Covers recent advancement in potato improvement in the post-genomics era after the potato genome sequencing in 2011. Includes integration of modern technological technologies in potato improvement. Implicates resequencing of potato genomes and discovery of SNP markers to accelerate next-generation potato breeding. Incorporates genomics-aided progress in germplasm management, pre-breeding genomics, gene mapping and cloning, transgenics, omics studies (transcriptomics, proteomics, metabolomics and phenomics), genome editing and bioinformatics.

Computer solutions to many difficult problems in science and engineering require the use of automatic search methods that consider a large number of possible solutions to the given problems. This book describes recent advances in the theory and practice of one such search method, called Genetic Algorithms. Genetic algorithms are evolutionary search techniques based on principles derived from natural population genetics, and are currently being applied to a variety of difficult problems in science, engineering, and artificial intelligence.

This study of macroeconomics combines treatment of opposing theories with a presentation of evidence to point the way toward a reconstructed macro research and policy programme.

The new edition of Introducing Genetics is a clear, concise, and accessible guide to inheritance and variation in individuals and populations. It first establishes the principles of Mendelian inheritance and the nature of chromosomes, before tackling quantitative and population genetics. The final three chapters introduce the molecular mechanisms that underlie genetics, including the techniques responsible for the current genetic revolution.

As genetics affects all living organisms, examples are taken from insects, plants, animals, and humans. Each chapter ends with a set of problems to help the reader develop their understanding of genetics.

Immunity studies in sharks over the past three decades have produced some remarkable discoveries. If one message rings true, it is that alternative animal model systems, such as sharks and their relatives, have contributed very substantially to a better understanding of the development evolution of our own immune system. Immunobiology of the Shark describes the cellular, genetic, and molecular specifics of immune systems in sharks. Diverse approaches were employed to study the immunobiology of the shark from basic microscopic observations to detailed genome annotation. The book also raises a series of fascinating questions, which can be addressed experimentally using today's technology. This book will be a valuable resource for mainstream immunologists, comparative immunologists, geneticists, ecologists, evolutionary biologists, and investigators engaged in shark research. The book also aims to illustrate the magnificence of these animals as model systems and underscores the importance of their study to further understand their complex, and often enigmatic, biology.

THE SUNDAY TIMES BESTSELLER AS HEARD ON BBC RADIO 4 BOOK OF THE WEEK 'The ultimate anti-racism guide' Caroline Criado Perez 'Seriously important' Bill Bryson 'A fascinating debunking of racial pseudoscience' Guardian Racist pseudoscience may be on the rise, but science is no ally to racists. Instead science and history can be powerful allies against bigotry, granting us the clearest view of how people actually are, rather than how we judge them to be. HOW TO ARGUE WITH A RACIST dismantles outdated notions of race by illuminating what modern genetics can and can't tell us about human difference. It is a vital manifesto for a twenty-first century understanding of human evolution and variation, and a timely weapon against the misuse of science to justify racism. Updated edition includes a new Preface from the author

Now updated for its second edition, Population Genetics is the classic, accessible introduction to the concepts of population genetics. Combining traditional conceptual approaches with classical hypotheses and debates, the book equips students to understand a wide array of empirical studies that are based on the first principles of population genetics. Featuring a highly accessible introduction to coalescent theory, as well as covering the major conceptual advances in population genetics of the last two decades, the second edition now also includes end of chapter problem sets and revised coverage of recombination in the coalescent model, metapopulation extinction and recolonization, and the fixation index.

Sorghum is one of the hardiest crop plants in modern agriculture and also one of the most versatile. Its seeds provide calorie for food and feed, stalks for building and industrial materials and its juice for syrup. This book provides an in-depth review of the cutting-edge knowledge in sorghum genetics and its applications in sorghum breeding. Each chapter is authored by specialists in their fields to report the latest trends and findings. The book showcases the definitive value of sorghum as a model system to study the genetic basis of crop productivity and stress tolerance and will provide a foundation for future studies in sorghum genetics, genomics, and breeding.

Offering a rich diversity of models, Bayesian phylogenetics allows evolutionary biologists, systematists, ecologists, and epidemiologists to obtain answers to very detailed phylogenetic questions. Suitable for graduate-level researchers in statistics and biology, Bayesian Phylogenetics: Methods, Algorithms, and Applications presents a snapshot of current trends in Bayesian phylogenetic research.

Encouraging interdisciplinary research, this book introduces state-of-the-art phylogenetics to the Bayesian statistical community and, likewise, presents state-of-the-art Bayesian statistics to the phylogenetics community. The book emphasizes model selection, reflecting recent interest in accurately estimating marginal likelihoods. It also discusses new approaches to improve mixing in Bayesian phylogenetic analyses in which the tree topology varies. In addition, the book covers divergence time estimation, biologically realistic models, and the burgeoning interface between phylogenetics and population genetics.

This book provides in-depth explorations of genetic cloning, including the history of cloning and the types of artificial cloning for both plants and animals, with fascinating examples. It also explains the possibility of using the gene therapy to cure diseases.

What should individuals and society do when genetic screening becomes widely available and with its impact on current and future generations still uncertain? How can our education systems around the world respond to these developments? Reproductive and genetic technologies (RGTs) are increasingly controversial and political. We are entering an era where we can design future humans, firstly, by genetic screening of "undesirable" traits or indeed embryos, but perhaps later by more radical genetic engineering. This has a profound effect on what we see as normal, acceptable and responsible. This book argues that these urgent and biopolitical issues should be central to how biology is taught as a subject. Debate about life itself has always been at the forefront of connected molecular, genetic and social/personal identity levels, and each of these levels requires processes of communication and debate, what Anthony Giddens called in passing life politics. In this book Padraig Murphy opens the term up, with examples from field research in schools, student responses to educational films exploring the future of RGTs, and science studies of strategic biotechnology and the lab practices of genetic screening. Life political debate is thoroughly examined and is identified as a way of connecting mainstream education of biology with future generations. Biotechnology, Education and Life Politics will appeal to post-graduates and academics involved with science education, science communication, communication studies and the sociology of education.

Exploring the revolutionary science behind the power of thought, this book will forever change how you think about your own thinking. This new updated and expanded 10th anniversary edition of The Biology of Belief contains stunning new scientific discoveries about the biochemical effects of the brain's functioning that show all the cells of your body are affected by your thoughts. Bruce H. Lipton PhD, a renowned cell biologist, describes the precise molecular pathways through which this occurs. Using simple language, illustrations, humour and everyday examples, he demonstrates how the new science of epigenetics is revolutionizing our understanding of the link between mind and matter, and the profound effects it has on our personal lives and the collective life of our species. It has been 10 years since the publication of The Biology of Belief, Bruce Lipton's seminal book on the relationship between mind and body that changed the way we think about our lives, our health and our planet. During that time, research in this field has grown exponentially - Lipton's ground-breaking experiments have now been endorsed by more than a decade of rigorous scientific study. In this greatly expanded edition, Lipton explores his own experiments and those of other leading-edge scientists that have unravelled in ever greater detail how truly connected the mind, body and spirit are. It is now widely recognized that genes and DNA do not control our biology. Instead, they are controlled by signals from outside the cell, including energetic messages emanating from our thoughts. This profoundly hopeful synthesis of the latest and best research in cell biology and quantum physics puts the power to create a healthy, joyous life back in our own hands. When we transform our conscious and subconscious thoughts, we transform our lives, and in the process help humanity evolve to a new level of understanding and peace.

As our ability to acquire massive amounts of information about genome variation accelerates it is becoming increasingly clear that to make maximum use of this information we also need well-structured, systematic data on the phenotypic consequences of genomic changes. Phenomics is the new discipline of using standardized measurement techniques to characterize the phenotypic effects of random or systematic genome modifications (for example randomly generated mutations or systematic gene knockouts). This approach is now being used in an increasing range of species and systems. In this book, experts working in phenomics in most of the major species and systems that are currently being studied present overviews of the field from their different, but overlapping perspectives.

A groundbreaking new exploration of the promises and perils of biotechnology -- and the future of American society.

Biotechnology offers exciting prospects for healing the sick and relieving suffering. But because our growing powers also enable alterations in the workings of the body and mind, they are becoming attractive to healthy people who would just like to look younger, perform better, feel happier, or become more "perfect."

This landmark book -- the product of more than sixteen months of research and reflection by the members of the President's Council on Bioethics -- explores the profound ethical and social consequences of today's biotechnical revolution. Almost every week brings news of novel methods for screening genes and testing embryos, choosing the sex and modifying the behavior of children, enhancing athletic performance, slowing aging, blunting painful memories, brightening mood, and altering basic temperaments. But we must not neglect the fundamental question: Should we be turning to biotechnology to fulfill our deepest human desires?

We want better children -- but not by turning procreation into manufacture or by altering their brains to gain them an edge over their peers. We want to perform better in the activities of life -- but not by becoming mere creatures of chemistry. We want longer lives -- but not at the cost of becoming so obsessed with our own longevity that we care little about future generations. We want to be happy -- but not by taking a drug that gives us happy feelings without the genuine loves, attachments, and achievements that are essential to true human flourishing. As we enjoy the benefits of biotechnology, members of the council contend, we need to hold fast to an account of the human being seen not in material or mechanistic or medical terms but in psychic, moral, and spiritual ones. By grasping the limits of our new powers, we can savor the fruits of the age of biotechnology without succumbing to its most dangerous temptations.

Beyond Therapy takes these issues out of the narrow circle of bioethics professionals and into the larger public arena, where matters of this importance rightly belong.

While numerous advanced statistical approaches have recently been developed for quantitative trait loci (QTL) mapping, the methods are scattered throughout the literature. Statistical Methods for QTL Mapping brings together many recent statistical techniques that address the data complexity of QTL mapping.

After introducing basic genetics topics and statistical principles, the author discusses the principles of quantitative genetics, general statistical issues of QTL mapping, commonly used one-dimensional QTL mapping approaches, and multiple interval mapping methods. He then explains how to use a feature selection approach to tackle a QTL mapping problem with dense markers. The book also provides comprehensive coverage of Bayesian models and MCMC algorithms and describes methods for multi-trait QTL mapping and eQTL mapping, including meta-trait methods and multivariate sequential procedures.

This book emphasizes the modern statistical methodology for QTL mapping as well as the statistical issues that arise during this process. It gives the necessary biological background for statisticians without training in genetics and, likewise, covers statistical thinking and principles for geneticists. Written primarily for geneticists and statisticians specializing in QTL mapping, the book can also be used as a supplement in graduate courses or for self-study by PhD students working on QTL mapping projects.

When Crime and Personality was first published in 1964, J.A.C. Brown, writing in the New Statesman, commented: 'There can be no doubt of the importance of Professor Eysenck's book on the nature and treatment of criminal behaviour.' This third edition, originally published in 1977, had been completely revised and brought up to date, and although the major theory linking personality and crime has been retained, many of the details have been changed in conformity with recent research of the time. The book presents a theory concerning the personality of criminals, and offers evidence to show that these personality features characterising criminals are based on genetic foundations. It is argued that criminality as a whole is not exclusively based on environmental factors as has so often been suggested, but has a strong biological basis. A good deal of evidence is reviewed showing that there are many data supporting this view, from studies of identical and fraternal twins, adopted children, and comparisons between criminals and non-criminals both in the Western world and in Communist countries. Professor Eysenck suggests that important consequences follow from such an attempt to redress the one-sided emphasis on environmental factors which had been so characteristic of the previous fifty years, and some of these consequences are described in detail. He further suggests that only proper understanding of the psychological factors making for antisocial behaviour will help in reversing the increasing burden that criminality places upon society. The book also takes issue with political arguments of the time regarding the origins of criminality, and shows that criminals behind the Iron Curtain show the same personality characteristics as do criminals in Western countries.

Advances in Genetics serial, Volume 110 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, all written by an international board of authors.

The success of individualized medicine, advanced crops, and new and sustainable energy sources requires thoroughly annotated genomic information and the integration of this information into a coherent model. A thorough overview of this field, Genome Annotation explores automated genome analysis and annotation from its origins to the challenges of next-generation sequencing data analysis. The book initially takes you through the last 16 years since the sequencing of the first complete microbial genome. It explains how current analysis strategies were developed, including sequencing strategies, statistical models, and early annotation systems. The authors then present visualization techniques for displaying integrated results as well as state-of-the-art annotation tools, including MAGPIE, Ensembl, Bluejay, and Galaxy. They also discuss the pipelines for the analysis and annotation of complex, next-generation DNA sequencing data. Each chapter includes references and pointers to relevant tools. As very few existing genome annotation pipelines are capable of dealing with the staggering amount of DNA sequence information, new strategies must be developed to accommodate the needs of today's genome researchers. Covering this topic in detail, Genome Annotation provides you with the foundation and tools to tackle this challenging and evolving area. Suitable for both students new to the field and professionals who deal with genomic information in their work, the book offers two genome annotation systems on an accompanying downloadable resources.

The ONLY textbook available on marine mammal physiology, a core topic in Marine Science undergrad teaching Builds on the unique overall theme 'How would you design a marine mammal?' which focuses on what an undergrad student would actually want to know. What would they ask? So rather than "What are the biochemical differences between marine and terrestrial mammals?" the book addresses "How can marine mammals dive for such a long time?" or "How do they stay warm in such cold water?" Organises the Table of Contents into common 'real' student questions. The book thus centres around the point of view of the student. This makes it accessible and student-focused. Consistency across all chapters Provides consistent Power Point slides that teachers can use when they don't know the field well AND that students can use as study guides. Offers Study Questions and future thinking/implications questions. A Driving Question for each chapter is highlighted in a box. A concluding chapter ties up loose ends and consolidates the driving questions from the individual chapters. Contains the contributions of well-respected, prominent scientists in the field. Author bios for each chapter showcase diversity in contributor pool. Focuses on physiological adaptations of marine mammals and connects them with the ecological context, including anthropogenic impacts. Discusses differences that might exist by type of marine mammal, development questions, and behavioral issues.

Advances in Genetics, Volume 109 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Epigenetic regulation of angiogenesis in tumor progression, RecBCD and Chi hotspots as determinants of self vs. non-self: A re-evaluation, Horizontal gene transfer to plants from Agrobacterium and related bacterial species, and more.

* FROM THE SUNDAY TIMES BESTSELLING AUTHOR OF HOW TO ARGUE WITH A RACIST * Throughout history, people have sought to improve society by reducing suffering, eliminating disease or enhancing desirable qualities in their children. But this wish goes hand in hand with the desire to impose control over who can marry, who can procreate and who is permitted to live. In the Victorian era, in the shadow of Darwin's ideas about evolution, a new full-blooded attempt to impose control over our unruly biology began to grow in the clubs, salons and offices of the powerful. It was enshrined in a political movement that bastardised science, and for sixty years enjoyed bipartisan and huge popular support. Eugenics was vigorously embraced in dozens of countries. It was also a cornerstone of Nazi ideology, and forged a path that led directly to the gates of Auschwitz. But the underlying ideas are not merely historical. The legacy of eugenics persists in our language and literature, from the words 'moron' and 'imbecile' to the themes of some of our greatest works of culture. Today, with new gene editing techniques, very real conversations are happening - including in the heart of British government - about tinkering with the DNA of our unborn children, to make them smarter, fitter, stronger. CONTROL tells the story of attempts by the powerful throughout history to dictate reproduction and regulate the interface of breeding and society. It is an urgently needed examination that unpicks one of the defining and most destructive ideas of the twentieth century. To know this history is to inoculate ourselves against its being repeated.

Application of Sampling and Detection Methods in Agricultural Plant Biotechnology describes detection methods for seed, plants and grain derived from biotechnology. This international handbook, based on a series of workshops carried out for governments in collaboration with ILSI and Co-published in partnership with the Cereals & Grains Association, provides the technical and practical information needed to develop, validate and use detection methods. This useful resource provides readers with the tools necessary to carry out reliable sampling, detection and interpretation of data.

A look at the extraordinary ways the brain turns thoughts into actions-and how this shapes our everyday lives Why is it hard to text and drive at the same time? How do you resist eating that extra piece of cake? Why does staring at a tax form feel mentally exhausting? Why can your child expertly fix the computer and yet still forget to put on a coat? From making a cup of coffee to buying a house to changing the world around them, humans are uniquely able to execute necessary actions. How do we do it? Or in other words, how do our brains get things done? In On Task, cognitive neuroscientist David Badre presents the first authoritative introduction to the neuroscience of cognitive control-the remarkable ways that our brains devise sophisticated actions to achieve our goals. We barely notice this routine part of our lives. Yet, cognitive control, also known as executive function, is an astonishing phenomenon that has a profound impact on our well-being. Drawing on cutting-edge research, vivid clinical case studies, and examples from daily life, Badre sheds light on the evolution and inner workings of cognitive control. He examines issues from multitasking and willpower to habitual errors and bad decision making, as well as what happens as our brains develop in childhood and change as we age-and what happens when cognitive control breaks down. Ultimately, Badre shows that cognitive control affects just about everything we do. A revelatory look at how billions of neurons collectively translate abstract ideas into concrete plans, On Task offers an eye-opening investigation into the brain's critical role in human behavior.

Strategies to Mitigate the Toxicity of Cancer Therapeutics, Volume 155 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters, each of which is written by an international board of authors.

A provocative and timely case for how the science of genetics can help create a more just and equal society In recent years, scientists like Kathryn Paige Harden have shown that DNA makes us different, in our personalities and in our health-and in ways that matter for educational and economic success in our current society. In The Genetic Lottery, Harden introduces readers to the latest genetic science, dismantling dangerous ideas about racial superiority and challenging us to grapple with what equality really means in a world where people are born different. Weaving together personal stories with scientific evidence, Harden shows why our refusal to recognize the power of DNA perpetuates the myth of meritocracy, and argues that we must acknowledge the role of genetic luck if we are ever to create a fair society. Reclaiming genetic science from the legacy of eugenics, this groundbreaking book offers a bold new vision of society where everyone thrives, regardless of how one fares in the genetic lottery.