The ageing of our population is a key societal issue across the globe. Although people are living longer, they need to be living longer in good health to continue to enjoy quality of life and independence and to prevent rises in health and social care costs. This timely and ground-breaking volume will provide an up-to-date overview of the factors that promote physical activity in later life. Despite advances in the fields of gerontology and geriatrics, sports and exercise science, sociology, health psychology, and public health, knowledge is largely contained within disciplines as reflected in the current provision of academic texts on this subject. To truly address the present and substantial societal challenges of population ageing, a multidisciplinary and collaborative approach is required. This handbook will inform researchers, students, and practitioners on the current evidence base for what physical activities need to be promoted among older people and how they can be implemented to maximise engagement. This handbook will be an invaluable resource for researchers, practitioners, policy makers, and students across the social sciences.

"Medicine at the Border" explores the pressing issues of border control and infectious disease in the nineteenth, twentieth and twenty-first centuries. The book places world health in world history, microbes and their management in globalization, and disease in the history of international relations, bringing together leading scholars on the history and politics of global health. The authors show how infectious disease has been central to the political, legal and commercial history of nationalism, colonialism and internationalism over the modern period.

The public is bombarded daily with reports about risk factors, many conflicting with each other, others accepted as "scientific truth" for awhile, then scientifically disproved, yet others questionable that later prove to be true. Physicians are faced with trying to make sense of those conflicting or questionable results in the scientific literature in order to guide their patients to the best possible decisions. The situation is not much easier for scientists who may waste years of their productive life, and considerable resources, basing their research efforts on what prove to be misleading earlier research findings. What this book does is to present, in non "academese" and with many examples from the general media and scientific journals, a guide to a critical reading of research reports, which, in turn, serves as a guide to researchers as to which approaches are likely to be regarded with raised eyebrows, and what they need to do to generate results that will be taken seriously. This stimulating and helpful book was written for informed consumers and physicians as well as for scientists evaluating the risk research literature or contemplating projects on risk research.

This book examines the HIV/AIDS epidemic in the United States using the concept of syndemics to contextualize the risk of both well-known, and a few lesser-known, subpopulations that experience disproportionately high rates of HIV and/or AIDS within the United States. Since discovery, HIV/AIDS has exposed a number of social, psychological, and biological aspects of disease transmission. The concept of "syndemics," or "synergistically interacting epidemics" has emerged as a powerful framework for understanding both the epidemiological patterns and the myriad of problems associated with HIV/AIDS around the world and within the United States. The book considers the disparities in HIV/AIDS in relation to social aspects, risk behavior and critical illness comorbidities. It updates and enhances our understanding of the HIV/AIDS epidemic in the United States and contributes to the expanding literature on the role of syndemics in shaping the public's health.

In this first volume of his history of epidemics in Britain, controversial physician Charles Creighton begins his examination of diseases in Britain from the first British epidemic in 664 AD to the end of the Great Plague in 1666. The work is broken down by time period and disease, ranging from Bede's record of the plague of 664-684 to 'the French pox', as well as outbreaks during sea voyages and in the early colonies. This work will be of value to medical historians and those with an interest in epidemiology.

The definitive reference for travel medicine, updated for 2020! "A beloved travel must-have for the intrepid wanderer." -Publishers Weekly "A truly excellent and comprehensive resource." -Journal of Hospital Infection The CDC Yellow Book offers everything travelers and healthcare providers need to know for safe and healthy travel abroad. This 2020 edition includes: * Country-specific risk guidelines for yellow fever and malaria, including expert recommendations and 26 detailed, country-level maps * Detailed maps showing distribution of travel-related illnesses, including dengue, Japanese encephalitis, meningococcal meningitis, and schistosomiasis * Guidelines for self-treating common travel conditions, including altitude illness, jet lag, motion sickness, and travelers' diarrhea * Expert guidance on food and drink precautions to avoid illness, plus water-disinfection techniques for travel to remote destinations * Specialized guidelines for non-leisure travelers, study abroad, work-related travel, and travel to mass gatherings * Advice on medical tourism, complementary and integrative health approaches, and counterfeit drugs * Updated guidance for pre-travel consultations * Advice for obtaining healthcare abroad, including guidance on different types of travel insurance * Health insights around 15 popular tourist destinations and itineraries * Recommendations for traveling with infants and children * Advising travelers with specific needs, including those with chronic medical conditions or weakened immune systems, health care workers, humanitarian aid workers, long-term travelers and expatriates, and last-minute travelers * Considerations for newly arrived adoptees, immigrants, and refugees Long the most trusted book of its kind, the CDC Yellow Book is an essential resource in an ever-changing field - and an ever-changing world.

This book provides an up-to-date review of fasciolosis, a disease caused by Fasciola hepatica and Fasciola gigantica, including its biology, transmission, epidemiology, host distribution, economic impact, and novel approaches for its diagnosis, treatment and prevention. It first offers a brief overview of the history of the disease, the genetic diversity of the parasite and its distribution, and the ecology of the vector snail, which belongs to the Lymnaeidae/Planorbidae family. It also examines the current strategies and novel approaches for controlling the parasite, diagnosing infections and vaccine development. Importantly, it highlights issues relating to the control of fasciolosis, including drug resistance, lack of effective diagnostics, and the parasite's long-term survival strategies based on regulation and modulation of the host immune system. Lastly, it discusses the novel control snail vectors using bait formulations, and synergetic and phototherapy treatment with chlorophyllin, which does not kill the vector.

This book is a fresh and readable account of the Covid-19 pandemic and how scientists and medical doctors are helping governments to manage the crisis. The book contains interviews and exchanges with dozens of scientists, doctors, experts, government representatives, and journalists. Why do some of the most scientifically advanced countries have the highest Covid-19 mortality? During the pandemic, the research community has been at the heart of-and actor in-a global scandal. Why has science failed? With the help of numerous testimonies from China, France, the UK and the USA in particular, the book provides an insider's view on this major crisis. Although the governments of these countries based their Covid-19 strategy on science, scientists failed to have a decisive influence on decision-makers-except in China-, which created genuine "time bombs." The accelerated development of vaccines does not erase past months' errors. The crisis led to the development of "science politics" at an unprecedented rate. More worryingly, experts themselves acknowledge that they did not rise to the challenge. Covid-19 also highlighted the weakness of democratic regimes and the power of technocapitalism. Countries pulled down their blinds, locked their doors, and promoted national approaches rather than international cooperation. The author proposes to set up an international framework on health risk to co-construct decision-making. He advocates political distancing in order to put the basics first: develop science, fight ignorance. The author, Michel Claessens on the Science for Policy Podcast from SAPEA

The case-control approach is a powerful method for investigating factors that may explain a particular event. It is extensively used in epidemiology to study disease incidence, one of the best-known examples being Bradford Hill and Doll's investigation of the possible connection between cigarette smoking and lung cancer. More recently, case-control studies have been increasingly used in other fields, including sociology and econometrics. With a particular focus on statistical analysis, this book is ideal for applied and theoretical statisticians wanting an up-to-date introduction to the field. It covers the fundamentals of case-control study design and analysis as well as more recent developments, including two-stage studies, case-only studies and methods for case-control sampling in time. The latter have important applications in large prospective cohorts which require case-control sampling designs to make efficient use of resources. More theoretical background is provided in an appendix for those new to the field.

This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.

This contributed book focuses on major aspects of statistical quality control, shares insights into important new developments in the field, and adapts established statistical quality control methods for use in e.g. big data, network analysis and medical applications. The content is divided into two parts, the first of which mainly addresses statistical process control, also known as statistical process monitoring. In turn, the second part explores selected topics in statistical quality control, including measurement uncertainty analysis and data quality. The peer-reviewed contributions gathered here were originally presented at the 13th International Workshop on Intelligent Statistical Quality Control, ISQC 2019, held in Hong Kong on August 12-14, 2019. Taken together, they bridge the gap between theory and practice, making the book of interest to both practitioners and researchers in the field of statistical quality control.

This volume brings together the world's leading experts on urban and transport planning, environmental exposures, physical activity, health and health impact assessment to discuss challenges and solutions in cities. The book provides a conceptual framework and work program for actions and outlines future research needs. It presents the current evidence-base, the benefits of and numerous case studies on integrating health and the environment into urban development and transport planning. Within cities there is a considerable variation in the levels of environmental exposures such as ambient air pollution, noise, and temperature, green space availability and physical activity. Many of these exposures, and their adverse health impacts, are related to and are being exacerbated by urban and transport planning and policy. Emerging research suggests that urban and transport planning indicators such as road network, distance to major roads, traffic density, household density, industry, and natural and green space can explain a large proportion of the variability in environmental exposures and therefore represent important and highly modifiable factors. The urban environment is a complex interlinked system. Decision-makers need not only better data on the complexity of factors in environmental and developmental processes affecting human health, but also an enhanced understanding of the linkages between these factors and health effects to determine at which level to target their actions most effectively. In recent years, there also has been a shift from trying to change at the national level to more comprehensive and ambitious actions being developed and implemented at the regional and local levels. Cities have come to the forefront of providing solutions for environmental issues such as climate change, which has co-benefits for health, but yet need better knowledge for wider health-centric action. This book provides the latest and most up-to-date information and studies for academics and practitioners alike.

Of the 758 species of hard ticks (family Ixodidae) currently known to science, 137 (18%) are found in the Neotropical Zoogeographic Region, an area that extends from the eastern and western flanks of the Mexican Plateau southward to southern Argentina and Chile and that also includes the Greater and Lesser Antilles and the Galapagos Islands. This vast and biotically rich region has long attracted natural scientists, with the result that the literature on Neotropical ticks, which are second only to mosquitoes as vectors of human disease and are of paramount veterinary importance, is enormous, diffuse, and often inaccessible to non-specialists. In this book, three leading authorities on the Ixodidae have combined their talents to produce a summary of essential information for every Neotropical tick species. Under each species name, readers will find an account of the original taxonomic description and subsequent redescriptions, followed by an overview of its geographic distribution and host relationships, including a discussion of human parasitism. Additional sections provide detailed analyses of tick distribution by country and zoogeographic subregion (the Caribbean, southern Mexico and Central America, South America, and the Galapagos Islands), together with a review of the phenomenon of invasive tick species and examination of the many valid and invalid names that have appeared in the Neotropical tick literature. The text concludes with an unprecedented tabulation of all known hosts of Neotropical Ixodidae, including the tick life history stages collected from each host. This book is an invaluable reference for biologists and biomedical personnel seeking to familiarize themselves with the Neotropical tick fauna.

Equipment Qualification in the Pharmaceutical Industry provides guidance and basic information for the preparation of a quality qualification program. It has been noted that there is a general lack of understanding in the industry, especially for those new to the industry, as to what constitutes a compliant qualification program. Even experienced professionals have felt a lack of security in reaching a compliant state. This book outlines a guideline for the preparation and execution of qualification protocols including the installation (IQ), operational (OQ), and performance (PQ) protocols. It discusses the importance of related qualification programs (e.g., quality systems, commissioning, computer system, and cleaning) and how to incorporate them into a fully compliant qualification program. Furthermore, it provides matrices of what could be included in each type of protocol for major types of process equipment. While primarily for people entering the pharmaceutical industry, those established in the field will benefit from the multiple examples and matrices as well as integration of related systems. Equipment Qualification in the Pharmaceutical Industry provides students and pharmaceutical scientists a guideline for the preparation and execution of qualification (installation, operational, and performance) protocols.

Congenital malformations are worldwide occurrences striking in every condition of society. These severe physical abnormalities which are present at birth and affecting every part of the body happen more often than usually realized, once in every 33 births. The most common, after heart defects, are those of the neural tube (the brain and spinal cord) which happen in as many as one in every 350 births. They have been noted as curiousities in man and beast throughout recorded history and received great attention in our time by various fields of study, for example, their faulty prenatal development by embryologists, familial patterns by geneticists, causation by environmentalists and variability by population scientists.

Attention turned much in recent years to the relation of these malformations to deficiency of a particular dietary ingredient, folic acid, a subject this book analyzes in depth. The greatest conundrum of all, which this latest matter like so much else hinges on, is the amazing fact of the tremendous, almost universal decrease in the frequency of these anomalies since early in the 20th century. The puzzle is 'What can this downward trend possibly mean?' and at bottom 'Whether it is part of a long-term cyclical pattern'. This fascinating biological phenomenon is explored in the book together with various other topics.

The most feared attribute of the human pathogen "Vibrio cholerae" is its ability to cause outbreaks that spread like wildfire, completely overwhelming public health systems and causing widespread suffering and death. This volume starts with a description of the contrasting patterns of outbreaks caused by the classical and El Tor biotypes of "V. cholerae." Subsequent chapters examine cholera outbreaks in detail, including possible sources of infection and molecular epidemiology on three different continents, the emergence of new clones through the bactericidal selection process of lytic cholera phages, the circulation and transmission of clones of the pathogen during outbreaks and novel approaches to modeling cholera outbreaks. A further contribution deals with the application of the genomic sciences to trace the spread of cholera epidemics and how this information can be used to control cholera outbreaks. The book closes with an analysis of the potential use of killed oral cholera vaccines to stop the spread of cholera outbreaks.

Encephalitis lethargica ('sleeping sickness') was a mysterious disorder that swept the world in the decade following the First World War, before disappearing without its cause having been identified. Around 85% of its victims, predominantly children, adolescents and younger adults, survived the acute disorder, but most developed severe neurological syndromes, particularly severe post-encephalitic parkinsonism and other severe motor abnormalities, that incapacitated them for the remainder of their lives. Despite its brief history, encephalitis lethargica played a major role in a variety medical discussions between the two World Wars, as this epitome of neuropsychiatric disease - attacking both motor and mental functions - appeared just as the separation of neurology and psychiatry had reached a critical point. Encephalitis lethargica sufferers presented an unprecedented combination of neurologic and psychiatric symptoms - including previously puzzling phenomena primarily associated with schizophrenia and hysteria, as well as behavioral changes and attention deficit disorders in children - that not only underscored the unity of mind and movement in the CNS, but also illuminated the critical role played by subcortical structures in consciousness and other higher mental functions that had formerly been associated with the soul and more recently presumed to be localized to the human cerebral cortex. Encephalitis lethargica exerted a greater influence on clinical and theoretic neuroscientific thought between the two World Wars than any other single disorder and had an enduring impact upon neurology and psychiatry. This book will be of interest to an educated audience active or interested in clinical (neurology, psychiatry, psychology) or laboratory neuroscience, particularly those interested in neuropsychiatry, as well as to those interested in the history of the biomedical sciences.

Basic Biostatistics for Medical and Biomedical Practitioners, Second Edition makes it easier to plan experiments, with an emphasis on sample size. It also shows what choices are available when simple tests are unsuitable and offers investigators an overview of how the kinds of complex tests that they won't do on their own work. The second edition presents a new, revised and enhanced version of the chapters, taking into consideration new developments and tools available, discussing topics, such as the basic aspects of statistics, continuous distributions, hypothesis testing, discrete distributions, probability in epidemiology and medical diagnosis, comparing means, regression and correlation. This book is a valuable source for students and researchers looking to expand or refresh their understanding of statistics as it applies to the biomedical and research fields. Based on the author's 40+ years of teaching statistics to medical fellows and biomedical researchers across a wide range of fields, it is a valuable source for researchers who need to understand more about biostatistics to apply it to their work.

Reproducibility in Biomedical Research: Epistemological and Statistical Problems explores the ideas and conundrums inherent in scientific research. It explores factors of reproducibility, including logic, distinguishing productive from unproductive irreproducibility, the scientific method, and the use of statistics. In multiple examples and six detailed case studies, the book demonstrates the misuse of logic resulting in unproductive irreproducibility, allowing researchers to develop their own logic and planning abilities. Biomedical researchers, clinicians, administrators of scientific institutions and funding agencies, journal editors, philosophers of science and medicine will find the arguments and explorations a valuable addition to their libraries.

In Dark Winter, world-leading epidemiologist Professor Raina MacIntyre navigates the past, present and future of pandemics and biosecurity. MacIntyre examines the history of biological warfare (and why it is called the 'poor man's nuke'), Soviet and US bioweapons programmes, developments in genetic engineering, synthetic biology and catastrophic laboratory accidents. She also explores the COVID-19 pandemic and the heated debate around its origins, and shares the analysis she has conducted in trying to determine whether it's a natural or unnatural pandemic. Looking ahead, MacIntyre outlines the future of genetic engineering, synthetic biology and bioterrorism, and the national and global security needed to manage quantum changes in technology, along with how we might avoid future pandemics.

This book includes research articles and expository papers on the applications of artificial intelligence and big data analytics to battle the pandemic. In the context of COVID-19, this book focuses on how big data analytic and artificial intelligence help fight COVID-19. The book is divided into four parts. The first part discusses the forecasting and visualization of the COVID-19 data. The second part describes applications of artificial intelligence in the COVID-19 diagnosis of chest X-Ray imaging. The third part discusses the insights of artificial intelligence to stop spread of COVID-19, while the last part presents deep learning and big data analytics which help fight the COVID-19.

It killed novelist George Orwell, Eleanor Roosevelt, and millions of others - rich and poor. Desmond Tutu, Amitabh Bachchan, and Nelson Mandela survived it, just. For centuries, tuberculosis has ravaged cities and plagued the human body. In Phantom Plague, Vidya Krishnan, traces the history of tuberculosis from the slums of 19th-century New York to modern Mumbai. In a narrative spanning century, Krishnan shows how superstition and folk-remedies, made way for scientific understanding of TB, such that it was controlled and cured in the West. The cure was never available to black and brown nations. And the tuberculosis bacillus showed a remarkable ability to adapt - so that at the very moment it could have been extinguished as a threat to humanity, it found a way back, aided by authoritarian government, toxic kindness of philanthropists, science denialism and medical apartheid. Krishnan's original reporting paints a granular portrait of the post-antibiotic era as a new, aggressive, drug resistant strain of TB takes over. Phantom Plague is an urgent, riveting and fascinating narrative that deftly exposes the weakest links in our battle against this ancient foe.

This book offers a radically different perspective on the topic of health inequity. Carey, Tai, and Griffiths use Perceptual Control Theory (PCT) to deconstruct current approaches to understanding, investigating, and addressing problems of health inequity. In the book, the authors propose that health inequity is not a problem per se. Disrupted control, they argue, is the problem that needs to be addressed. From this perspective, research, policy, and health practices directed at addressing health inequity in isolation will offer only partial solutions to the problems created by disrupted control. Addressing problems of disrupted control directly, however, has the potential to entirely resolve issues that are created by health inequity. The authors have extensive clinical and research experience in a wide range of contexts, including: cross-cultural settings; rural, remote, and underserved communities; community mental health settings; prisons; schools; and psychiatric wards. Drawing on these diverse experiences, the authors describe how adopting a Perceptual Control Theory perspective might offer promising new directions for researchers and practitioners who have an interest in addressing issues of inequity and social justice. With a Foreword written by Professor Neil Gilbert this book will provide fresh insights for academics, practitioners, and policymakers in the fields of public health, psychology, social policy, and healthcare.

This book allows readers to gain an in-depth understanding of the role of real-world data in pharmacoepidemiology, and highlights the strengths and limitations of the respective databases with regard to pharmacoepidemiological research. Over the past decade, the increasing use of real-world data in pharmacoepidemiological research has been accompanied by a growing recognition of the value of real-world evidence in clinical and regulatory decision-making. Electronic healthcare databases allow analyses of drug and vaccine utilization in routine care after approval, as well as investigations of their comparative effectiveness and safety. They are especially useful for the identification of rare risks and rare drug exposures over long periods of time, and as such sustainably extend the basis for drug safety research. This book provides an introduction to the role of real-world data in pharmacoepidemiological research and the main developments in the last 15 years. It also offers a comprehensive overview of the general classification characteristics of databases, together with their strengths and limitations, and a detailed description of 21 individual databases, written by professionals who work with or maintain them.

This book is the first one in which basic demographic models are rigorously formulated by using modern age-structured population dynamics, extended to study real-world population problems. Age structure is a crucial factor in understanding population phenomena, and the essential ideas in demography and epidemiology cannot be understood without mathematical formulation; therefore, this book gives readers a robust mathematical introduction to human population studies. In the first part of the volume, classical demographic models such as the stable population model and its linear extensions, density-dependent nonlinear models, and pair-formation models are formulated by the McKendrick partial differential equation and are analyzed from a dynamical system point of view. In the second part, mathematical models for infectious diseases spreading at the population level are examined by using nonlinear differential equations and a renewal equation. Since an epidemic can be seen as a nonlinear renewal process of an infected population, this book will provide a natural unification point of view for demography and epidemiology. The well-known epidemic threshold principle is formulated by the basic reproduction number, which is also a most important key index in demography. The author develops a universal theory of the basic reproduction number in heterogeneous environments. By introducing the host age structure, epidemic models are developed into more realistic demographic formulations, which are essentially needed to attack urgent epidemiological control problems in the real world.