This book is a part of the Sabkha Ecosystems series which was designed to provide information on sabkha ecosystems of different regions and to add to the collective knowledge available about saline ecosystems. The comprehensive coverage assists the reader gaining a thorough understanding of sabkha geology, hydrology, geomorphology, zoology, botany, ecology and ecosystem functioning, as well as sabkha conservation, utilization and development. Volume I focused on The Arabian Peninsula and Adjacent Countries, volume II was based on describing saline ecosystems of West and Central Asia , volume III referred to Africa and Southern Europe, while volume IV focused on Cash Crop Halophyte and Biodiversity Conservation. The present volume V focuses on Americans.

This book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett's esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett's esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer. Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer's Advances in Experimental Medicine and Biology series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research.

This work is motivated by the ongoing open question of how information in the outside world is represented and processed by the brain. Consequently, several novel methods are developed. A new mathematical formulation is proposed for the encoding and decoding of analog signals using integrate-and-fire neuron models. Based on this formulation, a novel algorithm, significantly faster than the state-of-the-art method, is proposed for reconstructing the input of the neuron. Two new identification methods are proposed for neural circuits comprising a filter in series with a spiking neuron model. These methods reduce the number of assumptions made by the state-of-the-art identification framework, allowing for a wider range of models of sensory processing circuits to be inferred directly from input-output observations. A third contribution is an algorithm that computes the spike time sequence generated by an integrate-and-fire neuron model in response to the output of a linear filter, given the input of the filter encoded with the same neuron model.

Drawing on shared research experiences and collaborative projects, this book offers a broad and timely perspective on research on the hand and its current challenges. It especially emphasizes the interdisciplinary context in which researchers need to be trained in contemporary science. From language to psychology, from neurology to the social sciences, and from art to philosophy and religion, the chapters discuss various aspects involved in hand research and therapy. On the basis of concrete and validated case studies, they approach hand function and gestures from different perspectives - not only neurological and medical, but also philosophical, evolutionary and anthropological. By highlighting the overlaps between different areas of research, the book seeks to foster better communication between researchers, and ultimately a better understanding of hand function and its recovery. It offers essential information and inspirations for students, researchers and practitioners in the fields of psychology, epistemology, bioengineering, neuroscience, anthropology and bioethics.

This highly acclaimed book brings the cumulative results of a century and a half of kinship studies in anthropology into the focus of current debates on the origin of modern humans in Africa and on an entangled bit of human evolutionary history commonly subsumed under the heading of the "peopling of the Americas." This erudite study is based on a database of some 2,500 kinship vocabularies representing roughly 600 African languages, 140 Australian languages, 500 Austronesian languages, 200 Papuan languages, 350 languages of Eurasia (excluding Indo-Europeans), 440 North and Middle American Indian languages, and 200 South American languages. This valuable reference will take the reader to the dawn of kinship studies in the 19th century Western science in order to elicit the wider context of anthropological interest in kinship systems and the interdisciplinary salience of the phenomenon of kinship. The book also examines the founder of kinship studies in anthropology, American lawyer and Iroquois ethnographer, Lewis Henry Morgan, and the circumstances of his life that generated his interest in human kinship. The study ventures into the intricacies of scientific and quasi-scientific debates in the 19th century, and treats 19th century science as embedded in a myth featuring divinity, humanity and animality as principal characters. This account is divided into four sections, each of which is structured as a triad (philosophy, psychology and physiology; logic, semiotics and reproduction; religion, hermeneutics and evolution; law, grammar and speech). This far-reaching historical journey aims at formulating an idea of what human kinship might be all about, especially in the light of the widespread uncertainties about this question caused by the constructivist turn in anthropology. Eventually our ideas regarding human origins, ancient population dispersals and the homeland of modern humans are inextricably linked to our ideas about kinship. As a book that brings together evolutionary and sociocultural anthropology, The Genius of Kinship will be a critical addition for all Anthropology collections.

Using historical and anthropological perspectives to examine mind-body relationships in western thought, this book interweaves topics that are usually disconnected to tell a big, important story in the histories of medicine, science, philosophy, religion, and political rhetoric. Beginning with early debates during the Scientific Revolution about representation and reality, Martensen demonstrates how investigators such as Vesalius and Harvey sought to transform long-standing notions of the body as dominated by spirit-like humors into portrayals that emphasized its solid tissues. Subsequently, Descartes and Willis and their followers amended this 'new' philosophy to argue for the primacy of the cerebral hemispheres and cranial nerves as they downplayed the role of the spirit, passion, and the heart in human thought and behaviour. None of this occurred in a social vacuum, and the book places these medical and philosophical innovations in the context of the religious and political crises of the Reformation and English Civil War and its aftermath. Patrons and their interests are part of the story, as are patients and new formulations of gender. John Locke's psychology and the emergence in England of a constitutional monarchy figure prominently, as do opponents of the new doctrines of brain and nerves and the emergent social order. The book's concluding chapter discusses how debates over investigative methods and models of body order that first raged over 300 years ago continue to influence biomedicine and the broader culture today. No other book on western mind-body relationships has attempted this.

The world within reach is characterised to a large extent by our ability to sense objects through touch. Research into the sensation of touch has a long history. However, it is only relatively recently that significant advances have been made in understanding how information about objects we touch is represented in both the peripheral and central divisions of the nervous systems. This volume draws together the increasing body of knowledge regarding the mechanisms underlying tactile sensation and how they relate to tactile perception.
Individual chapters address; the response of mechanoreceptors to stimuli (including movement and shape), the role of the somatosensory cortex in processing tactile information, the psychophysics and neurophysiology of the detection and categorisation of somesthetic stimuli, perceptual constancy, recent findings in regard to short term and long term plasticity in the somatosensory cortex and the psychophysical correlates of this plasticity, and parallel versus serial information processing in the cortex.
The authors look at past and current research, and comment on the direction of future investigation, relating findings from psychophysical studies of tactile behavior to our growing understanding of the underlying neural mechanisms.

Authored by world-class scientists and scholars, the Handbook of Natural Resources, Second Edition, is an excellent reference for understanding the consequences of changing natural resources to the degradation of ecological integrity and the sustainability of life. Based on the content of the bestselling and CHOICE awarded Encyclopedia of Natural Resources, this new edition demonstrates the major challenges that the society is facing for the sustainability of all wellbeing on planet Earth. The experience, evidence, methods, and models used in studying natural resources are presented in six stand-alone volumes, arranged along the main systems: land, water, and air. It reviews state-of-the-art knowledge, highlights advances made in different areas, and provides guidance for the appropriate use of remote sensing data in the study of natural resources on a global scale. The six volumes in this set cover: Terrestrial Ecosystems and Biodiversity; Landscape and Land Capacity; Wetlands and Habitats; Fresh Water and Watersheds; Coastal and Marine Environments; and finally Atmosphere and Climate. Written in an easy-to-reference manner, the Handbook of Natural Resources, Second Edition, as a complete set, is essential for anyone looking for a deeper understanding of the science and management of natural resources. Public and private libraries, educational and research institutions, scientists, scholars, and resource managers will benefit enormously from this set. Individual volumes and chapters can also be used in a wide variety of both graduate and undergraduate courses in environmental science and natural science courses at different levels and disciplines, such as biology, geography, Earth system science, ecology, etc.

In recent years concerns over the use of results of scientific advances, expectations about how medical decisions are made, and demographic changes have raised ethical questions about how resources are allocated, and how the principles of beneficence, and respect for patient autonomy are applied. The effect that bioethics can have on policy decisions and health care delivery demand an enhanced approach to our understanding of such complex issues. This volume opens a window to how empirical social research can be used to illuminate and answer such quandaries and offers a practical resource for those wishing to engage in this type of research. Through a thorough look at both quantitative and qualitative methods utilized in key research investigations in bioethics, the book examines the impact of such investigations on clinical and policy decision-making, scholarship and on the advancement of theory. The varied sociological and anthropological research examples that are presented allow readers to better understand the richness and breadth of such work as well as relevant practical and theoretical approaches.
Last, but not least, our aim with this book is to stimulate further discussion of avenues toward a more solid integration of bioethics and empirical social research and, in that process, further our understanding of the complex bioethical environment surrounding us.
PracticalOffers insights into clinical and policy implications of empirical research
In-depthEnhances understanding of methodologies as applied to bioethics
Comprehensive--Gives a range of examples of empirical bioethics studies
InterdisciplinaryGeared to a wide audience
Reference sourceincludes a largenumber of references

Recent advances in protein structural biology, coupled with new developments in human genetics, have opened the door to understanding the molecular basis of many metabolic, physiological, and developmental processes in human biology. Medical pathologies, and their chemical therapies, are increasingly being described at the molecular level. For single-gene diseases, and some multi-gene conditions, identification of highly correlated genes immediately leads to identification of covalent structures of the actual chemical agents of the disease, namely the protein gene products. Once the primary sequence of a protein is ascertained, structural biologists work to determine its three-dimensional, biologically active structure, or to predict its probable fold and/or function by comparison to the data base of known protein structures. Similarly, three-dimensional structures of proteins produced by microbiological pathogens are the subject of intense study, for example, the proteins necessary for maturation of the human HIV virus. Once the three-dimensional structure of a protein is known or predicted, its function, as well as potential binding sites for drugs that inhibit its function, become tractable questions. The medical ramifications of the burgeoning results of protein structural biology, from gene replacement therapy to "rational" drug design, are well recognized by researchers in biomedical areas, and by a significant proportion of the general population. The purpose of this book is to introduce biomedical scientists to important areas of protein structural biology, and to provide an insightful orientation to the primary literature that shapes the field in each subject.
The chapters in this volume cover aspects of protein structural biology which have led to the recognition of fundamental relationships between protein structure and function.

This book presents the theoretical foundations of Systems Biology, as well as its application in studies on human hosts, pathogens and associated diseases. This book presents several chapters written by renowned experts in the field. Some topics discussed in depth in this book include: computational modeling of multiresistant bacteria, systems biology of cancer, systems immunology, networks in systems biology.

Our genetic markers have come to be regarded as portals to the past. Analysis of these markers is increasingly used to tell the story of human migration; to investigate and judge issues of social membership and kinship; to rewrite history and collective memory; to right past wrongs and to arbitrate legal claims and human rights controversies; and to open new thinking about health and well-being. At the same time, in many societies genetic evidence is being called upon to perform a kind of racially charged cultural work: to repair the racial past and to transform scholarly and popular opinion about the "nature" of identity in the present. Genetics and the Unsettled Past considers the alignment of genetic science with commercial genealogy, with legal and forensic developments, and with pharmaceutical innovation to examine how these trends lend renewed authority to biological understandings of race and history. This unique collection brings together scholars from a wide range of disciplines-biology, history, cultural studies, law, medicine, anthropology, ethnic studies, sociology-to explore the emerging and often contested connections among race, DNA, and history. Written for a general audience, the book's essays touch upon a variety of topics, including the rise and implications of DNA in genealogy, law, and other fields; the cultural and political uses and misuses of genetic information; the way in which DNA testing is reshaping understandings of group identity for French Canadians, Native Americans, South Africans, and many others within and across cultural and national boundaries; and the sweeping implications of genetics for society today.

Computational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.

This detailed volume collects protocols for experimentation into how neurons connect to produce the extraordinary functionalities of the nervous system. Contributed by experts and pioneers in their respective techniques, the book covers synapses in the brain and in culture, their constituents, their structures, their dynamics, and the assemblies they form, all in the structure of a laboratory guide. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synapse Development: Methods and Protocols serves as an ideal guide to minimizing the barrier to entry for the integration of new approaches with existing expertise, producing syntheses that will foster novel perspectives on the many ways in which synapses form, transform, and transmit.

Our visual system can process information at both conscious and unconscious levels. Understanding the factors that control whether a stimulus reaches our awareness, and the fate of those stimuli that remain at an unconscious level, are the major challenges of brain science in the new millennium. Since its publication in 1984, Visual Masking has established itself as a classic text in the field of cognitive psychology. In the years since, there have been considerable advances in the cognitive neurosciences, and a growth of interest in the topic of consciousness, and the time is ripe for a new edition of this text. Where most current approaches to the study of visual consciousness adopt a 'steady-state' view, the approach presented in this book explores its dynamic properties. This new edition uses the technique of visual masking to explore temporal aspects of conscious and unconscious processes down to a resolution in the millisecond range. The 'time slices' through conscious and unconscious vision revealed by the visual masking technique can shed light on both normal and abnormal operations in the brain. The main focus of this book is on the microgenesis of visual form and pattern perception - microgenesis referring to the processes occurring in the visual system from the time of stimulus presentation on the retinae to the time, a few hundred milliseconds later, of its registration at conscious or unconscious perceptual and behavioural levels. The book takes a highly integrative approach by presenting microgenesis within a broad context encompassing visuo-temporal phenomena, attention, and consciousness.

Presents a comprehensive review of nonhuman primate audition and vocal communication. These are obviously intimately related topics, but are often addressed separately. The hearing abilities of primates have been tested experimentally in a large number of species across the primate order, and these studies have revealed both consistent patterns as well as interesting variation within and between taxonomic groups. Recent studies have shed light on how variation in anatomical structures along the auditory pathway relates to variation in auditory sensitivity. At the same time, ongoing studies of vocal communication in wild primate populations continue to reveal new insights into the social and environmental contexts of many primate calls, and the range of known primate vocalizations has increased dramatically with the development of more sophisticated and accessible auditory equipment and software that enables the recording and analysis of higher-fidelity and broader-band recordings, including documenting very high frequency (i.e. ultrasound) vocalizations. Historically the relative importance of primate calls has been evaluated qualitatively by the perception of the researcher, but new methods and approaches now enable a greater appreciation for how signals are used and perceived by the primates in question. The integration of anatomical and behavioral data on acoustic communication and the environmental correlates thereof has significant potential for reconstructing behavior in the fossil record. This confluence of factors and accumulating evidence for the sophistication and complexity in both the signal and its interpretation indicate that a book synthesizing this information across primates is warranted and represents an important contribution to the literature.

Evolution gave rise to a prominent insect diversity at every level of ecological niche. Since then, hordes of insects have threatened human and cattle health as well as most of all green lands and agricultural crops. Now, the insect problem expands from many mutant forms of yellow dengue fever mosquitoes to highly-resistant larvae of most all various phytophageous species. The tremendous expansion of insects is due not only to an increasing resistance capacity to insecticides, but also to a strong capacity for adapting to different climate and environmental changes, including global warming. Obviously insects display a number of rudimentary systems to build an extremely efficient organism to survive in a changing world. In many species, one pheromone molecule is enough to trigger mating behavior. Therefore, insects have become crucial models not only for evolutionary studies, but also for understanding specific mechanisms underlying sensory-based behaviors. Most of insect species such as ants, beetles, cockroaches, locusts, moths and mosquitoes largely rely on olfactory cues to explore the environment and find con-specifics or food sources. A conglomerate of renowned international scientific experts is gathered to expose the insect problem on the various continents of the planet and propose an alternative to the use of toxic insecticides. Sex pheromones, specific chemical signals necessary for reproduction, and pheromone detection in insects are described with full details of the olfactory mechanisms in the antennae and higher centers in the brain. Thus, new synthetic pheromones and/or plant odors with specific molecular target sites in the insect olfactory system are proposed for sustainable development in agricultural and entomological industries. Disrupting insect pheromone channels and plant odor detection mechanisms is solemnly envisioned as a unique way to control invasive insect pest species while preserving human and environment safety.

This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in many physiological functions as well as in many pathological conditions. This book offers up-to-date information on the physiological functions, signaling pathways and regulatory mechanisms of P2Y and TGR5 receptors. In addition, this book provides a comprehensive overview about the abnormalities of P2Y/TGR5 receptors and their contribution in the development and progression of pathological conditions. It also covers the currently available natural, chemical and pharmacological agents targeting these two receptor families and their therapeutic implications in P2Y and TGR5 associated disorders. This book is a valuable source for beginners and researchers to follow the rapidly progressing field of these two GPCR subfamily members.

Many breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems. Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct application of epigenetics in agriculture is also described. The chapter "Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses" is available open access under a CC BY 4.0 license via link.springer.com.