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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA

Advanced Mechanical Models of DNA Elasticity (Paperback): Yakov M. Tseytlin Advanced Mechanical Models of DNA Elasticity (Paperback)
Yakov M. Tseytlin
R2,224 R2,041 Discovery Miles 20 410 Save R183 (8%) Ships in 12 - 17 working days

Advanced Mechanical Models of DNA Elasticity includes coverage on 17 different DNA models and the role of elasticity in biological functions with extensive references. The novel advanced helicoidal model described reflects the direct connection between the molecule helix structure and its specific properties, including nonlinear features and transitions. It provides an introduction to the state of the field of DNA mechanics, known and widely used models with their short analysis, as well as coverage on experimental methods and data, the influence of electrical, magnetic, ionic conditions on the persistence length, and dynamics with viscosity influence. It then addresses the need to understand the nature of the non-linear overstretching transition of DNA under force and why DNA has a negative twist-stretch coupling.

Genomes and Evolution of Charophytes, Bryophytes, Lycophytes and Ferns, Volume 78 (Hardcover): Rensing Stefan Genomes and Evolution of Charophytes, Bryophytes, Lycophytes and Ferns, Volume 78 (Hardcover)
Rensing Stefan
R5,061 Discovery Miles 50 610 Ships in 12 - 17 working days

Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. The series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology, and ecology. Volume 78 focuses on the Genomes and Evolution of Charophytes, Bryophytes, Lycophytes, and Ferns. Sequencing of genomes of 'lower' animals such as sponges or hydrozoans has much informed our understanding of how metazoans evolved. On the plant side of things, sequencing and comparison of a moss and lycophyte genome with those of green algae and flowering plants has greatly informed our understanding of plant evolution. However, it has also become clear that we need to look into genomes of the closest algal relatives to land plants, the charophytes, and into further genomes of bryophytes, lycophytes, and ferns to unravel how land plants evolved.

Sex, Gender, and Epigenetics - From Molecule to Bedside (Paperback): Marianne J. Legato, Dov Feldberg, Marek Glezerman Sex, Gender, and Epigenetics - From Molecule to Bedside (Paperback)
Marianne J. Legato, Dov Feldberg, Marek Glezerman
R3,568 Discovery Miles 35 680 Ships in 12 - 17 working days

Sex, Gender, and Epigenetics: From Molecule to Bedside explores the complex interplay of sex and gender-based influences on gene expression via epigenetic mechanisms. The book provides an overview of the field and evidence gathered to-date that is followed by a discussion of epigenetic pathways by which biological sex and the impact of the environment collaborate to regulate genetic function. The book also analyzes the impact of ancestors' environmental experience on subsequent generations and describes the nature of sex-specific transmission of environmentally induced epigenetic modifications. Here, international leaders in the field discuss both sex-specific normal physiology and the experience of disease, with chapters dedicated to fetal programming, microbiome, cancer, bipolar disorder and schizophrenia, embryogenesis, and oocyte aging, among other topics.

Metabolic Phenotyping in Personalized and Public Healthcare (Hardcover): Jeremy Nicholson, Ara Darzi, Elaine Holmes, John C.... Metabolic Phenotyping in Personalized and Public Healthcare (Hardcover)
Jeremy Nicholson, Ara Darzi, Elaine Holmes, John C. Lindon
R2,606 Discovery Miles 26 060 Ships in 12 - 17 working days

Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches. In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics. In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream.

DNA Replication Across Taxa, Volume 39 (Hardcover): Laura Kaguni DNA Replication Across Taxa, Volume 39 (Hardcover)
Laura Kaguni
R3,573 Discovery Miles 35 730 Ships in 12 - 17 working days

DNA Replication Across Taxa, the latest volume in The Enzymes series summarizes the most important discoveries associated with DNA replication.

Visualizing RNA Dynamics in the Cell, Volume 572 (Hardcover): Grigory S. Filonov, Samie Jaffrey Visualizing RNA Dynamics in the Cell, Volume 572 (Hardcover)
Grigory S. Filonov, Samie Jaffrey
R4,679 Discovery Miles 46 790 Ships in 12 - 17 working days

Methods in Enzymology: Visualizing RNA Dynamics in the Cell continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods visualizing RNA dynamics in the cell, and includes sections on such topics as identification of RNA cis-regulatory sequences, IRAS, IMAGEtags, MERFISH, plant RNA labeling using MS2, and visualization of 5S dynamics in live cells using photostable corn probe.

Genomics: A Very Short Introduction (Paperback): John M. Archibald Genomics: A Very Short Introduction (Paperback)
John M. Archibald
R281 R231 Discovery Miles 2 310 Save R50 (18%) Ships in 9 - 15 working days

Genomics has transformed the biological sciences. From epidemiology and medicine to evolution and forensics, the ability to determine an organism's complete genetic makeup has changed the way science is done and the questions that can be asked of it. Its most celebrated achievement was the Human Genome Project, a technologically challenging endeavor that took thousands of scientists around the world 13 years and over 3 billion US dollars to complete. In this Very Short Introduction John Archibald explores the science of genomics and its rapidly expanding toolbox. Sequencing a human genome now takes only a few days and costs as little as $1,000. The genomes of simple bacteria and viruses can be sequenced in a matter of hours on a device that fits in the palm of your hand. The resulting sequences can be used to better understand our biology in health and disease and to 'personalize' medicine. Archibald shows how the field of genomics is on the cusp of another quantum leap; the implications for science and society are profound. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Omic Studies of Neurodegenerative Disease - Part A, Volume 121 (Hardcover): Michael J. Hurley Omic Studies of Neurodegenerative Disease - Part A, Volume 121 (Hardcover)
Michael J. Hurley
R4,649 Discovery Miles 46 490 Ships in 12 - 17 working days

Omic Studies of Neurodegenerative Disease: Part A is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields. The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research.

Applied Plant Genomics and Biotechnology (Hardcover): Palmiro Poltronieri, Yiguo Hong Applied Plant Genomics and Biotechnology (Hardcover)
Palmiro Poltronieri, Yiguo Hong
R4,175 R3,816 Discovery Miles 38 160 Save R359 (9%) Ships in 12 - 17 working days

Applied plant genomics and biotechnology reviews the recent advancements in the post-genomic era, discussing how different varieties respond to abiotic and biotic stresses, investigating epigenetic modifications and epigenetic memory through analysis of DNA methylation states, applicative uses of RNA silencing and RNA interference in plant physiology and in experimental transgenics, and plants modified to produce high-value pharmaceutical proteins. The book provides an overview of research advances in application of RNA silencing and RNA interference, through Virus-based transient gene expression systems, Virus induced gene complementation (VIGC), Virus induced gene silencing (Sir VIGS, Mr VIGS) Virus-based microRNA silencing (VbMS) and Virus-based RNA mobility assays (VRMA); RNA based vaccines and expression of virus proteins or RNA, and virus-like particles in plants, the potential of virus vaccines and therapeutics, and exploring plants as factories for useful products and pharmaceuticals are topics wholly deepened. The book reviews and discuss Plant Functional Genomic studies discussing the technologies supporting the genetic improvement of plants and the production of plant varieties more resistant to biotic and abiotic stresses. Several important crops are analysed providing a glimpse on the most up-to-date methods and topics of investigation. The book presents a review on current state of GMO, the cisgenesis-derived plants and novel plant products devoid of transgene elements, discuss their regulation and the production of desired traits such as resistance to viruses and disease also in fruit trees and wood trees with long vegetative periods. Several chapters cover aspects of plant physiology related to plant improvement: cytokinin metabolism and hormone signaling pathways are discussed in barley; PARP-domain proteins involved in Stress-Induced Morphogenetic Response, regulation of NAD signaling and ROS dependent synthesis of anthocyanins. Apple allergen isoforms and the various content in different varieties are discussed and approaches to reduce their presence. Euphorbiaceae, castor bean, cassava and Jathropa are discussed at genomic structure, their diseases and viruses, and methods of transformation. Rice genomics and agricultural traits are discussed, and biotechnology for engineering and improve rice varieties. Mango topics are presented with an overview of molecular methods for variety differentiation, and aspects of fruit improvement by traditional and biotechnology methods. Oilseed rape is presented, discussing the genetic diversity, quality traits, genetic maps, genomic selection and comparative genomics for improvement of varieties. Tomato studies are presented, with an overview on the knowledge of the regulatory networks involved in flowering, methods applied to study the tomato genome-wide DNA methylation, its regulation by small RNAs, microRNA-dependent control of transcription factors expression, the development and ripening processes in tomato, genomic studies and fruit modelling to establish fleshy fruit traits of interest; the gene reprogramming during fruit ripening, and the ethylene dependent and independent DNA methylation changes.

Evolution - What Everyone Needs to Know (R) (Paperback): Robin Dunbar Evolution - What Everyone Needs to Know (R) (Paperback)
Robin Dunbar
R342 R280 Discovery Miles 2 800 Save R62 (18%) Ships in 9 - 15 working days

Evolution is one of the most important processes in life. It not only explains the detailed history of life on earth, but its scope also extends into many aspects of our own contemporary behavior-who we are and how we got to be here, our psychology, our cultures-and greatly impacts modern advancements in medicine and conservation biology. Perhaps its most important claim for science is its ability to provide an overarching framework that integrates the many life sciences into a single unified whole. Yet, evolution-evolutionary biology in particular-has been, and continues to be, regarded with suspicion by many. Understanding how and why evolution works, and what it can tell us, is perhaps the single most important contribution to the public perception of science. This book provides an overview of the basic theory and showcases how widely its consequences reverberate across the life sciences, the social sciences and even the humanities. In this book, Robin Dunbar uses examples drawn from plant life, animals and humans to illustrate these processes. Evolutionary science has important advantages. Most of science deals with the microscopic world that we cannot see and invariably have difficulty understanding, but evolution deals with the macro-world in which we live and move. That invariably makes it much easier for the lay audience to appreciate, understand and enjoy. Evolution: What Everyone Needs to Know (R) takes a broad approach to evolution, dealing both with the core theory itself and its impact on different aspects of the world we live in, from the iconic debates of the nineteenth century, to viruses and superbugs, to human evolution and behavior.

Human Reproductive and Prenatal Genetics (Hardcover, 2nd edition): Peter C.K. Leung, Jie Qiao Human Reproductive and Prenatal Genetics (Hardcover, 2nd edition)
Peter C.K. Leung, Jie Qiao
R5,080 Discovery Miles 50 800 Ships in 12 - 17 working days

Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic. This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications.

Junk DNA - A Journey Through the Dark Matter of the Genome (Paperback): Nessa Carey Junk DNA - A Journey Through the Dark Matter of the Genome (Paperback)
Nessa Carey 2
R336 R274 Discovery Miles 2 740 Save R62 (18%) Ships in 9 - 15 working days

For decades, 98 per cent of our DNA was written off as 'junk' on the grounds that it did not code for proteins. From rare genetic diseases to Down's Syndrome, from viral infections to the ageing process, only now are the effects and the vital functions of these junk regions beginning to emerge. Scientists' rapidly growing knowledge of this often controversial field has already provided a successful cure for blindness and saved innocent people from death row via DNA fingerprinting, and looks set to revolutionise treatment for many medical conditions including obesity. From Nessa Carey, author of the acclaimed The Epigenetics Revolution, this is the first book for a general readership on a subject that may underpin the secrets of human complexity - even the very origins of life on earth.

Bayesian Evolutionary Analysis with BEAST (Hardcover): Alexei J. Drummond, Remco R. Bouckaert Bayesian Evolutionary Analysis with BEAST (Hardcover)
Alexei J. Drummond, Remco R. Bouckaert
R1,488 Discovery Miles 14 880 Ships in 12 - 17 working days

What are the models used in phylogenetic analysis and what exactly is involved in Bayesian evolutionary analysis using Markov chain Monte Carlo (MCMC) methods? How can you choose and apply these models, which parameterisations and priors make sense, and how can you diagnose Bayesian MCMC when things go wrong? These are just a few of the questions answered in this comprehensive overview of Bayesian approaches to phylogenetics. This practical guide: * Addresses the theoretical aspects of the field * Advises on how to prepare and perform phylogenetic analysis * Helps with interpreting analyses and visualisation of phylogenies * Describes the software architecture * Helps developing BEAST 2.2 extensions to allow these models to be extended further. With an accompanying website providing example files and tutorials (http://beast2.org/), this one-stop reference to applying the latest phylogenetic models in BEAST 2 will provide essential guidance for all users - from those using phylogenetic tools, to computational biologists and Bayesian statisticians.

DNA Replication & Mutation (Hardcover, New): Raymond P Leitner DNA Replication & Mutation (Hardcover, New)
Raymond P Leitner
R2,772 Discovery Miles 27 720 Ships in 12 - 17 working days

In this book, the authors present current research in the study of DNA replication and mutation, including connections between BLM and the Fanconi anemia pathway in the repair of replication fork damage; the mutagenic potential of methacrylates used in restorative dentistry; DNA mutation of the progranulin gene in familial frontotemporal lobar degeneration; effect of DNA polymerase a-inhibitor dehydroaltenusin on DNA replication in cultured cells; gel-based methods of DNA-binding zinc II complexes in the detection of DNA mutations and DNA mutations and genetic coding.

Molecular Machines - A Materials Science Approach (Hardcover): Giovanni Zocchi Molecular Machines - A Materials Science Approach (Hardcover)
Giovanni Zocchi
R1,589 R1,384 Discovery Miles 13 840 Save R205 (13%) Ships in 12 - 17 working days

Molecular Machines presents a dynamic new approach to the physics of enzymes and DNA from the perspective of materials science. Unified around the concept of molecular deformability-how proteins and DNA stretch, fold, and change shape-this book describes the complex molecules of life from the innovative perspective of materials properties and dynamics, in contrast to structural or purely chemical approaches. It covers a wealth of topics, including nonlinear deformability of enzymes and DNA; the chemo-dynamic cycle of enzymes; supra-molecular constructions with internal stress; nano-rheology and viscoelasticity; and chemical kinetics, Brownian motion, and barrier crossing. Essential reading for researchers in materials science, engineering, and nanotechnology, the book also describes the landmark experiments that have established the materials properties and energy landscape of large biological molecules. Molecular Machines is also ideal for the classroom. It gives graduate students a working knowledge of model building in statistical mechanics, making it an essential resource for tomorrow's experimentalists in this cutting-edge field. In addition, mathematical methods are introduced in the bio-molecular context-for example, DNA conformational transitions are used to illustrate the transfer matrix formalism. The result is a generalized approach to mathematical problem solving that enables students to apply their findings more broadly. Molecular Machines represents the next leap forward in nanoscience, as researchers strive to harness proteins, enzymes, and DNA as veritable machines in medicine, technology, and beyond.

Introduction To Computational Metagenomics (Hardcover): Zhong Wang Introduction To Computational Metagenomics (Hardcover)
Zhong Wang
R2,253 Discovery Miles 22 530 Ships in 9 - 15 working days

Breakthroughs in high-throughput genome sequencing and high-performance computing technologies have empowered scientists to decode many genomes including our own. Now they have a bigger ambition: to fully understand the vast diversity of microbial communities within us and around us, and to exploit their potential for the improvement of our health and environment. In this new field called metagenomics, microbial genomes are sequenced directly from the habitats without lab cultivation. Computational metagenomics, however, faces both a data challenge that deals with tens of tera-bases of sequences and an algorithmic one that deals with the complexity of thousands of species and their interactions.This interdisciplinary book is essential reading for those who are interested in beginning their own journey in computational metagenomics. It is a prism to look through various intricate computational metagenomics problems and unravel their three distinctive aspects: metagenomics, data engineering, and algorithms. Graduate students and advanced undergraduates from genomics science or computer science fields will find that the concepts explained in this book can serve as stepping stones for more advanced topics, while metagenomics practitioners and researchers from similar disciplines may use it to broaden their knowledge or identify new research targets.

Seed Genomics (Hardcover): PW Becraft Seed Genomics (Hardcover)
PW Becraft
R5,150 Discovery Miles 51 500 Ships in 12 - 17 working days

This up-to-date review of seed genomics, from basic seed biology to practical applications in crop science, provides a thorough background understanding of seed biology from a basic science perspective. A valuable resource for advanced graduate students, post-docs, researchers and professionals in the Plant and Crop Sciences, this book brings together top researchers in the field to cover three general themes: genomic approaches to studying seeds, genomic analysis of basic seed biology, and crop seed genomics.A valuable resource for advanced graduate students, post-docs, researchers and professionals in the Plant and Crop Sciences

Quantum DNA Healing - Consciousness Techniques for Altering Your Genetic Destiny (Paperback): Althea S Hawk Quantum DNA Healing - Consciousness Techniques for Altering Your Genetic Destiny (Paperback)
Althea S Hawk
R405 R274 Discovery Miles 2 740 Save R131 (32%) Ships in 12 - 17 working days

Sharing the discoveries that enabled her to successfully heal from her cancer, tumors, toxicity, and inflammatory-related conditions, the author explains how genes are not solely responsible for creating disease. She shows how human physiology interacts with the quantum energies of our external and personal environments and how the resulting information triggers the development and persistence of disease and chronic conditions. We each inherit susceptibilities, but it is our unique experience of these environmental factors, as well as our beliefs, thoughts, and emotions, that alter the way our genes are expressed. Detailing how our DNA is both quantum-energetic and biological-chemical, Hawk explains how your environment and your consciousness influence your quantum DNA, which in turn interacts with your biological DNA. By working directly with energetic information that affects how your quantum and biological DNA communicate, you can alter the expression of your genes by re-encoding the gene sequences on your physical DNA, erasing the imprint of illness and enabling your body to remember how to function properly.

Psychiatric Genomics (Paperback): Evangelia Eirini Tsermpini, Martin Alda, George P Patrinos Psychiatric Genomics (Paperback)
Evangelia Eirini Tsermpini, Martin Alda, George P Patrinos
R3,596 Discovery Miles 35 960 Ships in 12 - 17 working days

Psychiatric Genomics presents and synthesizes available knowledge in the field of psychiatric genomics, offering methodologies to advance new research and aid clinical translation. After providing an introduction to genomics and psychiatry, international experts discuss the genomic basis of schizophrenia, bipolar disorder, depression, personality disorders, anxiety disorders, addictions, eating disorders, and sleep disorders, among other disorders. In addition, recommendations for next steps in clinical implementation and drug discovery are discussed in-depth, with chapters dedicated to pharmacogenomics and antipsychotics, antidepressants and mood stabilizers, adverse drug reactions, implementation of pharmacogenomics in psychiatric clinics, and ethical issues. Finally, methods sections provide a solid grounding in research approaches and computational analytics, from using animal models in psychiatric genomics and accessing biobanks, to employing computational analysis, genome-wide association studies (GWAS), brain pathophysiology, and endophenotypes in psychiatric research.

Signals, Switches, Regulons, and Cascades - Control of Bacterial Gene Expression (Hardcover): David A. Hodgson, C. M. Thomas Signals, Switches, Regulons, and Cascades - Control of Bacterial Gene Expression (Hardcover)
David A. Hodgson, C. M. Thomas
R2,464 R2,017 Discovery Miles 20 170 Save R447 (18%) Ships in 12 - 17 working days

The use of DNA arrays and proteomics will transform the scale of our ability to describe the patterns of gene expression as bacteria respond to their environments. However, the ability to control bacteria in a clinical context or exploit them in industrial or environmental contexts also depends on understanding the regulatory mechanisms which connect input experience to output response at the genetic level. This book deals with our current knowledge of the circuits and networks that govern bacterial gene expression--from the single gene to the whole genome--and which provide the framework for explaining the data from the post genomics revolution.

The Epigenetics Revolution - How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance... The Epigenetics Revolution - How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance (Hardcover)
Nessa Carey
R745 R629 Discovery Miles 6 290 Save R116 (16%) Ships in 10 - 15 working days

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics.

Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.

Epigenetics in Precision Medicine, Volume 30 (Paperback): Jose Luis Garcia-Gimenez Epigenetics in Precision Medicine, Volume 30 (Paperback)
Jose Luis Garcia-Gimenez
R3,653 Discovery Miles 36 530 Ships in 12 - 17 working days

In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease.

Progress in Genomic Medicine - From Research to Clinical Application (Paperback): Moyra Smith Progress in Genomic Medicine - From Research to Clinical Application (Paperback)
Moyra Smith
R3,062 Discovery Miles 30 620 Ships in 12 - 17 working days

Progress in Genomic Medicine: From Research to Clinical Application provides a careful synthesis of the foundations, current trends and translational challenges in genomic medicine, clarifying pathways forward and enabling genomic medicine research and implementation across clinical settings and treatment development. Sections address the history and growth of genetic medicine, with a discussion of key studies in syndrome delineations, inherited diseases, biochemical genetics, and chromosome abnormalities, overview clinical applications made possible through genomic advances, with chapters on DNA sequencing for clinical genetic diagnosis, genotype-phenotype correlations in individuals and across populations, new-born screening for treatable genetic disorders, and more. In addition, social, ethical and public health aspects of applying genomic technologies are included throughout. Here, Dr. Smith applies her experience and participation in the field, across its major milestones, to put current research, clinical advances, and ongoing questions in context.

Epigenetics and Metabolomics, Volume 28 (Paperback): Paban K. Agrawala, Poonam Rana Epigenetics and Metabolomics, Volume 28 (Paperback)
Paban K. Agrawala, Poonam Rana; Series edited by Trygve Tollefsbol
R3,632 Discovery Miles 36 320 Ships in 12 - 17 working days

Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare.

Immortal - Our Cells, DNA, and Bodies (Paperback): David Goldman Immortal - Our Cells, DNA, and Bodies (Paperback)
David Goldman
R1,806 Discovery Miles 18 060 Ships in 12 - 17 working days

In recent times, the boundary between living and non-living has been blurred by advances in genomics, cell biology, and molecular neuroscience, whereby humans are repaired, enhanced, or made anew. Scientists and physicians are now able to keep cells, organs, and bodies alive indefinitely and can return cells or DNA to our bodies and make new cells for the purpose of treating disease or growing new tissue. Meanwhile, transhuman technologies create illusions of immortality. Immortal: Our Cells, DNA, and Bodies synthesizes what we know about life and death from a genetic, molecular, and cellular perspective, demarcates limits of knowledge, and poses new questions. Award-winning researcher and writer David Goldman examines in-depth three keys to understanding the nature and continuity of life: 1) epigenetic (ephemeral) vs genetic (durable) transgenerational memory; 2) life's cellular nature, and the ability to make bodies from cells; and 3) the distinction between bodies and persons. Grounded in recent scientific evidence and real-life cases that test our historical understanding of life and death, Goldman probes the nature of molecular continuity in the face of mortal extinction, encompassing how changes to the DNA code can be both long-lasting and transgenerational, and the continuous nature of cellular and molecular information transmission. In tying these themes together, Immortal asks us to apply fresh scientific concepts to examine, for ourselves, the continuity of being in the face of mortality.

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