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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA
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Genetic Recombination - Reviews and Protocols (Hardcover, 2004 ed.)
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Genetic Recombination - Reviews and Protocols (Hardcover, 2004 ed.)
Series: Methods in Molecular Biology, 262
Expected to ship within 10 - 15 working days
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Genetic recombination, in the broadest sense, can be defined as any
process in which DNA sequences interact and undergo a transfer of
information, producing new "recombinant" sequences that contain
information from each of the original molecules. All organisms have
the ability to carry out recombination, and this striking
universality speaks to the essential role recombination plays in a
variety of biological processes fundamentally important to the
maintenance of life. Such processes include DNA repair, regulation
of gene expression, disease etiology, meiotic chromosome
segregation, and evolution. One important aspect of recombination
is that it typically occurs only between sequences that display a
high degree of sequence identity. The stringent requirement for
homology helps to ensure that, under normal circumstances, a cell
is protected from deleterious rearrangements since a swap of
genetic information between two nearly identical sequences is not
expected to dramatically alter a genome. Recombination between
dissimilar sequences, which does happen on occasion, may have such
harmful consequences as chromosomal translocations, deletions, or
inversions. For many organisms, it is also important that
recombination rates are not too high lest the genome become
destabilized. Curiously, certain organisms, such as the trypanosome
parasite, actually use a high rate of recombination at a particular
locus in order to switch antigen expression continually and evade
the host immune system effectively.
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