Basic Neuroscience Protocols: Tips, Tricks, and Pitfalls contains explanatory sections that describe the techniques and what each technique really tells the researcher on a scientific level. These explanations describe relevant controls, troubleshooting, and reaction components for some of the most widely used neuroscience protocols that remain difficult for many neuroscientists to implement successfully. Having this additional information will help researchers ensure that their experiments work the first time, and will also minimize the time spent working on a technique only to discover that the problem was them, and not their materials.

Describes techniques in very specific detail with Step-by-step instructions, giving researchers in depth understandingOffers many details not present in other protocol booksDescribes relevant controls for each technique and what those controls meanChapters include references (key articles, books, protocols) for additional studyDescribes both the techniques and the habits necessary to get quality results, such as aseptic technique, aliquoting, and general laboratory rules "

This document is exclusively dedicated to DNA. It explains the secrets of DNA from all corners. Presented in a simple, lucid manner; it will useful to all involved in bioscience. In all it consists 12 chapters, figures, photos and a wholesome glossary of the terms related to DNA.

Biomarkers in Bipolar Disorders summarizes cutting-edge findings in biomarkers' research, emphasizing the most promising findings, tools and technologies relevant to drug development and personalized medicine. Key findings cover different levels of evidence such as genes, molecules, cells, systems, brain and behavior related to diagnosis (state and trait/endophenotypes), prediction of treatment response and follow-up outcomes, along with the most promising perspectives in each area. Each section includes a comprehensive and focused overview on the state-of-the-art and perspectives. The book concludes with a section on practical applications, encompassing diagnostics development (genetic testing, biomarkers), and new drug development. Edited by Dr. Rodrigo Machado-Vieira and Dr. Jair C. Soares, and contributed by leading experts in the field of biomarker research, this book will be become the leading tool for all researchers and clinicians in Bipolar Disorder.

Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body. The book begins with a historical review and link to future prospects for chemical carcinogenesis. It discusses major environmental xenobiotics and their risks in inducing cancer, along with content on toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development. Lastly, the book explores current achievements such as using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, and the development of anticancer drugs for specific toxicants.

Evolution, Chance, and God looks at the relationship between religion and evolution from a philosophical perspective. This relationship is fascinating, complex and often very controversial, involving myriad issues that are difficult to keep separate from each other. Evolution, Chance, and God introduces the reader to the main themes of this debate and to the theory of evolution, while arguing for a particular viewpoint, namely that evolution and religion are compatible, and that, contrary to the views of some influential thinkers, there is no chance operating in the theory of evolution, a conclusion that has great significance for teleology. One of the main aims of this book is not simply to critique one influential contemporary view that evolution and religion are incompatible, but to explore specific ways of how we might understand their compatibility, as well as the implications of evolution for religious belief. This involves an exploration of how and why God might have created by means of evolution, and what the consequences in particular are for the status of human beings in creation, and for issues such as free will, the objectivity of morality, and the problem of evil. By probing how the theory of evolution and religion could be reconciled, Sweetman says that we can address more deeply key foundational questions concerning chance, design, suffering and morality, and God's way of acting in and through creation.

New Frontiers and Applications of Synthetic Biology presents a collection of chapters from eminent synthetic biologists across the globe who have established experience and expertise working with synthetic biology. This book offers several important areas of synthetic biology which allow us to read and understand easily. It covers the introduction of synthetic biology and design of promoter, new DNA synthesis and sequencing technology, genome assembly, minimal cells, small synthetic RNA, directed evolution, protein engineering, computational tools, de novo synthesis, phage engineering, a sensor for microorganisms, next-generation diagnostic tools, CRISPR-Cas systems, and more. This book is a good source for not only researchers in designing synthetic biology, but also for researchers, students, synthetic biologists, metabolic engineers, genome engineers, clinicians, industrialists, stakeholders and policymakers interested in harnessing the potential of synthetic biology in many areas.

Research on natural and artificial brains is proceeding at a rapid pace. However, the understanding of the essence of consciousness has changed slightly over the millennia, and only the last decade has brought some progress to the area. Scientific ideas emerged that the soul could be a product of the material body and that calculating machines could imitate brain processes. However, the authors of this book reject the previously common dualism-the view that the material and spiritual-psychic processes are separate and require a completely different substance as their foundation. Reductive Model of the Conscious Mind is a forward-thinking book wherein the authors identify processes that are the essence of conscious thinking and place them in the imagined, simplified structure of cells able to memorize and transmit information in the form of impulses, which they call neurons. The purpose of the study is to explain the essence of consciousness to the degree of development of natural sciences, because only the latter can find a way to embed the concept of the conscious mind in material brains. The book is divided into three parts. Part 1 works to convince readers that the emergence of consciousness does not require detailed knowledge of the structure and morphology of the brain, with the exception of some specific properties of the neural network structure that the authors attempt to point out. Part 2 proves that the biological structure of many natural brains fulfills the necessary conditions for consciousness and intelligent thinking. Similarly, Part 3 shows the ways in which artificial creatures imitating natural brains can meet these conditions, which gives great hopes for building artificially intelligent beings endowed with consciousness. Covering topics that include cognitive architecture, the embodied mind, and machine learning, this book is ideal for cognitive scientists, philosophers of mind, neuroscientists, psychologists, researchers, academicians, and advanced-level students. The book can also help to focus the research of linguists, neurologists, and biophysicists on the biophysical basis of postulated information processing into knowledge structures.

Neuroprosthetics is a fast-growing area that brings together the fields of biomedical engineering and neuroscience as a means to interface the neural system directly to prostheses. Advancing research and applications in this field can assist in successfully restoring motor, sensory, and cognitive functions. Emerging Theory and Practice in Neuroprosthetics brings together the most up-to-date research surrounding neuroprosthetics advances and applications. Presenting several new results, concepts, and further developments in the area of neuroprosthetics, this book is an essential publication for researchers, upper-level students, engineers, and medical practitioners.

Lecture provides an overview of the progress made in molecular medicine applying genetics and genomics to the understanding, diagnosis, and treatment of human diseases. Specifically, the methods for identifying genes involved in human diseases are described. Examples from 10 genes and diseases will be provided, drawing on the author's research. Topics include examples from simple Mendelian diseases, such as cystic fibrosis, inherited cancers, oncogenes activated by chromosomal translocations, host genes involved in infectious disease, genes identified via genomewide association studies, pathogens causing cancer, and gene families contributing to multiple diseases. For each example, historical details will be provided as background for readers to understand the context and process of the discoveries, technologies explained, and current understanding and treatment implications detailed.

Neglected Tropical Diseases and other Infectious Diseases Affecting the Heart provides a comprehensive and systematic review on the literature surrounding Neglected Tropical Diseases and infectious diseases and how they affect the heart. Written by Emerging Leaders of the Interamerican Society of Cardiology (SIAC), the book includes the latest research findings, covering the cardiac involvement of a range of viral, bacterial and parasitic diseases, including COVID19, HIV, Zika, Lyme Disease, and more. Chapters cover epidemiology, the physiopathology of cardiovascular involvement, symptoms, diagnosis, and treatment options for each disease, making the book suitable to researchers, scientists, clinicians and physicians in the field.

Stem Cells and COVID-19 presents up-to-date knowledge on the effect of hematopoietic and mesenchymal stem cells to combat SARS-CoV-2 infection in its diagnosis, treatment and prevention. In addition, the book critically discusses challenges, highlighting outstanding questions and future perspectives. Written by global experts in the field for both pre-clinical and clinical practitioners, this comprehensive book delves into how stem cells have a strong potential in developing better diagnostic, treatment and preventive strategies in SARS-CoV-2 infection. Both hematopoietic and mesenchymal stem cells are critical to better understand the response of immune system to coronavirus infection in both healthy and co-morbid conditions in the development of effective vaccines and immunotherapies.

Dreaming is the cognitive state uniquely experienced by humans and integral to our creativity, the survival characteristic that allows for the rapid change and innovation that defines our species and provides the basis for our art, philosophy, science, and humanity. Yet there is little empiric or scientific evidence supporting the generally accepted dream-based theories of neuroconsciousness. "Dream Science" examines the cognitive science of dreaming and offers an evidence-based view of the phenomenon.

Today, such evidence-based breakthroughs in the field of dream science are altering our understanding of consciousness. Different forms of dreaming consciousness occur throughout sleep, and dreamlike states extend into wake. Each dream state is developed on a framework of memories, emotions, representational images, and electrophysiology, amenable to studies utilizing emerging and evolving technology. "Dream Science" discusses basic insights into the scientific study of dreaming, including the limits to traditional Freudian-based dream theory and the more modern evidence-based science. It also includes coverage of the processes of memory and parasomnias, the sleep-disturbance diagnoses related to dreaming. This comprehensive book is a scientific exploration of the mind-brain interface and a look into the future of dream science.
Provides a more evidence-based approach than any other work on the marketSingle source of integrated information on all aspects of dream science makes this a critical time-saving reference for researchers and cliniciansAuthored by one of the leaders in the field of dream research

"Conceptual Breakthroughs in Evolutionary Genetics" is a pithy, lively book occupying a special niche-the conceptual history of evolutionary genetics- not inhabited by any other available treatment. Written by a world-leading authority in evolutionary genetics, this work encapsulates and ranks 70 of the most significant paradigm shifts in evolutionary biology and genetics during the century-and-a-half since Darwin and Mendel. The science of evolutionary genetics is central to all of biology, but many students and other practitioners have little knowledge of its historical roots and conceptual developments. This book fills that knowledge gap in a thought-provoking and readable format.

This fascinating chronological journey along the many conceptual pathways to our modern understanding of evolutionary and genetic principles is a wonderful springboard for discussions in undergraduate or graduate seminars in evolutionary biology and genetics. But more than that, anyone interested in the history and philosophy of science will find much of value between its covers.
Provides a relative ranking of 70 seminal breakthroughs and paradigm shifts in the field of evolutionary biology and geneticsModular format permits ready access to each described subjectHistorical overview of a field whose concepts are central to all of biology and relevant to a broad audience of biologists, science historians, and philosophers of scienceExtensively cross-referenced with a guide to landmark papers and books for each topic

Wound Healing, and the Myofibroblast: A Historical and Biological Perspective is the fruit of an interdisciplinary and international collaboration involving a historian of medicine (Dr. Zampieri), a physician (Dr. Coen), and a researcher (Prof. Gabbiani, world-renowned for his discovery of the myofibroblast). This book aims to draw a concise yet complete description of the conceptual evolution of wound healing, fibrosis and fibrosis-related pathologies from antiquity to present time, as well as commenting on the role of the myofibroblast and the key cell type essential for tissue repair and fibrosis (from its identification in 1971 throughout its 50-years-old history). By viewing this complex and century-long history from different perspectives, the book's authors aim to draw an exhaustive overview, with the hope of inspiring new and fruitful basic and clinical research.

Early Childhood and Neuroscience is a practical guide to understanding the complex and challenging subject of neuroscience and its use (and misapplication) in early childhood policy and practice. The 2nd edition has been updated throughout and includes a new Foreword by Dr Laura Jana (Penn State University, USA), a new Introduction and three new chapters on: - the effects of childhood trauma - self-regulation - neurodiversity The book provides a balanced overview of the debates by weaving discussion on the opportunities of using neuroscience in early childhood practice with examination of the limitations and ethical implications throughout the chapters. This enables students to inform their own opinions about the discipline and its use in their future practice. Clear explanations of the main terms and theories are complemented with illustrative case studies of cutting-edge research from around the world, a glossary of key terms and suggestions for further reading. Reflective discussion questions give readers the chance to apply their theoretical knowledge to real-world contexts.

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases elucidates elaborately the role of caspase enzymes implicated in the initiation of molecular events leading to neuronal apoptosis in the neurodegenerative disease. The book starts with introduction to neuropathology, neurogenetics, and epidemiology of neurodegenerative disease and illustrates the involvement of human caspases, neuronal apoptosis, apoptotic pathways, genetic polymorphisms, and several other factors and underlying mechanisms in the pathology of Alzheimer's disease, Parkinson's disease, and Huntington's disease. An important focus in all chapters is the intricate mechanisms and interplay that occur during or leading to neuron death in neurodegenerative diseases, along with disease pathobiology.

Reciprocity in Population Biobanks: Relational Autonomy and the Duty to Inform in the Genomic Era begins by discussing how current judicial interpretation keeps standard of disclosure at the core of genomic research. The book then outlines multiple limitations individualistic autonomy faces in the context of gene and population biobanks, including an analysis of the complexities of benefit considerations in the research setting. Second, the book explores how individualistic autonomy fails to acknowledge the multilateral relationships implicated in genomic research, including those that affect the broader research community, research participants' families, and the general public. In carrying out this analysis, this book pays special attention to alternative approaches and ways researchers, public health officials, and judicial bodies might interact in years to come. In other words, implementing an understanding of relational autonomy that acknowledges and sustains the multilateral relationships found in genomic research without compromising the rights of participants. In short, this book proposes a reconceived duty to inform for researchers and a new standard of disclosure that is more meaningful and impactful for research participants and researchers.

Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through the evaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stress disorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understanding stress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range of recent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developments in noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods or development and across the life span. The book concludes by looking at possible transgenerational stress-induced epigenetic alterations on future offspring and important areas of research for public health, along with the potential for epigenetic therapeutics or "epidrugs."