Using "risk" as a conceptual lens, this book analyzes how communities across East Asia responded to the disruption unleashed by the COVID-19 pandemic. The contributors to this book look at how governments, societies, and individuals have perceived, experienced, dealt with and interpreted the pandemic and the transformations it has brought across countries like Japan, South Korea, Taiwan, Vietnam, and the Philippines. They examine pressing concerns such as infodemic, digital health literacy, media cynicism, telework, and digital inequalities in conjunction with issues such as public trust, identity formation, nationalism, and social fragmentation. They look at a wide range of questions relating to communication, mediation, and reactions to the challenges of the pandemic. An insightful resource for scholars of risk studies and of East Asian societies, the book is also a valuable reference for students and researchers of media and communication studies and sociology.

Key Features: Provides the taxonomy of the concepts and a navigation tool for the field of DTx. Covers important strategic aspects of the DTx industry, thereby helping investors, developers, and regulators gain a better appreciation of the potential value of DTx. Expounds on many existing and emerging state-of-the art scientific and technological tools, as well as data privacy, ethical and regulatory considerations for DTx product development. Presents several case studies of successful development of some of the most remarkable DTx products. Provides some perspectives and forward-looking statements on the future of digital medicine.

This comprehensive book looks at COVID-19, along with other recent infectious disease outbreaks, with the broad aim of providing constructive lessons and critical reflections from across a wide range of perspectives and disciplinary interests within the risk analysis field. The chapters in this edited volume probe the roles of risk communication, risk perception, and risk science in helping to manage the ever-growing pandemic that was declared a public health emergency of international concern in the beginning of 2020. A few chapters in the book also include relevant content discussing past disease outbreaks, such as Zika, Ebola and MERS-CoV. This book distils past and present knowledge, appraises current responses, introduces new ideas and data, and offers key recommendations, which will help illuminate different aspects of the global health crisis. It also explores how different constructive insights offered from a 'risk perspective' might inform decisions on how best to proceed in response as the pandemic continues. The chapters in this book were originally published as a special issue of the Journal of Risk Research.

Unique selling point: The Internet of Things (IoT), AI, and analytics are studied on how they can combat pandemics Core audience: Researchers and medical informatics professionals Place in the market: Academic reference title on timely topic also appealing to professionals

2020 was the first year of the COVID-19 pandemic, the most significant global pandemic since the 'Spanish flu' in 1918-1919. This book provides an analysis of the experience of the COVID-19 pandemic in a range of Commonwealth countries during 2020, covering public health, political, economic and international aspects. The Commonwealth, within which about one quarter of the world's population resides, provides a cross-section of the global experience of COVID-19. The Commonwealth ranges from highly populated countries such as India and Nigeria, to small island states and territories, encompassing also advanced industrialised countries and developing countries. The grouping also extends into many different regions of the world: Africa, South and Southeast Asia, Europe, the Americas and Oceania. In the first year of the pandemic, vaccines were still under development and national response strategies chosen by Commonwealth countries were diverse, spanning eradication, elimination, suppression and mitigation. The chapters in this book show the ways in which governments from a selection of Commonwealth countries responded to the multiple dimensions of the crisis, pointing to the factors that led to effective or less effective policies. This book originally appeared as a special issue of The Round Table.

This third edition volume expands on the previous editions with updated chapters on longitudinal studies, randomized trials, evidence-based decisions making, and a new section on changing health-related behaviors. The chapters in this book are organized into six parts: Part One focuses on framing clinical research questions and choosing a suitable design; biases that may occur in clinical research; and the ethics associated with doing conducting research on humans. Parts Two through Four discuss designs, measurements, and analysis that pertain to evaluation of risk in longitudinal studies; assessment of therapy in controlled trials; and evaluation of diagnostic tests. Part Five presents methods used in various components of evidence-based decision-making; and Part Six highlights interventions focused on changing health-related behaviors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of various types of bias, step-by-step, readily reproducible protocols for different research designs, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Clinical Epidemiology: Methods and Protocols, Third Edition is a valuable resource for clinicians and researchers who want to expand their works to humans and use their findings in the health system.

DIRECTLY APPLIES TO LIFE ON LAND SDG and CLIMATE CHANGE SDG. International organizations such as the Intergovernmental Panel on Climate Change (IPPC), World Health Organization, Food and Agriculture Organization and World Organization for Animal Health have all reminded us that health impacts of climate change will become some of societies' greatest challenges. How we respond or adapt to climate change will have profound implications for people, animals, biodiversity, economies and ecosystems today as well as in the future. The book provides, in one easy reference, all of the information Animal Health practitioners need from defining the climate change concept, providing science-based evidence of climate change degradation of animal (ecosystem) health and successful mitigation and reversal strategies. Despite being arguably the most important challenges of the 21st century, engagement, and leadership from the animal health sector on climate change remains hard to find. This book attempts to support animal health professionals by providing information, knowledge, and experiences they can use to remedy this situation. There is no other book that covers anything like the proposed subject matter to this level of completeness and detail. The publishing of a text of this nature could help erode the power of the climate denialism lobby, shifting the debate and allowing mitigation efforts to gain higher priority. The tone of the book has an understated sense of urgency, leaning slightly toward presenting as a 'Manual for the apocalypse'. This has potential to be a benchmark publication. The text not only defines climate change but takes a proactive approach with intervention and corrective action examples: each chapter ends with suggestions on teachable and actionable ideas that could be used to mobilize concepts and information provided into education or advocacy. In this way, the book not only brings key ideas, principles and information to understand the implications for climate change for animal health, but will help translate the book's offerings into education and intervention. Teachers and researchers could use this one-of-a-kind book to frame a course or seminar series heightening student career engagement and stewardship of a more sustainable and healthier planet.

This volume explores the implications of the COVID-19 pandemic for the sustainability of the present global political and economic system and the extent to which that system may as a result be undergoing transformation. Towards this aim, the contributing authors raise a number of key questions. First, what is likely to be the impact of the pandemic on the current global order based on neoliberal hyper-globalization? Second, what insights do earlier pandemics along with other inter-related crises such as those of climate, inequality, social reproduction, and continued fallout of the global financial crisis offer for understanding the medium- to long-term implications of COVID-19? Third, to what extent might the COVID pandemic lead to progressive political transformations? Towards this latter goal, the contributors to this volume also offer a number of suggestions as to what a post-COVID-19 world might look like and how post-COVID transformations might be channeled in a direction more conducive towards social justice and equality. The chapters in this book were originally published as a special issue of Globalizations.

Features Represents the first book to provide comprehensive coverage of model-assisted designs for various types of dose-finding and optimization clinical trials Describes the up-to-date theory and practice for model-assisted designs Presents many practical challenges and issues arising from early-phase clinical trials Illustrates with many real trial applications Offers numerous tips and guidance on designing dose finding and optimization trials Provides step-by-step illustration of using software to design trials Develops a companion website (www.trialdesign.org) to provide easy-to-use software to assist learning and implementing model-assisted designs.

This volume examines the ongoing, worldwide epidemiological transition in which acute infectious diseases are being superseded by chronic diseases as the predominant causes of morbidity and mortality; age at death has shifted from childhood to older adult ages; and life expectancy, population, and the proportion of older people are increasing. This transition constitutes a fundamental change in the human condition, and an understanding of the historical process behind it is thus of major importance. This study is the first to document the transition in a single country, drawing on records of cause-specific mortality since the eighteenth century in England, with comparative data from other Western countries. Alexander Mercer discusses possible causes of specific disease trends, reassessing the relative importance of "health interventions" and "standard of living" as determinants of increased life expectancy, and presents a new theory of how chronic diseases have developed. As specific microorganisms have been established as causal agents in chronic diseases that account for a significant proportion of "premature" deaths, the study suggests that a new conceptualization of the epidemiological transition is required, one that takes into account interrelationships between infectious diseases, between infections and chronic diseases, and between disorders underlying different chronic diseases. Alexander Mercer is an independent researcher and the author of Disease, Mortality and Population in Transition: Epidemiological-Demographic Change in England Since the Eighteenth Century as Part of a Global Phenomenon.

Continual improvements in data collection and processing have had a huge impact on brain research, producing data sets that are often large and complicated. By emphasizing a few fundamental principles, and a handful of ubiquitous techniques, Analysis of Neural Data provides a unified treatment of analytical methods that have become essential for contemporary researchers. Throughout the book ideas are illustrated with more than 100 examples drawn from the literature, ranging from electrophysiology, to neuroimaging, to behavior. By demonstrating the commonality among various statistical approaches the authors provide the crucial tools for gaining knowledge from diverse types of data. Aimed at experimentalists with only high-school level mathematics, as well as computationally-oriented neuroscientists who have limited familiarity with statistics, Analysis of Neural Data serves as both a self-contained introduction and a reference work.

Unique selling point: Combines theory with practice and applications for advanced intelligent healthcare informatics Core audience: Researchers and academics in healthcare informatics and machine learning Place in the market: Reference work

* A simple and systematic guide to the planning and performance of investigations concerned with health and disease and with health care * Offers researchers help in choosing a topic and to think about shaping objectives and ideas and to link these with the appropriate choice of method * Fully updated with new sections on the use of the Web and computer programmes freely available in the planning, performance or analysis of studies

Survival data analysis is a very broad field of statistics, encompassing a large variety of methods used in a wide range of applications, and in particular in medical research. During the last twenty years, several extensions of "classical" survival models have been developed to address particular situations often encountered in practice. This book aims to gather in a single reference the most commonly used extensions, such as frailty models (in case of unobserved heterogeneity or clustered data), cure models (when a fraction of the population will not experience the event of interest), competing risk models (in case of different types of event), and joint survival models for a time-to-event endpoint and a longitudinal outcome. Features Presents state-of-the art approaches for different advanced survival models including frailty models, cure models, competing risk models and joint models for a longitudinal and a survival outcome Uses consistent notation throughout the book for the different techniques presented Explains in which situation each of these models should be used, and how they are linked to specific research questions Focuses on the understanding of the models, their implementation, and their interpretation, with an appropriate level of methodological development for masters students and applied statisticians Provides references to existing R packages and SAS procedure or macros, and illustrates the use of the main ones on real datasets This book is primarily aimed at applied statisticians and graduate students of statistics and biostatistics. It can also serve as an introductory reference for methodological researchers interested in the main extensions of classical survival analysis.

Structural equation modeling (SEM) is a very general and flexible multivariate technique that allows relationships among variables to be examined. The roots of SEM are in the social sciences. In writing this textbook, the authors look to make SEM accessible to a wider audience of researchers across many disciplines, addressing issues unique to health and medicine. SEM is often used in practice to model and test hypothesized causal relationships among observed and latent (unobserved) variables, including in analysis across time and groups. It can be viewed as the merging of a conceptual model, path diagram, confirmatory factor analysis, and path analysis. In this textbook the authors also discuss techniques, such as mixture modeling, that expand the capacity of SEM using a combination of both continuous and categorical latent variables. Features: Basic, intermediate, and advanced SEM topics Detailed applications, particularly relevant for health and medical scientists Topics and examples that are pertinent to both new and experienced SEM researchers Substantive issues in health and medicine in the context of SEM Both methodological and applied examples Numerous figures and diagrams to illustrate the examples As SEM experts situated among clinicians and multidisciplinary researchers in medical settings, the authors provide a broad, current, on the ground understanding of the issues faced by clinical and health services researchers and decision scientists. This book gives health and medical researchers the tools to apply SEM approaches to study complex relationships between clinical measurements, individual and community-level characteristics, and patient-reported scales.

This stimulating book has become a go-to text for understanding the role that social factors play in the experience of health and many diseases. This extensively revised and updated third edition offers the most compelling case yet that stress, poverty, unhealthy lifestyles, and unpleasant living and working conditions can all be directly associated with illness. The book continues to build on the paradigm shift that has been emerging in twenty-first-century medical sociology, which looks beyond individual explanations for health and disease. As the field has headed toward a fundamentally different orientation, William Cockerham's work has been at the forefront of these changes, and he here marshals evidence and theory for those seeking a clear and authoritative guide to the realities of the social determinants of health. Of particular note in the latest edition is new material on the relationship between gender and health, implications of the life course for health behavior, the health effects of social capital, and the emergence of COVID-19. This engaging introduction to social epidemiology will be indispensable reading for all students and scholars of medical sociology, especially those with the courage to confront the possibility that society really does make people sick.

"This very informative book introduces classical and novel statistical methods that can be used by theoretical and applied biostatisticians to develop efficient solutions for real-world problems encountered in clinical trials and epidemiological studies. The authors provide a detailed discussion of methodological and applied issues in parametric, semi-parametric and nonparametric approaches, including computationally extensive data-driven techniques, such as empirical likelihood, sequential procedures, and bootstrap methods. Many of these techniques are implemented using popular software such as R and SAS."- Vlad Dragalin, Professor, Johnson and Johnson, Spring House, PA "It is always a pleasure to come across a new book that covers nearly all facets of a branch of science one thought was so broad, so diverse, and so dynamic that no single book could possibly hope to capture all of the fundamentals as well as directions of the field. The topics within the book's purview-fundamentals of measure-theoretic probability; parametric and non-parametric statistical inference; central limit theorems; basics of martingale theory; Monte Carlo methods; sequential analysis; sequential change-point detection-are all covered with inspiring clarity and precision. The authors are also very thorough and avail themselves of the most recent scholarship. They provide a detailed account of the state of the art, and bring together results that were previously scattered across disparate disciplines. This makes the book more than just a textbook: it is a panoramic companion to the field of Biostatistics. The book is self-contained, and the concise but careful exposition of material makes it accessible to a wide audience. This is appealing to graduate students interested in getting into the field, and also to professors looking to design a course on the subject." - Aleksey S. Polunchenko, Department of Mathematical Sciences, State University of New York at Binghamton This book should be appropriate for use both as a text and as a reference. This book delivers a "ready-to-go" well-structured product to be employed in developing advanced courses. In this book the readers can find classical and new theoretical methods, open problems and new procedures. The book presents biostatistical results that are novel to the current set of books on the market and results that are even new with respect to the modern scientific literature. Several of these results can be found only in this book.

Empirical Likelihood Methods in Biomedicine and Health provides a compendium of nonparametric likelihood statistical techniques in the perspective of health research applications. It includes detailed descriptions of the theoretical underpinnings of recently developed empirical likelihood-based methods. The emphasis throughout is on the application of the methods to the health sciences, with worked examples using real data. Provides a systematic overview of novel empirical likelihood techniques. Presents a good balance of theory, methods, and applications. Features detailed worked examples to illustrate the application of the methods. Includes R code for implementation. The book material is attractive and easily understandable to scientists who are new to the research area and may attract statisticians interested in learning more about advanced nonparametric topics including various modern empirical likelihood methods. The book can be used by graduate students majoring in biostatistics, or in a related field, particularly for those who are interested in nonparametric methods with direct applications in Biomedicine.

Bayesian Analysis of Infectious Diseases -COVID-19 and Beyond shows how the Bayesian approach can be used to analyze the evolutionary behavior of infectious diseases, including the coronavirus pandemic. The book describes the foundation of Bayesian statistics while explicating the biology and evolutionary behavior of infectious diseases, including viral and bacterial manifestations of the contagion. The book discusses the application of Markov Chains to contagious diseases, previews data analysis models, the epidemic threshold theorem, and basic properties of the infection process. Also described are the chain binomial model for the evolution of epidemics. Features: Represents the first book on infectious disease from a Bayesian perspective. Employs WinBUGS and R to generate observations that follow the course of contagious maladies. Includes discussion of the coronavirus pandemic as well as many examples from the past, including the flu epidemic of 1918-1919. Compares standard non-Bayesian and Bayesian inferences. Offers the R and WinBUGS code on at www.routledge.com/9780367633868

The Plague Years collects scholarly and essayistic reflections on literary, visual, and sonic representations of the COVID-19 and other pandemics. These are placed alongside poetry and short fiction written in the first two years of quarantine or isolation. This range expresses the intellectual and imaginative struggle and ingenuity entailed in coming to terms with the rampant spread of disease and its emotional, cultural, and political consequences. The contributions are from diverse contexts: Africa (from Egypt to South Africa), China, Japan, the US, and Scandinavia. They consider some of the array of contemporary engagements: poems translated from Mandarin about the traumas of the frontline, Chinese calligraphic poetry printed on cartons of PPE, comments on the literary history of representing epidemics and pandemics, political analyses of the post-truth present, and the role of life-writing and gaming in an interrupted world. Given the generative and creative obliquity of many of its parts, this collection shifts how one thinks about the diseased present and the archival pasts on which it draws. The chapters in this book were originally published as a special issue of English Studies in Africa.

Science abounds with problems where the data are noisy and the answer is not a straight line. Semiparametric regression analysis helps make sense of such data in application areas that include engineering, finance, medicine and public health. The book is geared towards researchers and professionals with little background in regression as well as statistically oriented scientists (biostatisticians, econometricians, quantitative social scientists, and epidemiologists) with knowledge of regression and the desire to begin using more flexible semiparametric models.

With the critical role of statistics in the design, conduct, analysis and reporting of clinical trials or observational studies intended for regulatory purposes, numerous guidelines have been issued by regulatory authorities around the world focusing on statistical issues related to drug development. However, the available literature on this important topic is sporadic, and often not readily accessible to drug developers or regulatory personnel. This book provides a systematic exposition of the interplay between the two disciplines, including emerging themes pertaining to the acceleration of the development of pharmaceutical medicines to serve patients with unmet needs. Features: Regulatory and statistical interactions throughout the drug development continuum The critical role of the statistician in relation to the changing regulatory and healthcare landscapes Statistical issues that commonly arise in the course of drug development and regulatory interactions Trending topics in drug development, with emphasis on current regulatory thinking and the associated challenges and opportunities The book is designed to be accessible to readers with an intermediate knowledge of statistics, and can be a useful resource to statisticians, medical researchers, and regulatory personnel in drug development, as well as graduate students in the health sciences. The authors' decades of experience in the pharmaceutical industry and academia, and extensive regulatory experience, comes through in the many examples throughout the book.

*Provides an overview of statistical and analytic methodologies in real-world evidence to generate insights on healthcare, with a special focus on the pharmaceutical industry *Examines timely topics of high relevance to industry such as bioethical considerations, regulatory standards and compliance requirements *Highlights emerging and current trends, and provides guidelines for best practices *Illustrates methods through examples and use-case studies to demonstrate impact *Provides guidance on software choices and digital applications for successful analytics.

The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the micro-organisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, the infectious diseases will undoubtedly persist as permanent and main threats to humanity for now and in the future. A total of four books are covered under the series of Infectious drug diseases. - Malarial drug delivery systems - Tubercular drug delivery systems - Viral drug delivery systems - Infectious disease drug delivery systems Infectious diseases are the world’s greatest killers that present one of the most significant health and security challenges. Humans have lived with emerging and re-emerging pathogens since before the documented history of civilization. The only determining fact today is - If the situation is “worse” or “better” than in past. The answer is probably “worse”, may be due significant increase in human population, increased cross-continent mobility, imbalanced (stressed) life style, irregular food habits leading to compromised innate immunity and over or under practiced hygiene routine. When the incidence of such a disease in people increases over 20 years or threatens to increase, it is called an “emerging” disease, and a growing number have made watch lists and headlines in nearly every country -like highly pathogenic H5N1 avian influenza, severe acute respiratory syndrome (SARS), Ebola virus, food- and waterborne illnesses, and a range of antimicrobial-resistant bacterial diseases TB. This book addresses current and new therapy developments in treating such infectious diseases, updates on finding new drugs, identification of innovative diagnostic methods, understanding of disease research models and clinical trials performances of new treatment modalities. Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of infectious diseases and related research.

COVID Transmission Modeling: An Insight into Infectious Diseases Mechanism provides an interdisciplinary overview of the COVID-19 pandemic crisis and covers various aspects of newer modeling techniques and practical solutions for health emergencies. This book aims to formulate various innovative and pragmatic mathematical, statistical, and epidemiological models using COVID-19 real data sets. It emphasizes interdisciplinary theoretical postulates derived from practical insights and knowledge of public health. Each of the book's 12 chapters provides invaluable and exploratory tools to enable explicit assumptions, highlights key health indicators, and determines the geometric progression and control measures of the disease. The present developed models will allow readers to extrapolate the exact reason for the outbreak and pave the way for scientific information on vaccine trials and socioeconomic, psychological, and disease burden worldwide. These advanced techniques of modeling and their applications are in greater need than ever for effective connection between mathematicians, statisticians, epidemiologists, researchers, clinicians, and policymakers for making appropriate decisions at the right time. With the advent of emerging health science, all models are demonstrated with real-life data sets and provided with illustrations and eye-catching graphs and diagrams so that the readers can easily understand the concept of COVID-19 pandemic interventions and their control measures, and their impact. Features Addresses all aspects of mitigation/control measures, estimation of transmission rate, economic impact assessment, genetic complexity of COVID-19, herd immunity, and various methods, including newer mathematical, statistical, and epidemiological models in the analysis of COVID-19 pandemic outbreak Covers the application of innovative, advanced statistical and epidemiological models and demonstrates possible solutions toward supportive treatment aspects of COVID-19 and its control measures Includes models that can easily be followed in formulating the mathematical derivations and key points Supplemented with ample illustrations, images, diagrams, and figures This book is aimed at postgraduate students studying medicine and healthcare, mathematics, and statistical information. Researchers will also find this book very helpful.