Peptidomics of Cancer-Derived Enzyme Products, Volume 42, the latest in The Enzymes series, is ideal for researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, with this volume featuring high-caliber, thematic articles on the topic of peptidomics of cancer-derived enzyme products. Specific chapters cover Circulating peptidome and tumor-resident proteolysis, Colon tumor secretopeptidome, Chemoenzymatic method for glycomics, Human plasma peptidome for pancreatic cancer, Lipoproteomics and quantitative proteomics, Salivaomics: Protein markers/extracellular RNA/DNA in saliva, and Enzyme-responsive vectors for cancer therapy.

Direct versus Indirect Realism: A Neurophilosophical Debate on Consciousness brings together leading neuroscientists and philosophers to explain and defend their theories on consciousness. The book offers a one-of-a-kind look at the radically opposing theories concerning the nature of the objects of immediate perception-whether these are distal physical objects or phenomenal experiences in the conscious mind. Each side-neuroscientists and philosophers-offers accessible, comprehensive explanations of their points-of-view, with each side also providing a response to the other that offers a unique approach on opposing positions. It is the only book available that combines thorough discussion of the arguments behind both direct and indirect realism in a single resource, and is required reading for neuroscientists, neurophilosophers, cognitive scientists and anyone interested in conscious perception and the mind-brain connection.

Principles of Hormone/Behavior Relations, Second Edition, provides an introduction to the underlying principles of endocrine regulation of behavior, a newly emerging area of research within neurobiology and endocrinology. It addresses the properties of hormone/behavior relations, including the influence of family background, timing issues, neuroanatomical features, cellular mechanisms, and the importance of environmental context and evolution. This new edition incorporates critical advances in the field, also including increased coverage of hormonal influences on food intake, and on the cardiovascular system. The addition of entirely new principles provides further coverage of epigenetics and appetite. Thoroughly revised and updated, this book is an ideal resource for neuroscientists and researchers engaging in this rapidly expanding field of study.

Coumarins are a group of compounds that have important roles as food constituents; as anti-oxidants, stabilisers, and immunomodulatory substances; as fluorescent markers for use in analysis, in lasers and in clinical use. Coumarins: Biology, Applications and Mode of Action predominantly focuses on the parent compound, coumarin, and its main metabolite in humans, 7-hydroxycoumarin. It describes in detail every facet of these compounds including history, toxicology, chemistry, metabolism, analysis, clinical, veterinary and other applications, their roles as immunomodulatory agents and speculates on their mode of action. Features include:
* New insights into mode of action of coumarins
* Comprehensive summary of new coumarin compounds
* Detailed accounts of methods used for analysis
* Applications of coumarins for diverse methods of analysis
This volume will be of interest to those working in biochemistry, chemistry, pharmacology, clinical sciences and toxicology.

Agenda Relevance is the first volume in the authors' omnibus investigation of
the logic of practical reasoning, under the collective title, A Practical Logic
of Cognitive Systems. In this highly original approach, practical reasoning is
identified as reasoning performed with comparatively few cognitive assets,
including resources such as information, time and computational capacity. Unlike
what is proposed in optimization models of human cognition, a practical reasoner
lacks perfect information, boundless time and unconstrained access to
computational complexity. The practical reasoner is therefore obliged to be a
cognitive economizer and to achieve his cognitive ends with considerable
efficiency. Accordingly, the practical reasoner avails himself of various
scarce-resource compensation strategies. He also possesses neurocognitive
traits that abet him in his reasoning tasks. Prominent among these is the
practical agent's striking (though not perfect) adeptness at evading irrelevant
information and staying on task. On the approach taken here, irrelevancies are
impediments to the attainment of cognitive ends. Thus, in its most basic sense,
relevant information is cognitively helpful information. Information can then be
said to be relevant for a practical reasoner to the extent that it advances or
closes some cognitive agenda of his. The book explores this idea with a
conceptual detail and nuance not seen the standard semantic, probabilistic and
pragmatic approaches to relevance; but wherever possible, the authors seek to
integrate alternative conceptions rather than reject them outright. A further
attraction of the agenda-relevance approach is the extent to which its principal
conceptual findings lend themselves to technically sophisticated re-expression
in formal models that marshal the resources of time and action logics and
label led deductive systems.

Agenda Relevance is necessary reading for researchers in logic, belief
dynamics, computer science, AI, psychology and neuroscience, linguistics,
argumentation theory, and legal reasoning and forensic science, and will repay
study by graduate students and senior undergraduates in these same fields.

Key features:

relevance
action and agendas
practical reasoning
belief dynamics
non-classical logics
labelled deductive systems

"

Birds catch the public imagination like no other group of animals; in addition, birders are perhaps the largest non-professional naturalist community. Genomics and associated bioinformatics have revolutionised daily life in just a few decades. At the same time, this development has facilitated the application of genomics technology to ecological and evolutionary studies, including biodiversity and conservation at all levels. This book reveals how the exciting toolbox of genomics offers new opportunities in all areas of avian biology. It presents contributions from prominent experts at the intersection of avian biology and genomics, and offers an ideal introduction to the world of genomics for students, biologists and bird enthusiasts alike. The book begins with a historical perspective on how genomic technology was adopted by bird ecology and evolution research groups. This led, as the book explains, to a revised understanding of avian evolution, with exciting consequences for biodiversity research as a whole. Lastly, these impacts are illustrated using seminal examples and the latest discoveries from avian biology laboratories around the world.

This book is a treatise on microbial ecotoxicology, discussing the effect of pollutants on microbial ecosystems and the role of microorganisms in ecosystems services. Emphasizing the microbial responses to pollution at different biological levels, it focuses on metabolic pathways, genetic adaptation and response at the whole-microbial community level. It also addresses the ecological indicators of ecosystem recovery, as well as microbial biomarkers and biosensors as tools for microbial ecotoxicology.

As part of its efforts to improve fertilizer use and efficiency in West Africa, and following the recent adoption of the West African fertilizer recommendation action plan (RAP) by ECOWAS, this volume focuses on IFDC's technical lead with key partner institutions and experts to build on previous and current fertilizer recommendations for various crops and countries in West Africa for wider uptake by public policy makers and fertilizer industry actors.

This book discusses the main stem cell niches under distinct pathophysiological conditions. The role of tissue microenvironments in stem cell regulation, as well as modern methodologies and new techniques for the identification and characterization of stem cell niches, are discussed by leading experts in the field. Chapters describe the major components of various stem cell microenvironments, such as cellular components, soluble factors, cell-cell interactions, extra-cellular matrix proteins, and physical forces. Stem Cell Microenvironments and Beyond is part of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students and researchers in the field of stem cells or cell biology as well as clinicians.

The laws of inheritance were considered quite superficial until 1903, when the chromosome theory of heredity was established by Sutton and Boveri. The discovery of the double helix and the genetic code led to our understanding of gene structure and function. For the past quarter of a century, remarkable progress has been made in the characterization of the human genome in order to search for coherent views of genes. The unit of inheritance termed factor or gene, once upon a time thought to be a trivial an imaginary entity, is now perceived clearly as the precise unit of inheritance that has continually deluged us with amazement by its complex identity and behaviour, sometimes bypassing the university of Mendel's law.
The aim of the fifth volume, entitled Genes and Genomes, is to cover the topics ranging from the structure of DNA itself to the structure of the complete genome, along with everything in between, encompassing 12 chapters. These chapters relate much of the information accumulated on the role of DNA in the organization of genes and genomes per se. Several distinguished scientists, all pre-eminent authorities in each field to share their expertise. Obviously, since the historical report on the double helix configuration in 1953, voluminous reports on the meteoric advances in genetics have been accumulated, and to cover every account in a single volume format would be a Herculean task. Therefore, only a few topics are chosen, which are of great interest to molecular geneticists. This volume is intended for advanced graduate students who would wish to keep abreast with the most recent trends in genome biology.

The leading scholars in the rapidly-growing field of language evolution give readable accounts of their theories on the origins of language and reflect on the most important current issues and debates. As well as providing a guide to their own published research in this area they highlight what they see as the most relevant research of others. The authors come from a wide range of disciplines involved in language evolution including linguistics, cognitive science, computational science, primatology, and archaeology.

Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination, Volume 600, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts.

Applying Neuroscience to Counseling Children and Adolescents: A Guide to Brain-Based, Experiential Interventions explores the neurobiological underpinnings of child and adolescent development and encourages readers to apply neuroscience-informed interventions and strategies to counseling practice. The book provides an overview and foundational perspective on neuroscience-informed child and adolescent counseling; covers models and modes of counseling from a neuroscience perspective; and examines common clinical presentations when working with children and adolescents. Individual chapters address ethical and cultural considerations, counseling theory and neuroscience, neuroscience of play, using neuroscience in working with parents and caregivers, and neuroscience-informed interventions to treat anxiety, depression, stress, trauma, substance misuse, and attention and behavioral issues. Each chapter features two primary cases, one for a young child and one for an adolescent, conceptualized from real-life clients. The chapters present practical interventions and a sample of counselor-client dialogue to help readers understand how an intervention might unfold during a session. Applying Neuroscience to Counseling Children and Adolescents bridges the gap between textbooks that cover neuroscience and counseling children and adolescents independently. It is an ideal supplemental text for courses on incorporating neuroscience in counseling.

The Handbook of Neurolinguistics is a state-of-the-art reference and resource book; it describes current research and theory in the many subfields of neurolinguistics and its clinical application. Thorough and clearly written, the Handbook provides an excellent overview of the field of neurolinguistics and its development.
The book is organized into five parts covering the history of neurolinguistics, methods in clinical and experimental neurolinguistics, experimental neurolinguistics, clinical neurolinguistics, and resources in neurolinguistics. The first four parts contain a wide range of topics which discuss all important aspects of the many subfields of neurolinguistics. Also included are the relatively new and fast developing areas of research in discourse, pragmatics, and recent neuroimaging techniques. The resources section provides currently available resources, both traditional and modern. The Handbook is useful to the newcomer to the field, as well as the expert searching for the latest developments in neurolinguistics.
Key Features
* Clearly written and well organized
* Provides extensive resources
* Discusses both history and current research
* Covers the many subfields of neurolinguistics as well the developing areas of research

Temporal Sampling and Representation Updating, Volume 236, addresses the gap between laboratory studies using static or predictable stimuli and the more complex change that is a characteristic of the real world. Topics in this new volume include a section on Unfolding the time course of emotion perception, Temporal sampling and representation updating for action in interception and grasping tasks, The influence of Cognitive Control and Attention on Temporal Sampling: Lessons from the Attentional Blink, Synchronizing tracking eye movements with the motion of a visual target, and Sampling feature distributions with visual search in heterogeneous displays.

Volume 2 has focused on aspects of the pituitary gland both anterior (growth hormone and prolactin receptors, and GH action) and posterior (vasopressin) pituitary. In addition, thyroid cancer and steroidogenic enzymes and precocious puberty are covered. Finally, the "hot topics" include leptin and growth factor signaling.

This book focuses on the morphology, exine ornamentation and the associated evolutionary trends of crabapple pollen and anatomical developmental patterns. To examine the genetic evolutionary patterns of crabapple pollen traits, we constructed an interval distribution function based on characteristic pollen parameters and used a binary trivariate data matrix (Xi Yi Zi) to reflect the exine ornamentation regularity of the pollen. Our findings should inform the taxonomic status of the genus Malus. Pollen electron micrographs from a total of 26 species and 81 cultivars of Malus were recorded in this book. All 107 figures and 642 scanned pollen images constitute primary data obtained by the authors. The images in this book are clear, three-dimensional, and aesthetically pleasing. They are accompanied with text descriptions and provided a method for the indication of the different types of information that can be expected. This book can provide a reference for scientific researchers, students, and teachers in tertiary institutions that are engaged in research concerning crabapple production.

This book examines the application of soybean genome sequences to comparative, structural, and functional genomics. Since the availability of the soybean genome sequence has revolutionized molecular research on this important crop species, the book also describes how the genome sequence has shaped research on transposon biology and applications for gene identification, tilling and positional gene cloning. Further, the book shows how the genome sequence influences research in the areas of genetic mapping, marker development, and genome-wide association mapping for identifying important trait genes and soybean breeding. In closing, the economic and botanical aspects of the soybean are also addressed.

Over the last few centuries, science has usurped domains of knowledge that were once the province of religion. At the same time, however, both science and religion have enforced strict boundaries throughout. Science can describe the world to us, but it cannot tell us about meaning or values. This is a compelling case for breaching this barrier - in effect, for a reunification of science and religion.

Non-motor Parkinson's: The Hidden Face-Management and the Hidden Face of Related Disorders, Volume 134, the latest release in the International Review of Neurobiology series, is an up-to-date and comprehensive textbook addressing non-motor aspects of Parkinson's disease, a key unmet need. Specific chapters in this updated release include Therapeutics and NMS in PD, Non-motor effects of conventional and transdermal therapies in PD, Infusion therapy, CDD and NMS in PD, DBS and NMS in PD, TMS and implications for NMS in PD, Botulinum toxin therapy and NMS in PD, and Nutrition and NMS in PD, amongst others. Including practical tips for non-specialists and clinical algorithms, the book contains contributions from over 40 opinion leaders in the field of movement disorders. It provides practitioners and researchers with a laboratory, to bedside, to caregiver perspective.

The Many Faces of RNA is the subject for the eighth SmithKline Beecham Pharmaceuticals Research Symposia. It highlights a rapidly developing area of scientific investigation. The style and format are deliberately designed to promote in-depth presentations and discussions and to facilitate the forging of collaborations between academic and industrial partners.
This symposium focuses on several of the many fundamental, advancing strategies for exploring RNA and its functions. It emphasizes the interplay between biology, chemistry, genomics, and molecular biology which is leading to exciting new insights and avenues of investigation. The book explores RNA as a therapeutic target, RNA as a tool, RNA and its interactions, along with chemical, computational, and structural investigations.

Michael P Hassell examines the population dynamics of the interaction between insect parasitoids and their hosts. He incorporates all the major recent advances in our understanding of these interactions to show how the resulting body of theory makes direct contact with systems in the field, and can provide us with an in-depth understanding of a whole area of population dynamics. Hassell gives us a new and authoritative synthesis of his subject, as well as an elegant and exciting demonstration of how ecological studies advance.