Neuroprotection in Alzheimer's Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer's disease will pave the path to better disease management and novel therapeutics.

Cancer Disparities, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. This latest volume presents a broad introduction to a spectrum of factors contributing to cancer disparities that include ancestral informative markers' role in properly identifying race based on genetic ancestry, basic biological pathways contributing to cancer disparities, epidemiological factors linked to cancer disparities, and social/behavioral factors influencing cancer disparities.

Communicable diseases have been an important part of human history. Epidemics afflicted populations, causing many deaths before gradually fading away and emerging again years after. Epidemics of infectious diseases are occurring more often, and spreading faster and further than ever, in many different regions of the world. The scientific community, in addition to its accelerated efforts to develop an effective treatment and vaccination, is also playing an important role in advising policymakers on possible non-pharmacological approaches to limit the catastrophic impact of epidemics using mathematical and machine learning models. Controlling Epidemics With Mathematical and Machine Learning Models provides mathematical and machine learning models for epidemical diseases, with special attention given to the COVID-19 pandemic. It gives mathematical proof of the stability and size of diseases. Covering topics such as compartmental models, reproduction number, and SIR model simulation, this premier reference source is an essential resource for statisticians, government officials, health professionals, epidemiologists, sociologists, students and educators of higher education, librarians, researchers, and academicians.

Brain Metastases from Primary Tumors Volume Three: Epidemiology, Biology, and Therapy of Melanoma and Other Cancers provides a comprehensive overview of the metastasis of cancer, the main cause of approximately 90% of cancer associated deaths, yet the mechanisms governing this clinically important process remain poorly understood. Melanoma is the third most common diagnosis among patients with brain metastases, after lung and breast cancer. Approximately 75% of patients with metastatic melanoma develop brain metastases during the course of their disease. Although tumorigenesis of melanoma remains poorly understood, recent advances in gene expression profiling have revealed molecular mechanisms of this deadly disease. In addition, high-throughput gene expression has many advantages over techniques in cancer transcriptomic studies and has led to the discovery of numerous diagnostic, prognostic, and therapeutic targets, which are also detailed in this book. The book discusses the link between primary tumors and brain metastasis of melanoma, including molecular mechanisms, treatment options, prognosis, and general applications. Comprehensive chapters discuss systemic therapy, integrin inhibitors, stereotaxic radiosurgery, and more, making this book a great resource for neurooncologists, neurosurgeons, neurologists, and cancer researchers.

In The Coronavirus Crisis and Its Teachings: Steps towards Multi-Resilience Roland Benedikter and Karim Fathi first describe the pluri-dimensional characteristics of the Coronavirus crisis. Then they draw the pillars for a more "multi-resilient" Post-Corona world including socio-political recommendations of how to generate it. The Coronavirus crisis proved to be a bundle crisis consisting of multiple, interconnected crisis dimensions. Before Corona, most concepts of a "resilient society" implied a rather isolated focus on only one crisis at a time. Future preparedness in the 21st century will require a multi- and transdisciplinary risk-management concept that the authors call "multi-resilience". "Multi-resilience" means to systematically enhance universal resilience competencies of societies, such as collective intelligence or overall responsiveness, being appliable to pluri-dimensional crisis contexts. If the Coronavirus crisis in retrospect will have contributed to implement multi-resilience, then it will ultimately have contributed to progress. This volume includes a Foreword by Jan Nederveen Pieterse and an Afterword by Manfred B. Steger.

Practical Implementation Science is designed for graduate health professional and advanced undergraduate students who want to master the steps of using implementation science to improve public health. Engaging and accessible, this textbook demonstrates how to implement evidence-based practices effectively through use of relevant theories, frameworks, models, tools, and research findings. Additional real-world case studies across public health, global health, and health policy provide essential context to the major issues facing implementation domestically and globally with consideration of communities in low-to-middle-income countries (LMIC).The textbook is organized around the steps involved in planning, executing, and evaluating implementation efforts to improve health outcomes in communities. Coverage spans assessing the knowledge-practice gap; selecting an evidence-based practice (EBP) to reduce the gap; assessing EBP fit and adapting the EBP; assessing barriers and facilitators of implementation; engaging stakeholders; creating an implementation structure; implementing the EBP; and evaluating the EBP effort. Each chapter includes a "how to" approach to conducting the task at hand. The text also addresses the practical importance of implementation science through disseminating EBPs; scaling up EBPs; sustaining EBPs; and de-implementing practices that are no longer effective. All chapters include learning objectives and summaries with emphasized Key Points for Practice, Common Pitfalls in Practice, and discussion questions to direct learning and classroom discussion. Fit for students of public health, health policy, nursing, medicine, mental health, behavioral health, allied health, and social work, Practical Implementation Science seeks to bridge the gap from scientific evidence to effective practice. Key Features: Soup to Nuts Approach - Distills the steps to selecting, adapting, implementing, evaluating, scaling up, and sustaining evidence-based practices Expert Insight - Editors and chapter authors bring years of experience from leading implementation programs and interventions Multidisciplinary Focus - Utilizes cases and research findings relevant to students of public health, medicine, nursing, mental health, behavioral health, and social work Case Studies and Real-World Examples - Blends frameworks, models, and tools with real-world examples for students interested in both domestic and global health eBook Access - Included with print purchase for use on most mobile devices or computers Instructor's Packet - Complete with an Instructor's Manual, PowerPoint slides, and a Sample Syllabus

Beginning with a survey of fundamental concepts associated with data integration, knowledge representation, and hypothesis generation from heterogeneous data sets, "Methods in Biomedical Informatics" provides a practical survey of methodologies used in biological, clinical, and public health contexts. These concepts provide the foundation for more advanced topics like information retrieval, natural language processing, Bayesian modeling, and learning classifier systems. The survey of topics then concludes with an exposition of essential methods associated with engineering, personalized medicine, and linking of genomic and clinical data. Within an overall context of the scientific method, "Methods in Biomedical Informatics" provides a practical coverage of topics that is specifically designed for: (1) domain experts seeking an understanding of biomedical informatics approaches for addressing specific methodological needs; or (2) biomedical informaticians seeking an approachable overview of methodologies that can be used in scenarios germane to biomedical research.
Contributors represent leading biomedical informatics experts: individuals who have demonstrated effective use of biomedical informatics methodologies in the real-world, high-quality biomedical applicationsMaterial is presented as a balance between foundational coverage of core topics in biomedical informatics with practical "in-the-trenches" scenarios.Contains appendices that function as primers on: (1) Unix; (2) Ruby; (3) Databases; and (4) Web Services.

Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side.

The Covid-19 pandemic has presented the world with unprecedented challenges. The effects on society have been comprehensive and affected every walk of life. In Pandemic Heroes and Heroines, Marguerite Bouvard offers the first book-length study of the pandemic's impact on one of the most vulnerable groups, front line medical workers charged with caring for the sick and providing general health and welfare.

Phytochemical Profiling of Commercially Important South African Plants comprises a carefully selected group of plant species that are of interest to researchers and industry partners who would like to investigate the commercialization of plant species. The book presents 25 botanicals selected based on commercial relevance. For each of the species, the following topics are covered: botanical description and distribution, phytochemistry (including chemical structures), HPTLC fingerprint analysis, UPLC analysis, and GC analysis (the latter only in the case of essential oil-bearing species). Using standard methodology, high-level chromatographic fingerprints have been developed for better understanding. Different methods are succinctly summarized allowing for the rapid identification of botanical raw materials and formulated consumer products. This book will be extremely valuable to researchers in the field who wish to rapidly identify the constituents and for those who want to prepare formulations of plant material for commercial applications. This work will also be a valuable resource in the field of pharmacognosy.

In the past two decades, several pandemics have ravaged the globe, giving us several lessons on infectious disease epidemiology, the importance of initial detection and characterization of outbreak viruses, the importance of viral epidemic prevention steps, and the importance of modern vaccines. Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment summarizes the improvements in the 21st century to overcome / prevent / treat global pandemic with future prospective. Divided into 9 chapters, the book begins with an in-depth introduction to the lessons learned from the first pandemic of the 21st century. It describes the history, present and future in terms of detection, prevention and treatment. Followed by chapters on the outbreak, treatment strategies and clinical management of several infectious diseases like MERS, SARD and COVID 19, Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment, presents chapters on immunotherapies and vaccine technologies to combat pandemic outbreak and challenges. The book finishes with a chapter on the current knowledge and technology to control pandemic outbreaks. All are presented in a practical short format, making this volume a valuable resource for very broad academic audience.

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2. It was first identified in December 2019 in Wuhan, Hubei, China, and has resulted in an ongoing pandemic. As of July 2020, more than 13.8 million cases have been reported across 188 countries and territories, resulting in more than 590,000 deaths. COVID 19: Tackling Global Pandemics through Scientific and Social Tools, is an amalgamation of scientific and social perspective. The book provides a selection of handpicked themes and topics relevant to COVID 19 pandemic across various disciplines delivered by experts in the domain. The Opinion section is a unique component of this book discussing important issues concerning the COVID 19. COVID 19: Tackling Global Pandemics through Scientific and Social Tools serves as single source of information ranging from clinical research to social science and even biotechnology to engineering in a single platform. But there is scarcity of a quality document that summarizes various aspects of a single event. Therefore, the purpose of this book is to provide scientific and social information on COVID 19 to all sectors of readers i.e. from students to researchers and even policy makers Divided into 13 chapters, the book begins with an in-depth introduction to the highly infectious disease COVID19. Followed by chapters on interventions, vaccine development, prevention and control COVID 19: Tackling Global Pandemics through Scientific and Social Tools also provides insights to current global situation, mathematical models and social factors like distancing and hand-washing. The book closes with a review on the use of artificial intelligence and engineered intervention. All are presented in a practical short format, making this volume a valuable resource for very broad academic audience.

IN THE WAR AGAINST DISEASES, THEY ARE THE SPECIAL FORCES.

They always keep a bag packed. They seldom have more than twenty-four hours' notice before they are dispatched. The phone calls that tell them to head to the airport, sometimes in the middle of the night, may give them no more information than the country they are traveling to and the epidemic they will tackle when they get there.

The universal human instinct is to run from an outbreak of disease. These doctors run toward it.

They are the disease detective corps of the U.S. Centers for Disease Control and Prevention (CDC), the federal agency that tracks and tries to prevent disease outbreaks and bioterrorist attacks around the world. They are formally called the Epidemic Intelligence Service (EIS) -- a group founded more than fifty years ago out of fear that the Korean War might bring the use of biological weapons -- and, like intelligence operatives in the traditional sense, they perform their work largely in anonymity. They are not household names, but over the years they were first to confront the outbreaks that became known as hantavirus, Ebola virus, and AIDS. Now they hunt down the deadly threats that dominate our headlines: West Nile virus, anthrax, and SARS.

In this riveting narrative, Maryn McKenna -- the only journalist ever given full access to the EIS in its fifty-three-year history -- follows the first class of disease detectives to come to the CDC after September 11, the first to confront not just naturally occurring outbreaks but the man-made threat of bioterrorism. They are talented researchers -- many with young families -- who trade two years of low pay and extremely long hours for the chance to be part of the group that has helped eradicate smallpox, push back polio, and solve the first major outbreaks of Legionnaires' disease, toxic shock syndrome, and "E. coli" O157.

Urgent, exhilarating, and compelling, "Beating Back the Devil" goes with the EIS as they try to stop epidemics -- before the epidemics stop us.

Molecular Tools and Infectious Disease Epidemiology examines the opportunities and methodologic challenges in the application of modern molecular genetic and biologic techniques to infectious disease epidemiology. The application of these techniques dramatically improves the measurement of disease and putative risk factors, increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. This book presents the key points of consideration when integrating molecular biology and epidemiology; discusses how using molecular tools in epidemiologic research affects program design and conduct; considers the ethical concerns that arise in molecular epidemiologic studies; and provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field. The book is recommended for graduate and advanced undergraduate students studying infectious disease epidemiology and molecular epidemiology; and for the epidemiologist wishing to integrate molecular techniques into his or her studies.