Over the last decades, we have seen more than three dozen new infectious diseases appear, some of which could kill millions of people with one or two unlucky gene mutations or one or two unfavourable environmental changes. The risks of pandemics only increase as the human population grows; therefore to direct our future we should examine our past. Howard Phillips provides the first look into the history of epidemics in South Africa, probing lethal episodes which significantly shaped this society over three centuries.

Focusing on devastating diseases such as smallpox, bubonic plague, Spanish influenza, polio and HIV/Aids, Plague, Pox and Pandemics probes their origin, their catastrophic course and their consequences in both the short and long term. Their impact ranges from the demographic to the political, the social, the economic, the spiritual, the psychological and the cultural. As each of these epidemics occurred at crucial moments in the country's history - early in European colonisation, in the midst of the mineral revolution, during the South African War and World War I, as industrialisation was getting under way, and within the eras of apartheid and post-apartheid - the book also examines how these processes affected and were affected by the five epidemics, thereby adding important dimensions to an understanding of each.

To those who read this book, South African history will not look the same again.

For those who could read between the lines, the censored news out of China was terrifying. But the president insisted there was nothing to worry about. Fortunately, we are still a nation of skeptics. Fortunately, there are those among us who study pandemics and are willing to look unflinchingly at worst-case scenarios.

Michael Lewis’s taut and brilliant nonfiction thriller pits a band of medical visionaries against the wall of ignorance that was the official response of the Trump administration to the outbreak of COVID-19. The characters you will meet in these pages are as fascinating as they are unexpected.

A thirteen-year-old girl’s science project on transmission of an airborne pathogen develops into a very grown-up model of disease control. A local public-health officer uses her worm’s-eye view to see what the CDC misses, and reveals great truths about American society. A secret team of dissenting doctors, nicknamed the Wolverines, has everything necessary to fight the pandemic: brilliant backgrounds, world-class labs, prior experience with the pandemic scares of bird flu and swine flu…everything, that is, except official permission to implement their work.

Michael Lewis is not shy about calling these people heroes for their refusal to follow directives that they know to be based on misinformation and bad science. Even the internet, as crucial as it is to their exchange of ideas, poses a risk to them. They never know for sure who else might be listening in.

A provocative, original and compelling history of catastrophes and their consequences.

Disasters are by their very nature hard to predict. Pandemics, like earthquakes, wildfires, financial crises and wars, are not normally distributed; there is no cycle of history to help us anticipate the next catastrophe. But when disaster strikes, we ought to be better prepared than the Romans were when Vesuvius erupted or medieval Italians when the Black Death struck. We have science on our side, after all. Yet the responses of a number of devloped countries to a new pathogen from China were badly bungled. Why?

The facile answer is to blame poor leadership. While populist rulers have certainly performed poorly in the face of the pandemic, more profund problems have been exposed by COVID-19. Only when we understand the central challenge posed by disaster in history can we see that this was also a failure of an administrative state and of economic elites that had grown myopic over much longer than just a few years. Why were so many Cassandras for so long ignored? Why did only some countries learn the right lessons from SARS and MERS? Why do appeals to 'the science' often turn out to be mere magical thinking?

Drawing from multiple disciplines, including history, economics and network science, Doom: The Politics Of Catastrophe is a global post mortem for a plague year. Drawing on preoccupations that have shaped his books for some twenty years, Niall Ferguson describes the pathologies that have done us so much damage: from imperial hubris to bureaucratic sclerosis and online schism. COVID-19 was a test failed by countries who must learn some serious lessons from history if they are to avoid the doom of irreversible decline.

This book reviews the three most popular methods (and their extensions) in applied economics and other social sciences: matching, regression discontinuity, and difference in differences. The book introduces the underlying econometric/statistical ideas, shows what is identified and how the identified parameters are estimated, and then illustrates how they are applied with real empirical examples. The book emphasizes how to implement the three methods with data: many data and programs are provided in the online appendix. All readers--theoretical econometricians/statisticians, applied economists/social-scientists and researchers/students--will find something useful in the book from different perspectives.

This book brings together current thought on several aspects of the use of pesticides in and around homes, schools and workplaces. The book addresses several parts of the process, from the discovery and development of new active ingredients, their formulation, use, longevity, environmental fate and human exposure.

Cancer is diagnosed in about 140 per million children in Britain each year. There is a 1 in 500 chance that a child will be affected in the first 15 years of life, the most frequently occurring types of cancer being leukaemia and brain tumours. This book covers the descriptive epidemiology of childhood cancer in Britain, based on the unique work of the National Registry of Childhood Tumours, the largest population-based specialist childhood cancer registry in the world. The book provides a detailed account of national incidence and survival rates for childhood cancer in Britain during 1991-2000, and trends during 1966-2000. There is also an account of childhood mortality for the period 1965-2004. The diagnoses are classified throughout according to the International Classification of Childhood Cancer, the first time the third edition of this standard classification has been used for prevalence of incidence, survival and mortality data. The chapter on incidence rates is relevant to planning of health service provision and design of research studies on aetiology, whilst the chapter on trends in incidence is relevant to the possible effects of changes in environmental and other risk factors. In addition to comprehensive tables of rates, age-incidence graphs are provided for all the major types of childhood cancer, and possible artefacts are also discussed. The survival data demonstrates how clinical progress over the past 40 years has led to a major increase in the number of cancer survivors. The role of the Registry, covering history, methodology, current and future uses, is also discussed. This definitive work is the culmination of decades of epidemiological research and is essential reading for anyone involved in paediatric oncology or cancer epidemiology.

Americans' health improved dramatically over the twentieth century. Public health programs for disease and injury prevention were responsible for much of this advance. Over the century, America's public health system grew dramatically, employing science and political authority in response to an increasing array of health problems. As the disease burden of the old scourges of infection, perinatal mortality, and dietary deficiencies began to lift, public health's mandate expanded to take on new health threats, such as those resulting from a changing workplace, the rise of the automobile, and chronic and complex conditions caused by smoking, diet and other lifestyle and environmental factors. Public health measures almost always occur on contested ground; accordingly, controversies and recriminations over past failures often persist. In contrast, public health's many successes, even the imperfect ones, become part of the fabric of everyday life, a fact already apparent early in the last century, when C.E.A. Winslow reminded his peers that the lives saved and healthy years extended were the "silent victories" of public health. In its exploration of ten major public health issues addressed in the 20th century, Silent Victories takes a unique approach: for each issue, leading scientists in the field trace the discoveries, practices and programs that reduced morbidity and mortality from disease and injury, and an accompanying chapter by a historian or social scientist highlights key moments or conflicts that shaped public health action on that issue. The book concludes with a look toward the challenges public health must face in the future. Silent Victories reveals the lessons of history in aformat designed to appeal to students, health professionals and the public seeking to understand how public health advanced the country's health in the 20th century, and the challenges to protecting health in the future.

A deeply reported, insightful, and literary account of humankind’s battles with epidemic disease, and their outsized role in deepening inequality along racial, ethnic, class, and gender lines—in the vein of Medical Apartheid and Killing the Black Body.

Epidemic diseases enter the world by chance, but they become catastrophic by human design.

With clear-eyed research and lush prose, A History of the World in Six Plagues shows that throughout history, outbreaks of disease have been exacerbated by and gone on to further expand the racial, economic, and sociopolitical divides we allow to fester in times of good health.

Princeton-trained historian Edna Bonhomme’s examination of humanity’s disastrous treatment of pandemic disease takes us across place and time from Port-au-Prince to Tanzania, and from plantation-era America to our modern COVID-19-scarred world to unravel shocking truths about the patterns of discrimination in the face of disease. Based on in-depth research and cultural analysis, Bonhomme explores Cholera, HIV/AIDS, the Spanish Flu, Sleeping Sickness, Ebola, and COVID-19 amidst the backdrop of unequal public policy. But much more than a remarkable history, A History of the World in Six Plaguesis also a rising call for change.

This book presents a logical system of critical appraisal, to allow readers to evaluate studies and to carry out their own studies more effectively. This system emphasizes the central importance of cause and effect relationships. Its great strength is that it is applicable to a wide range of issues, and both to intervention trials and observational studies. This system unifies the often different approaches used in epidemiology, health services research, clinical trials, and evidence-based medicine, starting from a logical consideration of cause and effect. The author's approach to the issues of study design, selection of subjects, bias, confounding, and the place of statistical methods has been praised for its clarity and interest. Systematic reviews, meta-analysis, and the applications of this logic to evidence-based medicine, knowledge-based health care, and health practice and policy are discussed. Current and often controversial examples are used, including screening for prostate cancer, publication bias in psychiatry, public health issues in developing countries, and conflicts between observational studies and randomized trials. Statistical issues are explained clearly without complex mathematics, and the most useful methods are summarized in the appendix. The final chapters give six applications of the critical appraisal of major studies: randomized trials of medical treatment and prevention, a prospective and a retrospective cohort study, a small matched case-control study, and a large case-control study. In these chapters, sections of the original papers are reproduced and the original studies placed in context by a summary of current developments.

The fascinating, untold story of the air we breathe, the hidden life it contains, and invisible dangers that can turn the world upside down

Every day we draw in two thousand gallons of air—and thousands of living things. From the ground to the stratosphere, the air teems with invisible life. This last great biological frontier remains so mysterious that it took over two years for scientists to finally agree that the Covid pandemic was caused by an airborne virus.

In Air-Borne, award-winning New York Times columnist and author Carl Zimmer leads us on an odyssey through the living atmosphere and through the history of its discovery. We travel to the tops of mountain glaciers, where Louis Pasteur caught germs from the air, and follow Amelia Earhart and Charles Lindbergh above the clouds, where they conducted groundbreaking experiments. We meet the long-forgotten pioneers of aerobiology including William and Mildred Wells, who tried for decades to warn the world about airborne infections, only to die in obscurity.

Air-Borne chronicles the dark side of aerobiology with gripping accounts of how the United States and the Soviet Union clandestinely built arsenals of airborne biological weapons designed to spread anthrax, smallpox, and an array of other pathogens. Air-Borne also leaves readers looking at the world with new eyes—as a place where the oceans and forests loft trillions of cells into the air, where microbes eat clouds, and where life soars thousands of miles on the wind.

Weaving together gripping history with the latest reporting on Covid and other threats to global health, Air-Borne surprises us on every page as it reveals the hidden world of the air.

This book is an account of a study which provided unique information on trends in growth and respiratory health in British children over 25 years, with methodological discussion and other major findings including risk factors for impaired growth, obesity, respiratory disease and the distribution of coronary heart disease factors. The book provides information on trends in growth, height weight for height and subcutaneous arm tissue, and in respiratory health, asthma attacks and related symptoms, in children aged 5 to 11 years, from 1972 to 1994. It provides information on risk factors for impaired growth, obesity and respiratory disease, and on the distribution of risk factors for coronary heart disease in children. The contribution of the National Health and Growth Study extended to topics such as the effects of changes in welfare policy, under-diagnosis and under-treatment of asthma, nocturnal enuresis, disturbed sleep, the impact of passive smoking on the health of children, and the relation of lung function to the child's intra-uterine environment and to passive smoking. The methodological issues in relation to the conduct of the study and analysis of the data are discussed in non-technical language. Each contribution of the study is discussed in relation to current literature, which is fully referenced throughout.

From preeminent LGBTQ scholar, social critic, and journalist Steven W. Thrasher comes a powerful and crucial exploration of one of the most pressing issues of our times: how viruses expose the fault lines of society.

Having spent a ground-breaking career studying the racialization, policing, and criminalization of HIV, Dr. Thrasher has come to understand a deeper truth at the heart of our society: that there are vast inequalities in who is able to survive viruses and that the ways in which viruses spread, kill, and take their toll are much more dependent on social structures than they are on biology alone.

Told through the heart-rending stories of friends, activists, and teachers navigating the novel coronavirus, HIV, and other viruses, Dr. Thrasher brings the reader with him as he delves into the viral underclass and lays bare its inner workings. In the tradition of Isabel Wilkerson’s Caste and Michelle Alexander’s The New Jim Crow, The Viral Underclass helps us understand the world more deeply by showing the fraught relationship between privilege and survival.

Infectious diseases have been a threat since the beginning of civilization, leading the world to constantly adapt and advance medical knowledge in order to survive. The way society responds to these diseases has changed significantly throughout the years due to an influx of new technology, information, and research. In order to ensure society is equipped to handle future battles with infectious diseases, it is essential to understand past outbreaks and how they were handled. Historical and Epidemiological Analyses on the Impact of Infectious Disease on Society considers the history of infectious disease from the dawn of man to the present and discusses the scope and impact they have had on society and humanity. This book also examines how nation-state conflicts have interwoven with microscopic conflicts. Covering a range of critical topics such as plague, lethality, and technology, this reference work is ideal for medical professionals, historians, researchers, scholars, practitioners, academicians, instructors, and students.

'A brilliant expose' - Danny Dorling Covid-19 has exposed the limits of a neoliberal public health orthodoxy. But instead of imagining radical change, the left is stuck in a rearguard action focused on defending the NHS from the wrecking ball of privatisation. Public health expert Christopher Thomas argues that we must emerge from Covid-19 on the offensive - with a bold, new vision for our health and care. He maps out five new frontiers for public health and imagines how we can move beyond safeguarding what we have to a radical expansion of the principles put forward by Aneurin Bevan, the founder of the NHS, over 70 years ago. Beyond recalibrating our approach to healthcare services, his blueprint includes a fundamental redesign of our economy through Public Health Net Zero; a bold new universal public health service fit to address the real causes of ill health; and a major recalibration in the efforts against the epidemiological reality of an era of pandemics.

Practical Implementation Science is designed for graduate health professional and advanced undergraduate students who want to master the steps of using implementation science to improve public health. Engaging and accessible, this textbook demonstrates how to implement evidence-based practices effectively through use of relevant theories, frameworks, models, tools, and research findings. Additional real-world case studies across public health, global health, and health policy provide essential context to the major issues facing implementation domestically and globally with consideration of communities in low-to-middle-income countries (LMIC).The textbook is organized around the steps involved in planning, executing, and evaluating implementation efforts to improve health outcomes in communities. Coverage spans assessing the knowledge-practice gap; selecting an evidence-based practice (EBP) to reduce the gap; assessing EBP fit and adapting the EBP; assessing barriers and facilitators of implementation; engaging stakeholders; creating an implementation structure; implementing the EBP; and evaluating the EBP effort. Each chapter includes a "how to" approach to conducting the task at hand. The text also addresses the practical importance of implementation science through disseminating EBPs; scaling up EBPs; sustaining EBPs; and de-implementing practices that are no longer effective. All chapters include learning objectives and summaries with emphasized Key Points for Practice, Common Pitfalls in Practice, and discussion questions to direct learning and classroom discussion. Fit for students of public health, health policy, nursing, medicine, mental health, behavioral health, allied health, and social work, Practical Implementation Science seeks to bridge the gap from scientific evidence to effective practice. Key Features: Soup to Nuts Approach - Distills the steps to selecting, adapting, implementing, evaluating, scaling up, and sustaining evidence-based practices Expert Insight - Editors and chapter authors bring years of experience from leading implementation programs and interventions Multidisciplinary Focus - Utilizes cases and research findings relevant to students of public health, medicine, nursing, mental health, behavioral health, and social work Case Studies and Real-World Examples - Blends frameworks, models, and tools with real-world examples for students interested in both domestic and global health eBook Access - Included with print purchase for use on most mobile devices or computers Instructor's Packet - Complete with an Instructor's Manual, PowerPoint slides, and a Sample Syllabus

WHO DECIDES WHICH FACTS ARE TRUE?
In 1998 Andrew Wakefield, a British gastroenterologist with a history of self-promotion, published a paper with a shocking allegation: the measles-mumps-rubella vaccine might cause autism. The media seized hold of the story and, in the process, helped to launch one of the most devastating health scares ever. In the years to come Wakefield would be revealed as a profiteer in league with class-action lawyers, and he would eventually lose his medical license. Meanwhile one study after another failed to find any link between childhood vaccines and autism.
Yet the myth that vaccines somehow cause developmental disorders lives on. Despite the lack of corroborating evidence, it has been popularized by media personalities such as Oprah Winfrey and Jenny McCarthy and legitimized by journalists who claim that they are just being fair to "both sides" of an issue about which there is little debate. Meanwhile millions of dollars have been diverted from potential breakthroughs in autism research, families have spent their savings on ineffective "miracle cures," and declining vaccination rates have led to outbreaks of deadly illnesses like Hib, measles, and whooping cough. Most tragic of all is the increasing number of children dying from vaccine-preventable diseases.
In "The Panic Virus "Seth Mnookin draws on interviews with parents, public-health advocates, scientists, and anti-vaccine activists to tackle a fundamental question: How do we decide what the truth is? The fascinating answer helps explain everything from the persistence of conspiracy theories about 9/11 to the appeal of talk-show hosts who demand that President Obama "prove" he was born in America.
"The Panic Virus "is a riveting and sometimes heart-breaking medical detective story that explores the limits of rational thought. It is the ultimate cautionary tale for our time.

Communicable diseases have been an important part of human history. Epidemics afflicted populations, causing many deaths before gradually fading away and emerging again years after. Epidemics of infectious diseases are occurring more often, and spreading faster and further than ever, in many different regions of the world. The scientific community, in addition to its accelerated efforts to develop an effective treatment and vaccination, is also playing an important role in advising policymakers on possible non-pharmacological approaches to limit the catastrophic impact of epidemics using mathematical and machine learning models. Controlling Epidemics With Mathematical and Machine Learning Models provides mathematical and machine learning models for epidemical diseases, with special attention given to the COVID-19 pandemic. It gives mathematical proof of the stability and size of diseases. Covering topics such as compartmental models, reproduction number, and SIR model simulation, this premier reference source is an essential resource for statisticians, government officials, health professionals, epidemiologists, sociologists, students and educators of higher education, librarians, researchers, and academicians.

Mathematical and Statistical Estimation Approaches in Epidemiology compiles t- oretical and practical contributions of experts in the analysis of infectious disease epidemics in a single volume. Recent collections have focused in the analyses and simulation of deterministic and stochastic models whose aim is to identify and rank epidemiological and social mechanisms responsible for disease transmission. The contributions in this volume focus on the connections between models and disease data with emphasis on the application of mathematical and statistical approaches that quantify model and data uncertainty. The book is aimed at public health experts, applied mathematicians and sci- tists in the life and social sciences, particularly graduate or advanced undergraduate students, who are interested not only in building and connecting models to data but also in applying and developing methods that quantify uncertainty in the context of infectious diseases. Chowell and Brauer open this volume with an overview of the classical disease transmission models of Kermack-McKendrick including extensions that account for increased levels of epidemiological heterogeneity. Their theoretical tour is followed by the introduction of a simple methodology for the estimation of, the basic reproduction number,R . The use of this methodology 0 is illustrated, using regional data for 1918-1919 and 1968 in uenza pandemics.