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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA

Metagenomics - Current Advances and Emerging Concepts (Paperback): Diana Marco Metagenomics - Current Advances and Emerging Concepts (Paperback)
Diana Marco
R5,642 Discovery Miles 56 420 Ships in 10 - 15 working days
The CRISPR/Cas System - Emerging Technology and Application (Paperback): Muhammad Jamal The CRISPR/Cas System - Emerging Technology and Application (Paperback)
Muhammad Jamal
R5,653 Discovery Miles 56 530 Ships in 10 - 15 working days
Genome Editing (Hardcover, 1st ed. 2016): Kursad Turksen Genome Editing (Hardcover, 1st ed. 2016)
Kursad Turksen
R3,601 Discovery Miles 36 010 Ships in 10 - 15 working days

This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions. Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.

Synthetic mRNA - Production, Introduction Into Cells, and Physiological Consequences (Hardcover, 1st ed. 2016): Robert E. Rhoads Synthetic mRNA - Production, Introduction Into Cells, and Physiological Consequences (Hardcover, 1st ed. 2016)
Robert E. Rhoads
R6,122 Discovery Miles 61 220 Ships in 10 - 15 working days

This volume presents detailed laboratory protocols for in vitro synthesis of mRNA with favorable properties, its introduction into cells by a variety of techniques, and the measurement of physiological and clinical consequences such as protein replacement and cancer immunotherapy. Synthetic techniques are described for structural features in mRNA that provide investigational tools such as fluorescence emission, click chemistry, photo-chemical crosslinking, and that produce mRNA with increased stability in the cell, increased translational efficiency, and reduced activation of the innate immune response. Protocols are described for clinical applications such as large-scale transfection of dendritic cells, production of GMP-grade mRNA, redirecting T cell specificity, and use of molecular adjuvants for RNA vaccines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Synthetic mRNA: Production, Introduction into Cells, and Physiological Consequences is a valuable and cutting-edge resource for both laboratory investigators and clinicians interested in this powerful and rapidly evolving technology.

Genes and DNA - A Beginner's Guide to Genetics and Its Applications (Paperback, New): Charlotte Omoto Genes and DNA - A Beginner's Guide to Genetics and Its Applications (Paperback, New)
Charlotte Omoto
R797 Discovery Miles 7 970 Ships in 12 - 17 working days

Covering newsworthy aspects of contemporary biology -- gene therapy, the Human Genome Project, DNA testing, and genetic engineering -- as well as fundamental concepts, this book, written specifically for nonbiologists, discusses classical and molecular genetics, quantitative and population genetics -- including cloning and genetic diseases -- and the many applications of genetics to the world around us, from genetically modified foods to genetic testing.

With minimal technical terminology and jargon, "Genes and DNA" facilitates conceptual understanding. Eschewing the organization of traditional genetics texts, the authors have provided an organic progression of information: topics are introduced as needed, within a broader framework that makes them meaningful for nonbiologists. The book encourages the reader to think independently, always stressing scientific background and current facts.

Understanding Forensic DNA (Hardcover): Suzanne Bell, John M. Butler Understanding Forensic DNA (Hardcover)
Suzanne Bell, John M. Butler
R1,222 Discovery Miles 12 220 Ships in 12 - 17 working days

Forensic DNA analysis plays a central role in the judicial system. A DNA sample can change the course of an investigation with immense consequences. Because DNA typing is recognized as the epitome of forensic science, increasing public awareness in this area is vital. Through several cases, examples and illustrations, this book explains the basic principles of forensic DNA typing, and how it integrates with law enforcement investigations and legal decisions. Written for a general readership, Understanding Forensic DNA explains both the power and the limitations of DNA analysis. This book dispels common misunderstandings regarding DNA analysis and shows how astounding match probabilities such as one-in-a-trillion are calculated, what they really mean, and why DNA alone never solves a case.

Plant Genotyping - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2015): Jacqueline Batley Plant Genotyping - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2015)
Jacqueline Batley
R4,568 Discovery Miles 45 680 Ships in 10 - 15 working days

The ability to produce vast amounts of DNA sequence data has enabled the discovery of molecular markers in model organisms, crops, as well as orphan species making genotyping the rate limiting factor, and this volume focuses on the different markers available and the low to high throughput genotyping of these markers. Given the diverse nature of some of these systems, an overview is provided on the identification of markers from sequence data, as well as data analysis with example applications once the genotyping data has been generated. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Plant Genotyping: Methods and Protocols is aimed at plant molecular biologists, geneticists, plant breeders and ecologists who have a target question and need to know the most suitable markers and genotyping system to use.

Modified Nucleic Acids (Hardcover, 1st ed. 2016): Kazuhiko Nakatani, Yitzhak Tor Modified Nucleic Acids (Hardcover, 1st ed. 2016)
Kazuhiko Nakatani, Yitzhak Tor
R3,944 Discovery Miles 39 440 Ships in 10 - 15 working days

This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.

Statistical Genomics - Methods and Protocols (Hardcover, 1st ed. 2016): Ewy Mathe, Sean Davis Statistical Genomics - Methods and Protocols (Hardcover, 1st ed. 2016)
Ewy Mathe, Sean Davis
R5,258 Discovery Miles 52 580 Ships in 10 - 15 working days

This volume expands on statistical analysis of genomic data by discussing cross-cutting groundwork material, public data repositories, common applications, and representative tools for operating on genomic data. Statistical Genomics: Methods and Protocols is divided into four sections. The first section discusses overview material and resources that can be applied across topics mentioned throughout the book. The second section covers prominent public repositories for genomic data. The third section presents several different biological applications of statistical genomics, and the fourth section highlights software tools that can be used to facilitate ad-hoc analysis and data integration. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible analysis protocols, and tips on troubleshooting and avoiding known pitfalls. Through and practical, Statistical Genomics: Methods and Protocols, explores a range of both applications and tools and is ideal for anyone interested in the statistical analysis of genomic data.

The Initiation of DNA Replication in Eukaryotes (Hardcover, 1st ed. 2016): Daniel L. Kaplan The Initiation of DNA Replication in Eukaryotes (Hardcover, 1st ed. 2016)
Daniel L. Kaplan
R6,314 Discovery Miles 63 140 Ships in 10 - 15 working days

Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

PCR Primer Design (Hardcover, 2nd ed. 2015): Chhandak Basu PCR Primer Design (Hardcover, 2nd ed. 2015)
Chhandak Basu
R6,331 Discovery Miles 63 310 Ships in 10 - 15 working days

This volume provides an overview on design PCR primers for successful DNA amplification. Chapters focus on primer design strategies for quantitative PCR, in silico PCR primer design, and primer design using software. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, PCR Primer Design, Second Edition seeks to aid molecular biology students, researchers, professors and PCR enthusiasts.

Alien Introgression in Wheat - Cytogenetics, Molecular Biology, and Genomics (Hardcover, 1st ed. 2015): Marta Molnar-Lang,... Alien Introgression in Wheat - Cytogenetics, Molecular Biology, and Genomics (Hardcover, 1st ed. 2015)
Marta Molnar-Lang, Carla Ceoloni, Jaroslav Dolezel
R5,776 Discovery Miles 57 760 Ships in 10 - 15 working days

This book provides an overview of the latest advancements in the field of alien introgression in wheat. The discovery and wide application of molecular genetic techniques including molecular markers, in situ hybridization, and genomics has led to a surge in interspecific and intergeneric hybridization in recent decades. The work begins with the taxonomy of cereals, especially of those species which are potential gene sources for wheat improvement. The text then goes on to cover the origin of wheat, breeding in connection with alien introgressions, and the problems of producing intergeneric hybrids and backcross derivatives. These problems can include crossability, sterility, and unequal chromosome transmission. The work then covers alien introgressions according to the related species used, as well as new results in the field of genomics of wild wheat relatives and introgressions.

Pyrosequencing - Methods and Protocols (Hardcover, 2nd ed. 2015): Ulrich Lehmann, Joerg Tost Pyrosequencing - Methods and Protocols (Hardcover, 2nd ed. 2015)
Ulrich Lehmann, Joerg Tost
R3,067 Discovery Miles 30 670 Ships in 10 - 15 working days

The primary purpose of this volume is to demonstrate the range of applications of the Pyrosequencing technology in research and diagnostics and to provide detailed protocols. Beginning with an up-to-date overview of the biochemistry, the volume continues with quantitative analysis of genetic variation, ratio of expressed alleles at the RNA level, analysis of DNA methylation, global DNA methylation assays, specialized applications for DNA methylation analysis including loss of imprinting, single blastocyst analysis, allele-specific DNA methylation patterns, DNA methylation patterns associated with specific histone modifications. The volume further details tools and protocols for the detection of viruses and bacteria, and genetic and epigenetic analyses for forensics using Pyrosequencing. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and adaptable, Pyrosequencing: Methods and Protocols, Second Edition will greatly aid doctorial students, postdoctoral investigators and research scientists studying different aspects of genetics and cellular and molecular biology.

Primer to Analysis of Genomic Data Using R (Paperback): Cedric Gondro Primer to Analysis of Genomic Data Using R (Paperback)
Cedric Gondro
R2,568 Discovery Miles 25 680 Ships in 10 - 15 working days

Through this book, researchers and students will learn to use R for analysis of large-scale genomic data and how to create routines to automate analytical steps. The philosophy behind the book is to start with real world raw datasets and perform all the analytical steps needed to reach final results. Though theory plays an important role, this is a practical book for graduate and undergraduate courses in bioinformatics and genomic analysis or for use in lab sessions. How to handle and manage high-throughput genomic data, create automated workflows and speed up analyses in R is also taught. A wide range of R packages useful for working with genomic data are illustrated with practical examples. The key topics covered are association studies, genomic prediction, estimation of population genetic parameters and diversity, gene expression analysis, functional annotation of results using publically available databases and how to work efficiently in R with large genomic datasets. Important principles are demonstrated and illustrated through engaging examples which invite the reader to work with the provided datasets. Some methods that are discussed in this volume include: signatures of selection, population parameters (LD, FST, FIS, etc); use of a genomic relationship matrix for population diversity studies; use of SNP data for parentage testing; snpBLUP and gBLUP for genomic prediction. Step-by-step, all the R code required for a genome-wide association study is shown: starting from raw SNP data, how to build databases to handle and manage the data, quality control and filtering measures, association testing and evaluation of results, through to identification and functional annotation of candidate genes. Similarly, gene expression analyses are shown using microarray and RNAseq data. At a time when genomic data is decidedly big, the skills from this book are critical. In recent years R has become the de facto< tool for analysis of gene expression data, in addition to its prominent role in analysis of genomic data. Benefits to using R include the integrated development environment for analysis, flexibility and control of the analytic workflow. Included topics are core components of advanced undergraduate and graduate classes in bioinformatics, genomics and statistical genetics. This book is also designed to be used by students in computer science and statistics who want to learn the practical aspects of genomic analysis without delving into algorithmic details. The datasets used throughout the book may be downloaded from the publisher's website.

Computational and Statistical Epigenomics (Hardcover, 2015 ed.): Andrew E. Teschendorff Computational and Statistical Epigenomics (Hardcover, 2015 ed.)
Andrew E. Teschendorff
R3,832 Discovery Miles 38 320 Ships in 10 - 15 working days

This book introduces the reader to modern computational and statistical tools for translational epigenomics research. Over the last decade, epigenomics has emerged as a key area of molecular biology, epidemiology and genome medicine. Epigenomics not only offers us a deeper understanding of fundamental cellular biology, but also provides us with the basis for an improved understanding and management of complex diseases. From novel biomarkers for risk prediction, early detection, diagnosis and prognosis of common diseases, to novel therapeutic strategies, epigenomics is set to play a key role in the personalized medicine of the future. In this book we introduce the reader to some of the most important computational and statistical methods for analyzing epigenomic data, with a special focus on DNA methylation. Topics include normalization, correction for cellular heterogeneity, batch effects, clustering, supervised analysis and integrative methods for systems epigenomics. This book will be of interest to students and researchers in bioinformatics, biostatistics, biologists and clinicians alike. Dr. Andrew E. Teschendorff is Head of the Computational Systems Genomics Lab at the CAS-MPG Partner Institute for Computational Biology, Shanghai, China, as well as an Honorary Research Fellow at the UCL Cancer Institute, University College London, UK.

CRISPR - Methods and Protocols (Hardcover, 2015 ed.): Magnus Lundgren, Emmanuelle Charpentier, Peter C. Fineran CRISPR - Methods and Protocols (Hardcover, 2015 ed.)
Magnus Lundgren, Emmanuelle Charpentier, Peter C. Fineran
R6,977 Discovery Miles 69 770 Ships in 10 - 15 working days

This volume presents a list of cutting-edge protocols for the study of CRISPR-Cas defense systems and their applications at the genomic, genetic, biochemical and structural levels. CRISPR: Methods and Protocols guides readers through techniques that have been developed specifically for the analysis of CRISPR-Cas and techniques adapted from standard protocols of DNA, RNA and protein biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, CRISPR: Methods and Protocols provides a broad list of tools and techniques to study the interdisciplinary aspects of the prokaryotic CRISPR-Cas defense systems.

RNA Scaffolds - Methods and Protocols (Hardcover, 2015 ed.): Luc Ponchon RNA Scaffolds - Methods and Protocols (Hardcover, 2015 ed.)
Luc Ponchon
R4,181 Discovery Miles 41 810 Ships in 10 - 15 working days

This volume provides techniques on recent developments that use RNA scaffolds as molecular tools. RNA Scaffolds: Methods and Protocols guides readers through methods on various domains as molecular biology, nanotechnologies, and structural biology. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Practical and authoritative, RNA Scaffolds: Methods and Protocols will serve as an invaluable reference for those interested in further study into this fascinating field.

DNA Replication - Methods and Protocols (Hardcover, 2nd ed. 2015): Sonya Vengrova, Jacob Dalgaard DNA Replication - Methods and Protocols (Hardcover, 2nd ed. 2015)
Sonya Vengrova, Jacob Dalgaard
R4,436 Discovery Miles 44 360 Ships in 10 - 15 working days

Updated and revised, this thorough volume covers a range of methods focusing on systems, including mammalian, yeast, bacterial and archaeal. This second edition of DNA Replication: Methods and Protocols describes approaches to analyze whole genomes to single molecules, as well as both in vivo and in vitro experiments. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, DNA Replication: Methods and Protocols, Second Edition provides a collections of methods intended for newcomers to this research field and for established laboratories.

Genome Mapping and Genomics in Human and Non-Human Primates (Hardcover, 2015 ed.): Ravindranath Duggirala, Laura Almasy, Sarah... Genome Mapping and Genomics in Human and Non-Human Primates (Hardcover, 2015 ed.)
Ravindranath Duggirala, Laura Almasy, Sarah Williams-Blangero, Solomon F.D. Paul, Chittaranjan Kole
R5,813 Discovery Miles 58 130 Ships in 10 - 15 working days

This book provides an introduction to the latest gene mapping techniques and their applications in biomedical research and evolutionary biology. It especially highlights the advances made in large-scale genomic sequencing. Results of studies that illustrate how the new approaches have improved our understanding of the genetic basis of complex phenotypes including multifactorial diseases (e.g., cardiovascular disease, type 2 diabetes, and obesity), anatomic characteristics (e.g., the craniofacial complex), and neurological and behavioral phenotypes (e.g., human brain structure and nonhuman primate behavior) are presented. Topics covered include linkage and association methods, gene expression, copy number variation, next-generation sequencing, comparative genomics, population structure, and a discussion of the Human Genome Project. Further included are discussions of the use of statistical genetic and genetic epidemiologic techniques to decipher the genetic architecture of normal and disease-related complex phenotypes using data from both humans and non-human primates.

Stress-Induced Mutagenesis (Paperback, 2013 ed.): David Mittelman Stress-Induced Mutagenesis (Paperback, 2013 ed.)
David Mittelman
R5,205 Discovery Miles 52 050 Ships in 10 - 15 working days

The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes. This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.

Omics in Plant Disease Resistance (Paperback): Vijai Bhadauria Omics in Plant Disease Resistance (Paperback)
Vijai Bhadauria
R5,679 Discovery Miles 56 790 Ships in 10 - 15 working days
Plant Functional Genomics - Methods and Protocols (Hardcover, 2nd ed. 2015): Jose M Alonso, Anna N Stepanova Plant Functional Genomics - Methods and Protocols (Hardcover, 2nd ed. 2015)
Jose M Alonso, Anna N Stepanova
R5,753 Discovery Miles 57 530 Ships in 10 - 15 working days

This second edition volume discusses the revolutionary development of faster and less expensive DNA sequencing technologies from the past 10 years and focuses on general technologies that can be utilized by a wide array of plant biologists to address specific questions in their favorite model systems. This book is organized into five parts. Part I examines the tools and methods required for identifying epigenetic and conformational changes at the whole-genome level. Part II presents approaches used to determine key aspects of a gene's function, such as techniques used to identify and characterize gene regulatory networks. This is followed by a discussion of tools used to analyze the levels of mRNA, mRNA translation rates and metabolites. Part III features a compilation of forward and reverse genetic approaches that include recent implementation of high-throughput sequencing in classical methodologies such as QTL mapping. The final two parts explore strategies to facilitate and accelerate the generation and testing of functional DNA elements and basic computational tools used to facilitate the use of systems biology approached by a broad spectrum of plant researchers. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Practical and timely, Plant Functional Genomics: Methods and Protocols, Second Edition highlights the latest developments in DNA sequencing technologies that are likely to continue shaping the future of functional genomics.

Quantitative Real-Time PCR - Methods and Protocols (Hardcover, 2014 ed.): Roberto Biassoni, Alessandro Raso Quantitative Real-Time PCR - Methods and Protocols (Hardcover, 2014 ed.)
Roberto Biassoni, Alessandro Raso
R5,654 Discovery Miles 56 540 Ships in 10 - 15 working days

Quantitative Real-Time PCR: Methods and Protocols focuses on different applications of qPCR ranging from microbiological detections (both viral and bacterial) to pathological applications. Several chapters deal with quality issues which regard the quality of starting material, the knowledge of the minimal information required to both perform an assay and to set the experimental plan, while the others focus on translational medicine applications that are ordered following an approximate logical order of their medical application. The last part of the book gives you an idea of an emerging digital PCR technique that is a unique qPCR approach for measuring nucleic acid, particularly suited for low level detection and to develop non-invasive diagnosis. Written for the Methods in Molecular Biology series, most chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Quantitative Real-Time PCR: Methods and Protocols aims to aid researchers seeking to devise new qPCR-based approaches related to his or her area of investigation.

RNA and DNA Diagnostics (Hardcover, 2015 ed.): Volker A. Erdmann, Stefan Jurga, Jan Barciszewski RNA and DNA Diagnostics (Hardcover, 2015 ed.)
Volker A. Erdmann, Stefan Jurga, Jan Barciszewski
R4,163 Discovery Miles 41 630 Ships in 10 - 15 working days

The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman's famous statement "What I cannot create, I do not understand."

Ten Years of Progress in GW/P Body Research (Paperback, 2013 ed.): Edward K.L. Chan, Marvin J. Fritzler Ten Years of Progress in GW/P Body Research (Paperback, 2013 ed.)
Edward K.L. Chan, Marvin J. Fritzler
R5,192 Discovery Miles 51 920 Ships in 10 - 15 working days

GW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chan's group in 2002. These bodies are now known to be active cytoplasmic foci involved with the new gene regulation process mediated by microRNA that leads to translational repression and mRNA degradation. The detailed biological functions of these cytoplasmic structures are still being uncovered and the idea for this book is to provide the history of the discovery and the major work from different laboratories that has led to the characterization and elucidation of the structure and function of these new multiple subcellular structures.

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