique guises. Why are most of us born with one nose, two legs, ten fingers and twenty-four ribs - and some of us not? Why do most of us stop growing in our teens - while others just keep going? Why do some us have heads of red hair - and others no hair at all? The human genome, we are told, makes us what we are. But how? Armand Marie Leroi takes us to the extremes of human mutation - from the grotesque to the beautiful, and often both at the same time - to explain how we become what we are. Through the tales of long-lived Croatian dwarves, ostrich-footed Wadoma tribesmen, sex-changing French convent girls, and many more wonders of human development, Leroi has written a brilliant narrative account of our genetic grammar and people whose bodies have revealed it.
SHORTLISTED FOR THE 2018 BAILLIE GIFFORD PRIZE FOR NON-FICTION
She Has Her Mother’s Laugh presents a profoundly original perspective on what we pass along from generation to generation. Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities . . .
But, award-winning science writer Carl Zimmer argues, heredity isn’t just about genes that pass from parent to child. Heredity continues within our own bodies, as a single cell gives rise to trillions of cells that make up our bodies. We say we inherit genes from our ancestors but we inherit other things that matter as much or more to our lives, from microbes to technologies we use to make life more comfortable. We need a new definition of what heredity is and, through Carl Zimmer’s lucid exposition and storytelling, this resounding tour de force delivers it.
Weaving together historical and current scientific research, his own experience with his two daughters, and the kind of original reporting expected of one of the world’s best science journalists, Zimmer ultimately unpacks urgent bioethical quandaries arising from new biomedical technologies, but also long-standing presumptions about who we really are and what we can pass on to future generations.
Genetic science is about to radically alter our lives. Sooner than you can imagine, human beings will be capable of diagnosing their own illnesses, designating the sex of their children, even designing the food they eat -- all as easily as using a cell phone. Now is the time for every one of us to take control of our DNA, and one man is uniquely qualified to show us how: Glenn McGee, bioethicist at the University of Pennsylvania, pioneer in the study of "home genetics," and the acknowledged wunderkind of the exciting world found at the nexus of life science and computer technology.
One of the most respected authorities in the field of genomics -- the study of the genetic "software" inside plants, animals, and us -- McGee takes us on an eye-opening journey behind the headlines and into the heart of this formidable cutting-edge science. Probing the far-ranging ethical and legal implications of genomic research, McGee tackles its most controversial and hotly debated aspects -- from patenting your DNA to genetic engineering at the supermarket -- and explodes unnecessary fears about this wondrous new knowledge.
We live in a brave new world. Beyond Genetics provides us with the knowledge we need to take the right steps forward into tomorrow ... and beyond.
This new third edition updates a best-selling encyclopedia. It includes about 56% more words than the 1,392-page second edition of 2003. The number of illustrations increased to almost 2,000 and their quality has improved by design and four colors. In addition, cross-references among entries are expanded and the statements are supported by references: more than 14,000 journal papers and more than 3,000 books are listed. The book includes approximately 1,800 current databases and web servers. Retractions and corrigenda are pointed out.This encyclopedia covers the basics and the latest in genomics, proteomics, genetic engineering, small RNAs, transcription factories, chromosome territories, stem cells, genetic networks, epigenetics, prions, hereditary diseases, and patents. Similar integrated information is not available in textbooks or on the Internet.
This new series presents innovative titles pertaining to human origins, evolution, and behavior from a multi-disciplinary perspective. Subject areas include but are not limited to biological and physical anthropology, prehistoric archaeology, evolutionary psychology, behavioral ecology, and evolutionary biology. The series volumes will be of interest primarily to students and scholars in these fields.
Until twenty years ago we had no idea which of our genes came from our father and which came from our mother. We took it for granted that our genes expressed themselves identically and that there was a 50/50 chance that they came from either parent. We also assumed that they worked in cooperation with each other. The biggest breakthrough in genetics in the past two decades has been the discovery of genomic imprinting, which allows us to trace genes to the parent of origin. David Haig has been at the forefront of theorizing these developments arguing that these "paternally and maternally active genes" comprising less than one percent of our total gene count are far from being cooperative, and have in fact been shown to be in competition with one another. If Haig's theory is correct, imprinted genes provide an extraordinary example of within-individual conflict, which is one of the most surprising developments in evolutionary biology in recent years. Examples like this are shaking up our fundamental ideas of what it means to be an individual.
This collection of Haig's papers provides a unique comprehensive overview of what is known. Each paper is followed by a commentary that links it to the others, provides background as needed, and brings readers up-to-date on developments thatoccurred after the paper's original publication. Because genomic imprinting raises questions across various fields in the life sciences, including evolutionary biology and developmental genetics, Haig's work is scattered through the literature to an unusual degree, and has never been collected in one volume.
The Pacific Symposium on Biocomputing (PSB) 2017 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2017 will be held on January 4 - 8, 2017 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2017 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's 'hot topics.' In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
A concise, clear writing style and a detailed and rich coverage of topics are the reasons that students found the first edition of the book so engaging and useful.Riding on this wave, all chapters within the second edition of this popular book have been thoroughly updated and expanded, especially the human and animal materials. A wider range of animals is covered, including dogs and cats as well as farm animals. The use of cord blood for therapy, pre-implantation genetic diagnosis and animal cloning are also explored and dealt with.
The million copy international bestseller, critically acclaimed and translated into over 25 languages. As influential today as when it was first published, The Selfish Gene has become a classic exposition of evolutionary thought. Professor Dawkins articulates a gene's eye view of evolution - a view giving centre stage to these persistent units of information, and in which organisms can be seen as vehicles for their replication. This imaginative, powerful, and stylistically brilliant work not only brought the insights of Neo-Darwinism to a wide audience, but galvanized the biology community, generating much debate and stimulating whole new areas of research. Forty years later, its insights remain as relevant today as on the day it was published. This 40th anniversary edition includes a new epilogue from the author discussing the continuing relevance of these ideas in evolutionary biology today, as well as the original prefaces and foreword, and extracts from early reviews. Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think.
The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world. The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology. The new Second Edition has been comprehensively revised and updated to include major advances in cancer biology over the past six years. Updates include current information on: The tumor microenvironment Metastatic dissemination Tumor immunology Cancer stem cells The epithelial-mesenchymal transition Multi-step tumorigenesis Invasion and metastasis Mutation of cancer cell genomes Greatly expanded treatment of traditional therapy Epigenetic contributions MicroRNA involvement The Warburg effect Besides its value as a textbook, The Biology of Cancer is a useful reference for individuals working in biomedical laboratories and for clinical professionals. Every copy of the book comes with an updated "Pathways in Human Cancer" poster and a DVD-ROM containing the book's art program, a greatly expanded selection of movies, audio file mini-lectures, Supplementary Sidebars, and a Media Guide.
This volume offers a much-needed compilation of essential reviews on diverse aspects of plant biology, written by eminent botanists. These reviews effectively cover a wide range of aspects of plant biology that have contemporary relevance. At the same time they integrate classical morphology with molecular biology, physiology with pattern formation, growth with genomics, development with morphogenesis, and classical crop-improvement techniques with modern breeding methodologies. Classical botany has been transformed into cutting-edge plant biology, thus providing the theoretical basis for plant biotechnology. It goes without saying that biotechnology has emerged as a powerful discipline of Biology in the last three decades. Biotechnological tools, techniques and information, used in combination with appropriate planning and execution, have already contributed significantly to economic growth and development. It is estimated that in the next decade or two, products and processes made possible by biotechnology will account for over 60% of worldwide commerce and output. There is, therefore, a need to arrive at a general understanding and common approach to issues related to the nature, possession, conservation and use of biodiversity, as it provides the raw material for biotechnology. More than 90% of the total requirements for the biotechnology industry are contributed by plants and microbes, in terms of goods and services. There are however substantial plant and microbial resources that are waiting for biotechnological exploitation in the near future through effective bioprospection. In order to exploit plants and microbes for their useful products and processes, we need to first understand their basic structure, organization, growth and development, cellular process and overall biology. We also need to identify and develop strategies to improve the productivity of plants. In view of the above, in this two-volume book on plant biology and biotechnology, the first volume is devoted to various aspects of plant biology and crop improvement. It includes 33 chapters contributed by 50 researchers, each of which is an expert in his/her own field of research. The book begins with an introductory chapter that gives a lucid account on the past, present and future of plant biology, thereby providing a perfect historical foundation for the chapters that follow. Four chapters are devoted to details on the structural and developmental aspects of the structures of plants and their principal organs. These chapters provide the molecular biological basis for the regulation of morphogenesis of the form of plants and their organs, involving control at the cellular and tissue levels. Details on biodiversity, the basic raw material for biotechnology, are discussed in a separate chapter, in which emphasis is placed on the genetic, species and ecosystem diversities and their conservation. Since fungi and other microbes form an important component of the overall biodiversity, special attention is paid to the treatment of fungi and other microbes in this volume. Four chapters respectively deal with an overview of fungi, arbuscularmycorrhizae and their relation to the sustenance of plant wealth, diversity and practical applications of mushrooms, and lichens (associated with a photobiont). Microbial endosymbionts associated with plants and phosphate solubilizing microbes in the rhizosphere of plants are exhaustively treated in two separate chapters. The reproductive strategies of bryophytes and an overview on Cycads form the subject matter of another two chapters, thus fulfilling the need to deal with the non-flowering Embryophyte group of plants. Angiosperms, the most important group of plants from a biotechnological perspective, are examined exhaustively in this volume. The chapters on angiosperms provide an overview and cover the genetic basis of flowers development, pre-and post-fertilization reproductive growth and development, seed biology and technology, plant secondary metabolism, photosynthesis, and plant volatile chemicals. A special effort has been made to include important topics on crop improvement in this volume. The importance of pollination services, apomixes, male sterility, induced mutations, polyploidy and climate changes is discussed, each in a separate chapter. Microalgalnutra-pharmaceuticals, vegetable-oil-based nutraceuticals and the importance of alien crop resources and underutilized crops for food and nutritional security form the topics of three other chapters in this volume. There is also a special chapter on the applications of remote sensing in the plant sciences, which also provides information on biodiversity distribution. The editors of this volume believe the wide range of basic topics on plant biology that have great relevance in biotechnology covered will be of great interest to students, researchers and teachers of botany and plant biotechnology alike.
** THE PERFECT STOCKING FILLER FOR YOUR FAVOURITE SCIENCE NERD. ** Part of the ALL-NEW LADYBIRD EXPERT SERIES. ____________ Who discovered genetics? How does gene inheritance work? Is DNA common to all living things? We inherit CODES from our parents. And these codes are written in the molecule DNA. This DNA means that we RESEMBLE each other, namely our families. This raises so many questions such as how does DNA influence evolution? How was it discovered? And what does it mean for the future of the human race? Discover the answers and more inside Adam Rutherford's Ladybird Expert - Genetics, the thrilling and accessible account that explains race and genetics, whether it is our DNA or the environment that influences us most, what are our chances of being related to royalty, genetic engineering and much more . . .
The New York Times, Boston Globe, Los Angeles Times and Indie Bound Bestseller
'Those who like to insist that blood is always thicker than water should read Inheritance, and let their own hearts slowly and gently expand.'-- The Observer
'All my life I had known there was a secret. What I hadn't known: the secret was me.'
In the spring of 2016, through a genealogy website to which she had whimsically submitted her DNA for analysis, Dani Shapiro received the stunning news that her father was not her biological father. Everything she had believed about her identity was a lie.
Shapiro's parents had died when she was in her twenties. With only a handful of figures on a webpage, Shapiro sets out to discover the truth about herself and her history.
Inheritance is a genetic detective story; a memoir that reads like a thriller. It is a book about secrets -secrets within families, kept out of shame or self-protectiveness; secrets we keep from one another in the name of love. It is a book about the extraordinary moment we live in a moment in which science and technology have outpaced not only medical ethics but also the capacities of the human heart to contend with the consequences of what we discover.
Willi Hennig (1913-76), founder of phylogenetic systematics, revolutionised our understanding of the relationships among species and their natural classification. An expert on Diptera and fossil insects, Hennig's ideas were applicable to all organisms. He wrote about the science of taxonomy or systematics, refining and promoting discussion of the precise meaning of the term 'relationship', the nature of systematic evidence, and how those matters impinge on a precise understanding of monophyly, paraphyly, and polyphyly. Hennig's contributions are relevant today and are a platform for the future. This book focuses on the intellectual aspects of Hennig's work and gives dimension to the future of the subject in relation to Hennig's foundational contributions to the field of phylogenetic systematics. Suitable for graduate students and academic researchers, this book will also appeal to philosophers and historians interested in the legacy of Willi Hennig.
Colin Farrelly contemplates the various ethical and social quandaries raised by the genetic revolution. Recent biomedical advances such as genetic screening, gene therapy and genome editing might be used to promote equality of opportunity, reproductive freedom, healthy aging, and the prevention and treatment of disease. But these technologies also raise a host of ethical questions: Is the idea of "genetically engineering" humans a morally objectionable form of eugenics? Should parents undergoing IVF be permitted to screen embryos for the sex of their offspring? Would it be ethical to alter the rate at which humans age, greatly increasing longevity at a time when the human population is already at potentially unsustainable levels? Farrelly applies an original virtue ethics framework to assess these and other challenges posed by the genetic revolution. Chapters discuss virtue ethics in relation to eugenics, infectious and chronic disease, evolutionary biology, epigenetics, happiness, reproductive freedom and longevity. This fresh approach creates a roadmap for thinking ethically about technological progress that will be of practical use to ethicists and scientists for years to come. Accessible in tone and compellingly argued, this book is an ideal introduction for students of bioethics, applied ethics, biomedical sciences, and related courses in philosophy and life sciences.
A leading neuroscientist explains why your personal traits are more innate than you think What makes you the way you are "and what makes each of us different from everyone else? In Innate, leading neuroscientist and popular science blogger Kevin Mitchell traces human diversity and individual differences to their deepest level: in the wiring of our brains. Deftly guiding us through important new research, including his own groundbreaking work, he explains how variations in the way our brains develop before birth strongly influence our psychology and behavior throughout our lives, shaping our personality, intelligence, sexuality, and even the way we perceive the world. We all share a genetic program for making a human brain, and the program for making a brain like yours is specifically encoded in your DNA. But, as Mitchell explains, the way that program plays out is affected by random processes of development that manifest uniquely in each person, even identical twins. The key insight of Innate is that the combination of these developmental and genetic variations creates innate differences in how our brains are wired "differences that impact all aspects of our psychology "and this insight promises to transform the way we see the interplay of nature and nurture. Innate also explores the genetic and neural underpinnings of disorders such as autism, schizophrenia, and epilepsy, and how our understanding of these conditions is being revolutionized. In addition, the book examines the social and ethical implications of these ideas and of new technologies that may soon offer the means to predict or manipulate human traits. Compelling and original, Innate will change the way you think about why and how we are who we are.
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