This title includes a number of Open Access chapters. This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation to genomics, proteomics, and transcriptomics. The topic of companion diagnostics is also covered. The book is broken into five sections. Part I examines the connection between omics and human disease. Part II looks at the applications for the fields of translational and personalized medicine. Part III focuses on molecular and genetic markers. Part IV describes the use of omics while studying pathogens, and Part V examines the applications for companion diagnostics. The book: * Introduces genomics, proteomics, and transcriptomics in relation to human disease and ailments * Considers the role of translation and personalized medicine in relation to genomics, proteomics, and transcriptomics * Covers molecular and genetic markers * Considers the role of genomics, proteomics, and transcriptomics in relation to pathogen detection, evolution, and infection * Covers companion diagnostics in relation to genomics, proteomics, and transcriptomics clinical applications and research

First published in 1990, this is a compilation of several important papers that have contributed to the foundation of population genetics, evolutionary biology and human genetics. The collection includes Haldane's first paper in genetics, which was published in 1915, reporting the first case of linkage in a mammal, and - fifty years later, in 1965 - his last paper in genetics on selection for a single pair of allelomorphs with complete replacement. Haldane's Rule, the only idea named after him, was published in 1922 and is still valid today. Other papers, which include many Haldane firsts, such as the first estimation of a human mutation rate, first human gene map, first papers in population genetics, first estimate of the probability of fixation of a new mutation, and first measurement of mutation impact on a population, leading to the "genetic load" concept, are included. The volume also includes a paper presenting an ancient logical system for interpreting scientific results.

This title includes a number of Open Access chapters. This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is broken into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice. The book includes chapters on these topics: * Gene expression in colon cancer tissue * Epigenetics in human acute kidney injury * Embryologically relevant candidate genes in MRKH patients * DNA methylation in common skeletal disorders * Causal relationships in genomics * Predicting severe asthma exacerbations in children * Epigenetic understanding of gene-environment interactions in psychiatric disorders

First published in 1957, this essential classic work bridged the gap between analytical and theoretical biology, thus setting the insights of the former in a context which more sensitively reflects the ambiguities surrounding many of its core concepts and objectives. Specifically, these five essays are concerned with some of the major problems of classical biology: the precise character of biological organisation, the processes which generate it, and the specifics of evolution. With regard to these issues, some thinkers suggest that biological organisms are not merely distinguishable from inanimate 'things' in terms of complexity, but are in fact radically different qualitatively: they exemplify some constitutive principle which is not elsewhere manifested. It is the desire to bring such ideas into conformity with our understanding of analytical biology which unifies these essays. They explore the contours of a conceptual framework sufficiently wide to embrace all aspects of living systems.

A cutting-edge examination of what it means to be human and to have a 'self' in the face of new scientific developments in genetic editing, cloning and neural downloading. After seeing his own cells used to grow clumps of new neurons - essentially mini-brains - Philip Ball begins to examine the concepts of identity and consciousness. Delving into humanity's deep evolutionary past to look at how complex creatures like us emerged from single-celled life, he offers a new perspective on how humans think about ourselves. In an age when we are increasingly encouraged to regard the 'self' as an abstract sequence of genetic information, or as a pattern of neural activity that might be 'downloaded' to a computer, he return us to the body - to flesh and blood - and anchors a conception of personhood in this unique and ephemeral mortal coil. How to Build a Human brings us back to ourselves - but in doing so, it challenges old preconceptions and values. It asks us to rethink how we exist in the world.

Recent debate about the ethical and regulatory dimensions of developments in genetics has sidelined societal and cultural aspects, which arguably are indispensable for a nuanced understanding of the complexities of the topic. Regulatory and ethical debates benefit from taking seriously this 'third dimension' of culture, which often determines the configurations and limits of the space within which scientific, ethical and legal debate can take place. To fill this gap, this volume brings together contributions exploring the mutual relationships between genetics, markets, societies and identities in genetics and genomics. It draws upon the recent transdisciplinary debate on how socio-cultural factors influence understandings of 'genetics2.0' and shows how individual and collective identities are challenged or reinforced by cultural meanings and practices of genetics. This book will become a standard reference for everyone seeking to make sense of the controversies and shifts in the field of genetics in the second decade of the twenty-first century.

Advances in molecular genetics have led to the increasing availability of genetic testing for a variety of inherited disorders. While this new knowledge presents many obvious health benefits to prospective individuals and their families it also raises complex ethical and moral dilemmas for families as well as genetic professionals. This book explores the ways in which genetic testing generates not only probabilities of potential futures, but also enjoys new forms of social, individual and professional responsibility. Concerns about confidentiality and informed consent involving children, the assessment of competence and maturity, the ability to engage in shared decision-making through acts of disclosure and choice, are just some of the issues that are examined in detail.

Pocket Guide to Gene Level Diagnostics in Clinical Practice is an abbreviated, pocket-size, quick-reference guide that provides a point-by-point synopsis of the vast wealth of information contained in CRC Handbook of Gene Level Diagnostics in Clinical Practice. All sections and subsections in the Pocket Guide are cross-referenced to corresponding pages in the Handbook. The book works well on its own as a quick reference, but also can be used in conjunction with the larger Handbook for detailed coverage and references to specific information. Pocket Guide to Gene Level Diagnostics in Clinical Practice also includes extensive supplements featuring material not included in the Handbook. These are intended to provide an up-dated, practical source of information useful to anyone involved in molecular diagnostic research and/or service. Supplements are cross-referenced to the main text of the Pocket Guide, that complement and enhance the material covered. Pocket Guide to Gene Level Diagnostics in Clinical Practice will be a handy reference for professionals and students in pathology, biotechnology, biology, and medicine.

Drawing on their extensive teaching experience, the authors bring the content to life using humorous and engaging language and show students how the principles of behavior relate to their everyday lives. The text's tried-and-true pedagogy make the content as clear as possible without oversimplifying the concepts. Each chapter includes study objectives, key terms, and review questions that encourage students to check their understanding before moving on, and incorporated throughout the text are real-world examples and case studies to illustrate key concepts and principles.This edition also features a new full-color design and nearly 400 color figures, tables, and graphs. The text is carefully tailored to the length of a standard academic semester and how behavior analysis courses are taught, with each section corresponding to a week's worth of coursework, and each chapter is integrated with the task list for Behavior Analyst Certification Board (BACB) certifications.

First published in 1923, this book explores the impact on development that heredity and environment has on children. Chaplin argues that too much reliance is placed on education and in fact parents, physicians and teachers should equally be taking into consideration the physical and mental constitution of the child, which could be linked to hereditary and environmental factors. In conjunction with the moral, spiritual and intellectual predispositions that the child may have, Chaplin argues the pros of eugenics (in the perspective of the early 20th century) and equally the importance of euthenics for future prosperity of generations to come.

This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including:

• host-pathogen interactions
• causal relationships between genes and the environment
• the effects of environmental chemicals on gene expression
• DNA methylation

The book also covers the analysis and provides models for understanding the epigenetics-pathology connection.

This book is designed for use by senior undergraduate and graduate students from several disciplines such as general, molecular, cellular biology, genetics, genomics, proteomics, and bioinformatics. It will also serve as a reference book for existing researchers and new investigators entering this rather unexplored field.

Although books exist on the evolution of aging, this is the first book written from the perspective of again as an adaptive program. It offers an insight into the implications of research on aging genetics, The author proposes the Demographic Theory of Senescence, whereby aging has been affirmatively selected because it levels the death rate over time helping stabilize population dynamics and prevent extinctions.

The maintenance of telomeres-repetitive sequences at the end of chromosome-is essential to health. Dysfunction in telomere maintenance pathways plays a role in aging, cancer, atherosclerosis and other diseases. This has led to telomere maintenance as a prime target for patient therapies. This book describes the advances in telomere research as it applies to human health and especially how lifestyle and dietary factors could modify the telomerase maintenance process. The book examines the mechanisms involved, the primary of which are oxidative stress and the role of sirtuins, and how they can be modified by dietary patterns such as Mediterranean diet.

The book on Trends in Quorum Sensing and Quorum Quenching: New Perspectives and Applications focuses on the recent advances in the field of quorum sensing in bacteria and the novel strategies developed for quorum sensing inhibition. The topics covered are multidisciplinary and wide-ranging,and includes quorum sensing phenomenon in pathogenic bacteria, food spoilers, and agriculturally relevant bacteria. The applications of quorum sensing inhibitors such as small molecules, bioactives, natural compounds, and quorum quenching enzymes in controlling bacterial infections in clinical settings, agriculture and aquaculture are discussed. The potential use of quorum quenching enzymes for mitigating biofouling is also covered. Special focus is given to exploring quorum sensing inhibitors from microbes and flora inhabiting biodiversity rich regions including tropical rain forests and marine environments. Key features: Covers the fundamental aspects, the progress and challenges in the field of quorum sensing and quorum quenching Reviews quorum sensing in Gram-positive and Gram-negative bacteria of clinical, agricultural, and industrial relevance Discusses the application and future trends of quorum sensing inhibitors from lab to clinical and environmental settings Provides comprehensive coverage on molecular mechanisms in bacterial signaling

Epigenetics refers to DNA and chromatin modifications that play an important role in the regulation of various genomic functions. This important book reviews human and cellular data that underline paradoxical findings with respect to the contribution of heredity and environment to phenotype. The contributors then reinterpret these experiments that incorporate epigenetic factors. Topics include DNA methylation, histone modifications, chromatin modifications, the role of epigenetic modifications and environment on gene expression, and integrating genomic medicine into clinical practice.

Key features: Presents summaries of key points after each chapter and includes color graphs to visualize the big-picture concepts Demonstrates how urban rooftop farms (URFs) can contribute to city greening and climate change mitigation worldwide while providing fresh locally-sourced produce for growing urban populations Provides cutting-edge ideas from the the emerging field of food law and places international and comparative legal concepts into an accessible context for non-lawyers Examines major disputes surrounding food products that have been brought before the World Trade Organization (WTO) to illustrate how trade trends have pushed toward GMO proliferation Uses examples of food labeling, pollinator protection, pesticide permitting, invasive species control, and GMO regulatory policy in the US and the EU to illustrate various methods of bringing public law to the forefront in the struggle toward achieving food integrity The proliferation of Genetically Modified Organisms (GMOs) in our increasingly globalized food system is trivializing the inherent risks to a sustainable world. Responding to the realities of climate change, urbanization, and a GMO-dominated industrialized food system, Gabriela Steier's seminal work addresses the interrelationship of these cutting-edge topics within a scholarly, legal context. In Advancing Food Integrity: GMO Regulation, Agroecology, and Urban Agriculture, Steier defines food integrity as the optimal measure of environmental sustainability and climate change resilience combined with food safety, security, and sovereignty for the farm-to-fork production and distribution of any food product. The book starts with a discussion of the food system and explores whether private law has sufficiently protected food or whether public law control is needed to safeguard food integrity. It proceeds to show how the proliferation of GMOs creates food insecurity by denying people's access to food through food system centralization. Steier discusses how current industrial agricultural policy downplays the dangers of GMO monocultures to crop diversity and biodiversity, thereby weakening food production systems. Striving to promote agroecology by providing a fresh and compelling narrative of interdisciplinary questions, Steier explores how farming can be geared toward more sustainable and environmentally friendly practices worldwide in the future. This book belongs in the libraries of all those interested in food law, environmental law, agroecology, sustainable agriculture, and urban living practices.

Covering theory, algorithms, and methodologies, as well as data mining technologies, Data Mining for Bioinformatics provides a comprehensive discussion of data-intensive computations used in data mining with applications in bioinformatics. It supplies a broad, yet in-depth, overview of the application domains of data mining for bioinformatics to help readers from both biology and computer science backgrounds gain an enhanced understanding of this cross-disciplinary field. The book offers authoritative coverage of data mining techniques, technologies, and frameworks used for storing, analyzing, and extracting knowledge from large databases in the bioinformatics domains, including genomics and proteomics. It begins by describing the evolution of bioinformatics and highlighting the challenges that can be addressed using data mining techniques. Introducing the various data mining techniques that can be employed in biological databases, the text is organized into four sections: Supplies a complete overview of the evolution of the field and its intersection with computational learning Describes the role of data mining in analyzing large biological databases-explaining the breath of the various feature selection and feature extraction techniques that data mining has to offer Focuses on concepts of unsupervised learning using clustering techniques and its application to large biological data Covers supervised learning using classification techniques most commonly used in bioinformatics-addressing the need for validation and benchmarking of inferences derived using either clustering or classification The book describes the various biological databases prominently referred to in bioinformatics and includes a detailed list of the applications of advanced clustering algorithms used in bioinformatics. Highlighting the challenges encountered during the application of classification on biologica

The concepts of veterinary genetics are crucial to understanding and controlling many diseases and disorders in animals. They are also crucial to enhancing animal production. Accessible and clearly presented, Introduction to Veterinary Genetics provides a succinct introduction to the aspects of genetics relevant to animal diseases and production. Now in its third edition, this is the only introductory level textbook on genetics that has been written specifically for veterinary and animal science students. Coverage includes: basic genetics, molecular biology, genomics, cytogenetics, immunogenetics, population genetics, quantitative genetics, biotechnology, and the use of molecular tools in the control of inherited disorders. This book describes in detail how genetics is being applied to artificial selection in animal production. It also covers the conservation of genetic diversity in both domesticated and wild animals. New for the Third Edition: End-of-chapter summaries provide quick recaps. Covers new topics: epigenetics, genomics and bioinformatics. Thoroughly revised according to recent advances in genetics. Introduction to Veterinary Genetics is still the only introductory genetics textbook for students of veterinary and animal science and will continue to be an indispensable reference tool for veterinary students and practitioners alike.

Plants exhibit forms of asymmetry analogous to "handedness" in bilaterally symmetrical animals. This book explores the evolutionary significance and development of asymmetry. Examples of genetic control include the direction of tendril or stem coiling of many climbing plants; the so-called spiral phyllotaxy and floral taxy; and contorted petal arrangement is another kind of left- right symmetry in plants; the direction of contortion is fixed in some but not in other plants. The book will underscore tha all phenomena related to handedness start during embryogenesis itself, with the occurrence of embryo rotation. Key selling features: First consolidated book on Plant Handedness Relates handedness, asymmetry and chirality to the evolution of different organizational levels in plant biology Emphasizes handedness as a vital governing force in plant functional evolution Provides a new perspective, hitherto ignored, into plant developemtn and evolution Describes how an age-old phenomenon can give scope for investigation from a very modern interdisciplinary approach

Although numerous studies have been made of the Western educated political elite of colonial Nigeria in particular, and of Africa in general, very few have approached the study from a perspective that analyzes the impacts of indigenous institutions on the lives, values, and ideas of these individuals. This book is about the diachronic impact of indigenous and Western agencies in the upbringing, socialization, and careers of the colonial Igbo political elite of southeastern Nigeria. The thesis argues that the new elite manifests the continuity of traditions and culture and therefore their leadership values and the impact they brought on African society cannot be fully understood without looking closely at their lived experiences in those indigenous institutions where African life coheres. The key has been to explore this question at the level of biography, set in the context of a carefully reconstructed social history of the particular local communities surrounding the elite figures. It starts from an understanding of their family and village life, and moves forward striving to balance the familiar account of these individuals in public life, with an account of the ongoing influences from family, kinship, age grades, marriage and gender roles, secret societies, the church, local leaders and others. The result is not only a model of a new approach to African elite history, but also an argument about how to understand these emergent leaders and their peers as individuals who shared with their fellow Africans a dynamic and complex set of values that evolved over the six decades of colonialism.

The study of the prehistory of East Asia is developing very rapidly. In uncovering the story of the flows of human migration that constituted the peopling of East Asia there exists widespread debate about the nature of evidence and the tools for correlating results from different disciplines. Drawing upon the latest evidence in genetics, linguistics and archaeology, this exciting new book examines the history of the peopling of East Asia, and investigates the ways in which we can detect migration, and its different markers in these fields of inquiry. Results from different academic disciplines are compared and reinterpreted in the light of evidence from others to attempt to try and generate consensus on methodology. Taking a broad geographical focus, the book also draws attention to the roles of minority peoples - hitherto underplayed in accounts of the region's prehistory - such as the Austronesian, Tai-Kadai and Altaic speakers, whose contribution to the regional culture is now becoming accepted. Past Human Migrations in East Asia presents a full picture of the latest research on the peopling of East Asia, and will be of interest to scholars of all disciplines working on the reconstruction of the peopling of East and North East Asia.

BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY Finalist for the Los Angeles Times Book Prize "A powerful mix of science and ethics . . . This book is required reading for every concerned citizen--the material it covers should be discussed in schools, colleges, and universities throughout the country."-- New York Review of Books Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR--a revolutionary new technology that she helped create--to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create "better" humans. Writing with fellow researcher Sam Sternberg, Doudna--who has since won the Nobel Prize for her CRISPR research--shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life. "The future is in our hands as never before, and this book explains the stakes like no other." -- George Lucas "An invaluable account . . . We owe Doudna several times over." -- Guardian

This title is a Pearson Global Edition. The Editorial team at Pearson has worked closely with educators around the world to include content which is especially relevant to students outside the United States. For all introductory genetics courses. This package includes Mastering. Focus on essential genetic topics and explore the latest breakthroughs Known for its focus on conceptual understanding, problem solving, and practical applications, the bestselling Essentials of Genetics strengthens problem-solving skills and explores the essential genetics topics that today's students need to understand. The 10th Edition has been extensively updated to provide comprehensive coverage of important, emerging topics such as CRISPR-Cas, epigenetics, and genetic testing. Additionally, a new Special Topics chapter covers Advances in Neurogenetics with a focus on Huntington Disease, and new essays on Genetics, Ethics, and Society emphasize ethical considerations that genetics is bringing into everyday life. The accompanying Pearson Modified Mastering Genetics online platform includes new tutorials on topics such as CRISPR-Cas and epigenetics. Reach every student by pairing this text with Pearson Modified Mastering Genetics Mastering (TM) is the teaching and learning platform that empowers you to reach every student. By combining trusted author content with digital tools and a flexible platform, Mastering personalizes the learning experience and improves results for each student. Pearson Modified Mastering Genetics should only be purchased when required by an instructor. Please be sure you have the correct ISBN and Course ID. Instructors, contact your Pearson representative for more information.

This volume focuses on filamentous fungi and highlights the advances of the past decade, both in methodology and in the understanding of genomic organization and regulation of gene and pathway expression. The approaches and techniques of molecular biology enable us to ask and answer fundamental questions about many aspects of fungal biology, and open the way to the directed manipulation of fungal genetics. Moreover, this book describes the development and advancement of fungal genes and the ways in which these are being exploited in species of economic importance either in biotechnology or in biochemistry.

With the rise of genomics, the life sciences have entered a new era. Maps of genomes have become the icons for a comprehensive knowledge of the organism on a previously unattained level of complexity, and the organisation of genetic knowledge in maps has been a major driving force in the establishment of the discipline. This book provides a comprehensive history of molecular genetics and genomics. The first section of the book shows how the genetic cartography of classical genetics was linked to the molecular analysis of gene structure through the introduction of new model organisms such as bacteria and through the invention of new experimental tools such as gene transfer. The second section addresses the moral and political economy of human genome sequencing in all its technical, epistemic, social and economic complexity. With detailed analyses of the scientific practices of mapping and its illustration of the diversity of mapping practices this book is a significant contribution to the history of genetics. A companion volume from the same editors - Classical Genetic Research and Its Legacy: The Mapping Cultures of Twentieth Century Genetics - covers the history of mapping procedures as they were developed in classical genetics.