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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA
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DNA Topoisomerase Protocols - Volume I: DNA Topology and Enzymes (Hardcover, 1999 ed.)
Loot Price: R3,063
Discovery Miles 30 630
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DNA Topoisomerase Protocols - Volume I: DNA Topology and Enzymes (Hardcover, 1999 ed.)
Series: Methods in Molecular Biology, 94
Expected to ship within 10 - 15 working days
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Beginning with the Escherichia coli co protein, or bacterial DNA
topoisomerase I, an ever-increasing number of enzymes has been
identified that catalyze changes in the linkage of DNA strands. DNA
topoisomerases are ubiquitous in nature and have been shown to play
critical roles in most p- cesses involving DNA, including DNA
replication, transcription, and rec- bination. These enzymes
further constitute the cellular targets of a number of clinically
important antibacterial and anticancer agents. Thus, further
studies of DNA topology and DNA topoisomerases are critical to
advance our und- standing of the basic biological processes
required for cell cycle progression, cell division, genomic
stability, and development. In addition, these studies will
continue to provide critical insights into the cytofoxic action of
drugs that target DNA topoisomerases. Such mechanistic studies have
already played an important role in the development and clinical
application of antimicrobial and chemotherapeutic agents. The two
volumes of DNA Topoisomerase Protocols are designed to help new and
established researchers investigate all aspects of DNA topology and
the function of these enzymes. The chapters are written by
prominent investigators in the field and provide detailed
background information and st- by-step experimental protocols. The
topics covered in Volume I; DNA Topology and Enzymes, range from
detailed methods to analyze various aspects of DNA structure, from
linking number, knotting/unknotting, site-specific recombi- tion,
and decatenation to the overexpression and purification of
bacterial and eukaryotic DNA topoisomerases from a variety of cell
systems and tissues.
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