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DNA Methylation Microarrays - Experimental Design and Statistical Analysis (Paperback)
Loot Price: R1,892
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DNA Methylation Microarrays - Experimental Design and Statistical Analysis (Paperback)
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Providing an interface between dry-bench bioinformaticians and
wet-lab biologists, DNA Methylation Microarrays: Experimental
Design and Statistical Analysis presents the statistical methods
and tools to analyze high-throughput epigenomic data, in
particular, DNA methylation microarray data. Since these
microarrays share the same underlying principles as gene expression
microarrays, many of the analyses in the text also apply to
microarray-based gene expression and histone modification
(ChIP-on-chip) studies. After introducing basic statistics, the
book describes wet-bench technologies that produce the data for
analysis and explains how to preprocess the data to remove
systematic artifacts resulting from measurement imperfections. It
then explores differential methylation and genomic tiling arrays.
Focusing on exploratory data analysis, the next several chapters
show how cluster and network analyses can link the functions and
roles of unannotated DNA elements with known ones. The book
concludes by surveying the open source software (R and
Bioconductor), public databases, and other online resources
available for microarray research. Requiring only limited knowledge
of statistics and programming, this book helps readers gain a solid
understanding of the methodological foundations of DNA microarray
analysis.
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