A deeply reported, insightful, and literary account of humankind’s battles with epidemic disease, and their outsized role in deepening inequality along racial, ethnic, class, and gender lines—in the vein of Medical Apartheid and Killing the Black Body.

Epidemic diseases enter the world by chance, but they become catastrophic by human design.

With clear-eyed research and lush prose, A History of the World in Six Plagues shows that throughout history, outbreaks of disease have been exacerbated by and gone on to further expand the racial, economic, and sociopolitical divides we allow to fester in times of good health.

Princeton-trained historian Edna Bonhomme’s examination of humanity’s disastrous treatment of pandemic disease takes us across place and time from Port-au-Prince to Tanzania, and from plantation-era America to our modern COVID-19-scarred world to unravel shocking truths about the patterns of discrimination in the face of disease. Based on in-depth research and cultural analysis, Bonhomme explores Cholera, HIV/AIDS, the Spanish Flu, Sleeping Sickness, Ebola, and COVID-19 amidst the backdrop of unequal public policy. But much more than a remarkable history, A History of the World in Six Plaguesis also a rising call for change.

Recent Advances in iPSC Disease Modeling, Volume One addresses how induced pluripotent stem cells can be used to model various diseases. This new volume teaches readers about current advances in the field, describing the use of induced pluripotent stem cells to model several diseases in vitro, and thus enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development and progression. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation specialists. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. Hence, these advantages have facilitated the identification of key targets and further defining on the molecular basis of several disorders.

The PCP's Bicentennial Edition Remington: The Science and Practice of Pharmacy, Twenty Third Edition, offers a trusted, completely updated source of information for education, training, and development of pharmacists. Published for the first time with Elsevier, this edition includes coverage of biologics and biosimilars as uses of those therapeutics have increased substantially since the previous edition. Also discussed are formulations, drug delivery (including prodrugs, salts, polymorphism. With clear, detailed color illustrations, fundamental information on a range of pharmaceutical science areas, and information on new developments in industry, pharmaceutical industry scientists, especially those involved in drug discovery and development will find this edition of Remington an essential reference. Intellectual property professionals will also find this reference helpful to cite in patents and resulting litigations. Additional graduate and postgraduate students in Pharmacy and Pharmaceutical Sciences will refer to this book in courses dealing with medicinal chemistry and pharmaceutics.

Bayesian analysis has developed rapidly in applications in the last two decades and research in Bayesian methods remains dynamic and fast-growing. Dramatic advances in modelling concepts and computational technologies now enable routine application of Bayesian analysis using increasingly realistic stochastic models, and this drives the adoption of Bayesian approaches in many areas of science, technology, commerce, and industry.
This Handbook explores contemporary Bayesian analysis across a variety of application areas. Chapters written by leading exponents of applied Bayesian analysis showcase the scientific ease and natural application of Bayesian modelling, and present solutions to real, engaging, societally important and demanding problems. The chapters are grouped into five general areas: Biomedical & Health Sciences; Industry, Economics & Finance; Environment & Ecology; Policy, Political & Social Sciences; and Natural & Engineering Sciences, and Appendix material in each touches on key concepts, models, and techniques of the chapter that are also of broader pedagogic and applied interest.

Vital Statistics of the United States: Births, Life Expectancy, Deaths, and Selected Health Data brings together a comprehensive collection of birth, mortality, and health data into a single volume. It provides a wealth of information compiled by the National Center for Health Statistics and other government agencies. Vital Statistics contains over 225 tables and is divided into four parts: Births, Mortality, Health, and Marriage and Divorce. Charts and graphs, available at applicable points in each chapter, illustrate some of the most vital trends in the data. In addition, updated definitions reflect the latest federal parameters for information about births, mortality, health, and marriages.

Obesity continues to accelerate resulting in an unprecedented epidemic that shows no significant signs of slowing down any time soon. The World Health Organization reports that in 2016, nearly 2 billion adults were overweight and that worldwide obesity has nearly tripled since 1975. Obesity: Global Impact and Epidemiology is an important tool in proving a link to new knowledge, serving researchers and clinicians. The field of obesity is evolving very quickly and there is an abundance of scientific data that has emerged and is emerging constantly. Researchers and physicians need new updated information about the epidemiology and global impact of obesity that come from authors that have a wide perspective in the field. For health professionals and researchers, there is a need to understand how obesity begins. While a simple question, the answer is very complex.

With our highly connected and interdependent world, the growing threat of infectious diseases and public health crisis has shed light on the requirement for global efforts to manage and combat highly pathogenic infectious diseases and other public health crisis on an unprecedented level. Such disease threats transcend borders. Reducing global threats posed by infectious disease outbreaks - whether naturally caused or resulting from a deliberate or accidental release - requires efforts that cross the disaster management pillars: mitigation, preparedness, response and recovery. This book addresses the issues of global health security along 4 themes: Emerging Threats; Mitigation, Preparedness, Response and Recovery; Exploring the Technology Landscape for Solutions; Leadership and Partnership. The authors of this volume highlight many of the challenges that confront our global security environment today. These range from politically induced disasters, to food insecurity, to zoonosis and terrorism. More optimistically, the authors also present some advances in technology that can help us combat these threats. Understanding the challenges that confront us and the tools we have to overcome them will allow us to face our future with confidence.

Incorporating many rare photographs--most never made public before--from the family albums of survivors who tell their stories in this volume, Harvard professor Julie Silver, M.D., and historian Daniel Wilson help readers understand the sheer terror that gripped parents of young children every spring and summer during the first half of the 20th century as polio epidemics ran rampant. Interviewed as part of the Polio Oral History Project directed by Silver and funded by Harvard, foundations, and private donors, the people featured in this book describe what is arguably the most feared scourge of modern times. Polio killed and maimed millions of Americans. Silver, Wilson, and their interviewees take us into homes and across time to understand the disease's effect on the family and the community. Testimonies are included from people who worked in polio wards, as well as from those involved in worldwide eradication efforts. The book also addresses the emergence of the polio and disability rights movement, the challenges of post-polio syndrome, and the state of polio research and developments today. And it explores the concern that polio could return in an even more vicious form as a result of bioterrorism. This work will be of interest to anyone intrigued by health and medical history; infectious disease and other epidemics; the psychological effects of disease on children, adults, and communities; politics in the Roosevelt era; and bioterrorism.

During the past twenty years there has been a dramatic increase in obesity in the United States. An estimated thirty percent of adults in the US are obese; in 1980, only fifteen percent were. The issue is gaining greater attention with the CDC and with the public health world in general. This book will offer practical information about the methodology of epidemiologic studies of obesity, suitable for graduate students and researchers in epidemiology, and public health practitioners with an interest in the issue.
The book will be structured in four main sections, with the majority of chapters authored by Dr. Hu, and some authored by specialists in specific areas. The first section will consider issues surrounding the definition of obesity, measurement techniques, and the designs of epidemiologic studies. The second section will address the consequences of obesity, looking at epidemiologic studies that focus on cardio-vascular disease, diabetes, and cancer The third section will look at determinants obesity, reviewing a wide range of risk factors for obesity including diet, physical activity and sedentary behaviors, sleep disorders, psychosocial factors, physical environment, biochemical and genetic predictors, and intrauterine exposures. In the final section, the author will discuss the analytical issues and challenges for epidemiologic studies of obesity.

This book presents the health reform experiences over the past three decades of twelve small and medium-sized nations that are not often included in international comparative studies in this field. The major conclusion of the study is that despite many similarities in policy goals, policy challenges and in the menu of policy options for countries that seek to offer universal coverage to their population, the health reforms of the nations in this book did not converge into one direction or model. However, we found several widespread policy experiences that are relevant for others, too.For example, user fees are unpopular everywhere. Governments often try to soften the consequences by exempting large groups of users, thus largely defeating the very purpose of those fees.As a second example, the introduction of new payment modes for medical care — like the shift from fee for service to case-based payment — took much longer than originally expected everywhere, and also failed to deliver their promises of improved transparency or efficiency gains A third example is that proposals are for universal coverage often ignore the challenges of implementing new financing models that elsewhere took decades if not centuries to develop.The conclusions contain both empirical findings and theoretical conclusions of interest to policy-makers and scholars of international comparison. It is accessible for academics, healthcare managers and students as well as a wider audience of readers interested in the changes in healthcare across the world.

This book seeks to better understand the meaning and implications of the UKs calamitous encounter with the COVID-19 global pandemic for the future of British neoliberalism. Construing COVID-19 as a political pandemic and mobilising a novel applied political philosophy approach, the authors cultivate fresh intellectual resources, both analytical and normative, to better understand why the UK failed the COVID-19 test and how it might 'fail forward' so as to strengthen its resilience. COVID-19 they argue, has intercepted the UK government's decades-long experimentation with neoliberalism at what appears to be a threshold moment in this model's life course. Neoliberalism has served as a key progenitor of the country's vulnerability: the pandemic has cruelly unveiled the failings of neoliberal logics and legacies which have placed the country at elevated risk and hampered its response. The pandemic in turn has attenuated underlying systemic maladies inherent in British neoliberalism and served as a great disruptor and potential accelerant of history; a consequential episode in the tumultuous life of this politico-economic model. To meaningfully 'build back better', a true renaissance of social democracy is needed. Drawing upon the neorepublican tradition of political philosophy, the authors confront neoliberalism's hegemonic but parochial concept of human freedom as non-interference and place the neorepublican idea of freedom as non-domination in the service of building a new UK social contract. This book will be of interest to political philosophers, political geographers, medical sociologists, public-health scholars, and epidemiologists, to stakeholders engaged in the public inquiry processes now gathering momentum globally and to architects of build back better programmes, especially in western advanced capitalist economies.

Ideal for high school and lower undergraduate readers, this book provides a holistic and multifaceted look at the state of health in the United States today by examining a wide variety of health indicators against necessary background and contextual information. Wellness by the Numbers: Understanding and Interpreting American Health Statistics presents the factual data that underlies health summaries-information that is not often readily available to readers. The statistical data regarding a variety of health indicators, accompanied by contextual information and analyses, serves to inform high school and lower undergraduate readers about the state of health in America today. Just as importantly, this book will document how scholars and health professionals analyze data to draw conclusions and sharpen readers' critical thinking skills. The book begins with an introductory essay that provides a conceptual framework for readers and a general overview of the topic of analyzing health across the nation. The "Locating Accurate and Current Data on Health-Related Information" section clearly explains the process of analyzing and interpreting statistical information, describes how to find authoritative sources of data, and defines the steps to reading and interpreting data and how to draw conclusions from the information. Each of the more than 40 key health topics includes an introduction of the particular health indicator being discussed, presents the data in tables, charts, or figures with concise analysis and interpretation, and concludes with discussion questions that challenge the reader to find additional meaning or patterns in the data. Provides up-to-date, easy-to-understand, and thematically organized information on many key health topics Covers a wide array of important and often controversial health topics, from cancer risk to depression to teen pregnancy Models data analysis and interpretation to demonstrate how scholars and health professionals analyze data to draw conclusions, thereby guiding readers through thinking critically about the information presented Presents thought-provoking discussion questions that invite readers to explore topics further and think more deeply about the information presented

Pandemics are disruptive. Thus, there is a need to prepare and plan actions in advance for identifying, assessing, and responding to such events to manage uncertainty and support sustainable livelihood and wellbeing. A detailed assessment of a continuously evolving situation needs to take place, and several aspects must be brought together and examined before the declaration of a pandemic even happens. Various health organizations; crisis management bodies; and authorities at local, national, and international levels are involved in the management of pandemics. There is no better time to revisit current approaches to cope with these new and unforeseen threats. As countries must strike a fine balance between protecting health, minimizing economic and social disruption, and respecting human rights, there has been an emerging interest in lessons learned and specifically in revisiting past and current pandemic approaches. Such approaches involve strategies and practices from several disciplines and fields including healthcare, management, IT, mathematical modeling, and data science. Using data science to advance in-situ practices and prompt future directions could help alleviate or even prevent human, financial, and environmental compromise, and loss and social interruption via state-of-the-art technologies and frameworks. Data Science Advancements in Pandemic and Outbreak Management demonstrates how strategies and state-of-the-art IT have and/or could be applied to serve as the vehicle to advance pandemic and outbreak management. The chapters will introduce both technical and non-technical details of management strategies and advanced IT, data science, and mathematical modelling and demonstrate their applications and their potential utilization within the identification and management of pandemics and outbreaks. It also prompts revisiting and critically reviewing past and current approaches, identifying good and bad practices, and further developing the area for future adaptation. This book is ideal for data scientists, data analysts, infectious disease experts, researchers studying pandemics and outbreaks, IT, crisis and disaster management, academics, practitioners, government officials, and students interested in applicable theories and practices in data science to mitigate, prepare for, respond to, and recover from future pandemics and outbreaks.

The definitive reference for travel medicine, updated for 2020! "A beloved travel must-have for the intrepid wanderer." -Publishers Weekly "A truly excellent and comprehensive resource." -Journal of Hospital Infection The CDC Yellow Book offers everything travelers and healthcare providers need to know for safe and healthy travel abroad. This 2020 edition includes: * Country-specific risk guidelines for yellow fever and malaria, including expert recommendations and 26 detailed, country-level maps * Detailed maps showing distribution of travel-related illnesses, including dengue, Japanese encephalitis, meningococcal meningitis, and schistosomiasis * Guidelines for self-treating common travel conditions, including altitude illness, jet lag, motion sickness, and travelers' diarrhea * Expert guidance on food and drink precautions to avoid illness, plus water-disinfection techniques for travel to remote destinations * Specialized guidelines for non-leisure travelers, study abroad, work-related travel, and travel to mass gatherings * Advice on medical tourism, complementary and integrative health approaches, and counterfeit drugs * Updated guidance for pre-travel consultations * Advice for obtaining healthcare abroad, including guidance on different types of travel insurance * Health insights around 15 popular tourist destinations and itineraries * Recommendations for traveling with infants and children * Advising travelers with specific needs, including those with chronic medical conditions or weakened immune systems, health care workers, humanitarian aid workers, long-term travelers and expatriates, and last-minute travelers * Considerations for newly arrived adoptees, immigrants, and refugees Long the most trusted book of its kind, the CDC Yellow Book is an essential resource in an ever-changing field - and an ever-changing world.

New Edition of a Classic Guide to Statistical Applications in the Biomedical Sciences

In the last decade, there have been significant changes in the way statistics is incorporated into biostatistical, medical, and public health research. Addressing the need for a modernized treatment of these statistical applications, Basic Statistics, Fourth Edition presents relevant, up-to-date coverage of research methodology using careful explanations of basic statistics and how they are used to address practical problems that arise in the medical and public health settings. Through concise and easy-to-follow presentations, readers will learn to interpret and examine data by applying common statistical tools, such as sampling, random assignment, and survival analysis.

Continuing the tradition of its predecessor, this new edition outlines a thorough discussion of different kinds of studies and guides readers through the important, related decision-making processes such as determining what information is needed and planning the collections process. The book equips readers with the knowledge to carry out these practices by explaining the various types of studies that are commonly conducted in the fields of medical and public health, and how the level of evidence varies depending on the area of research. Data screening and data entry into statistical programs is explained and accompanied by illustrations of statistical analyses and graphs. Additional features of the Fourth Edition include: A new chapter on data collection that outlines the initial steps in planning biomedical and public health studiesA new chapter on nonparametric statistics that includes a discussion and application of the Sign test, the Wilcoxon Signed Rank test, and the Wilcoxon Rank Sum test and its relationship to the Mann-Whitney U testAn updated introduction to survival analysis that includes the Kaplan Meier method for graphing the survival function and a brief introduction to tests for comparing survival functionsIncorporation of modern statistical software, such as SAS, Stata, SPSS, and Minitab into the presented discussion of data analysisUpdated references at the end of each chapter

"Basic Statistics," Fourth Edition is an ideal book for courses on biostatistics, medicine, and public health at the upper-undergraduate and graduate levels. It is also appropriate as a reference for researchers and practitioners who would like to refresh their fundamental understanding of statistical techniques.

This text uses a case-study approach to present the core principles of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 33 cases are carefully selected to cover key concepts and common diseases. Each chapter provides a specific patient report that includes the relevant history, pertinent clinical laboratory data, physical findings, and subsequent diagnosis. This is followed by a comprehensive discussion of the normal biochemical processes and reactions pertaining to the case, along with the pathophysiological mechanisms of the disease. In this third edition of the book, a new co-editor has aided in the substantially revised and more targeted selection of cases. The whole volume is now clearly focussed on intermediary metabolism and other topics central to biochemistry. There are new chapters on topics such as collagen structure, mitochondrial metabolism, and hyperhomocysteinemia and vascular disease. There is also more coverage of nutrional biochemistry, including new chapters on protein-calorie malnutrition, obesity, vitamin A deficiency, and iron metabolism.The best cases were retained from the previous edition, and have been completely rewritten and updated to include recent advances in diagnostic biochemistry and the status of current therapies. Although the first edition was intended primarily for medical students, through the years the book has proven useful for a wide variety of students interested in the health science professions.

Think statistics is just for statisticians? Think again! BASIC ALLIED HEALTH STATISTICS AND ANALYSIS, 5th Edition shows how Health Information Management (HIM) professionals wield the power of data to improve patient care delivery every day. To build a foundation for your success, this practical work-text demystifies stats by first demonstrating how to use calculations and then by offering practice in clinical case studies and practice problems. You'll think through the big issues in health care today, consider available data, choose the best statistical analysis, and then make recommendations--just like the pros. And once you have the basic math and stats down, nothing will hold you back! You can master applications such as vital statistics and mortality rates, census and occupancy rates, and more, all while meeting CAHIIM curriculum and competency standards.

Digestive Diseases in Sub-Saharan Africa: Changes and Challenges provides an in-depth examination into the rise of western digestive diseases in Sub-Saharan Africa (SSA). For those interested in the causes of the major diseases of the 'West', the patterns in Africa have always reflected on the emergence of western diseases and elucidated the pattern of these conditions and their clinical course. Coverage includes the present epidemiology of GI diseases in SSA, the trends that are occurring, and the context of other emerging diseases. Appropriate for researchers, gastroenterologists and internists, this book brings together the latest research in a single, complete volume.