Non-coding RNAs potentially play an active role in modulating gene transcription and epigenetic states. Several genes in differentiated cells may be under some form of RNA based transcriptional and epigenetic regulatory control. This form of regulation may be controlled by selective pressures and influence the adaptability of the cell. The concept that RNA can control epigenetic states impacts on our understanding of the basic fabric of the cell and may have therapeutic potential. Many studies have been carried out on the modulation of gene transcription by non-coding RNAs. This book, written by a group of distinguished scientists under the expert guidance of the editor Kevin V. Morris, represents an important overview and summary of the field to date. The thirteen chapters are organized into three sections: Non-coding RNAs: Form, Function and Diversity; Non-coding RNAs: Gene Regulation and Epigenetics; and Non-coding RNAs: Disease and Therapeutics. This up-to-date volume is an essenti

Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagnosis and treatment. Cancer nanotechnology offers new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions-including targeting, imaging, and therapy-have been intensively studied with the goal of overcoming the limitations of conventional cancer diagnosis and therapy. Thus theranostic nanomedicines have emerged in recent years to provide an efficient and safer alternative in cancer management. This book covers polymer-based therapies, lipid-based therapies, inorganic particle-based therapies, photo-related therapies, radiotherapies, chemotherapies, and surgeries. Multifunctional Theranostic Nanomedicines in Cancer offers an indispensable guide for researchers in academia, industry, and clinical settings; it is also ideal for postgraduate students; and formulation scientists working on cancer.

Nitric Oxide in Plant Biology: An Ancient Molecule with Emerging Roles is an extensive volume which provides a broad and detailed overview of Nitric Oxide (NO) in plant biology. The book covers the entirety of the crucial role NO plays in the plant lifecycle, from the regulation of seed germination and growth to synthesis, nitrogen fixation and stress response. Beginning with NO production and NO homeostasis, Nitric Oxide in Plant Biology goes on to cover a variety of NO roles, with a focus on NO signalling, crosstalk and stress responses. Edited by leading experts in the field and featuring the latest research from laboratories from across the globe, it is a comprehensive resource of interest to students and researchers working in plant physiology, agriculture, biotechnology, and the pharmaceutical and food industries.

An introduction to the history of genetics and the rethinking of evolutionism.

How do genes determine behavior? How much of behavior is nature versus nurture? How do behaviors evolve? Anholt and Mackay, leading scholars in the field of behavioral genetics, address these questions and much more in this comprehensive textbook that defines the emerging field of behavioral genetics. The provides a range of examples, such as laboratory studies on flies and mice, field observations on species as diverse as butterflies and meerkats, and human behavioral disorders. The book blends classical and modern genetic principles with neurobiological and ecological perspectives to teach students how to find and map genes that affect behaviors, as well as how the coordinated expression of ensembles of these genes enables the nervous system to express complex behaviors in response to changes in the environment. Principles of Behavioral Genetics introduces us to the fascinating science that aims to understand how our genes determine what makes us tick.
Principles of Behavioral Genetics presents a comprehensive overview of the relationship between genes, brain and behavior. Introductory chapters provide clear explanations of basic processes of the nervous system and fundamental principles of genetics of complex traits without excessive statistical jargon. Individual chapters describe the genetics of social interactions, olfaction and taste, memory and learning, circadian behavior, locomotion, sleep, and addiction, as well as the evolution of behavior. Whereas the focus is on genetics, neurobiological and ecological aspects are also included to provide intellectual breadth. The book uses examples that span the gamut from classical model organisms to non-model systems and human biology, and include both laboratory and field studies. Samples of historical information accentuate the text to provide the reader with an appreciation of the history of the field. All chapters contain general overviews, concise summaries, study questions that promote not only memorization but also contemplation of the material, and recommendations for further in-depth reading. An extensive glossary that defines the terminology used in the book is included. This textbook encompasses a broad definition of the emerging science of behavioral genetics.
* Defines the emerging science of behavioral genetics
* Engagingly written by two leading experts in behavioral genetics
* Clear explanations of basic quantitative genetic, neurogenetic and genomic applications to the study of behavior
* Numerous examples ranging from model organisms to non-model systems and humans
* Concise overviews and summaries for each chapter

Practical Biostatistics: A Step-by-Step Approach for Evidence-Based Medicine, Second Edition presents a complete resource of biostatistical knowledge meant for health sciences students, researchers and health care professionals. The book's content covers the investigator's hypothesis, collective health, observational studies, the biostatistics of intervention studies, clinical trials and additional concepts. Chapters are written in a didactic way, making them easier to comprehend by readers with little or no background on statistics. Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision-making using statistical analyses of scientific methods and outcomes to drive further experimentation and diagnosis. With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or hands-on guide on how to effectively incorporate biostatistics in clinical trials and research projects.

Drawing on their extensive teaching experience, the authors bring the content to life using humorous and engaging language and show students how the principles of behavior relate to their everyday lives. The text's tried-and-true pedagogy make the content as clear as possible without oversimplifying the concepts. Each chapter includes study objectives, key terms, and review questions that encourage students to check their understanding before moving on, and incorporated throughout the text are real-world examples and case studies to illustrate key concepts and principles.This edition also features a new full-color design and nearly 400 color figures, tables, and graphs. The text is carefully tailored to the length of a standard academic semester and how behavior analysis courses are taught, with each section corresponding to a week's worth of coursework, and each chapter is integrated with the task list for Behavior Analyst Certification Board (BACB) certifications.

In studying biology, one of the more difficult factors to predict is how parents' attributes will affect their children and how those children will affect their own children. Organizing and calculating those vast statistics can become extremely tedious without the proper mathematical and reproductive knowledge. Attractors and Higher Dimensions in Population and Molecular Biology: Emerging Research and Opportunities is a collection of innovative research on the methods and applications of population logistics. While highlighting topics including gene analysis, crossbreeding, and reproduction, this book is ideally designed for academics, researchers, biologists, and mathematicians seeking current research on modeling the reproduction process of a biological population.

This open access volume presents state-of-the-art inference methods in population genomics, focusing on data analysis based on rigorous statistical techniques. After introducing general concepts related to the biology of genomes and their evolution, the book covers state-of-the-art methods for the analysis of genomes in populations, including demography inference, population structure analysis and detection of selection, using both model-based inference and simulation procedures. Last but not least, it offers an overview of the current knowledge acquired by applying such methods to a large variety of eukaryotic organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, pointers to the relevant literature, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Statistical Population Genomics aims to promote and ensure successful applications of population genomic methods to an increasing number of model systems and biological questions.

Transcription Factors for Abiotic Stress Tolerance in Plants highlights advances in the understanding of the regulatory network that impacts plant health and production, providing important insights for improving plant resistance. Plant production worldwide is suffering serious losses due to widespread abiotic stresses increasing as a result of global climate change. Frequently more than one abiotic stress can occur at once, for example extreme temperature and osmotic stress, which increases the complexity of these environmental stresses. Modern genetic engineering technologies are one of the promising tools for development of plants with efficient yields and resilience to abiotic stresses. Hence deciphering the molecular mechanisms and identifying the abiotic stress associated genes that control plant response to abiotic stresses is a vital requirement in developing plants with increased abiotic stress resilience. Addressing the various complexities of transcriptional regulation, this book includes chapters on cross talk and central regulation, regulatory networks, the role of DOF, WRKY and NAC transcription factors, zinc finger proteins, CRISPR/CAS9-based genome editing, C-Repeat (CRT) binding factors (CBFs)/Dehydration responsive element binding factors (DREBs) and factors impacting salt, cold and phosphorous stress levels, as well as transcriptional modulation of genes involved in nanomaterial-plant interactions. Transcription Factors for Abiotic Stress Tolerance in Plants provides a useful reference by unravelling the transcriptional regulatory networks in plants. Researchers and advanced students will find this book a valuable reference for understanding this vital area.

Armed with extraordinary new discoveries about our genes, acclaimed science writer Matt Ridley turns his attention to the nature-versus-nurture debate in a thoughtful book about the roots of human behavior.

Ridley recounts the hundred years' war between the partisans of nature and nurture to explain how this paradoxical creature, the human being, can be simultaneously free-willed and motivated by instinct and culture. With the decoding of the human genome, we now know that genes not only predetermine the broad structure of the brain, they also absorb formative experiences, react to social cues, and even run memory. They are consequences as well as causes of the will.