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Gene Expression and Its Discontents - The Social Production of Chronic Disease (Hardcover, 2nd ed. 2016)
Loot Price: R5,654
Discovery Miles 56 540
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Gene Expression and Its Discontents - The Social Production of Chronic Disease (Hardcover, 2nd ed. 2016)
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This book describes how epigenetic context, in a large sense,
affects gene expression and the development of an organism, using
the asymptotic limit theorems of information theory to construct
statistical models useful in data analysis. The approach allows
deep understanding of how embedding context affects development. We
find that epigenetic information sources act as tunable catalysts,
directing ontogeny into characteristic pathways, a perspective
having important implications for epigenetic epidemiology. In sum,
environmental stressors can induce a broad spectrum of
developmental dysfunctions, and the book explores a number of
pandemic chronic diseases, using U.S. data at different scales and
levels of organization. In particular, we find the legacy of
slavery has been grossly compounded by accelerating industrial
decline and urban decay. Individual chapters are dedicated to
obesity and its sequelae, coronary heart disease, cancer, mental
disorders, autoimmune dysfunction, Alzheimer's disease, and other
conditions. Developmental disorders are driven by environmental
factors channeled by historical trajectory and are unlikely to
respond to medical interventions at the population level in the
face of persistent individual and community stress. Drugs powerful
enough to affect deleterious epigenetic programming will likely
have side effects leading to shortened lifespan. Addressing chronic
conditions and developmental disorders requires significant
large-scale changes in public policy and resource allocation.
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