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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA

Transposons and Retrotransposons - Methods and Protocols (Hardcover, 1st ed. 2016): Jose Luis Garcia Perez Transposons and Retrotransposons - Methods and Protocols (Hardcover, 1st ed. 2016)
Jose Luis Garcia Perez
R3,638 R2,913 Discovery Miles 29 130 Save R725 (20%) Shipped within 7 - 12 working days

This volume covers the latest protocols designed to identify and characterize TEs in genomes, ancient or recently inserted. Additionally, this book includes a series of protocols designed to understand how host genomes act to regulate the activity of TEs, from elegant genetic mobilization assays to key biochemical methods. Finally, this book also includes chapters that describe how TEs can be used for biotechnological applications. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Transposons and Retrotransposons: Methods and Protocols aims to ensure successful results in the further study of this vital field.

microRNA: Cancer - From Molecular Biology to Clinical Practice (Hardcover, 1st ed. 2015): Gaetano Santulli microRNA: Cancer - From Molecular Biology to Clinical Practice (Hardcover, 1st ed. 2015)
Gaetano Santulli
R3,164 R2,851 Discovery Miles 28 510 Save R313 (10%) Shipped within 7 - 12 working days

This volume thoroughly explores of the functional role of microRNAs in cancer. It not only expertly describes the molecular mechanisms underlying the malignant transformation process but also compiles cutting-edge research on microRNAs in several forms of cancer, including colorectal cancer, pancreatic cancer, leukemia/lymphoma, prostate cancer, lung cancer, ovarian cancer, and bone cancer. Distinguished experts, currently working in prestigious institutions, elegantly discuss these fundamental themes. The text, which opens with a foreword by the renowned Dr. Carlo M. Croce, is enhanced by abundant color photographs, schemes, diagrams, and tables that fully support and complement the content. microRNA: Cancer is an ideal companion to both microRNA: Basic Science andmicroRNA: Medical Evidence. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.

microRNA: Medical Evidence - From  Molecular Biology to Clinical Practice (Hardcover, 1st ed. 2015): Gaetano Santulli microRNA: Medical Evidence - From Molecular Biology to Clinical Practice (Hardcover, 1st ed. 2015)
Gaetano Santulli
R3,575 R3,236 Discovery Miles 32 360 Save R339 (9%) Shipped within 7 - 12 working days

This volume explores microRNA function in a wide array of human disorders, providing a clinical basis for precision medicine and personalized therapies using these molecules. The twenty-one chapters, all authored by internationally-renowned experts, open with an introduction contextualizing microRNA manipulation within today's initiatives towards precision medicine. The following chapters explore the clinical role of microRNAs in the diagnosis and treatment of metabolic and cardiovascular disorders, focusing on mitochondrial fitness, arterial hypertension, cardiovascular remodeling, cerebrovascular disease, pulmonary hypertension, diabetic kidney disease, and kidney transplantation. The subsequent chapters discuss the importance of microRNAs in the wound healing process and in skin disease, in the pathogenesis of allergy, in human ovulation, and in infection. The book concludes with chapters which outline the emerging role of microRNAS in doping and detail microRNA profiling. microRNA: Medical Evidence is an ideal companion to both microRNA: Basic Scienceand microRNA: Cancer. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from themolecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.

microRNA: Basic Science - From  Molecular Biology to Clinical Practice (Hardcover, 1st ed. 2015): Gaetano Santulli microRNA: Basic Science - From Molecular Biology to Clinical Practice (Hardcover, 1st ed. 2015)
Gaetano Santulli
R3,406 R2,682 Discovery Miles 26 820 Save R724 (21%) Shipped within 7 - 12 working days

This volume explores microRNA pathophysiology, focusing on basic concepts in molecular and cellular biology. Chapters contributed by leading scientists examine recently discovered pathways in several processes, including aging, diabetes, cardiovascular disease, hematopoiesis, and mitochondrial fitness. The authors contextualize microRNAs within epigenetics and micropeptidomics, angiongenesis and atherosclerosis, endometrial pathophysiology, and more. Throughout, numerous color photographs, diagrams of molecular pathways, and tables enhance the text. microRNA: Basic Science is an ideal companion to both microRNA: Medical Evidenceand microRNA: Cancer. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.

Mitochondrial DNA - Methods and Protocols (Hardcover, 3rd ed. 2016): Matthew McKenzie Mitochondrial DNA - Methods and Protocols (Hardcover, 3rd ed. 2016)
Matthew McKenzie
R3,460 R2,735 Discovery Miles 27 350 Save R725 (21%) Shipped within 7 - 12 working days

This third edition is comprised of well-established protocols that are considered the gold standard in the field as well as new methodologies for mitochondrial DNA analysis. of Mitochondrial DNA: Methods and Protocols describes protocols for detecting mutations in mitochondrial DNA, techniques to assess mitochondrial DNA damage, visualization of mitochondrial DNA in situ, detection of mitochondrial DNA nucleoids within the mitochondria, methods for analyzing mitochondrial DNA replication, mitochondrial DNA-encoded protein translation and mitochondrial DNA copy number, the latest technologies for modifying the mitochondrial genome and methods for the purification of proteins involved in the replication and transcription of mitochondrial DNA. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mitochondrial DNA: Methods and Protocols, Third Edition will be useful not only for mitochondrial researchers but also for scientists studying human diseases where mitochondrial DNA variation has been recognized as an important pathogenic factor, including cancer and neurodegeneration.

DNA Repair and Replication - Mechanisms and Clinical Significance (Paperback): Roger J. A. Grand, John J. Reynolds DNA Repair and Replication - Mechanisms and Clinical Significance (Paperback)
Roger J. A. Grand, John J. Reynolds
R1,107 Discovery Miles 11 070 Shipped within 7 - 12 working days

DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response, emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease, with particular focus on both the causes and treatments which make use of DNA Damage Repair (DDR) pathways. Key Selling Features: Chapters written by leading researchers Includes description of replication processes, causes of damage, and methods of repair

Latent Fingerprint Examination - Elements, Human Factors & Recommendations (Hardcover): Eva Accursio Latent Fingerprint Examination - Elements, Human Factors & Recommendations (Hardcover)
Eva Accursio
R4,832 R3,655 Discovery Miles 36 550 Save R1,177 (24%) Shipped within 7 - 12 working days

Fingerprints have provided a valuable method of personal identification in forensic science and criminal investigations for over 100 years. Fingerprints left at crime scenes generally are latent prints -- unintentional reproductions of the arrangement of ridges on the skin made by the transfer of materials (such as amino acids, proteins, polypeptides, and salts) to a surface. Palms and the soles of feet also have friction ridge skin that can leave latent prints. The examination of a latent print consists of a series of steps involving a comparison of the latent print to a known (or exemplar) print. Courts have accepted latent print evidence for the past century. However, several high-profile cases in the United States and abroad have highlighted the fact that human errors can occur, and litigation and expressions of concern over the evidentiary reliability of latent print examinations and other forensic identification procedures has increased in the last decade. This book discusses latent print examinations in detail, and provides methods to improving the practice through a systems approach.

Tumor Profiling - Methods and Protocols (Hardcover, 1st ed. 2019): Sarah S Murray Tumor Profiling - Methods and Protocols (Hardcover, 1st ed. 2019)
Sarah S Murray
R3,334 R2,840 Discovery Miles 28 400 Save R494 (15%) Shipped within 7 - 12 working days

This book provides a practical guide to current methods for profiling and interpreting genomic alterations in tumors. Chapters detail methods to interrogate DNA variation, RNA expression, and epigenetic changes using both next-generation sequencing and microarray techniques, common bioinformatics and annotation tools to glean relevant driver genomic events, and different performance characteristics as well as quality metrics necessary for the robust validation of tumor profiling as a diagnostic test for medical laboratories. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Tumor Profiling: Methods and Protocols aims to be a useful resource for learning about technical details, applications, and strengths and limitations of the latest technologies as applied to this increasingly important field.

A Primer of Molecular Population Genetics (Hardcover): Asher D. Cutter A Primer of Molecular Population Genetics (Hardcover)
Asher D. Cutter
R2,013 Discovery Miles 20 130 Shipped within 7 - 12 working days

What are the genomic signatures of adaptations in DNA? How often does natural selection dictate changes to DNA? How does the ebb and flow in the abundance of individuals over time get marked onto chromosomes to record genetic history? Molecular population genetics seeks to answer such questions by explaining genetic variation and molecular evolution from micro-evolutionary principles. It provides a way to learn about how evolution works and how it shapes species by incorporating molecular details of DNA as the heritable material. It enables us to understand the logic of how mutations originate, change in abundance in populations, and become fixed as DNA sequence divergence between species. With the revolutionary advances in genomic data acquisition, understanding molecular population genetics is now a fundamental requirement for today's life scientists. These concepts apply in analysis of personal genomics, genome-wide association studies, landscape and conservation genetics, forensics, molecular anthropology, and selection scans. This book introduces, in an accessible way, the bare essentials of the theory and practice of molecular population genetics.

Bacterial Genomics - Genome Organization and Gene Expression Tools (Hardcover): Aswin Sai Narain Seshasayee Bacterial Genomics - Genome Organization and Gene Expression Tools (Hardcover)
Aswin Sai Narain Seshasayee
R1,561 R1,445 Discovery Miles 14 450 Save R116 (7%) Shipped within 7 - 12 working days

The study of bacterial genetics has revolutionised with the development of genome sequencing, which let us catalogue the gene content of various clinically and industrially important bacteria and opened up the field of comparative genomics. The research findings on bacterial genetics were further enhanced by the development of allied techniques that allowed interrogation of the interactions and functions of the many components of the genome. These developments accelerated with the widespread adoption of quantitative deep-sequencing approaches. This process allowed both comparative and functional genomics on an unprecedented scale by presenting powerful tools to investigate multiple layers of bacterial adaptation and evolution. This book presents the application of genomic tools to examine bacterial adaptation. The emphasis is on data analysis and interpretation. Much of the material is drawn from the recent, primary literature, which is the most powerful tool in the cutting-edge and fast-growing field of bacterial research.

Our Posthuman Future - Consequences of the Biotechnology Revolution (Paperback, Main): Francis Fukuyama Our Posthuman Future - Consequences of the Biotechnology Revolution (Paperback, Main)
Francis Fukuyama 2
R259 Discovery Miles 2 590 Shipped within 7 - 11 working days

Is a baby whose personality has been chosen from a gene supermarket still a human? If we choose what we create what happens to morality? Is this the end of human nature? The dramatic advances in DNA technology over the last few years are the stuff of science fiction. It is now not only possible to clone human beings it is happening. For the first time since the creation of the earth four billion years ago, or the emergence of mankind 10 million years ago, people will be able to choose their children's' sex, height, colour, personality traits and intelligence. It will even be possible to create 'superhumans' by mixing human genes with those of other animals for extra strength or longevity. But is this desirable? What are the moral and political consequences? Will it mean anything to talk about 'human nature' any more? Is this the end of human beings? Our Posthuman Future is a passionate analysis of the greatest political and moral problem ever to face the human race.

Anatomy of Gene Regulation - A Three-Dimensional Structural Analysis (Paperback): Panagiotis A. Tsonis Anatomy of Gene Regulation - A Three-Dimensional Structural Analysis (Paperback)
Panagiotis A. Tsonis
R1,498 R1,408 Discovery Miles 14 080 Save R90 (6%) Shipped within 7 - 12 working days

Anatomy of Gene Regulation is the first book to present the parts and processes of gene regulation at the three-dimensional level. Vivid structures of nucleic acids and their companion proteins are revealed in full-color, three dimensional form. Beginning with a general introduction to three-dimensional structures, the book looks at the organization of the genome, the structure of DNA, DNA replication and transcription, splicing, protein synthesis, and ultimate protein death. This concise and unique synthesis and its accompanying web site offer insight into gene regulation, and into the development of methods to interfere with regulation at diseased states.

The Cosmic Serpent - DNA and the Origins of Knowledge (Paperback, New edition): Jeremy Narby The Cosmic Serpent - DNA and the Origins of Knowledge (Paperback, New edition)
Jeremy Narby
R307 R249 Discovery Miles 2 490 Save R58 (19%) Shipped within 7 - 11 working days

This adventure in science and imagination, which the Medical Tribune said might herald "a Copernican revolution for the life sciences," leads the reader through unexplored jungles and uncharted aspects of mind to the heart of knowledge. In a first-person narrative of scientific discovery that opens new perspectives on biology, anthropology, and the limits of rationalism, The Cosmic Serpent reveals how startlingly different the world around us appears when we open our minds to it.

Genome Informatics 2010: Genome Informatics Series Vol. 24 - Proceedings Of The 10th Annual International Workshop On... Genome Informatics 2010: Genome Informatics Series Vol. 24 - Proceedings Of The 10th Annual International Workshop On Bioinformatics And Systems Biology (Ibsb 2010) (Hardcover, New)
Satoru Miyano, Tatsuya Akutsu, Minoru Kanehisa, Edda Klipp
R2,024 R1,880 Discovery Miles 18 800 Save R144 (7%) Shipped within 7 - 12 working days

This volume contains 18 peer-reviewed papers based on the presentations at the 10th Annual International Workshop on Bioinformatics and Systems Biology (IBSB 2010) held at Kyoto University from July 26 to July 28, 2010. This workshop started in 2001 as an event for doctoral students and young researchers to present and discuss their research results and approaches in bioinformatics and systems biology. It is part of a collaborative educational program involving leading institutions and leaders committed to the following programs:

* Boston Graduate Program in Bioinformatics, Boston University

* Berlin The International Research Training Group (IRTG) "Genomics and Systems Biology of Molecular Networks"

* Kyoto The JSPS International Training Program (ITP) "International Research and Training Program of Bioinformatics and Systems Biology"

* Tokyo Global COE Program "Center of Education and Research for Advanced Genome-Based Medicine"

Genes for Development, Cell Growth & Infectious Diseases - A Decade of Pasteur Riken Collaboration (Paperback): Gabriel... Genes for Development, Cell Growth & Infectious Diseases - A Decade of Pasteur Riken Collaboration (Paperback)
Gabriel Gachelin, Yoji Ikawa, Shunsuke Ishii, Philippe Kourilsky, Moshe Yaniv
R1,170 R906 Discovery Miles 9 060 Save R264 (23%) Shipped within 7 - 12 working days

This work which was published to mark the tenth anniversary of the collaboration between the Institut Pasteur and the Riken Institute in Japan, covers a number of research fields in which both laboratories are active: precocious development in mice and the effect on them of disactivating genes, nuclear oncogenes and their role in controlling cell division, and the molecular bases of bacterial and viral infections. There are also chapters dealing with specific aspects of immune recognition, the genetics of sexual determination in humans and a new technique for studying the human genome. This book is intended for researchers and physicians in the fields of immunology, genetics, bacteriology/virology, cancerology, developmental biology, cellular biology and neurobiology.

Essentials of Nucleic Acid Analysis - A Robust Approach (Hardcover): Jacquie T. Keer, Lyndsey Birch Essentials of Nucleic Acid Analysis - A Robust Approach (Hardcover)
Jacquie T. Keer, Lyndsey Birch; Contributions by John Marriott, Sally Hopkins, Vicki J. Barwick
R3,210 Discovery Miles 32 100 Shipped within 7 - 12 working days

Over the last decade there has been a rapid development of molecular techniques, with an increasing range of instrumentation now available. The development of accompanying reference literature has not kept pace with technological advances and this poses significant challenges to the analyst. Essentials of Nucleic Acid Analysis sets out to guide the analyst through the steps needed to obtain good quality results in DNA analysis. The underlying principles for achieving this goal were formulated by LGC (formerly the Laboratory of the Government Chemist) as the six principles for ensuring valid analytical measurement, which are detailed in the introduction. The reader is also provided with guidelines for method validation and quality control of established and emerging DNA measurement techniques. The authors of each chapter are practitioners of the art of DNA analysis in areas where the quality of the result is critical. Technical details and examples of application of key techniques in nucleic acid analysis are provided while highlighting best practice, available standards and practical advice on improving measurement quality. This book provides an indispensable handbook and premier reference for those working in the widely varying areas and specifically in the fields of food analysis and forensic applications.

Optimal High-Throughput Screening - Practical Experimental Design and Data Analysis for Genome-Scale RNAi Research (Paperback):... Optimal High-Throughput Screening - Practical Experimental Design and Data Analysis for Genome-Scale RNAi Research (Paperback)
Xiaohua Douglas Zhang
R554 Discovery Miles 5 540 Shipped within 7 - 12 working days

This concise, self-contained, and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing, and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.

DNA Methylation - Principles, Mechanisms & Challenges (Hardcover): Tatiana V Tatarinova, Gaurav Sablok DNA Methylation - Principles, Mechanisms & Challenges (Hardcover)
Tatiana V Tatarinova, Gaurav Sablok
R3,158 R2,387 Discovery Miles 23 870 Save R771 (24%) Shipped within 7 - 12 working days

DNA methylation is a cryptic phenomenon that invokes the methylation of the cytosines in nuclear DNA and is responsible for a wide variety of essential processes, starting from cellular differentiation (embryogenesis), transposon silencing, miRNA dependent methylation and gene regulation. This book presents an overview of different aspects of DNA methylation with a focus on its basic principles and mechanisms and gene silencing. Also discussed, is the role of DNA methylation in plants; epigenetic control of circadian clock operation; photoperiodic flowering; and DNA methylation in cancer and its role in multiple sclerosis.

Biocode - The New Age of Genomics (Paperback): Dawn Field, Neil Davies Biocode - The New Age of Genomics (Paperback)
Dawn Field, Neil Davies
R173 R153 Discovery Miles 1 530 Save R20 (12%) Shipped within 4 - 9 working days

The living world runs on genomic software - what Dawn Field and Neil Davies call the 'biocode' - the sum of all DNA on Earth. In Biocode, they tell the story of a new age of scientific discovery: the growing global effort to read and map the biocode, and what that might mean for the future. The structure of DNA was identified in 1953, and the whole human genome was mapped by 2003. Since then the new field of genomics has mushroomed and is now operating on an industrial scale. Genomes can now be sequenced rapidly and increasingly cheaply. The genomes of large numbers of organisms from mammals to microbes, have been mapped. Getting your genome sequenced is becoming affordable for many. You too can check paternity, find out where your ancestors came from, or whether you are at risk of some diseases. Some check out the pedigree of their pets, while others turn genomes into art. A stray hair is enough to crudely reconstruct the face of the owner. From reading to constructing: the first steps to creating artificial life have already been taken. Some may find the rapidity of developments, and the potential for misuse, alarming. But they also open up unprecedented possibilities. The ability to read DNA has changed how we view ourselves and understand our place in nature. From the largest oceans, to the insides of our guts, we are able to explore the biosphere as never before, from the genome up. Sequencing technology has made the invisible world of microbes visible, and biodiversity genomics is revealing whole new worlds within us and without. The findings are transformational: we are all ecosystems now. Already the first efforts at 'barcoding' entire ecological communities and creating 'genomic observatories' have begun. The future, the authors argue, will involve biocoding the entire planet.

DNA: A Graphic Guide to the Molecule that Shook the World (Hardcover, Revised): Israel Rosenfield, Edward Ziff, Borin Van Loon DNA: A Graphic Guide to the Molecule that Shook the World (Hardcover, Revised)
Israel Rosenfield, Edward Ziff, Borin Van Loon
R1,052 R788 Discovery Miles 7 880 Save R264 (25%) Shipped within 7 - 12 working days

With humor, depth, and philosophical and historical insight, "DNA" reaches out to a wide range of readers with its graphic portrayal of a complicated science. Suitable for use in and out of the classroom, this volume covers DNA's many marvels, from its original discovery in 1869 to early-twentieth-century debates on the mechanisms of inheritance and the deeper nature of life's evolution and variety.

Even readers who lack a background in science and philosophy will learn a tremendous amount from this engaging narrative. The book elucidates DNA's relationship to health and the cause and cure of disease. It also covers the creation of new life forms, nanomachines, and perspectives on crime detection, and considers the philosophical sources of classical Darwinian theory and recent, radical changes in the understanding of evolution itself. Already these developments have profoundly affected our notions about living things. Borin Van Loon's humorous illustrations recount the contributions of Gregor Mendel, Frederick Griffith, James Watson, and Francis Crick, among other biologists, scientists, and researchers, and vividly depict the modern controversies surrounding the Human Genome Project and cloning.

Biomolecular Archaeology - An Introduction (Paperback): T. A Brown, Keri Brown Biomolecular Archaeology - An Introduction (Paperback)
T. A Brown, Keri Brown
R877 R689 Discovery Miles 6 890 Save R188 (21%) Shipped within 7 - 13 working days

Illustrated thoroughly, Biomolecular Archaeology is the first book to clearly guide students through the study of ancient DNA: how to analyze biomolecular evidence (DNA, proteins, lipids and carbohydrates) to address important archaeological questions. * The first book to address the scope and methods of this new cross-disciplinary area of research for archaeologists * Offers a completely up-to-date overview of the latest research in this innovative subject * Guides students who wish to become biomolecular archaeologists through the complexities of both the scientific methods and archaeological goals. * Provides an essential component to undergraduate and graduate archaeological research

Untangling the Double Helix - DNA Entanglement and the Action of the DNA Topoisomerases (Paperback): James C. Wang Untangling the Double Helix - DNA Entanglement and the Action of the DNA Topoisomerases (Paperback)
James C. Wang
R696 Discovery Miles 6 960 Shipped within 7 - 12 working days

The problem of unraveling two intertwined strands during the duplication of DNA was recognized shortly after the proposal of the DNA double helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled manner, thereby allowing strands to be passed through each other and thus untangled not just during DNA replication, but also during many other basic cellular processes. Because of their intimate involvement in the workings of the cell, topoisomerases are also the logical targets of many antibiotics (including Cipro) and anticancer agents. This book, written by James Wang, the discoverer of the first topoisomerase and a leader in the field since, presents ten chapters covering the historical backdrop of the DNA entanglement problem and the discovery of the DNA topoisomerases, how DNA topoisomerases perform their magic in DNA replication, transcription, genetic recombination and chromosome condensation, and how they are targets of therapeutic agents. The book should appeal to readers from undergraduates upwards with interests in the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.

Genomics and Clinical Diagnostics (Hardcover): David Whitehouse, Ralph Rapley Genomics and Clinical Diagnostics (Hardcover)
David Whitehouse, Ralph Rapley
R2,020 Discovery Miles 20 200 Shipped within 7 - 12 working days

Genomics and genome technology is having, and continues to have, a major impact on all areas of bioscience research providing insights into the key area of molecular mechanisms of cells in health and disease. This is causing a profound effect on biomedical science and is accelerating the development of new diagnostic applications. This book provides a timely, graduate level introduction to the fast-paced area of genomics and clinical diagnostic technologies and introduces the concept of applications based on this area. The initial chapters focus on principal molecular technologies that underpin the information in the later chapters. In addition to introductory areas of nucleic acids and techniques in molecular biology, bioinformatics and proteomics, other key diagnostic areas such as the use of immunological reagents are covered. The later chapters provide more specialised examples of currently used diagnostic technologies and insights into selected key diagnostic challenges including specific examples of molecular microbial diagnostics and molecular biomarkers in oncology. The running themes through the chapters provides an insight into current and future perspectives in this rapidly evolving field.

Optimal High-Throughput Screening - Practical Experimental Design and Data Analysis for Genome-Scale RNAi Research (Hardcover):... Optimal High-Throughput Screening - Practical Experimental Design and Data Analysis for Genome-Scale RNAi Research (Hardcover)
Xiaohua Douglas Zhang
R1,610 R1,511 Discovery Miles 15 110 Save R99 (6%) Shipped within 7 - 12 working days

This concise, self-contained, and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing, and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.

The Foxtail Millet Genome (Hardcover, 1st ed. 2017): Manoj Prasad The Foxtail Millet Genome (Hardcover, 1st ed. 2017)
Manoj Prasad
R3,336 R2,997 Discovery Miles 29 970 Save R339 (10%) Shipped within 7 - 12 working days

This book presents up-to-date information on foxtail millet genomics, with a particular focus on its agronomic importance, genome architecture, marker development, evolutionary and diversity studies, comparative genomics and stress biology. The topics discussed have the potential to open up a new era of crop improvement in foxtail millet and other related grass species. Foxtail millet (Setaria italica L.) is the oldest domesticated crop in the world (domesticated >8700 years ago) and it has been extensively grown in the semi-arid regions of Asia, Europe and the Americas as a food and fodder crop ever since. Further, as a C4 crop with close genetic relatedness to several biofuel grasses, foxtail millet has been promoted as a model plant. In view of its importance, the US Department of Energy Joint Genome Institute and Beijing Genomics Institute have independently sequenced the genome of foxtail millet. The availability of the draft genome sequence has advanced the genomics and genetics of this important crop, resulting in the development of large-scale genome-wide molecular markers and demonstration of their utility in genomics-assisted breeding, as well as the identification of the molecular and biological roles of several stress-responsive gene families in connection with abiotic stress tolerance. In addition, several open access databases have been developed to make these resources for crop improvement through structural and functional genomics widely available.

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