Scientists and researchers from top labs around the world share their expertise!
This unique text integrates tree transgenesis, functional genomics, and structural genomics to present, for the first time, a unified approach to research on the molecular biology of forest trees. A distinguished panel of scientists, researchers, and educators from around the world have combined their efforts to present the most up-to-date information and make Molecular Genetics and Breeding of Forest Trees an important addition to your professional or teaching collection. Helpful tables and figures make important points easy to access and understand.
To make it easier to find the specific information you're looking for, Molecular Genetics and Breeding of Forest Trees is divided into four sections: Forest Tree Functional Genomics, Molecular Biology of Wood Formation, Forest Tree Transgenesis, and Genome Mapping in Forest Trees. Within these sections, you'll find the most up-to-date information on: functional genomics EST databases proteomics in forest trees genomics of wood formation and in vitro systems for the study of wood formation genetic transformation of forest trees stable expression of foreign genes modification of flowering in forest trees genome mapping in forest trees microsatellite DNA markers in forest trees exploring the transcriptome of the ectomycorrhizal symbiosis in trees

Scientists and researchers from top labs around the world share their expertise!
This unique text integrates tree transgenesis, functional genomics, and structural genomics to present, for the first time, a unified approach to research on the molecular biology of forest trees. A distinguished panel of scientists, researchers, and educators from around the world have combined their efforts to present the most up-to-date information and make Molecular Genetics and Breeding of Forest Trees an important addition to your professional or teaching collection. Helpful tables and figures make important points easy to access and understand.
To make it easier to find the specific information you're looking for, Molecular Genetics and Breeding of Forest Trees is divided into four sections: Forest Tree Functional Genomics, Molecular Biology of Wood Formation, Forest Tree Transgenesis, and Genome Mapping in Forest Trees. Within these sections, you'll find the most up-to-date information on: functional genomics EST databases proteomics in forest trees genomics of wood formation and in vitro systems for the study of wood formation genetic transformation of forest trees stable expression of foreign genes modification of flowering in forest trees genome mapping in forest trees microsatellite DNA markers in forest trees exploring the transcriptome of the ectomycorrhizal symbiosis in trees

In this timely book, expert international authors critically review all of the most important topics in this exciting field. This book is unique in that it is the first to review the area from a molecular biology and genomics perspective. Topics covered include: aerobic and anaerobic biodegradation of aromatic compounds; molecular detection methods (e.g. microautoradiography, mRNA analyses, etc.); genome-based predictive modeling; elucidation of regulatory networks; bioavailability; chemotaxis and transport issues; functional genomic analyses; natural attenuation; community fingerprinting and metagenomics; biotreatment; and biocatalysts engineering. The book will be essential reading for microbial degradation and bioremediation scientists, and of general interest for microbiologists working in field of environmental microbiology.

Computers have become an essential component of modern biology. They help to manage the vast and increasing amount of biological data and continue to play an integral role in the discovery of new biological relationships. This in silico approach to biology has helped to reshape the modern biological sciences. With the biological revolution now among us, it is imperative that each scientist develop and hone today's bioinformatics skills, if only at a rudimentary level. Bioinformatics Methods and Protocols was conceived as part of the Methods in Molecular Biology series to meet this challenge and to provide the experienced user with useful tips and an up-to-date overview of current developments. It builds upon the foundation that was provided in the two-volume set published in 1994 entitled Computer Analysis of Sequence Data. We divided Bioinformatics Methods and Protocols into five parts, including a thorough survey of the basic sequence analysis software packages that are available at most institutions, as well as the design and implemen- tion of an essential introductory Bioinformatics course. In addition, we included sections describing specialized noncommercial software, databases, and other resources available as part of the World Wide Web and a stimul- ing discussion of some of the computational challenges biologists now face and likely future solutions.

The fourth edition of this well-known text provides students, researchers and technicians in the area of medicine, genetics and cell biology with a concise, understandable introduction to the structure and behavior of human chromosomes. It covers both basic and up-to-date material on normal and defective chromosomes, and this new edition is particularly enhanced by the complete revision of the material on the molecular genetics of chromosomes and chromosomal defects.

From Thanksgiving to fast food to anorexia nervosa, Food in the USA brings together essential reading on these topics and is the only substantial collection of essays on food and culture in America. The broad range of essay topics include: the corporate food industry, soup kitchens, meateating, fast food, waitressing, Coca-Cola, Aunt Jemima, the Passover Seder, soul food, diabetes and nutrition. Together, the collection provides a fascinating look at how and why we are what we eat.

This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue. As the functions of these stem cells vary, this is very important for the application of stem cells in cell therapy. This book describes the many recent developments that have revealed completely different roles of distinct stem cells within the same organ. Stem Cells Heterogeneity in Different Organs provides a timely update on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. Taken with its companion volumes, Stem Cells Heterogeneity: Novel Concepts and Stem Cells Heterogeneity in Cancer, this book is essential reading for advanced cell biology students as well as researchers and clinicians working with stem cells.

Since its introduction in the late 1980s, DNA analysis has revolutionized the forensic sciences: it has helped to convict the guilty, exonerate the wrongfully convicted, identify victims of mass atrocities, and reunite families whose members have been separated by war and repressive regimes. Yet, many of the scientific, legal, societal, and ethical concepts that underpin forensic DNA analysis remain poorly understood, and their application often controversial. Told by over twenty experts in genetics, law, and social science, Silent Witness relates the history and development of modern DNA forensics and its application in both the courtroom and humanitarian settings. Across three thematic sections, Silent Witness tracks the scientific advances in DNA analysis and how these developments have affected criminal and social justice, whether through the arrests of new suspects, as in the case of the Golden State Killer, or through the ability to identify victims of war, terrorism, and human rights abuses, as in the cases of the disappeared in Argentina and the former Yugoslavia and those who perished during the 9/11 attacks. By providing a critical inquiry into modern forensic DNA science, Silent Witness underscores the need to balance the benefits of using forensic genetics to solve crime with the democratic right to safeguard against privacy invasion and unwarranted government scrutiny, and raises the question of what it means to be an autonomous individual in a world where the most personal elements of one's identity are now publicly accessible.

Create improved crops with these techniques for plant cell culture This comprehensive book presents the basic concepts and applied techniques of plant cell and tissue culture. More and more, commercial plant breeding and development employs these methods to protect crops from weather, pests, and disease. Covering the history of in vitro breeding as well as emerging research trends, In Vitro Plant Breeding offers specific techniques for crop improvement and breeding. Designed as a text for undergraduate students, In Vitro Plant Breeding presents the theory of tissue culture as well as practical techniques. Its step-by-step instructions and clear illustrations facilitate learning and laboratory work. In Vitro Plant Breeding gives in-depth information and the latest research on the vital concepts and techniques of in vitro breeding, including: applications of plant tissue culture morphogenesis and organogenesis micropropagation producing haploid plants in vitro in vitro pollination and fertilization problems of embryo culture somatic hybridization protoplast technology selection of desirable traits cryopreservation and plant breeding micrograftingThis helpful book is plentifully illustrated with examples, schematic descriptions, and tables to make the concepts clear and easy to learn. In Vitro Plant Breeding is an essential resource.

An accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens Network of Excellence. Bioinformatics is essential for annotating the structure and function of genes, proteins and the analysis of complete genomes and to molecular biology and biochemistry.

Included is an overview of bioinformatics, the full spectrum of genome annotation approaches including; genome analysis and gene prediction, gene regulation analysis and expression, genome variation and QTL analysis, large scale protein annotation of function and structure, annotation and prediction of protein interactions, and the organization and annotation of molecular networks and biochemical pathways. Also covered is a technical framework to organize and represent genome data using the DAS technology and work in the annotation of two large genomic sets: HIV/HCV viral genomes and splicing alternatives potentially encoded in 1% of the human genome.

This book is about Saffron (Crocus sativus L.) that is the most expensive spice in the world. Though there are other books on saffron but none of them has comprehensive information on saffron genome, transcriptome, proteome, metabolome and microbiome. The book has been divided into five sections and 17 chapters that cover all the areas related to its cultivation, market & economy, genomics, transcriptomics, proteomics, metabolomics, tissue culture, microbiomics, metagenomics etc. In addition a chapter on molecular markers and their use in molecular genetic mapping in saffron that lacks genetic diversity as a sterile plant paves a way for selection of elite varieties based on the epigenetic variability. A section on in-vitro propagation elaborates on the corm production under controlled conditions. In summary this book encompasses most of the information available on this golden spice

This volume presents state-of-the-art empirical studies working in a paradigm that has become known as human behavioral ecology. The emergence of this approach in anthropology was marked by publication by Aldine in 1979 of an earlier collection of studies edited by Chagnon and Irons entitled Evolutionary Biology and Human Social Behavior: An Anthropological Perspective. During the two decades that have passed since then, this innovative approach has matured and expanded into new areas that are explored here.

The book opens with an introductory chapter by Chagnon and Irons tracing the origins of human behavioral ecology and its subsequent development. Subsequent chapters, written by both younger scholars and established researchers, cover a wide range of societies and topics organ-ized into six sections. The first section includes two chapters that provide historical background on the development of human behavioral ecology and com-pare it to two complementary approaches in the study of evolution and human behavior, evolutionary psychology, and dual inheritance theory. The second section includes five studies of mating efforts in a variety of societies from South America and Africa. The third section covers parenting, with five studies on soci-eties from Africa, Asia, and North America. The fourth section breaks somewhat with the tradition in human behavioral ecology by focusing on one particularly problematic issue, the demographic transition, using data from Europe, North America, and Asia. The fifth section includes studies of cooperation and helping behaviors, using data from societies in Micronesia and South America. The sixth and final section consists of a single chapter that places the volume in a broader critical and comparative context.

The contributions to this volume demonstrate, with a high degree of theoretical and methodological sophistication--the maturity and freshness of this new paradigm in the study of human behavior. The volume will be of interest to anthropologists and other professions working on the study of cross-cultural human behavior.

In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and variations in method ease the way to understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov Chain Monte Carlo method for joint linkage and segregation analysis.

The series of Conferences on the Spectroscopy of Biological Molecules aims to stimulate research and development in this area of Science. The relationship between the structure and the biological activity of such materials as proteins, lipids, and nucleic acids is fundamental. The 5th European Conference on the Spectroscopy of Biological Molecules (ECSBM) is held at the Hotel Poseidon Club, Loutraki, Greece, on 5-10 September 1993. The scientific contents are remained the same as in the past conferences. Emphasis is given to vibrational spectroscopy, mainly infrared and Raman applied to the study of structure and dynamics of proteins, nucleic acids, porphyrins, carbohydrates, membranes, etc. Most of the contributions describe molecular dynamics and excitation processes, in particular the electronic-vibrational excitations, which are studied by Fr-Raman, Fourier Transform Infrared (Fr-IR) coupled often with microscopy and chromatography. Contributions also include Fr-Raman and FT-IR instrumentation and new developments in this area, and applications in Biology and Medicine. Furthermore, there is a plenary lecture in Mass Spectrometry and its applications in biomedical analysis, and a session devoted to Nuclear Magnetic Resonance (NMR) and its application in the study of biological molecules. Several contributions are devoted to other methods, such as CD, optical absorption, fluorescence and molecular graphics simulations. This volume of ECSBM contains shon articles by the invited and contributed lectures as well as from the Poster presentations from many European and non-European countries.

Researched and written by a group of highly respected professionals in the fields of biochemistry, microbiology, and molecular genetics, this resource offers a comprehensive treatment on the role of metal ions in regulating genes. In addition to looking at the toxicity effects of metal, this text explores the role of metal ions in normal metabolisms, examining both prokaryotes and eukaryotes. Metal Ions in Gene Regulation should prove an essential reference for all microbiologists, biochemists, bioinorganic chemists, and molecular biologists, especially those interested in gene regulation.

This volume provides a collection of protocols from researchers in the statistical genomics field. Chapters focus on integrating genomics with other “omics” data, such as transcriptomics, epigenomics, proteomics, metabolomics, and metagenomics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Statistical Genomics hopes that by covering these diverse and timely topics researchers are provided insights into future directions and priorities of pan-omics and the precision medicine era.

Over time, it has become clear that changes in stem cells do occur during aging, not only in their number but also in their relationship to their microenvironment and their functionality as reflected in changes to their metabolome. Stem Cells and Aging: Methods and Protocols brings together chapters from expert contributors with protocols critical for exploring the biology of stem cell aging, all of which is key for understanding these age-related stem cell changes at a basic biology level and at the level of their impacts for regenerative medicine. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy to use, Stem Cells and Aging: Methods and Protocols serves as an ideal reference to guide investigators toward further valuable answers to the problems of our aging population.

Every cell has developed mechanisms to respond to changes in its environment and to adapt its growth and metabolism to unfavorable conditions. The unicellular eukaryote yeast has long proven as a particularly useful model system for the analysis of cellular stress responses, and the completion of the yeast genome sequence has only added to its powerThis volume comprehensively reviews both the basic features of the yeast genral stress response and the specific adapations to different stress types (nutrient depletion, osmotic and heat shock as well as salt and oxidative stress). It includes the latest findings in the field and discusses the implications for the analysis of stress response mechanisms in higher eukaryotes as well.

This volume explores pericytes' roles under distinct pathological conditions, ranging from tumors, ALS, Alzheimer's disease, Multiple Sclerosis, stroke, diabetes, atherosclerosis, muscular dystrophies and more. Together with its companion volumes Pericyte Biology in Different Organs and Pericyte Biology - Novel Concepts, Pericyte Biology in Disease presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cell biology and clinicians involved with these specific diseases.

This detailed volume provides a comprehensive resource covering the existing and state-of-the-art tools in the field of profiling chromatin accessibility and its dynamics. Beginning with a section on bulk-cell methods for profiling chromatin accessibility and nucleosome positioning that rely on enzymatic cleavage of accessible DNA and produce information about relative accessibility, the book continues with methods that use single-molecule and enzymatic approaches to solving the problem of mapping absolute occupancy/accessibility, emerging tools for mapping DNA accessibility and nucleosome positioning in single cells, imaging-based methods for visualizing accessible chromatin in its nuclear context, as well as computational methods for the processing and analysis of chromatin accessibility datasets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Chromatin Accessibility: Methods and Protocols serves as an extensive and useful reference for researchers studying different facets of chromatin accessibility in a wide variety of biological contexts. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

In the recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated. This proceedings volume will contain chapters based upon the presentation of the 2nd International Conference on Alcohol and Cancer in Colorado, 2013. The various topics explore the affects of alcohol on: liver and breast cancer; cell signaling and cancer; stem cells; biomarkers and metabolomics; aerodigestive cancers; cancer and the immune system and more.

Cyanobacteria are a fascinating and versatile group of bacteria of immense biological importance. Thought to be amongst the first organisms to colonize the earth, these bacteria are the photosynthetic ancestors of chloroplasts in eukaryotes, such as plants and algae. In addition, they can fix nitrogen, survive in very hostile environments (e.g. down to -60-degreesC), are symbiotic, have circadian rhythms, exhibit gliding mobility, and can differentiate into specialized cell types called heterocysts. This makes them ideal model systems for studying fundamental processes, such as nitrogen fixation and photosynthesis. In addition, cyanobacteria produce an array of bioactive compounds, some of which could become novel anti-microbial agents, anti-cancer drugs, UV protectants, etc. The amazing versatility of cyanobacteria has attracted huge scientific interest in recent years. Given that 24 genomes sequences have been completed and many more projects are currently underway, the point has been reached where there is an urgent need to summarize and review the current molecular biology, genomics, and evolution of these important organisms. This volume brings together the expertise and enthusiasm of an international panel of leading cyanobacterial researchers to provide a state-of-the art overview of the field. Topics covered include: evolution, comparative genomics, gene transfer, molecular ecology and environmental genomics, stress responses, bioactive compounds, circadian clock, structure of the photosynthetic apparatus, membrane systems, carbon acquisition, nitrogen assimilation, C/N balance sensing, and much more. This book will be essential for anyone with an interest in cyanobacteria, bacterial photosynthesis, bacterial nitrogen fixation, and symbiosis.

Though the Genome Project will eventually result in the sequencing of the human genome, as well as the genomes of several other organisms, there will still be a need for good statistics for family studies of complex diseases. The papers in this volume are contributions by some of the leading researchers in the field to the current topics in statistical genetics. One section deals with DNA sequence matching and issues related to forensics, while another deals with statistical problems of modeling phylogenies and inferential difficulties related to the complex tree structures produced, as well as the method of coalescence.