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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > General

Manipulation of the Avian Genome (Paperback): Ann M. Gibbins, Robert J. Etches Manipulation of the Avian Genome (Paperback)
Ann M. Gibbins, Robert J. Etches
R1,871 Discovery Miles 18 710 Ships in 12 - 17 working days

Many genes have been cloned from chicken cells, and during the next decade numerous laboratories will be concentrating their resources in developing ways of using these tools. Manipulation of the Avian Genome contains the most recent information from leading research laboratories in the areas of developmental and molecular genetics of the chicken. This information was presented at the Keystone Symposium held at Lake Tahoe in March, 1991. The book discusses potential applications of emerging technology in basic science and poultry production. Various techniques for altering genomic DNA, such as microinjection, retroviral vectors, and lipofection are covered. Genome evaluation using DNA fingerprinting and conventional breeding techniques are presented.

Genetic Theory of Reality (Paperback, Revised ed.): James Mark Baldwin, Jaan Valsiner Genetic Theory of Reality (Paperback, Revised ed.)
James Mark Baldwin, Jaan Valsiner
R1,558 Discovery Miles 15 580 Ships in 12 - 17 working days

James Mark Baldwin left a legacy that has yet to be fully examined, one with profound implications for science and the humanities. In some sense it paralleled that of his friend Charles Sanders Peirce, whose semiotics became understood only a century later. Baldwin was trying to make sense of complex biological and social processes which only now have come into the limelight as biological sciences, and slowly but surely, have re-emerged in psychology.

Baldwin's focus on development, based on the observation of his own children and extrapolated to his general theoretical scheme, is fully in line with where our contemporary biological sciences are heading. This is exemplified by the bounded flexibility of the work of the genetic system. The general principle of persistent exploration of the environment with the result of creating novelty, which was the core of Baldwin's theoretical system, has since the 1960s become the guiding idea in genetics. Contemporary developmental science is rooted in Baldwin's thinking.

In his new introduction, Jaan Valsiner shows that Baldwin's Genetic Theory of Reality demonstrates how human beings are in their nature social beings, establishes an alternative conceptualization of evolutionary theory, and formulates a system of developmental logic, all of which serve as the foundation for developmental psychology as a whole. This is a work of social science rediscovery long overdue.

Principles and Practices of Plant Genomics, Volume 3 - Advanced Genomics (Hardcover): Chittaranjan Kole, Albert G. Abbott Principles and Practices of Plant Genomics, Volume 3 - Advanced Genomics (Hardcover)
Chittaranjan Kole, Albert G. Abbott
R4,847 R3,975 Discovery Miles 39 750 Save R872 (18%) Ships in 12 - 17 working days

This book presents the basic and applied aspects of sequencing of genes and genomes and their implication in the fine-scale elucidation of the plant genomes. The third volume presents an overview on the advances of plant genomics made in the past century; deliberations on the genomics resources; concepts, tools, strategies, and achievements of comparative, evolutionary, and functional genomics and whole-genome sequencing. It also presents critical reviews on the already completed genome initiatives and glimpses on the currently progressing genome initiatives. This volume is an ideal reference book for students, scholars and scientists in academia, industry, and government.

Bacterial Genetics and Genomics (Hardcover): Lori Snyder Bacterial Genetics and Genomics (Hardcover)
Lori Snyder
R5,323 Discovery Miles 53 230 Ships in 12 - 17 working days

Our understanding of bacterial genetics has progressed as the genomics field has advanced. Genetics and genomics complement and influence each other; they are inseparable. Under the novel insights from genetics and genomics, once-believed borders in biology start to fade: biological knowledge of the bacterial world is being viewed under a new light and concepts are being redefined. Species are difficult to delimit and relationships within and between groups of bacteria - the whole concept of a tree of life - is hotly debated when dealing with bacteria. The DNA within bacterial cells contains a variety of features and signals that influence the diversity of the microbial world. This text assumes readers have some knowledge of genetics and microbiology but acknowledges that it can be varied. Therefore, the book includes all of the information that readers need to know in order to understand the more advanced material in the book.

Genetics, Genomics and Breeding of Sunflower (Hardcover): Jinguo Hu, Gerald Seiler, C Kole Genetics, Genomics and Breeding of Sunflower (Hardcover)
Jinguo Hu, Gerald Seiler, C Kole
R5,698 Discovery Miles 56 980 Ships in 12 - 17 working days

The sunflower has fascinated mankind for centuries. The oilseed sunflower contributes approximately ten percent of the world 's plant-derived edible oil and the confection type sunflower holds a considerable share of the directly consumed snacks market. In addition, sunflower is also grown as an ornamental for cut flowers, as well as in home gardens. We are now embarking on the age of genomics which will expedite the process of genetic improvement of crops. There has been an explosion of information on genetic markers, DNA sequences, and genomic resources for most major food crops including sunflower. This volume is intended to bridge traditional research with modern molecular investigations on sunflower.

Algorithms in Bioinformatics - A Practical Introduction (Hardcover): Wing-Kin Sung Algorithms in Bioinformatics - A Practical Introduction (Hardcover)
Wing-Kin Sung
R2,623 Discovery Miles 26 230 Ships in 12 - 17 working days

Thoroughly Describes Biological Applications, Computational Problems, and Various Algorithmic Solutions Developed from the author's own teaching material, Algorithms in Bioinformatics: A Practical Introduction provides an in-depth introduction to the algorithmic techniques applied in bioinformatics. For each topic, the author clearly details the biological motivation and precisely defines the corresponding computational problems. He also includes detailed examples to illustrate each algorithm and end-of-chapter exercises for students to familiarize themselves with the topics. Supplementary material is available at http://www.comp.nus.edu.sg/~ksung/algo_in_bioinfo/ This classroom-tested textbook begins with basic molecular biology concepts. It then describes ways to measure sequence similarity, presents simple applications of the suffix tree, and discusses the problem of searching sequence databases. After introducing methods for aligning multiple biological sequences and genomes, the text explores applications of the phylogenetic tree, methods for comparing phylogenetic trees, the problem of genome rearrangement, and the problem of motif finding. It also covers methods for predicting the secondary structure of RNA and for reconstructing the peptide sequence using mass spectrometry. The final chapter examines the computational problem related to population genetics.

The Semantic Theory of Evolution (Hardcover): Marcello Barbieri The Semantic Theory of Evolution (Hardcover)
Marcello Barbieri
R3,034 Discovery Miles 30 340 Ships in 12 - 17 working days

Originally published in 1985, The Semantic Theory of Evolution addresses the notion that life is not shaped by the single law of natural selection, but instead by a plurality of laws that resemble grammatical rules in language. This remarkable work presents a semantic theory centering on the concept of the ribotype. Supported by both sound facts and logical arguments, this analysis reaches beyond the established cadre of biological thought to unravel many of life's mysteries and paradoxes, including the origin of the cell and the nucleus and the evolution of ribosomes.

Human Evolution - An Introduction for the Behavioural Sciences (Hardcover): Graham Richards Human Evolution - An Introduction for the Behavioural Sciences (Hardcover)
Graham Richards
R3,468 Discovery Miles 34 680 Ships in 12 - 17 working days

Originally published in 1987, Human Evolution looks at theories of the evolution of human behaviour (contemporary at the time of publication). The book reviews competing theories of psychological and social evolution and provides a detailed historical introduction to the subject. A key theoretical concern which emerges in the book includes the psychological significance of the human evolution issue itself. The period of human evolution covered ranges from the demise of the Miocene hominoids, to the emergence of 'civilization'. Topics covered include: functions of 'origin myths', history of the study of human evolution, methods and data-bases, theories of the nature of 'hominisation', origins of bipedalism, language and tool-use, theories of social evolution, theories of cave art and the spread of Homo sapiens to America and Australia.

Rates of Evolution (Hardcover): K.S.W. Campbell, M.F. Day Rates of Evolution (Hardcover)
K.S.W. Campbell, M.F. Day
R3,187 Discovery Miles 31 870 Ships in 12 - 17 working days

Originally published in 1987 Rates of Evolution is an edited collection drawn from a symposium convened to bring together palaeontologists, geneticists, molecular biologists and developmental biologists to examine some aspects of the problem of evolutionary rates. The book asks questions surrounding the study of evolution, such as did large morphological changes really occur rapidly at various times in the geological past, or is the fossil record too imperfect to be of value in assessing rates of morphological change? What is the measure of 'rapid' change? Is stasis at any taxonomic level established? Is it possible to relate genomic and morphological change? What is the role of regulatory and executive genes in controlling evolutionary change? Does the transfer of genetic material between different taxa provide the possibility of increasing evolutionary rates? Featuring contributions from leading researchers, this book will interest anthropologists, palaeontology and scientists of evolution and genetics.

Functional Affinities of Man, Monkeys, and Apes - A Study of the Bearings of Physiology and Behaviour on the Taxonomy and... Functional Affinities of Man, Monkeys, and Apes - A Study of the Bearings of Physiology and Behaviour on the Taxonomy and Phylogeny of Lemurs, Monkeys, Apes, and Man (Hardcover)
S. Zuckerman
R3,041 Discovery Miles 30 410 Ships in 12 - 17 working days

Originally published in 1933 Functional Affinities of Man, Monkeys and Apes gives a taxonomic and phylogenetic survey and the findings of diverse experimental investigations of lemurs, monkeys, and apes. The book discusses the inter-relationships of different Primates and emphasizes seldom-used approaches to the question of primate phylogeny. The book attempts to show how little they have been systematically tried, and argues for a regard to the proper place of functional investigations in the study of the classification and evolution of Primates. This book will be of interest to anthropologists, scientists and historians alike.

The Future of Man - The BBC Reith Lectures 1959 (Hardcover): P.B. Medawar The Future of Man - The BBC Reith Lectures 1959 (Hardcover)
P.B. Medawar
R2,730 Discovery Miles 27 300 Ships in 12 - 17 working days

Originally published in 1960, The Future of Man is a chronicle of Professor Medwar's Reith lectures of 1959. The book outlines his predictions about the future estate of man, with the 'process of foretelling, rather than with what is actually foretold'. He asks, can we predict the future size of populations? What is the evidence and theoretical background for the belief that human intelligence is declining? Could human beings become uniformly excellent or is inborn diversity and inequality a necessary part of the texture of human populations? The lectures tried to answer these questions and attempts to end with a definition of the biological standing of man. This book will be of interest to anthropologists, biologists and natural historians.

Homo Sapiens - From Man to Demigod (Hardcover): Bernhard Rensch Homo Sapiens - From Man to Demigod (Hardcover)
Bernhard Rensch
R3,039 Discovery Miles 30 390 Ships in 12 - 17 working days

Originally published in 1972, Homo Sapiens examines how humans emerged from among the millions of other species and achieved our unique position within the animal kingdom. The book examines what direction future evolution will take and what may be regarded as the 'meaning' of human existence. It stipulates that these are the questions for which no real basis of discussion existed before the 20th century, and at the time of publication, some were still without a definite answer. The book sets out analyse these questions and the continuing debate that has arisen from their study. This is an account of the uniqueness of man in the animal kingdom, how this uniqueness arose during evolution, and what traces of it can be detected in animals other than man. The book describes the mental and physical evolution of man, from his earliest ancestors to the present day. He also gives an account of man's cultural development seeking to establish that there is an underlying principal of cultural evolution, a principle that has been denied by many historians. Later chapters deal with the future and with possible forecasts of mankind's further physical, intellectual and cultural evolution.

The Uniqueness of the Individual (Hardcover): P.B. Medawar The Uniqueness of the Individual (Hardcover)
P.B. Medawar
R2,739 Discovery Miles 27 390 Ships in 12 - 17 working days

Originally published in 1957, The Uniqueness of the Individual is a collection of 9 essays published from the ten years preceding publication. The essays deal with some of the central problems of biology. These are among the questions put and answered from the standpoint of modern experimental biology. What is ageing and how is it measured? What theories have been held to account for it, and with what success? Did ageing evolve, and if so how? Is Lamarckism and adequate explanation of evolutionary process? Does evolution sometimes go wrong? Do human beings evolve in a way peculiar to themselves? Other essays touch upon the problems of scientific method and of growth and transformation. This book will be of interest to natural historians, evolutionists and anthropologists.

Handbook of Nonmedical Applications of Liposomes: From Gene Delivery and Diagnostics to Ecology - From Gene Delivery and... Handbook of Nonmedical Applications of Liposomes: From Gene Delivery and Diagnostics to Ecology - From Gene Delivery and Diagnosis to Ecology (Hardcover)
Yechezkel Barenholz; Contributions by Leaf Huang, Donald F.H. Wallach, Guy Vanlerberghe, Brigitte Sternberg, …
R5,108 Discovery Miles 51 080 Ships in 12 - 17 working days

First published in 1996, liposomes have become an important model in fundamental biomembrane research, including biophysical, biochemical, and cell biological studies of membranes and cell function. They are thoroughly studied in several applications, such as drug delivery systems in medical applications and as controlled release systems, microencapsulating media, signal carriers, support matrices, and solubilizers in other applications. While medical applications have been extensively reviewed in recent literature, there is a need for easily accessible information on applications for liposomes beyond pharmacology and medicine. The Handbook of Nonmedical Applications of Liposomes fills this void.This unique new handbook series presents recent developments in the use of liposomes in many scientific disciplines, from studies on the origin of life, protein function, and vesicle shapes, to applications in cosmetics, diagnostics, ecology, bioreclamation, and the food industry. In these volumes many of the top experts contribute extensive reviews of their work.

Genetics and Genomics of Brachypodium (Hardcover, 1st ed. 2016): John P. Vogel Genetics and Genomics of Brachypodium (Hardcover, 1st ed. 2016)
John P. Vogel
R5,496 Discovery Miles 54 960 Ships in 12 - 17 working days

Grasses dominate many natural ecosystems and produce the bulk calories consumed by humans either directly in the form of grains or indirectly through forage/grain fed animals. In addition, grasses grown as biomass crops are poised to become a significant source of renewable energy. Despite their economic and environmental importance, research into the unique aspects of grass biology has been hampered by the lack of a truly tractable experimental model system. Over that past decade, the small, annual grass Brachypodium distachyon has emerged as a viable model system for the grasses. This book describes the development of extensive experimental resources (e.g. whole genome sequence, efficient transformation methods, insertional mutant collections, large germplasm collections, recombinant inbred lines, resequenced genomes) that have led many laboratories around the world to adopt B. distachyon as a model system. The use of B. distachyon to address a wide range of biological topics (e.g. disease resistance, cell wall composition, abiotic stress tolerance, root growth and development, floral development, natural diversity) is also discussed.

Understanding Genes (Hardcover, New Ed): Kostas Kampourakis Understanding Genes (Hardcover, New Ed)
Kostas Kampourakis
R1,225 Discovery Miles 12 250 Ships in 12 - 17 working days

What are genes? What do genes do? These questions are not simple and straightforward to answer; at the same time, simplistic answers are quite prevalent and are taken for granted. This book aims to explain the origin of the gene concept, its various meanings both within and outside science, as well as to debunk the intuitive view of the existence of 'genes for' characteristics and disease. Drawing on contemporary research in genetics and genomics, as well as on ideas from history of science, philosophy of science, psychology and science education, it explains what genes are and what they can and cannot do. By presenting complex concepts and research in a comprehensible and rigorous manner, it examines the potential impact of research in genetics and genomics and how important genes actually are for our lives. Understanding Genes is an accessible and engaging introduction to genes for any interested reader.

Systems Biology and Bioinformatics - A Computational Approach (Hardcover): Kayvan Najarian, Siamak Najarian, Shahriar... Systems Biology and Bioinformatics - A Computational Approach (Hardcover)
Kayvan Najarian, Siamak Najarian, Shahriar Gharibzadeh, Christopher N. Eichelberger
R5,672 Discovery Miles 56 720 Ships in 12 - 17 working days

The availability of molecular imaging and measurement systems enables today's biologists to swiftly monitor thousands of genes involved in a host of diseases, a critical factor in specialized drug development. Systems Biology and Bioinformatics: A Computational Approach provides students with a comprehensive collection of the computational methods used in what is being coined the digital era of biology. Written by field experts with proven track records, this authoritative textbook first provides an introduction to systems biology and its impact on biology and medicine. The book then reviews the basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the high-throughput biological experiments that produce databases. The text includes techniques to discover genes, perform nucleotide and amino acid sequence matching, and estimate static gene dynamic pathways. The book also explains how to use system-oriented models to predict the behavior of biological systems for important applications such as rational drug design. The numerous examples and problem sets allow students to confidently explore practical systems biology applications using real examples with real biological data, making Systems Biology and Bioinformatics: A Computational Approach an ideal text for senior undergraduate and first-year graduate students.

How to Argue With a Racist - History, Science, Race and Reality (Paperback): Adam Rutherford How to Argue With a Racist - History, Science, Race and Reality (Paperback)
Adam Rutherford
R280 R229 Discovery Miles 2 290 Save R51 (18%) Ships in 9 - 15 working days

THE SUNDAY TIMES BESTSELLER AS HEARD ON BBC RADIO 4 BOOK OF THE WEEK 'The ultimate anti-racism guide' Caroline Criado Perez 'Seriously important' Bill Bryson 'A fascinating debunking of racial pseudoscience' Guardian Racist pseudoscience may be on the rise, but science is no ally to racists. Instead science and history can be powerful allies against bigotry, granting us the clearest view of how people actually are, rather than how we judge them to be. HOW TO ARGUE WITH A RACIST dismantles outdated notions of race by illuminating what modern genetics can and can't tell us about human difference. It is a vital manifesto for a twenty-first century understanding of human evolution and variation, and a timely weapon against the misuse of science to justify racism. Updated edition includes a new Preface from the author

Companion Diagnostics (CDx) in Precision Medicine (Hardcover): Il-Jin Kim Companion Diagnostics (CDx) in Precision Medicine (Hardcover)
Il-Jin Kim
R3,513 Discovery Miles 35 130 Ships in 12 - 17 working days

There is a new trend in anti-cancer therapeutics development: a targeted therapy and precision medicine that targets a subgroup of patients with specific biomarkers. An in vitro diagnostic (IVD) assay is required to identify a subgroup of cancer patients who would benefit from the targeted therapy, or not likely benefit, or have a high risk of side effects from the specific drug treatment. This IVD or medical device is called a companion diagnostic (CDx) assay. It is key to have a robust CDx assay or device for the success of targeted therapy and precision medicine. This book covers the technical, historical, clinical, and regulatory aspects of CDx in precision medicine. Clearly, more and more newly developed oncology drugs will require accompanying CDx assays, and this book, with chapters contributed by renowned oncologists, provides a comprehensive foundation for the knowledge and application of CDx for precision medicine.

Genomics and Society - Legal, Ethical and Social Dimensions (Paperback): George Gaskell, Martin W. Bauer Genomics and Society - Legal, Ethical and Social Dimensions (Paperback)
George Gaskell, Martin W. Bauer
R1,772 Discovery Miles 17 720 Ships in 12 - 17 working days

From the mid 1990s to the present day, agricultural biotechnology - GM crops and foods - has been the focus of debate and conflict in many European countries. Contrasting views of risks and benefits, trust in science and regulation, the understanding of science, media coverage and mobilization of the public by civil society groups - all have been cited as drivers of public opinion. Designed in part to allay public concerns about GM agriculture, a European moratorium led to a new regulatory framework. The long running controversy is a signal that the public's view cannot be ignored in the development and implementation of new technologies arising out of genomics. Yet, agricultural biotechnologies are but one development in this area. Genetic testing and the uses of genetic information, the cloning of human cells and tissues, and transgenic animals are potentially no less challenging for the public and regulators alike. This volume, by an international group of social scientists from Europe, North America and Japan, presents a series of comparative perspectives on the social, ethical and legal implications of genomics. The aim is to capture lessons from the controversies of the 1990s and to raise the level of debate on the societal implications of new developments in genomics.

Comparative Genomics and Proteomics in Drug Discovery - Vol 58 (Hardcover): Kevin Coward, John Parrington Comparative Genomics and Proteomics in Drug Discovery - Vol 58 (Hardcover)
Kevin Coward, John Parrington
R5,225 Discovery Miles 52 250 Ships in 12 - 17 working days

Comparative Genomics and Proteomics in Drug Discovery gives an overview of how emerging genomic and proteomic technologies are making significant contributions to global drug discovery programs, and in particular the key role that comparative genomics and proteomics play within this strategy. Each chapter is written by respected authorities, with hands-on experience, from both academic and pharmaceutical backgrounds.

On Genetic Interests - Family, Ethnicity and Humanity in an Age of Mass Migration (Paperback): Frank Salter On Genetic Interests - Family, Ethnicity and Humanity in an Age of Mass Migration (Paperback)
Frank Salter
R1,458 Discovery Miles 14 580 Ships in 12 - 17 working days

From an evolutionary perspective, individuals have a vi- tal interest in the reproduction of their genes. Yet this interest is overlooked by social and political theory at a time when we need to steer an adaptive course through the unnatural modern world of uneven population growth and decline, global mobility, and loss of family and communal ties. In modern Darwinian theory, bearing children is only one way to reproduce. Since we share genes with our families, ethnic groups, and the species as a whole, ethnocentrism and humanism can be adaptive. They can also be hazardous when taken to extremes. "On Genetic Interests" canvasses strategies and ethics for conserving our genetic interests in an environmentally sustainable manner sensitive to the interests of others.

" This] is a fresh and deep contribution to the sociobiology of humans, combining genetics with social science in original ways."--Edward O. Wilson, Harvard University

"The book greatly expands Hamiltonian kin selection' by making ethnies in control of territory the central arena of selfish genery' in a modern world of mass migration."--Pierre van den Berghe, University of Washington, Seattle

"Salter argues that all humans have a vital interest in genetic continuity that is threatened by mass migration. Salter advocates non-aggressive universal nationalism' as part of a balanced fitness portfolio' that includes investments in three levels of genetic interests--family, ethny, and the species as a whole. The synthesis is persuasive; the policy formulations provocative."--Irenus Eibl-Eibesfeldt, Max Planck Society

"Five stars for Salter--he has provided us with a deep and compelling explanation of what most people know and what guides much of their behavior, but fear to acknowledge publicly."--Michael T. McGuire, UCLA

"We are indeed all part of each other, as John Donne insisted even before the help of evolutionary genetics. But we are more part of some than others, and the nature of these boundaries of ethnic kinship has been ignored, avoided or denied. After Salter's virtuoso synthesis we can no longer duck these issues which become more important daily."--Robin Fox, Rutgers University
"Frank Salter" is an Australian political scientist who has been a researcher with the Max Planck Society, Andechs, Germany, since 1991.

Welcome to the Genome - A User's Guide to the Genetic Past, Present, and Future, 2nd Edition (Paperback, 2nd Edition): R.... Welcome to the Genome - A User's Guide to the Genetic Past, Present, and Future, 2nd Edition (Paperback, 2nd Edition)
R. DeSalle
R1,357 Discovery Miles 13 570 Ships in 12 - 17 working days

This volume offers readers an opportunity to learn about how genomes are sequenced, what discoveries have so far come out of this scientific revolution, and about the ethical dimensions of this advancing technology. The revised edition focuses on the new advances in genome technology and builds upon the strong basic biological format that was established in the original publication. It also takes advantage of the recent major advances in genome level sequencing and analysis to demonstrate the vast increase in biological knowledge over the past decade.

Neurobehavioral Genetics - Methods and Applications, Second Edition (Hardcover, 2nd edition): Byron C. Jones, Pierre Mormede Neurobehavioral Genetics - Methods and Applications, Second Edition (Hardcover, 2nd edition)
Byron C. Jones, Pierre Mormede
R5,278 Discovery Miles 52 780 Ships in 12 - 17 working days

A complete background to concepts and principles of behavioral genetics, Neurobehavioral Genetics: Methods and Applications, Second Edition features a broad spectrum of the most current techniques in neurobehavioral genetics in a single source. International researchers incorporate several new developments in the field, including: -Developmental neurobehavioral genetics -Gene-gene interaction -New approaches in bioinformatics -Gene expression -Single gene techniques Based on various studies of living organisms ranging from primates to rodents to invertebrates, this edition offers a contemporary approach to examining the relationship between the genetic mechanisms in the brain and behavior. The authors examine how past and recent advances in methods and knowledge come together in the comparative genetics of behavior. They introduce the reader to experimental approaches available for the genetic study of emotionality, focusing on the use of animal models. This edition explores studies in neurogenetic disorders, including schizophrenia and bipolar disorders, examines genetic traits in personality such as altruism, and evaluates aggression in mice and humans. It also discusses the applications of quantitative methods and molecular genetics in basic and clinical research. Neurobehavioral Genetics: Methods and Applications, Second Edition brings together new techniques and methods to promote a better understanding of genetics and their effects on behavior. The book is an excellent resource for investigators who want to incorporate genetic methods into neurobehavioral and psychiatric research.

Gaucher Disease (Hardcover): Anthony H. Futerman, Ari Zimran Gaucher Disease (Hardcover)
Anthony H. Futerman, Ari Zimran
R6,896 Discovery Miles 68 960 Ships in 12 - 17 working days

In September of 2007 Gaucher Disease received a commendation in the Haematology category of the 2007 British Medical Association Medical Book Competition! Although rare in the general population, Gaucher disease is the most prevalent of the lysosomal storage disorders, making research into this particular orphan disorder an invaluable prototype for the diagnosis, research, and treatment of others. Like many rare conditions, Gaucher disease has benefited from the explosion of medical research in the last decade, the amount of new information on this disease is staggering and the rate of new discoveries has left previous books on the subject unable to provide useful, up-to-date information. The most current, fully comprehensive reference to date, Gaucher Disease provides valuable information for academic and industry scientists, and clinicians. Outlining the latest research on the biochemical mechanisms and pathology of lysosomal storage disorders, this book covers diverse topics including animal models, crystallography, imaging and radionuclide evaluation. It not only addresses the developmental basis for current treatments like the now widely available enzyme replacement therapy, but also includes chapters introducing new therapies on the horizon. With contributions from world-renowned experts in substrate reduction therapy, pharmaceutical chaperone therapy, hematopoietic stem cell transplantation and gene therapy, as well as chapters on a second generation of enzyme replacement therapy, this book explores the full spectrum of possibilities offered by the most recent advances in medicine. Some of the most interesting aspects of the book include the discussions on patient management, those touching on the ethics of research, and the societal aspects of treating rare diseases with expensive therapy.

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