|
Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
|
Buy Now
High-Resolution Profiling of Protein-RNA Interactions (Hardcover, 2015 ed.)
Loot Price: R3,507
Discovery Miles 35 070
You Save: R582
(14%)
|
|
|
High-Resolution Profiling of Protein-RNA Interactions (Hardcover, 2015 ed.)
Series: Springer Theses
Expected to ship within 12 - 19 working days
|
The work reported in this book represents an excellent example of
how creative experimentation and technology development,
complemented by computational data analysis, can yield important
insights that further our understanding of biological entities from
a systems perspective. The book describes how the study of a single
RNA-binding protein and its interaction sites led to the
development of the novel 'protein occupancy profiling' technology
that for the first time captured the mRNA sequence space contacted
by the ensemble of expressed RNA binders. Application of protein
occupancy profiling to eukaryotic cells revealed that extensive
sequence stretches in 3' UTRs can be contacted by RBPs and that
evolutionary conservation as well as negative selection act on
protein-RNA contact sites, suggesting functional importance.
Comparative analysis of the RBP-bound sequence space has the
potential to unravel putative cis-acting RNA elements without a
priori knowledge of the bound regulators. Here, Dr. Munschauer
provides a comprehensive introduction to the field of
post-transcriptional gene regulation, examines state-of-the-art
technologies, and combines the conclusions from several journal
articles into a coherent and logical story from the frontiers of
systems-biology inspired life science. This thesis, submitted to
the Department of Biology, Chemistry and Pharmacy at Freie
Universitat Berlin, was selected as outstanding work by the Berlin
Institute for Medical Systems Biology at the Max-Delbrueck Center
for Molecular Medicine, Germany.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
|
You might also like..
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.
Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
