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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > General

Data Mining for Bioinformatics (Hardcover): Sumeet Dua, Pradeep Chowriappa Data Mining for Bioinformatics (Hardcover)
Sumeet Dua, Pradeep Chowriappa
R2,908 Discovery Miles 29 080 Ships in 12 - 17 working days

Covering theory, algorithms, and methodologies, as well as data mining technologies, Data Mining for Bioinformatics provides a comprehensive discussion of data-intensive computations used in data mining with applications in bioinformatics. It supplies a broad, yet in-depth, overview of the application domains of data mining for bioinformatics to help readers from both biology and computer science backgrounds gain an enhanced understanding of this cross-disciplinary field. The book offers authoritative coverage of data mining techniques, technologies, and frameworks used for storing, analyzing, and extracting knowledge from large databases in the bioinformatics domains, including genomics and proteomics. It begins by describing the evolution of bioinformatics and highlighting the challenges that can be addressed using data mining techniques. Introducing the various data mining techniques that can be employed in biological databases, the text is organized into four sections: Supplies a complete overview of the evolution of the field and its intersection with computational learning Describes the role of data mining in analyzing large biological databases-explaining the breath of the various feature selection and feature extraction techniques that data mining has to offer Focuses on concepts of unsupervised learning using clustering techniques and its application to large biological data Covers supervised learning using classification techniques most commonly used in bioinformatics-addressing the need for validation and benchmarking of inferences derived using either clustering or classification The book describes the various biological databases prominently referred to in bioinformatics and includes a detailed list of the applications of advanced clustering algorithms used in bioinformatics. Highlighting the challenges encountered during the application of classification on biologica

Microscale Technologies for Cell Engineering (Hardcover, 1st ed. 2016): Ankur Singh, Akhilesh K Gaharwar Microscale Technologies for Cell Engineering (Hardcover, 1st ed. 2016)
Ankur Singh, Akhilesh K Gaharwar
R4,852 R3,807 Discovery Miles 38 070 Save R1,045 (22%) Ships in 12 - 17 working days

This book offers readers cutting-edge research at the interface of polymer science and engineering, biomedical engineering, materials science, and biology. State-of-the-art developments in microscale technologies for cell engineering applications are covered, including technologies relevant to both pluripotent and adult stem cells, the immune system, and somatic cells of the animal and human origin. This book bridges the gap in the understanding of engineering biology at multiple length scale, including microenvironmental control, bioprocessing, and tissue engineering in the areas of cardiac, cartilage, skeletal, and vascular tissues, among others. This book also discusses unique, emerging areas of micropatterning and three-dimensional printing models of cellular engineering, and contributes to the better understanding of the role of biophysical factors in determining the cell fate. Microscale Technologies for Cell Engineering is valuable for bioengineers, biomaterial scientists, tissue engineers, clinicians, immunoengineers, immunologists and stem cell biologists, as it offers a review of the current cutting-edge cell engineering research at multiple length scale and will be valuable in developing new strategies for efficient scale-up and clinical translation.

African Cultural Values - Igbo Political Leadership in Colonial Nigeria, 1900-1996 (Paperback): Raphael Chijoke Njoku African Cultural Values - Igbo Political Leadership in Colonial Nigeria, 1900-1996 (Paperback)
Raphael Chijoke Njoku
R1,624 Discovery Miles 16 240 Ships in 12 - 17 working days

Although numerous studies have been made of the Western educated political elite of colonial Nigeria in particular, and of Africa in general, very few have approached the study from a perspective that analyzes the impacts of indigenous institutions on the lives, values, and ideas of these individuals. This book is about the diachronic impact of indigenous and Western agencies in the upbringing, socialization, and careers of the colonial Igbo political elite of southeastern Nigeria. The thesis argues that the new elite manifests the continuity of traditions and culture and therefore their leadership values and the impact they brought on African society cannot be fully understood without looking closely at their lived experiences in those indigenous institutions where African life coheres. The key has been to explore this question at the level of biography, set in the context of a carefully reconstructed social history of the particular local communities surrounding the elite figures. It starts from an understanding of their family and village life, and moves forward striving to balance the familiar account of these individuals in public life, with an account of the ongoing influences from family, kinship, age grades, marriage and gender roles, secret societies, the church, local leaders and others. The result is not only a model of a new approach to African elite history, but also an argument about how to understand these emergent leaders and their peers as individuals who shared with their fellow Africans a dynamic and complex set of values that evolved over the six decades of colonialism.

Past Human Migrations in East Asia - Matching Archaeology, Linguistics and Genetics (Paperback): Alicia Sanchez-Mazas, Roger... Past Human Migrations in East Asia - Matching Archaeology, Linguistics and Genetics (Paperback)
Alicia Sanchez-Mazas, Roger Blench, Malcolm D. Ross, Ilia Peiros, Marie Lin
R1,658 Discovery Miles 16 580 Ships in 12 - 17 working days

The study of the prehistory of East Asia is developing very rapidly. In uncovering the story of the flows of human migration that constituted the peopling of East Asia there exists widespread debate about the nature of evidence and the tools for correlating results from different disciplines. Drawing upon the latest evidence in genetics, linguistics and archaeology, this exciting new book examines the history of the peopling of East Asia, and investigates the ways in which we can detect migration, and its different markers in these fields of inquiry. Results from different academic disciplines are compared and reinterpreted in the light of evidence from others to attempt to try and generate consensus on methodology. Taking a broad geographical focus, the book also draws attention to the roles of minority peoples - hitherto underplayed in accounts of the region's prehistory - such as the Austronesian, Tai-Kadai and Altaic speakers, whose contribution to the regional culture is now becoming accepted. Past Human Migrations in East Asia presents a full picture of the latest research on the peopling of East Asia, and will be of interest to scholars of all disciplines working on the reconstruction of the peopling of East and North East Asia.

Low-Cost Methods for Molecular Characterization of Mutant Plants - Tissue Desiccation, DNA Extraction and Mutation Discovery:... Low-Cost Methods for Molecular Characterization of Mutant Plants - Tissue Desiccation, DNA Extraction and Mutation Discovery: Protocols (Hardcover, 2015 ed.)
Bradley J. Till, Joanna Jankowicz-Cieslak, Owen A. Huynh, Mayada M. Beshir, Robert G. Laport, …
R1,595 Discovery Miles 15 950 Ships in 10 - 15 working days

This book offers low-cost and rapid molecular assays for the characterization of mutant plant germplasm. Detailed protocols are provided for the desiccation of plant tissues; the extraction of high-quality DNA for downstream applications; the extraction of single-strand-specific nucleases for single nucleotide polymorphism; and small insertion/deletion discovery using standard agarose gel electrophoresis. The methods described can be applied in any laboratory equipped for basic molecular biology and do away with the need for expensive freezers and toxic organic compounds. With the appropriate validation of sample quality and longevity, they can provide sufficient DNA for a variety of molecular applications, such as marker studies and TILLING, at approximately one tenth of the cost per sample when compared to commercial kits.

Cancer Stem Cells - Methods and Protocols (Paperback, 2009 ed.): John S Yu Cancer Stem Cells - Methods and Protocols (Paperback, 2009 ed.)
John S Yu
R2,924 Discovery Miles 29 240 Ships in 10 - 15 working days

Cancer is a devastating disease that affects millions of people in the world. Our the- pies for tumors have mostly been based on classical chemotherapy and antiproliferative treatments. More recently, directed therapies against a causative oncogene have led to prominent reduction in tumor rates for some cancers. For instance, chronic myelogenous leukemia that is due to a BCR-ABL translocation can be targeted with Gleevec. Despite these advances in individual tumors, a number of patients are treated for their primary tumors and ultimately relapse. Relapsing tumors can be due to resistance to chemotherapy or to antioncogene drugs. Another hypothesis is that heterogeneity in the tumor leads to an inability of classical chemotherapy to completely eradicate all cells of the tumor. This concept of heterogeneity has led some investigators to propose a cancer stem cell model. As patients are treated with chemotherapy, most of the dividing cells are killed, but this leaves a small subset of cells that have the ability to remake the entire tumor. These are cancer stem cells. They possess the signals of self-renewal and yet can also differentiate. If one could understand more about the cells that remain after classical chemotherapy or the cells that can remake the tumor among the heterogeneous population, this information would have a huge impact on our treatment of cancer.

Essentials of Genetics plus Pearson Modified Mastering Genetics with Pearson eText, Global Edition (Paperback, 10th edition):... Essentials of Genetics plus Pearson Modified Mastering Genetics with Pearson eText, Global Edition (Paperback, 10th edition)
William S. Klug, Michael R Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
R2,395 Discovery Miles 23 950 Ships in 12 - 17 working days

This title is a Pearson Global Edition. The Editorial team at Pearson has worked closely with educators around the world to include content which is especially relevant to students outside the United States. For all introductory genetics courses. This package includes Mastering. Focus on essential genetic topics and explore the latest breakthroughs Known for its focus on conceptual understanding, problem solving, and practical applications, the bestselling Essentials of Genetics strengthens problem-solving skills and explores the essential genetics topics that today's students need to understand. The 10th Edition has been extensively updated to provide comprehensive coverage of important, emerging topics such as CRISPR-Cas, epigenetics, and genetic testing. Additionally, a new Special Topics chapter covers Advances in Neurogenetics with a focus on Huntington Disease, and new essays on Genetics, Ethics, and Society emphasize ethical considerations that genetics is bringing into everyday life. The accompanying Pearson Modified Mastering Genetics online platform includes new tutorials on topics such as CRISPR-Cas and epigenetics. Reach every student by pairing this text with Pearson Modified Mastering Genetics Mastering (TM) is the teaching and learning platform that empowers you to reach every student. By combining trusted author content with digital tools and a flexible platform, Mastering personalizes the learning experience and improves results for each student. Pearson Modified Mastering Genetics should only be purchased when required by an instructor. Please be sure you have the correct ISBN and Course ID. Instructors, contact your Pearson representative for more information.

Biotechnology of Fungal Genes (Hardcover, New): V.K. Gupta, M. Ayyachamy Biotechnology of Fungal Genes (Hardcover, New)
V.K. Gupta, M. Ayyachamy
R5,410 Discovery Miles 54 100 Ships in 12 - 17 working days

This volume focuses on filamentous fungi and highlights the advances of the past decade, both in methodology and in the understanding of genomic organization and regulation of gene and pathway expression. The approaches and techniques of molecular biology enable us to ask and answer fundamental questions about many aspects of fungal biology, and open the way to the directed manipulation of fungal genetics. Moreover, this book describes the development and advancement of fungal genes and the ways in which these are being exploited in species of economic importance either in biotechnology or in biochemistry.

From Molecular Genetics to Genomics - The Mapping Cultures of Twentieth-Century Genetics (Paperback): Jean-Paul Gaudilliere,... From Molecular Genetics to Genomics - The Mapping Cultures of Twentieth-Century Genetics (Paperback)
Jean-Paul Gaudilliere, Hans-Joerg Rheinberger
R1,069 R974 Discovery Miles 9 740 Save R95 (9%) Ships in 12 - 17 working days

With the rise of genomics, the life sciences have entered a new era. Maps of genomes have become the icons for a comprehensive knowledge of the organism on a previously unattained level of complexity, and the organisation of genetic knowledge in maps has been a major driving force in the establishment of the discipline. This book provides a comprehensive history of molecular genetics and genomics. The first section of the book shows how the genetic cartography of classical genetics was linked to the molecular analysis of gene structure through the introduction of new model organisms such as bacteria and through the invention of new experimental tools such as gene transfer. The second section addresses the moral and political economy of human genome sequencing in all its technical, epistemic, social and economic complexity. With detailed analyses of the scientific practices of mapping and its illustration of the diversity of mapping practices this book is a significant contribution to the history of genetics. A companion volume from the same editors - Classical Genetic Research and Its Legacy: The Mapping Cultures of Twentieth Century Genetics - covers the history of mapping procedures as they were developed in classical genetics.

Genetic Testing - Accounts of Autonomy, Responsibility and Blame (Hardcover, New): Michael Arribas-Ayllon, Srikant Sarangi,... Genetic Testing - Accounts of Autonomy, Responsibility and Blame (Hardcover, New)
Michael Arribas-Ayllon, Srikant Sarangi, Angus Clarke
R4,210 Discovery Miles 42 100 Ships in 12 - 17 working days

"Advances in molecular genetics have led to the increasing availability of genetic testing for a variety of inherited disorders. While this new knowledge presents many obvious health benefits to prospective individuals and their families it also raises complex ethical and moral dilemmas for families as well as genetic professionals. This book explores the ways in which genetic testing generates not only probabilities of potential futures, but also enjoys new forms of social, individual and professional responsibility. Concerns about confidentiality and informed consent involving children, the assessment of competence and maturity, the ability to engage in shared decision-making through acts of disclosure and choice, are just some of the issues that are examined in detail"--Provided by publisher.

Nucleic Acid Testing for Human Disease (Paperback): Attila Lorincz Nucleic Acid Testing for Human Disease (Paperback)
Attila Lorincz
R1,803 Discovery Miles 18 030 Ships in 12 - 17 working days

Nucleic Acid Testing for Human Disease describes various techniques including target and signal amplification-based NAT procedures, microarrays, bead-based multiplex assays, in situ hybridization, and SNP techniques. This book discusses RNA expression profiling and laboratory issues such as the need for proper validation of tests intended for routine use. It focuses on specific applications of NATs to human disease diagnosis and treatment, from viral, bacterial, fungal, and protozoan detection to genetic exploration by SNP determinations, patterns of RNA expression, and the growing relevance of epigenetic changes. It also offers different perspectives on future directions in the field.

Methods in Genomic Neuroscience (Paperback): Hemin R. Chin, Steven O. Moldin Methods in Genomic Neuroscience (Paperback)
Hemin R. Chin, Steven O. Moldin
R1,784 Discovery Miles 17 840 Ships in 12 - 17 working days

The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable scope are now being routinely solved in neuroscience and many other areas of biomedical research. The results of these studies, in turn, are having, and will continue to have, profound impact on experimental approaches and designs for manipulating genes, the genome, and model organisms as a means of gaining insights into nervous system functioning and complex behavior. Methods in Genomic Neuroscience provides newcomers and experienced researchers with a reference guide for applying powerful, state-of-the-art molecular genetic techniques to the study of neural and behavioral systems. It thereby provides a foundation by which data on gene expression and function may be used to develop new therapeutic strategies for brain diseases. Authored by researchers in the forefront of genomic neuroscience, the book addresses state-of-the-art tools and technologies for global analysis of genes influencing the nervous system and its disorders. An emphasis is placed on massively parallel approaches for analyzing the avalanche of data that is being generated from the full genomic sequence of humans and model systems. Specific topics include human sequence variation, methods for discovering disease vulnerability genes, gene-environmental interaction, gene expression analysis using DNA microarrays, random mutagenesis, gene trap approaches for studying brain development, neural stem cells, gene targeting, and gene delivery.

Genetics, Genomics and Breeding of Conifers (Hardcover, New): Christophe Plomion, Jean Bousquet, Chittaranjan Kole Genetics, Genomics and Breeding of Conifers (Hardcover, New)
Christophe Plomion, Jean Bousquet, Chittaranjan Kole
R5,421 Discovery Miles 54 210 Ships in 12 - 17 working days

The new research described in this book demonstrates that the interplay of a host of founding conditions can frequently produce profound differences in population expansion rates and maintenance of genetic diversity in contrasting populations that differ, often only to slight degrees, in initial founding conditions. The goals of this book are twofold. First, it serves as a user's manual for the computer program NEWGARDEN (provided) designed to enable investigations, using computer generated populations, of population growth and genetic variation resulting from user-specified differences in initial founding conditions. Second, the book provides a series differences in geometric spacing among plant founders, can result in significant differences in demographic and genetic variation trajectories for the ensuring populations.

Phylogenomic Data Acquisition - Principles and Practice (Paperback): W. Bryan Jennings Phylogenomic Data Acquisition - Principles and Practice (Paperback)
W. Bryan Jennings
R1,772 Discovery Miles 17 720 Ships in 12 - 17 working days

Phylogenomics is a rapidly growing field of study concerned with using genome-wide data-usually in the form of DNA sequence loci-to infer the evolution of genes, genomes, and the Tree of Life. Accordingly, this discipline connects many areas in biology including molecular and genomic evolution, systems biology, molecular systematics, phylogeography, conservation genetics, DNA barcoding, and others. With the advent of Next Generation Sequencing in addition to advances in computer hardware and software over the past decade, researchers can now generate unparalleled phylogenomic datasets that are helping to illuminate many areas in the life sciences. This book is an introduction to the principles and practices of gathering these data. Phylogenomic Data Acquisition: Principles and Practice is intended for a broad cross-section of biologists and anyone else interested in learning how to obtain phylogenomic data using the latest methods.

Handbook of Detection of Enzymes on Electrophoretic Gels (Paperback, 2nd edition): Gennady P. Manchenko Handbook of Detection of Enzymes on Electrophoretic Gels (Paperback, 2nd edition)
Gennady P. Manchenko
R1,813 Discovery Miles 18 130 Ships in 12 - 17 working days

Still widely used as gene markers, isozymes detected by zymogram techniques have proven valuable in a range of other biological applications over the last few years. Along with these new applications, many new techniques have also emerged. Yet more than eight years since the Handbook of Detection of Enzymes on Electrophoretic Gels was first published, it remains the only book completely devoted to zymogram methods. The time has come to bring its contents up to date. New in the Second Edition: An overview of new applications of enzyme electrophoresis and zymogram techniques Zymogram techniques for approximately 100 enzymes not included in the first edition, bringing the total to more than 900 methods for detecting more than 400 different enzymes Information on subunit structure included within the enzyme sheets to facilitate interpretation of isozyme patterns detected on zymograms An appendix containing information on the buffer systems most commonly used for enzyme electrophoresis in starch, cellulose acetate, and polyacrylamide gels. The second edition of this bestselling handbook makes significant additions to the set of reliable gene markers suitable for electrophoretic analysis. It also strengthens the value of enzyme electrophoresis as a powerful tool proven successful in solving a variety of problems encountered across many biological areas, including the post-genome biology.

Genetics, Genomics, and Breeding of Grapes (Hardcover): Anne-Francoise Adam-Blondon, Jose-Miguel Martinez-Zapater, Chittaranjan... Genetics, Genomics, and Breeding of Grapes (Hardcover)
Anne-Francoise Adam-Blondon, Jose-Miguel Martinez-Zapater, Chittaranjan Kole
R5,407 Discovery Miles 54 070 Ships in 12 - 17 working days

Grapevine is a highly valuable crop worldwide, both from cultural as well as commercial point of view. One major advantage this crop has is that it is well adapted to scarce water conditions. Grapes are also a valuable source of health-promoting compounds such as polyphenols. The main object of grapevine breeding is to develop varieties of high quality, that are resistant to pathogens and at the same time well adapted to a changing environment. Since the beginning of the XXI century, there has been a concerted effort by the international scientific community to develop genomic tools and resources for grapevine culminating in its complete genome sequence. These efforts and their usefulness for grapevine breeding or viticulture improvement are reviewed and discussed in this book by globally reputed scientists in the field.

Genome - The Autobiography Of A Species In 23 Chapters (Paperback): Matt Ridley Genome - The Autobiography Of A Species In 23 Chapters (Paperback)
Matt Ridley
R449 R374 Discovery Miles 3 740 Save R75 (17%) Ships in 10 - 15 working days

The genome's been mapped.
But what does it mean?

Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life.

"Genome" offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.

Phylogenomics - A Primer (Hardcover, 2nd edition): Rob Desalle, Michael Tessler, Jeffrey Rosenfeld Phylogenomics - A Primer (Hardcover, 2nd edition)
Rob Desalle, Michael Tessler, Jeffrey Rosenfeld
R6,434 Discovery Miles 64 340 Ships in 12 - 17 working days

Phylogenomics: A Primer, Second Edition is for advanced undergraduate and graduate biology students studying molecular biology, comparative biology, evolution, genomics, and biodiversity. This book explains the essential concepts underlying the storage and manipulation of genomics level data, construction of phylogenetic trees, population genetics, natural selection, the tree of life, DNA barcoding, and metagenomics. The inclusion of problem-solving exercises in each chapter provides students with a solid grasp of the important molecular and evolutionary questions facing modern biologists as well as the tools needed to answer them.

Genetics, Genomics and Breeding of Potato (Hardcover): James M. Bradeen, Chittaranjan Kole Genetics, Genomics and Breeding of Potato (Hardcover)
James M. Bradeen, Chittaranjan Kole
R5,677 Discovery Miles 56 770 Ships in 12 - 17 working days

In this volume, world leaders in potato research review historical and contemporary discoveries resulting in a range of advances. Topics include nutritional quality, yield, disease and insect resistance, processing, plant growth and development, and other aspects. The book also examines research yielding significant molecular resources that facilitate breeding, linkage and gene mapping, cytology, functional and structural genomics, proteomics, and metabolomics. Future research developments that are likely to significantly advance efforts to understand and improve the potato are also explored.

The Masterpiece of Nature - The Evolution and Genetics of Sexuality (Hardcover): Graham Bell The Masterpiece of Nature - The Evolution and Genetics of Sexuality (Hardcover)
Graham Bell
R5,296 Discovery Miles 52 960 Ships in 12 - 17 working days

Originally published in 1982, The Masterpiece of Nature examines sex as representative of the most important challenge to the modern theory of evolution. The book suggests that sex evolved, not as the result of normal Darwinian processes of natural selection, but through competition between populations or species - a hypothesis elsewhere almost universally discredited. The book also discusses the nature of sex and its consequences for the individual and for the population, as well as various other theories of sex. Since the value of these theories is held to reside wholly in their ability to predict the patterns of sexuality observed in nature, the book seeks to provide an extensive review of the circumstances in which sexuality is attenuated or lost throughout the animal kingdom, and these facts are then used to weigh up the merits of the rival theories. This book will be of interest to researchers in the area of genetics, ecology and evolutionary biology.

Gene Biotechnology (Hardcover, 3rd edition): William Wu, Helen H. Zhang, Michael J. Welsh, Peter B. Kaufman Gene Biotechnology (Hardcover, 3rd edition)
William Wu, Helen H. Zhang, Michael J. Welsh, Peter B. Kaufman
R5,434 Discovery Miles 54 340 Ships in 12 - 17 working days

Covering state-of-the-art technologies and a broad range of practical applications, the Third Edition of Gene Biotechnology presents tools that researchers and students need to understand and apply today's biotechnology techniques. Many of the currently available books in molecular biology contain only protocol recipes, failing to explain the principles and concepts behind the methods outlined or to inform the reader of possible pitfalls in the methods described. Filling these gaps, this book: Discusses a wide variety of approaches, from very basic methods to the latest, most sophisticated technologies Contains clearly detailed, step-by-step protocols with helpful troubleshooting tips Addresses the needs of researchers in academic and commercial environments Guides graduate students in designing, implementing, and evaluating experimental projects. Each chapter covers the principles underlying methods and techniques, and includes step-by-step descriptions of each protocol, notes, tips, and a troubleshooting guide. The book includes sections on how to write a research paper for publication in English-language journals, how to protect research discoveries and inventions via patents, and practical methods of bio-calculation. Written by a team of internationally recognized scientists, Gene Biotechnology presents protocols as well as clear and simple explanations of the key principles and concepts behind the methods. It is a single, logically organized source for the most important new methodologies. This unique resource provides the tools to help ensure success in contemporary molecular and cellular biology research.

Handbook of Hidden Markov Models in Bioinformatics (Paperback): Martin Gollery Handbook of Hidden Markov Models in Bioinformatics (Paperback)
Martin Gollery
R1,846 Discovery Miles 18 460 Ships in 12 - 17 working days

Demonstrating that many useful resources, such as databases, can benefit most bioinformatics projects, the Handbook of Hidden Markov Models in Bioinformatics focuses on how to choose and use various methods and programs available for hidden Markov models (HMMs). The book begins with discussions on key HMM and related profile methods, including the HMMER package, the sequence analysis method (SAM), and the PSI-BLAST algorithm. It then provides detailed information about various types of publicly available HMM databases, such as Pfam, PANTHER, COG, and metaSHARK. After outlining ways to develop and use an automated bioinformatics workflow, the author describes how to make custom HMM databases using HMMER, SAM, and PSI-BLAST. He also helps you select the right program to speed up searches. The final chapter explores several applications of HMM methods, including predictions of subcellular localization, posttranslational modification, and binding site. By learning how to effectively use the databases and methods presented in this handbook, you will be able to efficiently identify features of biological interest in your data.

Manipulation of the Avian Genome (Paperback): Ann M. Gibbins, Robert J. Etches Manipulation of the Avian Genome (Paperback)
Ann M. Gibbins, Robert J. Etches
R1,871 Discovery Miles 18 710 Ships in 12 - 17 working days

Many genes have been cloned from chicken cells, and during the next decade numerous laboratories will be concentrating their resources in developing ways of using these tools. Manipulation of the Avian Genome contains the most recent information from leading research laboratories in the areas of developmental and molecular genetics of the chicken. This information was presented at the Keystone Symposium held at Lake Tahoe in March, 1991. The book discusses potential applications of emerging technology in basic science and poultry production. Various techniques for altering genomic DNA, such as microinjection, retroviral vectors, and lipofection are covered. Genome evaluation using DNA fingerprinting and conventional breeding techniques are presented.

Principles and Practices of Plant Genomics, Volume 3 - Advanced Genomics (Hardcover): Chittaranjan Kole, Albert G. Abbott Principles and Practices of Plant Genomics, Volume 3 - Advanced Genomics (Hardcover)
Chittaranjan Kole, Albert G. Abbott
R4,847 R3,975 Discovery Miles 39 750 Save R872 (18%) Ships in 12 - 17 working days

This book presents the basic and applied aspects of sequencing of genes and genomes and their implication in the fine-scale elucidation of the plant genomes. The third volume presents an overview on the advances of plant genomics made in the past century; deliberations on the genomics resources; concepts, tools, strategies, and achievements of comparative, evolutionary, and functional genomics and whole-genome sequencing. It also presents critical reviews on the already completed genome initiatives and glimpses on the currently progressing genome initiatives. This volume is an ideal reference book for students, scholars and scientists in academia, industry, and government.

Bacterial Genetics and Genomics (Hardcover): Lori Snyder Bacterial Genetics and Genomics (Hardcover)
Lori Snyder
R5,323 Discovery Miles 53 230 Ships in 12 - 17 working days

Our understanding of bacterial genetics has progressed as the genomics field has advanced. Genetics and genomics complement and influence each other; they are inseparable. Under the novel insights from genetics and genomics, once-believed borders in biology start to fade: biological knowledge of the bacterial world is being viewed under a new light and concepts are being redefined. Species are difficult to delimit and relationships within and between groups of bacteria - the whole concept of a tree of life - is hotly debated when dealing with bacteria. The DNA within bacterial cells contains a variety of features and signals that influence the diversity of the microbial world. This text assumes readers have some knowledge of genetics and microbiology but acknowledges that it can be varied. Therefore, the book includes all of the information that readers need to know in order to understand the more advanced material in the book.

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