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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA

The Tangled Tree - A Radical New History of Life (Paperback): David Quammen The Tangled Tree - A Radical New History of Life (Paperback)
David Quammen 1
R257 R179 Discovery Miles 1 790 Save R78 (30%) Shipped within 7 - 12 working days

Longlisted for the National Book Award for Nonfiction and A New York Times Notable Book of 2018. Our understanding of the `tree of life', with powerful implications for human genetics, human health and our own human nature, has recently completely changed. This book is about a new method of telling the story of life on earth - through molecular phylogenetics. It involves a fairly simple method - the reading of the deep history of life by looking at the variation in protein molecules found in living organisms. For instance, we now know that roughly eight per cent of the human genome arrived not through traditional inheritance from directly ancestral forms, but sideways by viral infection. In The Tangled Tree, acclaimed science writer David Quammen chronicles these discoveries through the lives of the researchers who made them - such as Carl Woese, the most important little-known biologist of the twentieth century; Lynn Margulis, the notorious maverick whose wild ideas about `mosaic' creatures proved to be true; and Tsutomu Wantanabe, who discovered that the scourge of antibiotic-resistant bacteria is a direct result of horizontal gene transfer, bringing the deep study of genome histories to bear on a global crisis in public health. Quammen explains how molecular studies of evolution have brought startling recognitions about the tangled tree of life - including where we humans fit into it. Thanks to new technologies, we now have the ability to alter even our genetic composition - through sideways insertions, as nature has long been doing. The Tangled Tree is a brilliant exploration of our transformed understanding of evolution and of life's history itself.

Blueprint - How DNA Makes Us Who We Are (Paperback): Robert Plomin Blueprint - How DNA Makes Us Who We Are (Paperback)
Robert Plomin 1
R259 R158 Discovery Miles 1 580 Save R101 (39%) Shipped within 7 - 12 working days

'Mind-blowing ... It is a hugely important book ... His story is crucial' Matt Ridley, The Times One of the world's top behavioural geneticists argues that we need a radical rethink about what makes us who we are The blueprint for our individuality lies in the 1% of DNA that differs between people. Our intellectual capacity, our introversion or extraversion, our vulnerability to mental illness, even whether we are a morning person - all of these aspects of our personality are profoundly shaped by our inherited DNA differences. In Blueprint, Robert Plomin, a pioneer in the field of behavioural genetics, draws on a lifetime's worth of research to make the case that DNA is the most important factor shaping who we are. Our families, schools and the environment around us are important, but they are not as influential as our genes. This is why, he argues, teachers and parents should accept children for who they are, rather than trying to mould them in certain directions. Even the environments we choose and the signal events that impact our lives, from divorce to addiction, are influenced by our genetic predispositions. Now, thanks to the DNA revolution, it is becoming possible to predict who we will become, at birth, from our DNA alone. As Plomin shows us, these developments have sweeping implications for how we think about parenting, education, and social mobility. A game-changing book by a leader in the field, Blueprint shows how the DNA present in the single cell with which we all begin our lives can impact our behaviour as adults.

The Tangled Tree - A Radical New History of Life (Hardcover, Edition): David Quammen The Tangled Tree - A Radical New History of Life (Hardcover, Edition)
David Quammen 1
R480 R334 Discovery Miles 3 340 Save R146 (30%) Shipped within 7 - 12 working days

Longlisted for the National Book Award for Nonfiction and A New York Times Notable Book of 2018. Our understanding of the `tree of life', with powerful implications for human genetics, human health and our own human nature, has recently completely changed. This book is about a new method of telling the story of life on earth - through molecular phylogenetics. It involves a fairly simple method - the reading of the deep history of life by looking at the variation in protein molecules found in living organisms. For instance, we now know that roughly eight per cent of the human genome arrived not through traditional inheritance from directly ancestral forms, but sideways by viral infection. In The Tangled Tree, acclaimed science writer David Quammen chronicles these discoveries through the lives of the researchers who made them - such as Carl Woese, the most important little-known biologist of the twentieth century; Lynn Margulis, the notorious maverick whose wild ideas about `mosaic' creatures proved to be true; and Tsutomu Wantanabe, who discovered that the scourge of antibiotic-resistant bacteria is a direct result of horizontal gene transfer, bringing the deep study of genome histories to bear on a global crisis in public health. Quammen explains how molecular studies of evolution have brought startling recognitions about the tangled tree of life - including where we humans fit into it. Thanks to new technologies, we now have the ability to alter even our genetic composition - through sideways insertions, as nature has long been doing. The Tangled Tree is a brilliant exploration of our transformed understanding of evolution and of life's history itself.

The Compact Guide: Dna (Paperback): Kat Arney The Compact Guide: Dna (Paperback)
Kat Arney 1
R210 R146 Discovery Miles 1 460 Save R64 (30%) Shipped within 7 - 12 working days
Unravelling the Double Helix - The Lost Heroes of DNA (Hardcover): Gareth Williams Unravelling the Double Helix - The Lost Heroes of DNA (Hardcover)
Gareth Williams 1
R487 R392 Discovery Miles 3 920 Save R95 (20%) Shipped within 7 - 12 working days

Unravelling the Double Helix covers the most colourful period in the history of DNA, from the discovery of 'nuclein' in the late 1860s to the landmark publication of James Watson's The Double Helix in 1968. These hundred years included the advent of the Nobel Prize, antibiotics, X-ray crystallography and the atom bomb as well as two devastating world wars - events which are strung along the narrative thread of DNA like beads on a necklace. The story of DNA is a saga packed with awful mistakes as well as brilliant science, with a wonderful cast of heroes and villains. Surprisingly, much of it is unfamiliar. The elucidation of the double helix was one of the most brilliant gems of twentieth-century science, but some of the scientists who played crucial roles have been airbrushed out of history. Others were plunged into darkness when the spotlight fell on James Watson, Francis Crick, Maurice Wilkins and Rosalind Franklin. Watson and Crick solved a magnificent mystery, but Gareth Williams shows that their contribution was to click into place the last few pieces of a gigantic jigsaw puzzle assembled over several decades.

Blueprint - How DNA Makes Us Who We Are (Paperback): Robert Plomin Blueprint - How DNA Makes Us Who We Are (Paperback)
Robert Plomin 1
R320 R252 Discovery Miles 2 520 Save R68 (21%) Shipped within 4 - 8 working days

One of the world's top behavioural geneticists argues that we need a radical rethink about what makes us who we are The blueprint for our individuality lies in the 1% of DNA that differs between people. Our intellectual capacity, our introversion or extraversion, our vulnerability to mental illness, even whether we are a morning person - all of these aspects of our personality are profoundly shaped by our inherited DNA differences. In Blueprint, Robert Plomin, a pioneer in the field of behavioural genetics, draws on a lifetime's worth of research to make the case that DNA is the most important factor shaping who we are. Our families, schools and the environment around us are important, but they are not as influential as our genes. This is why, he argues, teachers and parents should accept children for who they are, rather than trying to mould them in certain directions. Even the environments we choose and the signal events that impact our lives, from divorce to addiction, are influenced by our genetic predispositions. Now, thanks to the DNA revolution, it is becoming possible to predict who we will become, at birth, from our DNA alone. As Plomin shows us, these developments have sweeping implications for how we think about parenting, education, and social mobility. A game-changing book by a leader in the field, Blueprint shows how the DNA present in the single cell with which we all begin our lives can impact our behaviour as adults.

Analyzing Network Data in Biology and Medicine - An Interdisciplinary Textbook for Biological, Medical and Computational... Analyzing Network Data in Biology and Medicine - An Interdisciplinary Textbook for Biological, Medical and Computational Scientists (Paperback)
Natasa Przulj
R1,036 R906 Discovery Miles 9 060 Save R130 (13%) Shipped within 7 - 12 working days

The increased and widespread availability of large network data resources in recent years has resulted in a growing need for effective methods for their analysis. The challenge is to detect patterns that provide a better understanding of the data. However, this is not a straightforward task because of the size of the data sets and the computer power required for the analysis. The solution is to devise methods for approximately answering the questions posed, and these methods will vary depending on the data sets under scrutiny. This cutting-edge text introduces biological concepts and biotechnologies producing the data, graph and network theory, cluster analysis and machine learning, before discussing the thought processes and creativity involved in the analysis of large-scale biological and medical data sets, using a wide range of real-life examples. Bringing together leading experts, this text provides an ideal introduction to and insight into the interdisciplinary field of network data analysis in biomedicine.

Who We Are and How We Got Here - Ancient DNA and the new science of the human past (Paperback): David Reich Who We Are and How We Got Here - Ancient DNA and the new science of the human past (Paperback)
David Reich 1
R282 R209 Discovery Miles 2 090 Save R73 (26%) Shipped within 7 - 12 working days

The past few years have seen a revolution in our ability to map whole genome DNA from ancient humans. With the ancient DNA revolution, combined with rapid genome mapping of present human populations, has come remarkable insights into our past. This important new data has clarified and added to our knowledge from archaeology and anthropology, helped resolve long-existing controversies, challenged long-held views, and thrown up some remarkable surprises. The emerging picture is one of many waves of ancient human migrations, so that all populations existing today are mixes of ancient ones, as well as in many cases carrying a genetic component from Neanderthals, and, in some populations, Denisovans. David Reich, whose team has been at the forefront of these discoveries, explains what the genetics is telling us about ourselves and our complex and often surprising ancestry. Gone are old ideas of any kind of racial 'purity', or even deep and ancient divides between peoples. Instead, we are finding a rich variety of mixtures. Reich describes the cutting-edge findings from the past few years, and also considers the sensitivities involved in tracing ancestry, with science sometimes jostling with politics and tradition. He brings an important wider message: that we should celebrate our rich diversity, and recognize that every one of us is the result of a long history of migration and intermixing of ancient peoples, which we carry as ghosts in our DNA. What will we discover next?

Francis Crick - Discoverer of the Genetic Code (Paperback): Matt Ridley Francis Crick - Discoverer of the Genetic Code (Paperback)
Matt Ridley
R231 R161 Discovery Miles 1 610 Save R70 (30%) Shipped within 7 - 12 working days

Acclaimed author Matt Ridley traces the colourful life of the man who discovered the structure of DNA, the building blocks of life. Building on a biographical tradition that can be traced back to Aubrey's `Brief Lives', Dr Johnson's `Lives of the Poets' and Lytton Strachey's `Eminent Victorians', this exciting and ground-breaking new series pairs great biographers, historians and novelists with iconic subjects, the writing bristling with original and distinctive points of view. On 28 February 1953, Francis Crick walked into the Eagle pub in Cambridge and announced that he and his American colleague James Watson `had found the secret of life'. In fact, they had indeed done so. That morning, Crick and Watson had worked out the structure of DNA (deoxyribonucleic acid). They had discovered its 'double helix' form, one which could replicate itself, confirming theories that it carried life's hereditary information. Matt Ridley's life of Crick begins with his birth in 1916 at the home of a shoe factory owner, his early explosive experiments at primary school and time developing torpedoes in the Navy. After his seismic DNA discovery, which won him the Nobel Prize before he'd even gained a PhD, the scientist's later work was rarely uncontroversial. From California, he proposed that life began when micro-organisms from another planet were dropped here by a spaceship sent to Earth, and maintained that the 'human soul' was entirely explicable in terms of brain activity. Matt Ridley's entertaining account traces the colourful and entirely original work behind one of mankind's greatest discoveries and displays the life of a scientist considered of the very first rank.

The Secret Life of Genes (Paperback): Derek Harvey The Secret Life of Genes (Paperback)
Derek Harvey
R285 R233 Discovery Miles 2 330 Save R52 (18%) Shipped within 4 - 8 working days

Genes have a huge impact on who we are, from defining us as humans, to governing how we behave. Whether controlling our cells or creating new forms of life, discover how DNA makes each of us unique. In The Secret Life of Genes, you'll learn all about the past, present and future of the human genome. Filled with colourful, graphic illustrations to help you to understand the world of genetics, from the basics to the most complex theories, this book brings the inner workings of the human body to life. Derek Harvey answers the biggest questions, from the nature of inheritance, evolution and reproduction, to how genes are arranged and how DNA is read. Take a trip through the history of the world's DNA and unlock the future of the field.

Rosalind Franklin (Paperback, New Ed): Brenda Maddox Rosalind Franklin (Paperback, New Ed)
Brenda Maddox 3
R259 R182 Discovery Miles 1 820 Save R77 (30%) Shipped within 7 - 12 working days

'A most moving and important biography, as well as an impressive account of a major event in the history of science'
Lewis Wolpert, 'Literary Review'

Although Rosalind Franklin took the crucial photograph of DNA revealing its double helix structure, her work was overlooked when, four years after her death, three men – Maurice Wilkins of King's College London, Francis Crick of the Cavendish Laboratory and James Watson of Cambridge – were awarded the Nobel Prize for the discovery of DNA.

In this compelling biography of Franklin, Brenda Maddox tells the story of a remarkably single-minded, forthright and tempestuous young woman, who at the age of fifteen decided she wanted to be a scientist, but who was airbrushed out of the greatest scientific discovery of the twentieth century.

'Maddox is a dab hand at drawing a heroine out from behind the long shadows cast by men and her Franklin emerges as a determined, combative woman – a perfectionist who is plagued with self doubt'
Vanessa Thorpe, 'Observer'

'This magnificent biography gives a gripping yet nuanced account that resists the stock story-line of Franklin as the wronged heroine. What really happened is far more intriguing.'
Gail Vines, 'Independent'

'An exhilarating and vivid tale of scientific and personal politics at a time of rapid change in British science.'
Jane Gregory, 'New Scientist'

Alternative pre-mRNA Splicing - Theory and Protocols (Paperback): Stefan Stamm, Chris Smith, Reinhard Luhrmann Alternative pre-mRNA Splicing - Theory and Protocols (Paperback)
Stefan Stamm, Chris Smith, Reinhard Luhrmann
R2,374 R1,691 Discovery Miles 16 910 Save R683 (29%) Shipped within 7 - 13 working days

This book was written for graduate and medical students, as well as clinicians and postdoctoral researchers. It describes the theory of alternative pre-mRNA splicing in
twelve introductory chapters and then introduces protocols and their theoretical background relevant for experimental research. These 43 practical chapters cover: Basic methods, Detection of splicing events, Analysis of alternative pre-mRNA splicing in vitro and in vivo, Manipulation of splicing events, and Bioinformatic analysis of alternative splicing.
A theoretical introduction and practical guide for molecular biologists, geneticists, clinicians and every researcher interested in alternative splicing.
Website: www.wiley-vch.de/home/splicing

Tag-based Next Generation Sequencing (Hardcover): Matthias Harbers, Guenter Kahl Tag-based Next Generation Sequencing (Hardcover)
Matthias Harbers, Guenter Kahl
R4,235 R2,976 Discovery Miles 29 760 Save R1,259 (30%) Shipped within 7 - 13 working days

Tag-based approaches were originally designed to increase the throughput of capillary sequencing, where concatemers of short sequences were first used in expression profiling. New Next Generation Sequencing methods largely extended the use of tag-based approaches as the tag lengths perfectly match with the short read length of highly parallel sequencing reactions. Tag-based approaches will maintain their important role in life and biomedical science, because longer read lengths are often not required to obtain meaningful data for many applications. Whereas genome re-sequencing and de novo sequencing will benefit from ever more powerful sequencing methods, analytical applications can be performed by tag-based approaches, where the focus shifts from 'sequencing power' to better means of data analysis and visualization for common users. Today Next Generation Sequence data require powerful bioinformatics expertise that has to be converted into easy-to-use data analysis tools. The book's intention is to give an overview on recently developed tag-based approaches along with means of their data analysis together with introductions to Next-Generation Sequencing Methods, protocols and user guides to be an entry for scientists to tag-based approaches for Next Generation Sequencing.

Minicircle and Miniplasmid DNA Vectors - The Future of Non-viral and Viral Gene Transfer (Hardcover): Martin Schleef Minicircle and Miniplasmid DNA Vectors - The Future of Non-viral and Viral Gene Transfer (Hardcover)
Martin Schleef
R2,316 R1,633 Discovery Miles 16 330 Save R683 (29%) Shipped within 7 - 13 working days

This first title on the topic provides complete coverage, including the molecular basis, production and possible biomedical applications. Written by the most prominent academic researchers in the field as well as by researchers at one of the world's leading companies in industrial production of minicircle DNA, this practical book is aimed at everyone who is directly or indirectly involved in the development of gene therapies.

DNA Is You! - The Marvelous Science Behind Your One-of-a-Kind-ness (Hardcover): Beatrice the Biologist DNA Is You! - The Marvelous Science Behind Your One-of-a-Kind-ness (Hardcover)
Beatrice the Biologist
R268 R174 Discovery Miles 1 740 Save R94 (35%) Shipped within 7 - 12 working days

Learn all about how your DNA makes you who you are-an awesome, unique individual-in this fun and simple illustrated guide! Did you know your sense of purpose is determined by your genes? And that DNA determines your reaction to poison ivy, and maybe even your sex drive? In DNA Is You!, the author behind Beatrice the Biologist uses her trademark humor to break down the ins and outs of DNA to give you the low-down on each trait, one by one. She provides the answers to questions like: how dependent are traits on your parents' genes? Are they based on mutations or influenced by the environment? What kind of studies have been performed on genetics, and what have they discovered? Home DNA tests are more popular than ever, and DNA Is You! takes a look at the weird and wild scientific factors that can change your genes-like that dimples are dominant, how someone gets two different eye colors, and which genes determine whether or not you'll need glasses. Learn more about how you got to be who you are with DNA Is You! and understand yourself-and your family-a little bit better!

Post-Transcriptional Gene Regulation - RNA Processing in Eukaryotes (Hardcover): Jane Wu Post-Transcriptional Gene Regulation - RNA Processing in Eukaryotes (Hardcover)
Jane Wu
R2,571 R1,809 Discovery Miles 18 090 Save R762 (30%) Shipped within 7 - 13 working days

Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post-transcriptional gene regulation thereby focusing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA editing and others, the book also discusses the critical role of RNA processing for the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, clinics as well as pharmaceutical industry.

The Cosmic Serpent (Paperback, New Ed): Jeremy Narby The Cosmic Serpent (Paperback, New Ed)
Jeremy Narby 1
R212 R174 Discovery Miles 1 740 Save R38 (18%) Shipped within 7 - 12 working days

Whilst living amongst Peruvian Indians, anthropologist Jeremy Narby learned of their phenomenal knowledge of plants and biochemical interactions, gained under the influence of the hallucinogen ayahuasca. Despite his initial scepticism, Narby found himself engaged in an increasingly obsessive quest. He researched cutting-edge scholarship in subjects as diverse as molecular biology, shamanism, neurology and mythology, which led him inexorably to the conclusion that the Indians' claims were literally true: to a consciousness prepared with drugs, biochemical knowledge could indeed be transmitted, through DNA itself.

Genome Data Analysis (Paperback, 1st ed. 2019): Ju Han Kim Genome Data Analysis (Paperback, 1st ed. 2019)
Ju Han Kim
R1,795 R1,420 Discovery Miles 14 200 Save R375 (21%) Shipped within 7 - 12 working days

This textbook describes recent advances in genomics and bioinformatics and provides numerous examples of genome data analysis that illustrate its relevance to real world problems and will improve the reader's bioinformatics skills. Basic data preprocessing with normalization and filtering, primary pattern analysis, and machine learning algorithms using R and Python are demonstrated for gene-expression microarrays, genotyping microarrays, next-generation sequencing data, epigenomic data, and biological network and semantic analyses. In addition, detailed attention is devoted to integrative genomic data analysis, including multivariate data projection, gene-metabolic pathway mapping, automated biomolecular annotation, text mining of factual and literature databases, and integrated management of biomolecular databases. The textbook is primarily intended for life scientists, medical scientists, statisticians, data processing researchers, engineers, and other beginners in bioinformatics who are experiencing difficulty in approaching the field. However, it will also serve as a simple guideline for experts unfamiliar with the new, developing subfield of genomic analysis within bioinformatics.

Global Genes, Local Concerns - Legal, Ethical, and Scientific Challenges in International Biobanking (Hardcover): Timo Minssen,... Global Genes, Local Concerns - Legal, Ethical, and Scientific Challenges in International Biobanking (Hardcover)
Timo Minssen, Janne R. Herrmann, Jens Schovsbo
R2,305 Discovery Miles 23 050 Shipped within 7 - 12 working days

Large-scale, interoperable biobanks are an increasingly important asset in today's life science research and, as a result, multiple types of biobanks are being established around the globe with very different financial, organizational and legal set-ups. With interdisciplinary chapters written by lawyers, sociologists, doctors and biobank practitioners, Global Genes, Local Concerns identifies and discusses the most pressing issues in contemporary biobanking. This timely book addresses pressing questions such as: how do national biobanks best contribute to translational research?; What are the opportunities and challenges that current regulations present for translational use of biobanks?; How does inter-biobank coordination and collaboration occur on various levels?; and how could academic and industrial exploitation, ownership and IPR issues be addressed and facilitated? Identifying that biobanks' foundational and operational set-ups should be legally and ethically sound, while at the same time reflecting the hopes and concerns of all the involved stakeholders, this book contributes to the continued development of international biobanking by highlighting and analysing the complexities in this important area of research. Academics in the fields of law and ethics, health law and biomedical law, as well as biobank managers and policymakers will find this insightful book a stimulating and engaging read.

Bioinformatics and Functional Genomics (Hardcover, 3rd Edition): Jonathan Pevsner Bioinformatics and Functional Genomics (Hardcover, 3rd Edition)
Jonathan Pevsner
R2,426 R1,742 Discovery Miles 17 420 Save R684 (28%) Shipped within 7 - 13 working days

The bestselling introduction to bioinformatics and genomics now in its third edition Widely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go-to source for students and professionals involved in biomedical research. This book provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include: * Extensive revisions and a slight reorder of chapters for a more effective organization * A brand new chapter on next-generation sequencing * An expanded companion website, also updated as and when new information becomes available * Greater emphasis on a computational approach, with clear guidance of how software tools work and introductions to the use of command-line tools such as software for next-generation sequence analysis, the R programming language, and NCBI search utilities The book is complemented by lavish illustrations and more than 500 figures and tables - many newly-created for the third edition to enhance clarity and understanding. Each chapter includes learning objectives, a problem set, pitfalls section, boxes explaining key techniques and mathematics/statistics principles, a summary, recommended reading, and a list of freely available software. Readers may visit a related Web page for supplemental information such as PowerPoints and audiovisual files of lectures, and videocasts of how to perform many basic operations: www.wiley.com/go/pevsnerbioinformatics. Bioinformatics and Functional Genomics, Third Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.

Quantitative Genetics And Its Connections With Big Data And Sequenced Genomes (Hardcover): Charles J. Mode Quantitative Genetics And Its Connections With Big Data And Sequenced Genomes (Hardcover)
Charles J. Mode
R1,457 R1,102 Discovery Miles 11 020 Save R355 (24%) Shipped within 7 - 12 working days

The book gives an overview of developments in Quantitative Genetics and variance component analysis in an era of Big Data and Sequenced Genomes. It provides a detailed description of a direct method of estimation that will be a useful means of extracting information from a large set of data that was inconceivable 10 to 20 years ago.The book is a combination of a history of variance component analysis and a forward looking view as to how direct methods of estimation arise from the availability of big data sets and sequenced genomes of each individual in the sample.Many papers and books on quantitative genetics versions of the general linear model from statistics are useful for analyzing the data, using relatively small sets of data. In this book, new methods of direct estimation are introduced and analyzed that are appropriate for an era of big sets of data and sequences genomes. These direct methods of estimation are based on taking conditional expectations rather the methods of least squares that characterize many applications of the general linear model of statistics.

Electrophoresis in Practice - A Guide to Methods and Applications of DNA and Protein Separations (Hardcover, 5th Edition):... Electrophoresis in Practice - A Guide to Methods and Applications of DNA and Protein Separations (Hardcover, 5th Edition)
Reiner Westermeier
R2,589 R1,828 Discovery Miles 18 280 Save R761 (29%) Shipped within 7 - 13 working days

This fifth edition of the successful, long-selling classic has been completely revised and expanded, omitting some topics on obsolete DNA electrophoresis, but now with a completely new section on electrophoretic micro-methods and on-the-chip electrophoresis. The text is geared towards advanced students and professionals and contains extended background sections, protocols and a trouble-shooting section. It is now also backed by a supplementary website providing all the figures for teaching purposes, as well as a selection of animated figures tested in many workshops to explain the underlying principles of the different electrophoretic methods.

Bioinformatics Data Skills - Reproducible and Robust Research with Open Source Tools (Paperback): Vince Buffalo Bioinformatics Data Skills - Reproducible and Robust Research with Open Source Tools (Paperback)
Vince Buffalo
R930 R614 Discovery Miles 6 140 Save R316 (34%) Shipped within 7 - 12 working days

Learn the data skills necessary for turning large sequencing datasets into reproducible and robust biological findings. With this practical guide, you'll learn how to use freely available open source tools to extract meaning from large complex biological data sets. At no other point in human history has our ability to understand life's complexities been so dependent on our skills to work with and analyze data. This intermediate-level book teaches the general computational and data skills you need to analyze biological data. If you have experience with a scripting language like Python, you're ready to get started. Go from handling small problems with messy scripts to tackling large problems with clever methods and tools Process bioinformatics data with powerful Unix pipelines and data tools Learn how to use exploratory data analysis techniques in the R language Use efficient methods to work with genomic range data and range operations Work with common genomics data file formats like FASTA, FASTQ, SAM, and BAM Manage your bioinformatics project with the Git version control system Tackle tedious data processing tasks with with Bash scripts and Makefiles

The Material Gene - Gender, Race, and Heredity after the Human Genome Project (Paperback): Kelly E. Happe The Material Gene - Gender, Race, and Heredity after the Human Genome Project (Paperback)
Kelly E. Happe
R506 R434 Discovery Miles 4 340 Save R72 (14%) Shipped within 7 - 12 working days

Winner of the 2014 Diamond Anniversary Book Award Finalist for the 2014 National Communications Association Critical and Cultural Studies Division Book of the Year Award In 2000, the National Human Genome Research Institute announced the completion of a "draft" of the human genome, the sequence information of nearly all 3 billion base pairs of DNA. Since then, interest in the hereditary basis of disease has increased considerably. In The Material Gene, Kelly E. Happe considers the broad implications of this development by treating "heredity" as both a scientific and political concept. Beginning with the argument that eugenics was an ideological project that recast the problems of industrialization as pathologies of gender, race, and class, the book traces the legacy of this ideology in contemporary practices of genomics. Delving into the discrete and often obscure epistemologies and discursive practices of genomic scientists, Happe maps the ways in which the hereditarian body, one that is also normatively gendered and racialized, is the new site whereby economic injustice, environmental pollution, racism, and sexism are implicitly reinterpreted as pathologies of genes and by extension, the bodies they inhabit. Comparing genomic approaches to medicine and public health with discourses of epidemiology, social movements, and humanistic theories of the body and society, The Material Gene reworks our common assumption of what might count as effective, just, and socially transformative notions of health and disease.

Quantitative Genetics And Its Connections With Big Data And Sequenced Genomes (Paperback): Charles J. Mode Quantitative Genetics And Its Connections With Big Data And Sequenced Genomes (Paperback)
Charles J. Mode
R788 R625 Discovery Miles 6 250 Save R163 (21%) Shipped within 7 - 12 working days

The book gives an overview of developments in Quantitative Genetics and variance component analysis in an era of Big Data and Sequenced Genomes. It provides a detailed description of a direct method of estimation that will be a useful means of extracting information from a large set of data that was inconceivable 10 to 20 years ago.The book is a combination of a history of variance component analysis and a forward looking view as to how direct methods of estimation arise from the availability of big data sets and sequenced genomes of each individual in the sample.Many papers and books on quantitative genetics versions of the general linear model from statistics are useful for analyzing the data, using relatively small sets of data. In this book, new methods of direct estimation are introduced and analyzed that are appropriate for an era of big sets of data and sequences genomes. These direct methods of estimation are based on taking conditional expectations rather the methods of least squares that characterize many applications of the general linear model of statistics.

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