This book discusses the emerging field of industrial neuroscience, and reports on the authors' cutting-edge findings in the evaluation of mental states, including mental workload, cognitive control and training of personnel involved either in the piloting of aircraft and helicopters, or in managing air traffic. It encompasses neuroimaging and cognitive psychology techniques and shows how they have been successfully applied in the evaluation of human performance and human-machine interactions, and to guarantee a proper level of safety in such operational contexts. With an introduction to the most relevant concepts of neuroscience, neurophysiological techniques, simulators and case studies in aviation environments, it is a must-have for both students and scientists in the field of aeronautic and biomedical engineering, as well as for various professionals in the aviation world. This is the first book to intensively apply neurosciences to the evaluation of human factors and mental states in aviation.

Applying Neuroscience to Counseling Children and Adolescents: A Guide to Brain-Based, Experiential Interventions explores the neurobiological underpinnings of child and adolescent development and encourages readers to apply neuroscience-informed interventions and strategies to counseling practice. The book provides an overview and foundational perspective on neuroscience-informed child and adolescent counseling; covers models and modes of counseling from a neuroscience perspective; and examines common clinical presentations when working with children and adolescents. Individual chapters address ethical and cultural considerations, counseling theory and neuroscience, neuroscience of play, using neuroscience in working with parents and caregivers, and neuroscience-informed interventions to treat anxiety, depression, stress, trauma, substance misuse, and attention and behavioral issues. Each chapter features two primary cases, one for a young child and one for an adolescent, conceptualized from real-life clients. The chapters present practical interventions and a sample of counselor-client dialogue to help readers understand how an intervention might unfold during a session. Applying Neuroscience to Counseling Children and Adolescents bridges the gap between textbooks that cover neuroscience and counseling children and adolescents independently. It is an ideal supplemental text for courses on incorporating neuroscience in counseling.

Blanco's Overview of Alpha-1 Antitrypsin Deficiency: History, Biology, Pathophysiology, Related Diseases, Diagnosis, and Treatment is a robust introduction to topics associated with Alpha-1 Antitrypsin Deficiency (AATD). Included are topics ranging from the history of the disease, biology, pathophysiology, related diseases, including the two major manifestations of the disease (liver disease and lung disease), and diagnosis and treatment. The book addresses the need for the amalgamation of current and novel concepts and practices in the field of AATD. AATD is under-recognized in the medical community and, as a result, it is underdiagnosed. The book provides increased awareness and understanding of the condition to improve diagnosis rates and enhance patient care. This book is an essential tool and reference, beneficial to clinicians who screen and treat AATD patients, as well as research scientists working in the AATD field at junior and senior levels.

Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson's disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike.

This book explores the subject of artificial psychology and how the field must adapt human neuro-psychological testing techniques to provide adequate cognitive testing of advanced artificial intelligence systems. It shows how classical testing methods will reveal nothing about the cognitive nature of the systems and whether they are learning, reasoning, and evolving correctly; for these systems, the authors outline how testing techniques similar to/adapted from human psychological testing must be adopted, particularly in understanding how the system reacts to failure or relearning something it has learned incorrectly or inferred incorrectly. The authors provide insights into future architectures/capabilities that artificial cognitive systems will possess and how we can evaluate how well they are functioning. It discusses at length the notion of human/AI communication and collaboration and explores such topics as knowledge development, knowledge modeling and ambiguity management, artificial cognition and self-evolution of learning, artificial brain components and cognitive architecture, and artificial psychological modeling. Explores the concepts of Artificial Psychology and Artificial Neuroscience as applied to advanced artificially cognitive systems; Provides insight into the world of cognitive architectures and biologically-based computing designs which will mimic human brain functionality in artificial intelligent systems of the future; Provides description and design of artificial psychological modeling to provide insight into how advanced artificial intelligent systems are learning and evolving; Explores artificial reasoning and inference architectures and the types of modeling and testing that will be required to "trust" an autonomous artificial intelligent systems.

This book examines the long-term fate of invasive species by detailing examples of invaders from different zoological and botanical taxa from various places around the world. Readers will discover what happened, after a century or so, to 'classical' invaders like rabbits in Australia, house sparrows in North America, minks in Europe and water hyacinths in Africa and Asia. Chapters presented in the book focus on eighteen species in the form of in-depth case studies including: earthworms, zebra mussels, Canadian water weed, Himalayan balsam, house sparrows, rabbits, crayfish plague, Colorado beetles, water hyacinths, starlings, Argentine ant, Dutch elm disease, American mink, cane toad, raccoons, Canadian beavers, African killer bees and warty comb jelly. Invaded areas described are in Africa, Asia, Australia, Europe, North America, Pacific islands, and South America. Readers will get some ideas about the likely future of current invaders from the fate of old ones. This book is intended for undergraduates studying environmental sciences, researchers and members of environmental NGO's.

This book presents the main drivers of benthic structure and processes in estuaries from the 8,000 km-Brazilian coast, assesses the influence of natural and human disturbance, and discusses their ecological importance and management needs. Estuaries are unique coastal ecosystems often with low biodiversity that sustain and provide essential ecological services to mankind. These ecosystems include a variety of habitats with their own sediment and fauna dynamics, all of them globally altered or threatened by human activities. Mangroves, saltmarshes, tidal flats and other confined estuarine systems are under increasing stress by overfishing and other human activities leading to habitat and species loss. Combined changes in estuarine hydromorphology and in climate pose severe threats to estuarine ecosystems at a global scale.

The abiotic stresses like drought, temperature, cold, salinity, heavy metals etc. affect a great deal on the yield performance of the agricultural crops. To cope up with these challenges, plant breeding programs world-wide are focussing on the development of stress tolerant varieties in all crop species. Significant genomic advances have been made for abiotic stress tolerance in various crop species in terms of availability of molecular markers, QTL mapping, genome-wide association studies (GWAS), genomic selection (GS) strategies, and transcriptome profiling. The broad-range of articles involving genomics and breeding approaches deepens our existing knowledge about complex traits. The chapters are written by authorities in their respective fields. This book provides comprehensive and consolidated account on the applications of the most recent findings and the progress made in genomics assisted breeding for tolerance to abiotic stresses in many important major crop species with a focus on applications of modern strategies for sustainable agriculture. The book is especially intended for students, molecular breeders and scientists working on the genomics-assisted genetic improvement of crop species for abiotic stress tolerance.

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.

Neuromodulation: Comprehensive Textbook of Principles, Technologies, and Therapies, Second Edition, serves as a comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. Since the publication of the first edition seven years ago, there has been an explosion of knowledge in neuromodulation, optogenetics, bioelectronics medicine and brain computer interfacing. Users will find unique discussions of the fundamental principles of neuromodulation and therapies, and how they are applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The book focuses on comprehensive coverage of spinal cord stimulation, non-interventional and interventional brain stimulation, peripheral nerve stimulation, and the emerging fields of neuromodulation, including optogenetics and bioelectronics medicine.

The idea of creation and creativity is among the most powerful and pervasive of metaphors bequeathed to the modern world by the scriptures of Judaism, Christianity and Islam. Twelve specialists here explore the original sources and contemporary manifestations of the theme in both high and low culture, from the Book of Genesis to James Joyce's Ulysses, Children of Gebalawi by the Egyptian novelist Naguib Mahfouz, and the Polish poetry of Wislawa Szymborska, and to popular films, such as Bruce Almighty and Animatrix, and animation films for children. Even current debates on genetics and ecology and the public exhibition of plastinated human bodies invoke these same themes, and make this volume a topical contribution to cultural studies today. Jonneke Bekkenkamp, Why on Earth? Creation and Creativity in the Vocabularies of Patricia de Martelaere, Wislawa Szymborska and Julia Cameron Athalya Brenner, Recreating the Biblical Creation for Western Children: Provisional Reflections on Some Case Studies Wim Drees, Vocabularies of Creation and Creativity in Debates on Genetics and Ecology Jan Willem van Henten, Playing God in the Movies: Bruce Almighty and the Preposterous History of Genesis 1:26-27 Alistair Hunter, Creation out of (almost) Nothing or Does God Wear Genes? Alison Jasper, Mysteries under Your Skin David Jasper, 'Down through all Christian minstrelsy': Genesis, James Joyce and Contemporary Vocabularies of Creation Louise Joy Lawrence, Tracing Tricksters: Creation and Creativity in John's Gospel Richard van Leeuwen, Creation and Revelation in Naguib Mahfouz's Novel Children of Gebelawi Lloyd Ridgeon, Is the God of Islam an Evil Creator? Caroline Vander Stichele and Todd Penner, Terminatrix: Visualizing the End of Creation in Animatrix

Neuroglia, the third edition, is the long-awaited revision of the most highly regarded reference volume on glial cells. This indispensable edition has been completely revised, greatly enlarged, and enhanced with four-color figures throughout, all in response to the tremendous amount of new information that has accumulated since the previous edition seven years ago. Glial cells are, without doubt, the new stars in the neuroscience and neurology communities. Neglected in research for years, it is now evident that the brain only functions in a concerted action of all the cells, namely glia and neurons. Seventy one chapters comprehensively discuss virtually every aspect of normal glial cell anatomy, physiology, biochemistry and function, and consider the central roles of these cells in neurological diseases including stroke, Alzheimer disease, multiple sclerosis, Parkinson's disease, neuropathy, and psychiatric conditions. More than 20 new chapters have been added to accommodate the unprecedented growth of knowledge about the basic biology of glia and the sophisticated manner in which they partner with neurons in the course of normal brain function. Lavishly illustrated and meticulously edited, the third edition remains the most convenient and maximally useful reference available. This new edition is an essential reference for both newcomers to the field as well as established investigators. Neuroglia belongs on every neuroscientist's bookshelf and will be a great asset for educators and neurological clinicians as well.

This volume focuses on the latest methods used to sequence, assemble, and analyze insect genomes. The collection of protocols in this book provides an introduction to the workflows and bioinformatics tools available for researchers. The chapters cover a range of useful topics such as determining genome size by flow cytometry; High Molecular Weight DNA extraction; improvements to a genome assembly provided by long-range sequencing approaches; assessments of orthology and single-copy genes at different phylogenetic levels; detecting regulatory regions with FAIRE, RAMPAGE, and computational analysis of cis-regulatory modules in insects; bioinformatics analysis of epigenetic modifications, high-throughput scanning of insect genomes (TEEseq) for the presence of endosymbionts, and leveraging genome sequence information to design RNAi strategies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Insect Genomics: Methods and Protocols is a valuable resource for graduate students, postdocs, and novice research scientists who are interested in learning more about this developing field.

An expert palaeoarchaeologist reveals how our understanding of the evolution of our species has been transformed by momentous discoveries and technological advancements. Who are we? How do scientists define Homo sapiens, and how does our species differ from the extinct hominins that came before us? This illuminating book explores how the latest scientific advances, especially in genetics, are revolutionizing our understanding of human evolution. Paul Pettitt reveals the extraordinary story of how our ancestors adapted to unforgiving and relentlessly changing climates, leading to remarkable innovations in art, technology and society that we are only now beginning to comprehend. Drawing on twenty-five years of experience in the field, Paul Pettitt immerses readers in the caves and rockshelters that provide evidence of our African origins, dispersals to the far reaches of Eurasia, Australasia and ultimately the Americas. Popular accounts of the evolution of Homo sapiens emphasize biomolecular research, notably genetics, but this book also draws from the wealth of information from specific excavations and artefacts, including the author's own investigations into the origins of art and how it evolved over its first 25,000 years. He focuses in particular on behaviour, using archaeological evidence to bring an intimate perspective on lives as they were lived in the almost unimaginably distant past.

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals.

Neurobiology of Chinese Herb Medicine, Volume 135 is a valuable book for anyone interested in alternative medicine or the scientific research surrounding ancient herbal medicine. This updated volume in the series includes chapters that delve into timely topics, including the Effects of Lycium Barbarum on the Visual System, the Effect of Chinese Herbal Medicine on Alzheimer's Disease, the Effect and Mechanism of Chinese Herbal Medicine on Parkinson's Disease, the Neurobiology of Chinese Herbal Medicine on Major Depressive Disorder, the Treatment of Insomnia with Traditional Chinese Herbal Medicine, and the Metabolic Factors and Adult Neurogenesis: Impacts of Chinese Herbal Medicine on Brain Repair in Neurological Diseases. This series is ideal for Chinese herbal medicine practitioners who are working in a clinical environment, although the clinical applications of Chinese medicinal herbs presented provide useful references and guidance for any clinical practice that specializes in the treatment of various conditions.

Nature's Machines: An Introduction to Organismal Biomechanics presents the fundamental principles of biomechanics in a concise, accessible way while maintaining necessary rigor. It covers the central principles of whole-organism biomechanics as they apply across the animal and plant kingdoms, featuring brief, tightly-focused coverage that does for biologists what H. M. Frost's 1967 Introduction to Biomechanics did for physicians. Frequently encountered, basic concepts such as stress and strain, Young's modulus, force coefficients, viscosity, and Reynolds number are introduced in early chapters in a self-contained format, making them quickly available for learning and as a refresher. More sophisticated, integrative concepts such as viscoelasticity or properties of hydrostats are covered in the later chapters, where they draw on information from multiple earlier sections of the book. Animal and plant biomechanics is now a common research area widely acknowledged by organismal biologists to have broad relevance. Most of the day-to-day activities of an animal involve mechanical processes, and to the extent that organisms are shaped by adaptive evolution, many of those adaptations are constrained and channelized by mechanical properties. The similarity in body shape of a porpoise and a tuna is no coincidence. Many may feel that they have an intuitive understanding of many of the mechanical processes that affect animals and plants, but careful biomechanical analyses often yield counterintuitive results: soft, squishy kelp may be better at withstanding pounding waves during storms than hard-shelled mollusks; really small swimmers might benefit from being spherical rather than streamlined; our bones can operate without breaking for decades, whereas steel surgical implants exhibit fatigue failures in a few months if not fully supported by bone.

Before Mendel, who came closest to the truth about heredity? This book examines the activities of sheep breeders able to transform the appearance and qualities of their stock by combining different traits of body or wool into new patterns. Exploiting what were then untried procedures - individual trait selection, very close inbreeding and progeny testing - they demonstrated inheritance from both sexes and showed how it could be stabilised. Major advances in breeding are associated with the English farmer Robert Bakewell (1725-1795). By the following century, when the same procedures had been established at breeding centres in central Europe, theory as well as practice became the subject of wider attention. In the Brno Sheep Breeders' Society, discussions of patterns of heredity finally gave way to the physiological question, 'What is inherited and how?' The question was posed by Cyrill Napp, abbot of the monastery to which Mendel was admitted six years later.