Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not equipped with the necessary knowledge to take advantage of this powerful tool. Hence, the primary purpose of our book is to supplement this unmet need by providing an easily accessible platform for students and researchers starting their career in life sciences. This book aims to avoid sophisticated computational algorithms and programming. Instead, it focuses on simple DIY analysis and interpretation of biological data with personal computers. Our belief is that once the beginners acquire these basic skillsets, they will be able to handle most of the bioinformatics tools for their research work and to better understand their experimental outcomes. Our second title of this volume set In Silico Life Sciences: Medicine provides hands-on experience in analyzing high throughput molecular data for the diagnosis, prognosis, and treatment of monogenic or polygenic human diseases. The key concepts in this volume include risk factor assessment, genetic tests and result interpretation, personalized medicine, and drug discovery. This volume is expected to train readers in both single and multi-dimensional biological analysis using open data sets, and provides a unique learning experience through clinical scenarios and case studies.

Animal Models for Examining Social Influences on Drug Addiction, Volume 140 in the International Review of Neurobiology series, provides insights on social factors that mediate drug addiction. This book discusses current research and projects, with specific chapters focusing on Social Influences on Nicotine-related Behaviors in Rodents, Models of Alcohol Intake in Social Contexts, Social Factors in Ethanol Sensitization, Social Modulation of Heroin Intake, Amphetamines and Social Aspects of Addiction, Amphetamines and Social Aspects of Addiction, Social Models of Cannabis Use, Oxytocin and Rodent Models of Addiction, Social Place Preference and Reward, Social Defeat Stress, and more.

Even before the myth of Prometheus, fire played a crucial ecological role around the world. Numerous plant communities depend on fire to generate species diversity in both time and space. Without fire such ecosystems would become sterile monocultures. Recent efforts to prohibit fire in fire dependent communities have contributed to more intense and more damaging fires. For these reasons, foresters, ecologists, land managers, geographers, and environmental scientists are interested in the behavior and ecological effects of fires. This book will be the first to focus on the chemistry and physics of fire as it relates to the ways in which fire behaves and the impacts it has on ecosystem function. Leading international contributors have been recruited by the editors to prepare a didactic text/reference that will appeal to both advanced students and practicing professionals.

Neurobiology of the Placebo Effect, Part II, Volume 139, the latest release in the International Review of Neurobiology series, is the second part of a two-volume set that provides the latest placebo studies in clinically relevant models. Specific chapters cover the History of placebo effects in medicine, Lumping or Splitting: Towards a taxonomy of placebo and related effects, Theories and brain mechanisms of placebo analgesia, Pain Modulation: From CPM to placebo and nocebo effects in experimental and clinical pain, Modulation of the motor system by placebo and nocebo effects, and the role of sleep in learning placebo effects, amongst other topics.

This book provides a broad overview how extremophiles can be used in biotechnology, including for the production and degradation of compounds. It reviews various recent discoveries and applications related to a large variety of extremophiles, considering both prokaryotes as well as eukaryotes.

Islands with large colonies of seabirds are found throughout the globe. Seabird islands provide nesting and roosting sites for birds that forage at sea, deposit marine nutrients on land, and physically alter these islands. Habitats for numerous endemic and endangered animal and plant species, seabird islands are therefore biodiversity hotspots with high priority for conservation.
Successful campaigns to eradicate predators (e.g., rats and cats) from seabird islands have been conducted worldwide. However, removal of predators will not necessarily lead to natural recovery of seabirds or other native species. Restoration of island ecosystems requires social acceptance of eradications, knowledge of how island food webs function, and a long-term commitment to measuring and assisting the recovery process.
This book, written collaboratively by and for ecologists and resource managers, provides the first large-scale cross-system compilation, comparison, and synthesis of the ecology of seabird island systems. Offering a new conceptual framework into which to fit the impacts of seabirds on island ecology, this is an essential resource for academics and resource managers alike.

Signal Processing for Neuroscientists, Second Edition provides an introduction to signal processing and modeling for those with a modest understanding of algebra, trigonometry and calculus. With a robust modeling component, this book describes modeling from the fundamental level of differential equations all the way up to practical applications in neuronal modeling. It features nine new chapters and an exercise section developed by the author. Since the modeling of systems and signal analysis are closely related, integrated presentation of these topics using identical or similar mathematics presents a didactic advantage and a significant resource for neuroscientists with quantitative interest. Although each of the topics introduced could fill several volumes, this book provides a fundamental and uncluttered background for the non-specialist scientist or engineer to not only get applications started, but also evaluate more advanced literature on signal processing and modeling.

Although Charles Darwin's theory of evolution laid the foundations of modern biology, it did not tell the whole story. Most remarkably, "The Origin of Species" said very little about, of all things, the origins of species. Darwin and his modern successors have shown very convincingly how inherited variations are naturally selected, but they leave unanswered how variant organisms come to be in the first place.In "Symbiotic Planet," renowned scientist Lynn Margulis shows that symbiosis, which simply means members of different species living in physical contact with each other, is crucial to the origins of evolutionary novelty. Ranging from bacteria, the smallest kinds of life, to the largest--the living Earth itself--Margulis explains the symbiotic origins of many of evolution's most important innovations. The very cells we're made of started as symbiotic unions of different kinds of bacteria. Sex--and its inevitable corollary, death--arose when failed attempts at cannibalism resulted in seasonally repeated mergers of some of our tiniest ancestors. Dry land became forested only after symbioses of algae and fungi evolved into plants. Since all living things are bathed by the same waters and atmosphere, all the inhabitants of Earth belong to a symbiotic union. Gaia, the finely tuned largest ecosystem of the Earth's surface, is just symbiosis as seen from space. Along the way, Margulis describes her initiation into the world of science and the early steps in the present revolution in evolutionary biology; the importance of species classification for how we think about the living world; and the way "academic apartheid" can block scientific advancement. Written with enthusiasm and authority, this is a book that could change the way you view our living Earth.

Integration and Visualization of Gene Selection and Gene Regulatory Networks for Cancer Genome helps readers identify and select the specific genes causing oncogenes. The book also addresses the validation of the selected genes using various classification techniques and performance metrics, making it a valuable source for cancer researchers, bioinformaticians, and researchers from diverse fields interested in applying systems biology approaches to their studies.

This book presents a comprehensive and innovative understanding of the role of shallow coastal ecosystems in carbon cycling, particularly marine carbon sequestration. Incorporating a series of forward-looking chapters, the book combines thorough reviews of the global literature and regional assessments-mainly around the Indo-Pacific region and Japan-with global perspectives to provide a thorough assessment of carbon cycling in shallow coastal systems. It advocates the expansion of blue-carbon ecosystems (mangroves, seagrass meadows, and salt marshes) into macroalgal beds, tidal flats, coral reefs, and urbanized shallow waters, demonstrating the potential of these ecosystems as new carbon sinks. Moreover, it discusses not only topics that are currently the focus of blue-carbon studies, i.e., sedimentary carbon stock and accumulation rate, but also CO2 gas exchange between the atmosphere and shallow coastal ecosystems, carbon storage in the water column as refractory organic carbon, and off-site carbon storage. Including highly original contributions, this comprehensive work inspires research beyond the specific regions covered by the chapters. The suite of new concepts and approaches is refreshing and demonstrates that blue-carbon research is indeed a vibrant new field of research, providing deep insights into neglected aspects of carbon cycling in the marine environment. At the same time the book provides guidance for policy makers to deliver benefits to society, for example the inclusion of blue carbon as a carbon offset scheme or the Nationally Determined Contribution (NDC) in the Paris Agreement, and also for building resilience in coastal socio-ecosystems through better management. This book is intended for all those interested in the science and management of coastal ecosystems.

This volume is devoted to the memory of the eminent carcinologist Professor Ruiyu Liu (1922-2012) of the Institute of Oceanology of Chinese Academy of Sciences, Qingdao, China. Since 1949, Professor Liu had devoted his life to studying taxonomy, systematics, ecology, zoogeography and aquaculture and published a total of more than 210 papers and monographs. He described two new genera, fifty-two new species and one new subspecies, including not only crustaceans but also cnidarians, polychaetes and molluscs. In this volume forty of his friends and colleagues put together sixteen papers to honour Professor Liu, and named after him three new genera and eleven new species. First published as a Special Issue of Crustaceana 93(11-12): 1233-1546.

Scholars and policymakers alike agree that innovation in the biosciences is key to future growth. The field continues to shift and expand, and it is certainly changing the way people live their lives in a variety of ways. With a large share of federal research dollars devoted to the biosciences, the field is just beginning to live up to its billing as a source of innovation, economic productivity and growth. Vast untapped potential to imagine and innovate exists in the biosciences given new tools now widely available. In The Biologist's Imagination, William Hoffman and Leo Furcht examine the history of innovation in the biosciences, tracing technological innovation from the late eighteenth century to the present and placing special emphasis on how and where technology evolves. Place is often key to innovation, from the early industrial age to the rise of the biotechnology industry in the second half of the twentieth century. The book uses the distinct history of bioinnovation to discuss current trends as they relate to medicine, agriculture, energy, industry, ecosystems, and climate. Fast-moving research fields like genomics, synthetic biology, stem cell research, neuroscience, bioautomation and bioprinting are accelerating these trends. Hoffman and Furcht argue that our system of bioscience innovation is itself in need of innovation. It needs to adapt to the massive changes brought about by converging technologies and the globalization of higher education, workforce skills, and entrepreneurship. The Biologist's Imagination is both a review of past models for bioscience innovation and a forward-looking, original argument for what future models should take into account.

Handbook of Ultrasonic Vocalization: Window into the Mammalian Brain, Volume 25, is an exhaustive resource on ultrasonic vocalizations in vertebrates, providing full coverage of all aspects of these vocalizations. The book also demonstrates the usefulness of ultrasonic vocalizations in studies of animal communication, sociobiological states, and in mammalian models of affective disorders, addictions and neurodevelopmental disorders, making it an indispensable resource for researchers using animal models. The book begins with the evolution of vocal communication before discussing mechanisms of ultrasound production, perception and the brain systems involved in emotional arousal that are responsible for the generation of vocalization and emotional states. In addition, the book covers studies of neuroactive agents and sociopsychological conditions that can regulate the outcome of ultrasonic vocalization and provide clues about animals' internal states. Critically, the book also includes thorough coverage of pharmacological investigations using ultrasonic vocalizations, increasingly being utilized for studies in affective disorders, psychoses, addiction and alcoholism. No other book provides such extensive coverage of this rapidly growing field of study.

Professor Linda M. Fedigan, Member of the Order of Canada and a Fellow of the Royal Society of Canada, has made major contributions to our understanding of the behavioural ecology of primates. Furthermore, Linda Fedigan pioneered and continues to advance scholarship on the role of women in science, as well as actively promoting the inclusion of women in the academy. A symposium in honour of her career was held in Banff (Alberta, Canada) in December 2016, during which former and current students and collaborators, as well as scientists with similar research interests, presented and discussed their work and their connections to Linda Fedigan. These presentations and discussions are here presented as chapters in this festschrift. The original works presented in this book are organized around four major research areas that have been greatly advanced and influenced by Linda Fedigan: Primate life histories Sex roles, gender, and science Primate-environment interactions Primate adaptation to changing environments

This collaborative book by five distinguished scholars in overlapping fields suggests that fruitful living is extremely hard work and that social harmony requires the unlocking and the emancipation of the human brain - the core cerebral source for advancing human coherence, connectivity, cohesion and civility. The stakes are simply too high for stakeholders across our country not to respond to the ongoing and escalating crisis of human division and the desperate need for engagement, enlightenment, and acceptance of human diversity. The authors strongly encourage academic and practitioner psychologists, as well as other students and social scientists, to join a timely framed narrative for greater progress in diversity. Neurodiversity aims to encourage dialogue, discourse, and discovery about what may be obvious to many but avoided by most - because its forces us to look inward instead of outward. We can make such inward observations, through the lenses of psychology, cognition, mindfulness, and underleveraged brain capacity amid modern cultural neuroscience. This is critically important - particularly in a time marked by the widespread amplification of ambiguity, angst, ambivalence, and anger. This book focuses on "crucial thinking" versus "critical thinking." The authors pose fundamental questions -- about what we are calling a form of cognitive "levitation" and taxonomical "climbing" (CBDT) -- to think about purposes of intellectual discourse, not necessarily to seek empirical evidence. A special feature of this book is the inclusion of sample student learning outcomes as "provisos" throughout the narrative. We have attempted to integrate the student learning outcomes in the text's narrative and connect them to the sections where they are inserted for the reader. The book's embedded taxonomies can also facilitate the instruction, composition, and conceptualization of targeted student learning outcomes.

This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologically active novel molecular entities. It presents a clear concept of the molecular mechanism of different drug targets and explores methods to help understand drug resistance. In addition, it includes chapters dedicated to natural-product- derived medicines, combinatorial drug discovery, the CryoEM technique for structure-based drug design and big data in drug discovery. The book offers an invaluable resource for graduate and postgraduate students, as well as for researchers in academic and industrial laboratories working in the areas of chemoinformatics, medicinal and pharmaceutical chemistry and pharmacoinformatics.

Human Reproductive and Prenatal Genetics presents the latest material from a detailed molecular, cellular and translational perspective. Considering its timeliness and potential international impact, this all-inclusive and authoritative work is ideal for researchers, students, and clinicians worldwide. Currently, there are no comprehensive books covering the field of human reproductive and prenatal genetics. As such, this book aims to be among the largest and most useful references available. Named a Highly Commended book in the Basic and Clinical Sciences by the British Medical Association.

The earth is continuously changing and evolving yet it is unclear how environmental changes will affect us in years to come. What changes are inevitable? What changes, if any, are beneficial? And what can we do as citizens of this planet to protect it and our future generations?

Larry Slobodkin, one of the leading pioneers of modern ecology, offers compelling answers to these questions in A Citizen's Guide to Ecology. He provides many insights into ecology and the processes that keep the world functioning. This important guide introduces observations that underlie arguments about all aspects of the natural environment--including both global and local issues. To clarify difficult concepts, Slobodkin uses lake, ocean, and terrestrial ecosystems to explain ecological energy flows and relationships on a global scale.

The book presents a clear and current understanding of the ecological world, and how individual citizens can participate in practical decisions on ecological issues. It tackles such issues as global warming, ecology and health, organic farming, species extinction and adaptation, and endangered species.

An excellent introduction and overview, A Citizen's Guide to Ecology helps us to understand what steps we as humans can take to keep our planet habitable for generations to come.

"This beautifully written book brings together careful observation, personal reflection, and theoretical understanding to explain the major environmental problems that confront us. Dr. Slobodkin's superb and sweeping work invites us to contemplate a great many facts and a few large values to motivate a clear and compelling response to losses of biodiversity, the problem of invasive species, global warming, and other environmental concerns."--Mark Sagoff, School of Public Affairs, University of Maryland

Biodiversity and Evolution includes chapters devoted to the evolution and biodiversity of organisms at the molecular level, based on the study of natural collections from the Museum of Natural History. The book starts with an epistemological and historical introduction and ends with a critical overview of the Anthropocene epoch.