Secondary Findings in Genomic Research offers a single, highly accessible resource on interpreting, managing and disclosing secondary findings in genomic research. With chapters written by experts in the field, this book is the first to concisely explain the ethical and practical issues raised by secondary genomics findings for a multi and interdisciplinary audience of genomic researchers, translational scientists, clinicians, medical students, genetic counselors, ethicists, legal experts and law students, public policy specialists and regulators. Contributors from Europe, North America, and Asia effectively synthesize perspectives from a spectrum of different scientific, societal, and global contexts, and offer pragmatic approaches to a range of topics, including oversight, governance and policy surrounding secondary genomic results, criteria for identifying results for return, communication and consent, stakeholders' attitudes and perspectives, disclosing results, and clinical, patient-centered protocols.

Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research.

While the field of vision science has grown significantly in the past three decades, there have been few comprehensive books that showed readers how to adopt a computional approach to understanding visual perception, along with the underlying mechanisms in the brain. Understanding Vision explains the computational principles and models of biological visual processing, and in particular, of primate vision. The book is written in such a way that vision scientists, unfamiliar with mathematical details, should be able to conceptually follow the theoretical principles and their relationship with physiological, anatomical, and psychological observations, without going through the more mathematical pages. For those with a physical science background, especially those from machine vision, this book serves as an analytical introduction to biological vision. It can be used as a textbook or a reference book in a vision course, or a computational neuroscience course for graduate students or advanced undergraduate students. It is also suitable for self-learning by motivated readers. in addition, for those with a focused interest in just one of the topics in the book, it is feasible to read just the chapter on this topic without having read or fully comprehended the other chapters. In particular, Chapter 2 presents a brief overview of experimental observations on biological vision; Chapter 3 is on encoding of visual inputs, Chapter 5 is on visual attentional selection driven by sensory inputs, and Chapter 6 is on visual perception or decoding. Including many examples that clearly illustrate the application of computational principles to experimental observations, Understanding Vision is valuable for students and researchers in computational neuroscience, vision science, machine and computer vision, as well as physicists interested in visual processes.

This is an edited book with original scientific papers of the results of the 6th International Congress on Fossil Insects, Arthropods and Amber (FossilX3) held in Byblos, Lebanon in April, 2013. In the tradition of previous congresses, researchers from around the world gathered to discuss the latest developments and to build new co-operative endeavours. Recognizing that the future of our science is one of interdisciplinary collaboration, these meetings steadily grow in importance, and proceedings such as this reveal the latest hypotheses and conclusions, while inspiring others toward newer and greater goals.

The Neuromodulation Casebook is a case-based volume for practical, hands-on decision-making using realistic case examples from the field of neuromodulation. It encompasses a variety of techniques and therapies, ranging from deep brain stimulation for a multitude of disorders, to spinal cord stimulation, peripheral nerve stimulation, cortical stimulation and cranial nerve stimulation, as well as non-invasive therapies and other implanted types of devices that interface with the nervous system. Allowing readers to better learn via case-based examples, this practical volume depicts real examples of decisions neuroscientists and neurosurgeons need to make every day from leaders in the field. This book serves as a companion text to the editor's previous titles Essential Neuromodulation and Innovative Neuromodulation for neuroscience, neural engineering and biomedical engineering courses.

BEST: Implementing Career Development Activities for Biomedical Research Trainees provides an instructional guide for institutions wanting to create, supplement or improve their career and professional development offerings. Each chapter provides an exclusive perspective from an administrator from the 17 Broadening Experiences in Scientific Training (BEST) institutions. The book can aid institutions who train graduate students in a variety of careers by teaching faculty and staff how to create and implement career development programming, how to highlight the effectiveness of offerings, how to demonstrate that creating a program from scratch is doable, and how to inform faculty and staff on getting institutional buy-in. This is a must-have for graduate school deans and faculty and staff who want to implement and institutionalize career development programing at their institutions. It is also ideal for graduate students and postdocs.

Lucretius' account of the origin of life, the origin of species, and human prehistory (first century BC) is the longest and most detailed account extant from the ancient world. It is a mechanistic theory that does away with the need for any divine design, and has been seen as a forerunner of Darwin's theory of evolution. This commentary seeks to locate Lucretius in both the ancient and modern contexts. The recent revival of creationism makes this study particularly relevant to contemporary debate, and indeed, many of the central questions posed by creationists are those Lucretius attempts to answer.

Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Cardiovascular, Respiratory, and Gastrointestinal Disorders, Seventh Edition includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies. This comprehensive, yet practical, resource emphasizes theory and research fundamentals relating to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine. Updated sections in this release cover the genetics of cardiovascular, respiratory and gastrointestinal disorders, with an emphasis on genetic determinants and new pathways for diagnosis, prevention and disease management. In addition, genetic researchers, students and health professionals will find new and fully revised chapters on the molecular genetics of congenital heart defects, inherited cardiomyopathies, hypertension, cystic fibrosis, asthma, hereditary pulmonary emphysema, inflammatory bowel disease, and bile pigment metabolism disorders among other conditions.

"Genes, Culture, and Human Evolution: A Synthesis"is a textbook on human evolution that offers students a unique combination of cultural anthropology and genetics.
Written by two geneticists---including a world-renowned scientist and founder of the Human Genome Diversity Project---and a socio-cultural anthropologist.
Based on recent findings in genetics and anthropology that indicate the analysis of human culture and evolution demands an integration of these fields of study.
Focuses on evolution---or, rather, co-evolution---viewed from the standpoint of genes and culture, and their inescapable interactions.
Unifies cultural and genetic concepts rather than rehashing nonempirical sociobiological musings.
Demonstrates that empirical genetic evidence, based on modern DNA analysis and population studies, provides an excellent foundation for understanding human cultural diversity.

This book is a collection of essays exploring adaptive systems from many perspectives, ranging from computational applications to models of adaptation in living and social systems. The essays on computation discuss history, theory, applications, and possible threats of adaptive and evolving computations systems. The modeling chapters cover topics such as evolution in microbial populations, the evolution of cooperation, and how ideas about evolution relate to economics.
The title Perspectives on Adaptation in Natural and Artificial Systems honors John Holland, whose 1975 Book, Adaptation in Natural and Artificial Systems has become a classic text for many disciplines in which adaptation play a central role. The essays brought together here were originally written to honor John Holland, and span most of the different areas touched by his wide-ranging and influential research career. The authors include some of the most prominent scientists in the fields of artificial intelligence evolutionary computation, and complex adaptive systems. Taken together, these essays present a broad modern picture of current research on adaptation as it relates to computers, living systems, society, and their complex interactions.

The brain is a cognitive organ, and regions of the brain that traverse brainstem and cortical sites orchestrate the expression of bodily sensibility: intelligent action. They can appear perfunctory or intimate, calculating a sum or selecting a mate. Schulkin presents neuroscientific research demonstrating that thought is not on one side and bodily sensibility on the other; from a biological point of view, they are integrated. Schulkin further argues that this integration has important implications for judgements about the emotions, art and music, moral sensibilities, attraction and revulsion, and our perpetual inclination to explain ourselves and our surroundings. He begins the book by setting forth a view of the emotions not as a bodily burden to be borne, but rather as a great source of information. He then moves on to other domains, claiming that underlying the experience of aesthetics in at least some instances is the interplay between expectation and disappointment from its infraction, and suggesting that, among other things, repulsion and attraction to the cries and joys of others consitutes moral responsiveness. This book should appeal to researchers in behavioral neuroscience, emotion, and psychophysiology, as well as cognitive and social psychologists and philosophers of mind.

This book provides an up-to-date review and analysis of the carrot's nuclear and organellar genome structure and evolution. In addition, it highlights applications of carrot genomic information to elucidate the carrot's natural and agricultural history, reproductive biology, and the genetic basis of traits important in agriculture and human health. The carrot genome was sequenced in 2016, and its relatively small diploid genome, combined with the fact that it is the most complete root crop genome released to date and the first-ever Euasterid II genome to be sequenced, mean the carrot has an important role in the study of plant development and evolution. In addition, the carrot is among the top ten vegetables grown worldwide, and the abundant orange provitamin A carotenoids that account for its familiar orange color make it the richest crop source of vitamin A in the US diet, and in much of the world. This book includes the latest genetic maps, genetic tools and resources, and covers advances in genetic engineering that are relevant for plant breeders and biologists alike.

Mitochondrial Medicine: A Primer for Health Care Providers and Translational Researchers is an applied, holistic resource that addresses the evolving and multidisciplinary area of mitochondrial disease. The book discusses the fundamentals of mitochondrial medicine in humans, as well as the pathophysiology, diagnosis and treatment of mitochondrial diseases. Three all-inclusive sections examine the role of mitochondria in common medical conditions, such as diabetes, heart failure and the full range of inherited mitochondrial diseases. Sections cover the genetic and biochemical basis of both mitochondrial DNA deletion syndromes and point mutation syndromes, their clinical presentation, treatment plans, genetic counseling, prenatal testing, and ongoing research. While providing a solid foundation in its topic area, each chapter in the book is written in an accessible format with illustrative case studies, thus making it a quick bedside or clinical laboratory reference.

Nowhere on Earth is the challenge for ecological understanding greater, and yet more urgent, than in those parts of the globe where human activity is most intense - cities. People need to understand how cities work as ecological systems so they can take control of the vital links between human actions and environmental quality, and work for an ecologically and economically sustainable future. An ecosystem approach integrates biological, physical and social factors and embraces historical and geographical dimensions, providing our best hope for coping with the complexity of cities. This book is the first of its kind to bring together leaders in the biological, physical and social dimensions of urban ecosystem research with leading education researchers, administrators and practitioners, to show how an understanding of urban ecosystems is vital for urban dwellers to grasp the fundamentals of ecological and environmental science, and to understand their own environment.

Complexes of physically interacting proteins constitute fundamental functional units that drive almost all biological processes within cells. A faithful reconstruction of the entire set of protein complexes (the "complexosome") is therefore important not only to understand the composition of complexes but also the higher level functional organization within cells. Advances over the last several years, particularly through the use of high-throughput proteomics techniques, have made it possible to map substantial fractions of protein interactions (the "interactomes") from model organisms including Arabidopsis thaliana (a flowering plant), Caenorhabditis elegans (a nematode), Drosophila melanogaster (fruit fly), and Saccharomyces cerevisiae (budding yeast). These interaction datasets have enabled systematic inquiry into the identification and study of protein complexes from organisms. Computational methods have played a significant role in this context, by contributing accurate, efficient, and exhaustive ways to analyze the enormous amounts of data. These methods have helped to compensate for some of the limitations in experimental datasets including the presence of biological and technical noise and the relative paucity of credible interactions. In this book, we systematically walk through computational methods devised to date (approximately between 2000 and 2016) for identifying protein complexes from the network of protein interactions (the protein-protein interaction (PPI) network). We present a detailed taxonomy of these methods, and comprehensively evaluate them for protein complex identification across a variety of scenarios including the absence of many true interactions and the presence of false-positive interactions (noise) in PPI networks. Based on this evaluation, we highlight challenges faced by the methods, for instance in identifying sparse, sub-, or small complexes and in discerning overlapping complexes, and reveal how a combination of strategies is necessary to accurately reconstruct the entire complexosome.

This book looks at how three kinds of strongly electric fishes literally became "electrical," and how they helped to change the sciences and medicine. These fishes are the flat torpedo rays common to the Mediterranean, the electric catfishes of Africa, and an "eel" from South America. The discovery of the electrical nature of these fishes in the second half of the 18th century was the starting point of the two fundamental advances in the sciences: on the physiological side, the demonstration that nerve conduction and muscle excitation are electrical phenomena, and on the physical side, the invention of the electric battery. Starting with catfish tomb drawings from Ancient Egypt and colorful descriptions of torpedoes from the Classical Era, the authors show how these fishes were both fascinating and mysterious to the ancients. After all, not only could they produce torpor and temporary numbness when touched, they could stun through intermediaries, such as wet nets and spears.
Various explanations were given for these remarkable actions in ancient times, including the idea that they might release some sort of cold venom. Through the Renaissance, they also tended to be associated with occult and magical qualities. During the 1600s, natural philosophers speculated that rapid movements of specialized muscles could account for their actions. This idea was widely accepted until the 1750s, when the possibility that their shocks might be electrical began to be discussed.
Showing how researchers set forth to provide support for fish electricity is a major focus of this book. Here the authors transport us into the jungles of South America and later show how some live eels were transported to London, where John Walsh demonstrated in1776 that they can actually spark.
Subsequent chapters deal with further evidence for specialized fish electricity and how electric fishes helped to change ideas about even our own physiology. The authors also show how these fish remained a part of medicine, and how Volta modeled his revolutionary "pile" or electric battery on their anatomy.
From beginning to end, this drama is firmly anchored in the philosophy and science of the day. Moreover, with biographical information about the key players, readers can fully appreciate what they were thinking as they tried to understand one of Nature's greatest puzzles - a mystery that would transform nerve and muscle physiology in ways that earlier generations could not have anticipated. Although a scholarly volume, the book's style is generally narrative and, with its hundreds of magnificent illustrations, it should appeal to a large audience.