Transcription Factors for Abiotic Stress Tolerance in Plants highlights advances in the understanding of the regulatory network that impacts plant health and production, providing important insights for improving plant resistance. Plant production worldwide is suffering serious losses due to widespread abiotic stresses increasing as a result of global climate change. Frequently more than one abiotic stress can occur at once, for example extreme temperature and osmotic stress, which increases the complexity of these environmental stresses. Modern genetic engineering technologies are one of the promising tools for development of plants with efficient yields and resilience to abiotic stresses. Hence deciphering the molecular mechanisms and identifying the abiotic stress associated genes that control plant response to abiotic stresses is a vital requirement in developing plants with increased abiotic stress resilience. Addressing the various complexities of transcriptional regulation, this book includes chapters on cross talk and central regulation, regulatory networks, the role of DOF, WRKY and NAC transcription factors, zinc finger proteins, CRISPR/CAS9-based genome editing, C-Repeat (CRT) binding factors (CBFs)/Dehydration responsive element binding factors (DREBs) and factors impacting salt, cold and phosphorous stress levels, as well as transcriptional modulation of genes involved in nanomaterial-plant interactions. Transcription Factors for Abiotic Stress Tolerance in Plants provides a useful reference by unravelling the transcriptional regulatory networks in plants. Researchers and advanced students will find this book a valuable reference for understanding this vital area.

The second edition of Instant Notes in Bioinformatics introduced the readers to the themes and terminology of bioinformatics. It is divided into three parts: the first being an introduction to bioinformatics in biology; the second covering the physical, mathematical, statistical and computational basis of bioinformatics, using biological examples wherever possible; the third describing applications, giving specific detail and including data standards. The applications covered are sequence analysis and annotation, transcriptomics, proteomics, metabolite study, supramolecular organization, systems biology and the integration of-omic data, physiology, image analysis, and text analysis.

Interpreting Complex Forensic DNA Evidence is a handy guide to recent advances-and emerging issues-in interpreting complex DNA evidence and profiles for use in criminal investigations. In certain cases, DNA cannot be connected to a specific biological material such as blood, semen or saliva. How or when the DNA was deposited may be an issue. The possibility of generating DNA profiles from touched objects, where there may not be a visible deposit, has expanded the scope and number of exhibits submitted for DNA analysis. With such advances, and increasing improvements in technological capabilities in testing samples, this means it is possible to detect ever smaller amounts of DNA. There are also many efforts underway to seek was to interpret DNA profiles that are sub-optimal-either relative to the amount required by the testing kit and, potentially, the quality of the obtained sample. Laboratories often use enhancements in order to obtain a readable DNA profile. The broad-reaching implications of improving DNA sensitivity have led to this next, emerging generation of more complex profiles. Examples partial profiles that do not faithfully reflect the proposed donor, or mixtures of partial DNA from multiple people. A complexity threshold has been proposed to limit interpretation of poor-quality data. Research is now addressing the interpretation of transfer of trace amounts of DNA. Complex issues are arising in trial that need to be reconciled as such complexity has added challenges to the interpretation of evidence and its introduction or dismissal in certain cases in the courts. Key Features: Addresses DNA transfer, from person-to-person as well as to objects Outlines each stage required to produce a DNA profile from an exhibit-including collection, handling, storage, and analysis Discusses ethics, subjectivity, and bias-including cognitive dissonance-as they relate specifically to complex DNA evidence Highlights current techniques and the latest advances in DNA analysis, including advances in familial DNA searches Interpreting Complex Forensic DNA Evidence provides tools to assist the criminal investigator, forensic expert, and legal professional when posed with a DNA result in a forensic report or testimony. The result-and any associated statistic-may not reveal any ambiguity, complexity, or the assumptions involved in deriving it. Questions from resolved criminal cases are posed, and the relevant forensic literature, provided for the reader to assess a DNA result and any associated statistic. Case studies throughout illustrate concepts and emphasize the need for conclusions in the forensic report that are supported by the data.

"Introducing Proteomics" gives a concise and coherent overview of every aspect of current proteomics technology, which is a rapidly developing field that is having a major impact within the life and medical sciences.

This student-friendly book, based on a successful course developed by the author, provides its readers with sufficient theoretical background to be able to plan, prepare, and analyze a proteomics study.

The text covers the following: Separation TechnologiesAnalysis of Peptides/Proteins by Mass SpectrometryStrategies in Proteomics

This contemporary text also includes numerous examples and explanations for why particular strategies are better than others for certain applications. In addition, "Introducing Proteomics" includes extensive references and a list of relevant proteomics information sources; essential for any student.

This no-nonsense approach to the subject tells students exactly what they need to know, leaving out unnecessary information. The student companion site enhances learning and provides answers to the end of chapter problems.

"I think this book will be a popular and valuable resource for students and newcomers to the field who would like to have an overview and initial understanding of what proteomics is about. The contents are well organized and address the major issues."
--Professor Walter Kolch, Director, Systems Biology Ireland & Conway Institute, University College Dublin

Companion Website
www.wiley.com/go/lovric

In 1994 Professor Bryan Sykes, a leading world authority on DNA and human evolution, was called in to examine the frozen remains of a man trapped in glacial ice in northern Italy. News of the discovery of the Ice Man and his age, which was put at over five thousand years old, fascinated the world. But what made the story particularly extraordinary was that Professor Sykes was also able to track down a living generic relative of the Ice Man, a woman living in Britain today. How was he able to locate a living relative of a man who died thousands of years ago? In The Seven Daughters of Eve, Bryan Sykes gives us a first hand account of his research into a remarkable gene which passes undiluted from generation to generation through the maternal line and shows how it is being used to track our genetic ancestors through time and space. After plotting thousands of DNA sequences from all over the world he found that they had clustered around a handful of distinct groups. In Europe there are only seven. The conclusion: almost everyone of native European descent, wherever they live in the world, can trace their ancestry back to one of seven women, the Seven Daughters of Eve. He has named them

An introduction to machine learning methods and their applications to problems in bioinformatics Machine learning techniques are increasingly being used to address problems in computational biology and bioinformatics. Novel computational techniques to analyze high throughput data in the form of sequences, gene and protein expressions, pathways, and images are becoming vital for understanding diseases and future drug discovery. Machine learning techniques such as Markov models, support vector machines, neural networks, and graphical models have been successful in analyzing life science data because of their capabilities in handling randomness and uncertainty of data noise and in generalization. From an internationally recognized panel of prominent researchers in the field, Machine Learning in Bioinformatics compiles recent approaches in machine learning methods and their applications in addressing contemporary problems in bioinformatics. Coverage includes: feature selection for genomic and proteomic data mining; comparing variable selection methods in gene selection and classification of microarray data; fuzzy gene mining; sequence-based prediction of residue-level properties in proteins; probabilistic methods for long-range features in biosequences; and much more. Machine Learning in Bioinformatics is an indispensable resource for computer scientists, engineers, biologists, mathematicians, researchers, clinicians, physicians, and medical informaticists. It is also a valuable reference text for computer science, engineering, and biology courses at the upper undergraduate and graduate levels.

Developmental biology is seemingly well understood, with development widely accepted as being a series of programmed changes through which an egg turns into an adult organism, or a seed matures into a plant. However, the picture is much more complex than that: is it all genetically controlled or does environment have an influence? Is the final adult stage the target of development and everything else just a build-up to that point? Are developmental strategies the same in plants as in animals? How do we consider development in single-celled organisms? In this concise, engaging volume, Alessandro Minelli, a leading developmental biologist, addresses these key questions. Using familiar examples and easy-to-follow arguments, he offers fresh alternatives to a number of preconceptions and stereotypes, awakening the reader to the disparity of developmental phenomena across all main branches of the tree of life.

RNAi technology are used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. This book reviews the selective and robust effect of RNAi on gene expression which makes it a valuable research tool, both in cell culture and in living organisms because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest. This book will introduce new technology in the study of RNA interference in microorganisms, plants and animals.

Data from molecular genetics have changed our views on the origin, spread and timescale of our species across this planet. But how can we reveal more detail about the demography of ancient human populations? For example, is it possible to determine when and how many people arrived at a certain continent, and which route they took from a choice of geographically plausible options? One of the most promising tools for such investigation is computer simulation incorporating various demographic scenarios. The simulation outcomes must be evaluated by teams with archaeological expertise, since archaeological evidence is generally the best evidence currently available on the population histories of geographical regions. This book is a summary of the landmark conference held in Cambridge in 2005, where specialists in simulations and molecular genetics as well as archaeologists came together to present and evaluate the state of the art, and to discuss future possibilities.

DNA testing and its forensic analysis are recognized as the "gold standard" in forensic identification science methods. However, there is a great need for a hands-on step-by-step guide to teach the forensic DNA community how to interpret DNA mixtures, how to assign a likelihood ratio, and how to use the subsequent likelihood ratio when reporting interpretation conclusions. Forensic DNA Profiling: A Practical Guide to Assigning Likelihood Ratios will provide a roadmap for labs all over the world and the next generation of analysts who need this foundational understanding. The techniques used in forensic DNA analysis are based upon the accepted principles of molecular biology. The interpretation of a good-quality DNA profile generated from a crime scene stain from a single-source donor provides an unambiguous result when using the most modern forensic DNA methods. Unfortunately, many crime scene profiles are not single source. They are described as mixed since they contain DNA from two or more individuals. Interpretation of DNA mixtures represents one of the greatest challenges to the forensic DNA analyst. As such, the book introduces terms used to describe DNA profiles and profile interpretation. Chapters explain DNA extraction methods, the polymerase chain reaction (PCR), capillary electrophoresis (CE), likelihood ratios (LRs) and their interpretation, and population genetic models-including Mendelian inheritance and Hardy-Weinberg equilibrium. It is important that analysts understand how LRs are generated in a probabilistic framework, ideally with an appreciation of both semicontinuous and fully continuous probabilistic approaches. KEY FEATURES: * The first book to focus entirely on DNA mixtures and the complexities involved with interpreting the results * Takes a hands-on approach offering theory with worked examples and exercises to be easily understood and implementable by laboratory personnel * New methods, heretofore unpublished previously, provide a means to innovate deconvoluting a mixed DNA profile, assign an LR, and appropriately report the weight of evidence * Includes a chapter on assigning LRs for close relatives (i.e., "It's not me, it was my brother"), and discusses strategies for the validation of probabilistic genotyping software Forensic DNA Profiling fills the void for labs unfamiliar with LRs, and moving to probabilistic solutions, and for labs already familiar with LRs, but wishing to understand how they are calculated in more detail. The book will be a welcome read for lab professionals and technicians, students, and legal professionals seeking to understand and apply the techniques covered.

** NEW YORK TIMES NUMBER ONE BESTSELLER ** The Gene is the story of one of the most powerful and dangerous ideas in our history from the author of The Emperor of All Maladies. The story begins in an Augustinian abbey in 1856, and takes the reader from Darwin's groundbreaking theory of evolution, to the horrors of Nazi eugenics, to present day and beyond - as we learn to "read" and "write" the human genome that unleashes the potential to change the fates and identities of our children. Majestic in its scope and ambition, The Gene provides us with a definitive account of the epic history of the quest to decipher the master-code that makes and defines humans - and paints a fascinating vision of both humanity's past and future. For fans of Sapiens by Yuval Noah Harari, A Brief History of Time by Stephen Hawking and Being Mortal by Atul Gwande. 'Siddhartha Mukherjee is the perfect person to guide us through the past, present, and future of genome science' Bill Gates 'A thrilling and comprehensive account of what seems certain to be the most radical, controversial and, to borrow from the subtitle, intimate science of our time...Read this book and steel yourself for what comes next' Sunday Times

Ice is melting around the world and glaciers are disappearing. Water, which has been solid for thousands and even millions of years, is being released into streams, rivers, lakes and oceans. Embedded in this new fluid water, and now being released, are ancient microbes whose effects on today's organisms and ecosystems is unknown and unpredictable. These long sleeping microbes are becoming physiologically active and may accelerate global climate change. This book explores the emergence of these microbes. The implications for terrestrial life and the life that might exist elsewhere in the universe are explored. Key Selling Points: Explores the role of long frozen ancient microbes will have when released due to global warming Describes how ice preserves microbes and microbial genomes for thousands or millions of years Reviews work done on permafrost microbiology Identifies potential health hazards and environmental risks Examines implications for the search for extraterrestrial life.

New research and innovations in the field of science are leading to life-changing and world-altering discoveries like never before. What does the horizon of science look like? Who are the scientists that are making it happen? And, how are we to introduce these revolutions to a society in which a segment of the population has become more and more skeptical of science? Climate change is the biggest challenge facing our nation, and scientists are working on renewable energy sources, meat alternatives, and carbon dioxide sequestration. At the same time, climate change deniers and the politicization of funding threaten their work. CRISPR, (Clustered Regularly Interspaced Short Palindromic Repeats) repurposes bacterial defense systems to edit genes, which can change the way we live, but also presents real ethical problems. Optogenetics will help neuroscientists map complicated neural circuitry deep inside the brain, shedding light on treating Alzheimer's and Parkinson's disease. Zimmer also investigates phony science ranging from questionable "health" products to the fervent anti-vaccination movement. Zimmer introduces readers to the real people making these breakthroughs. Concluding with chapters on the rise of women in STEM fields, the importance of US immigration policies to science, and new, unorthodox ways of DIY science and crowdsource funding, The State of Science shows where science is, where it is heading, and the scientists who are at the forefront of progress.

"A Companion to Genethics" is the first substantial study of the multifaceted dimensions of the genetic revolution and its philosophical, ethical, social and political significance.
Brings together the best and most influential writing about the ethics of genetics;
Includes 33 newly-commissioned essays, all written by prominent figures in the field;
Shows how there is scarcely a part of our lives left unaffected by the impact of the new genetics.

Potato is a crop grown on all inhabited continents of the globe. It is included in the top five crops of the world, used as staple food in several countries, and the number of people daily consuming the potato may surpass one billion. Despite the high quantities of seed potato produced worldwide, there are yield gaps due to challenges such as abiotic stresses, pests, climate change and poor production practices. A region-wide critical analysis of yield declining factors can help formulate management strategies that can improve potato yields. Bridging yield gaps in potato will ultimately ensure the role of this crop in securing current and future food security. Potato Production Worldwide presents information on this global crop from its history, morphology, and taxonomy to the growth and development of the potato crop, including the latest strategies in addressing today's biotic and abiotic challenges. This book identifies the reasons for yield gaps in various potato production regions of the world, as well as presenting the best production practices, pest management strategies and approaches to deal with climate change from the perspective of potato production. Chapters provide important insights into potato production cultures and approaches in the major potato production countries. Potato Production Worldwide will be a valuable resource for researchers, scientists and students seeking a comprehensive view of successful potato production.

The use of molecular markers has revolutionized ecological genetics in the last 20 years. The fundamental problem facing new researchers is which of the many markers should be used and how the resulting data should then be analyzed. Until now, these guidelines have been hidden away in specialist journals. "Ecological Genetics" addresses this fundamental problem in clear, accessible language, suitable for upper-level undergraduates through to research-level professionals.

The major topics in "Ecological Genetics" are treated within separate chapters, including:
genetic diversity of populations and species
gene flow
phylogeography, and
speciationWithin each chapter the potentially suitable molecular markers are described and the resulting data from each type of marker are discussed, including the underlying concepts of the various modes of analysis. These are illustrated with examples from both the plant and animal kingdoms.

Researchers embarking on molecular approaches to ecological genetics (for instance, final-year undergraduates and new postgraduates) will find the book essential, and more experienced researchers will also find it of interest.

A leading neuroscientist explains why your personal traits are more innate than you think What makes you the way you are-and what makes each of us different from everyone else? In Innate, leading neuroscientist and popular science blogger Kevin Mitchell traces human diversity and individual differences to their deepest level: in the wiring of our brains. Deftly guiding us through important new research, including his own groundbreaking work, he explains how variations in the way our brains develop before birth strongly influence our psychology and behavior throughout our lives, shaping our personality, intelligence, sexuality, and even the way we perceive the world. We all share a genetic program for making a human brain, and the program for making a brain like yours is specifically encoded in your DNA. But, as Mitchell explains, the way that program plays out is affected by random processes of development that manifest uniquely in each person, even identical twins. The key insight of Innate is that the combination of these developmental and genetic variations creates innate differences in how our brains are wired-differences that impact all aspects of our psychology-and this insight promises to transform the way we see the interplay of nature and nurture. Innate also explores the genetic and neural underpinnings of disorders such as autism, schizophrenia, and epilepsy, and how our understanding of these conditions is being revolutionized. In addition, the book examines the social and ethical implications of these ideas and of new technologies that may soon offer the means to predict or manipulate human traits. Compelling and original, Innate will change the way you think about why and how we are who we are.

Plants exhibit forms of asymmetry analogous to "handedness" in bilaterally symmetrical animals. This book explores the evolutionary significance and development of asymmetry. Examples of genetic control include the direction of tendril or stem coiling of many climbing plants; the so-called spiral phyllotaxy and floral taxy; and contorted petal arrangement is another kind of left- right symmetry in plants; the direction of contortion is fixed in some but not in other plants. The book will underscore tha all phenomena related to handedness start during embryogenesis itself, with the occurrence of embryo rotation. Key selling features: First consolidated book on Plant Handedness Relates handedness, asymmetry and chirality to the evolution of different organizational levels in plant biology Emphasizes handedness as a vital governing force in plant functional evolution Provides a new perspective, hitherto ignored, into plant developemtn and evolution Describes how an age-old phenomenon can give scope for investigation from a very modern interdisciplinary approach

Darwinian theory, with genes at its center, still frames our discussion of evolution. Yet now the picture within the frame-a portrait rendered in detail at the cellular and molecular level-contains the real stuff of today's big questions about living organisms. Genetics and molecular biology have revealed a new realm of complexity in life, with major implications for how we understand evolution.

Genetics and the Logic of Evolution provides a much-needed overview and analysis of general principles and patterns of evolution in light of contemporary biology. Taking a functional approach to explain how genes are used across the diverse range of species, the authors consider:

• Basic concepts and principles of biological complexity
• Alternative and supplemental principles to Darwinian theory
• Building blocks of life: how DNA, RNA, and genes work in single-cell and multi-cellular organisms
• Communication within an organism
• Detection and perception of the environment
• Evolutionary order and disorder and the sometimes fluid relationships between phenotypes and genotypes

Working outwards from the molecular level, Genetics and the Logic of Evolution moves its discourse towards a broader sense of life and how organisms live it. Written to be both scientifically rigorous and accessible to the layman, this treatment offers students and practitioners a refreshingly grand tour of the most important generalizations to emerge from recent biological research.

This is a detailed history of one of the most important and dramatic episodes in modern science, recounted from the novel vantage point of the dawn of the information age and its impact on representations of nature, heredity, and society. Drawing on archives, published sources, and interviews, the author situates work on the genetic code (1953-70) within the history of life science, the rise of communication technosciences (cybernetics, information theory, and computers), the intersection of molecular biology with cryptanalysis and linguistics, and the social history of postwar Europe and the United States.
Kay draws out the historical specificity in the process by which the central biological problem of DNA-based protein synthesis came to be metaphorically represented as an information code and a writing technology--and consequently as a "book of life." This molecular writing and reading is part of the cultural production of the Nuclear Age, its power amplified by the centuries-old theistic resonance of the "book of life" metaphor. Yet, as the author points out, these are just metaphors: analogies, not ontologies. Necessary and productive as they have been, they have their epistemological limitations. Deploying analyses of language, cryptology, and information theory, the author persuasively argues that, technically speaking, the genetic code is not a code, DNA is not a language, and the genome is not an information system (objections voiced by experts as early as the 1950s).
Thus her historical reconstruction and analyses also serve as a critique of the new genomic biopower. Genomic textuality has become a fact of life, a metaphor literalized, she claims, as human genome projects promise new levels of control over life through the meta-level of information: control of the word (the DNA sequences) and its editing and rewriting. But the author shows how the humbling limits of these scriptural metaphors also pose a challenge to the textual and material mastery of the genomic "book of life."

Genetics, like all scientific disciplines, is a human endeavor. Thus, the lives of geneticists - their friendships, colleagues and associations - play an important role in the historical development of the science. This book summarizes the history of genetics by reviewing the lives of the prominent and influential researchers beginning with the earliest and simplest branches of genetics (studies of inheritance and mutation) and ending with the human genome project - the pinnacle of genetics research of the 20th century. Key selling features: Summarizes the lives of important genetics researchers Reviews the development of important foundational concepts Highlights the way new technologies and methods have advanced the study of genetics Explores the influence of genetics in other biomedical fields Avoids simplistic chronological summary of genetics

Drawing on cutting-edge ideas from the biological and cognitive sciences, this book presents both an innovative neuro-computational model of language comprehension and a state-of-the-art review of current topics in neurolinguistics. It explores a range of newly-emerging topics in the biological study of language, building them into a framework which views language as grounded in endogenous neural oscillatory behaviour. This allows the author to formulate a number of hypotheses concerning the relationship between neurobiology and linguistic computation. Murphy also provides an extensive overview of recent theoretical and experimental work on the neurobiological basis of language, from which the reader will emerge up-to-date on major themes and debates. This lively overview of contemporary issues in theoretical linguistics, combined with a clear theory of how language is processed, is essential reading for scholars and students across a range of disciplines.

Providing a review of the recent advances and technologies in the rapidly expanding field of genetics, embryology and molecular biology, this book also investigates the possibilities for future research and development. There are sections covering manipulation of the embryo, and the mapping and engineering of the genome. Topics discussed range from nuclear transfer to the possibilities and techniques involved in the development of xenotransplantation.

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists.