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Brain Metastases from Primary Tumors, Volume 3 - Epidemiology, Biology, and Therapy of Melanoma and Other Cancers (Hardcover)
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Brain Metastases from Primary Tumors, Volume 3 - Epidemiology, Biology, and Therapy of Melanoma and Other Cancers (Hardcover)
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Brain Metastases from Primary Tumors Volume Three: Epidemiology,
Biology, and Therapy of Melanoma and Other Cancers provides a
comprehensive overview of the metastasis of cancer, the main cause
of approximately 90% of cancer associated deaths, yet the
mechanisms governing this clinically important process remain
poorly understood. Melanoma is the third most common diagnosis
among patients with brain metastases, after lung and breast cancer.
Approximately 75% of patients with metastatic melanoma develop
brain metastases during the course of their disease. Although
tumorigenesis of melanoma remains poorly understood, recent
advances in gene expression profiling have revealed molecular
mechanisms of this deadly disease. In addition, high-throughput
gene expression has many advantages over techniques in cancer
transcriptomic studies and has led to the discovery of numerous
diagnostic, prognostic, and therapeutic targets, which are also
detailed in this book. The book discusses the link between primary
tumors and brain metastasis of melanoma, including molecular
mechanisms, treatment options, prognosis, and general applications.
Comprehensive chapters discuss systemic therapy, integrin
inhibitors, stereotaxic radiosurgery, and more, making this book a
great resource for neurooncologists, neurosurgeons, neurologists,
and cancer researchers.
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