This Book is comprised of solutions for the treatment of cognitive diseases with Bionics or Bioinspired Algorithms using future technologies such as artificial intelligence, machine learning, Internet of Things (IoT), data science, and more. Studying the behavior of nature and providing the medical engineering solutions would not only be unique but would result in substantial contribution in solution of so many cognitive disease problems which are not detected correctly in initial stages. This publication would be a breakthrough in the field of medical science, especially in the field of cognitive diseases by providing solutions in the form of algorithms and devices that could be useful for the brain disease patient for early detection. This book is essential for various medical research centers, engineering institutions across the world, medical colleges, biomedical research centers, and electronics and communication research centers.

This book reprints Human Guinea Pigs, by Kenneth Mellanby, a seminal work in the history of medical ethics and human subject research that has been nearly unavailable for over 40 years. Detailing the use of World War II conscientious objectors who volunteered for experimentation on scabies transmission, Mellanby's book offers insight into one approach to human subject experimentation before the development of ethical oversight regulations. His work was initially published prior to the articulation of the Nuremberg Code, which makes his subsequent position as a reporter for the British Medical Journal at the Nuremberg Trials very interesting, particularly given his sometimes controversial opinions on Nazi medical experimentation. This book reprints the second edition together with commentary essays that situate Mellanby's ethical approach in historical context and relative to contemporary approaches. This volume is of particular interest to scholars of the history of human subject research.

The second edition of this book brings together a cutting edge international team of contributors to critically review the current knowledge regarding the effectiveness of training interventions designed to improve cognitive functions in different target populations. Since the publication of the first volume, the field of cognitive research has rapidly evolved. There is substantial evidence that cognitive and physical training can improve cognitive performance, but these benefits seem to vary as a function of the type and the intensity of interventions and the way training-induced gains are measured and analyzed. This book will address the new topics in psychological research and aims to resolve some of the currently debated issues. This book offers a comprehensive overview of empirical findings and methodological approaches of cognitive training research in different cognitive domains (memory, executive functions, etc.), types of training (working memory training, video game training, physical training, etc.), age groups (from children to young and older adults), target populations (children with developmental disorders, aging workers, MCI patients etc.), settings (laboratory-based studies, applied studies in clinical and educational settings), and methodological approaches (behavioral studies, neuroscientific studies). Chapters feature theoretical models that describe the mechanisms underlying training-induced cognitive and neural changes. Cognitive Training: An Overview of Features and Applications, Second Edition will be of interest to researchers, practitioners, students, and professors in the fields of psychology and neuroscience.

This volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today. Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication. Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems. This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology.

For decades, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics has served as the ultimate resource for clinicians integrating genetics into medical practice. With nearly 5,000 pages of detailed coverage, contributions from over 250 of the world's most trusted authorities in medical genetics, and a series of 11 volumes available for individual sale, the Seventh Edition of this classic reference includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies to complete its coverage of this growing field for medical students, residents, physicians, and researchers involved in the care of patients with genetic conditions. This comprehensive yet practical resource emphasizes theory and research fundamentals related to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine more broadly. In Metabolic Disorders, leading physicians and researchers thoroughly examine medical genetics as applied to a range of metabolic disorders, with emphasis on understanding the genetic mechanisms underlying these disorders, diagnostic approaches, and therapeutics that make use of current genomic technologies and translational studies. Here genetic researchers, students, and health professionals will find new and fully revised chapters on the genetic basis of body mass, amino acid, carbohydrate, iron, copper, lipo protein, and lipid metabolic disorders, as well as organic acidemias, fatty acid oxidation, and peroxisome disorders among others. With regular advances in genomic technologies propelling precision medicine into the clinic, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Seventh Edition bridges the gap between high-level molecular genetics and practical application and serves as an invaluable clinical tool for health professionals and researchers.

Repetitive sequences play a major role as a pattern-building device and are a basic syntagmatic linguistic means on all language levels in spoken and signed languages. Little attention has been paid to investigating them in multimodal language use. Do gestures exhibit different types of repetitive sequences? Do they build complex units based on these types and if so, how is the pattern building to be described? How is the interrelation of gestural and spoken units in such complex units? Is it possible to identify repetitive patterns that are comparable to spoken and signed languages and/or patterns specific to the gestural modality? Based on a corpus-analysis of multimodal usage-events, 7 chapters explore gestural repetitions with regard to their structure, semantic and syntactic relevance for multimodal utterances, and cognitive saliency. Fine-grained cognitive-linguistic analyses of multimodal usage events reveal that gestural repetitions are not only a basic principle of building patterns in spoken and signed languages, but also in gestures. By addressing questions of mediality and multimodality of language-in-use, the book contributes to the investigation of repetition as a fundamental means of sign and meaning construction (crosscutting modalities) and enhances the understanding of the multimodal character of language in use.

This book provides a comprehensive overview of recent research on estuaries of the east coast of India, and how changing biogeochemical dynamics as a result of climate change and human activity have impacted estuaries and other open water ecosystems. Though estuaries only cover a very small portion of the earth's hydrosphere, they are some of the most biogeochemically active regions among the global water bodies. As such, this book focuses on estuaries of the east coast of India going all the way to the Bay of Bengal, which is the world's largest freshwater input from perennial rivers and rain-fed estuaries, and is therefore a unique area of study. Through its unique coverage of the Bay of Bengal in particular, the book presents a new perspective not present in the literature on estuary biogeochemistry and ecosystem dynamics. Moreover, the book addresses SDG 13 (Climate Action) and 14 (Life below Water), with a focus on ecosystem services of the natural aquatic system.The book will be useful to researchers, policy makers, coastal managers and marine sustainability scientists and organizations.

The scalp and cortex lie like pages of an open book on which the cortex enciphers vast quantities of information and knowledge. They are recorded and analyzed as temporal and spatial patterns in the electroencephalogram and electrocorticogram. This book describes basic tools and concepts needed to measure and decipher the patterns extracted from the EEG and ECoG.

This book emphasizes the need for single trial analysis using new methods and paradigms, as well as large, high-density spatial arrays of electrodes for pattern sampling. The deciphered patterns reveal neural mechanisms by which brains process sensory information into precepts and concepts. It describes the brain as a thermodynamic system that uses chemical energy to construct knowledge.

The results are intended for use in the search for the neural correlates of intention, attention, perception and learning; in the design of human brain-computer interfaces enabling mental control of machines; and in exploring and explaining the physicochemical foundation of biological intelligence.

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Biodiversity has been a key concept in international conservation since the 1980s, yet historians have paid little attention to its origins. Uncovering its roots in tropical fieldwork and the southward expansion of U.S. empire at the turn of the twentieth century, Megan Raby details how ecologists took advantage of growing U.S. landholdings in the circum-Caribbean by establishing permanent field stations for long-term, basic tropical research. From these outposts of U.S. science, a growing community of American ""tropical biologists"" developed both the key scientific concepts and the values embedded in the modern discourse of biodiversity. Considering U.S. biological fieldwork from the era of the Spanish-American War through the anticolonial movements of the 1960s and 1970s, this study combines the history of science, environmental history, and the history of U.S.-Caribbean and Latin American relations. In doing so, Raby sheds new light on the origins of contemporary scientific and environmentalist thought and brings to the forefront a surprisingly neglected history of twentieth-century U.S. science and empire.

A familiar trope of cognitive science, linguistics, and the philosophy of psychology over the past forty or so years has been the idea of the mind as a modular system-that is, one consisting of functionally specialized subsystems responsible for processing different classes of input, or handling specific cognitive tasks like vision, language, logic, music, and so on. However, one of the major achievements of neuroscience has been the discovery that the brain has incredible powers of renewal and reorganization. This "neuroplasticity," in its various forms, has challenged many of the orthodox conceptions of the mind which originally led cognitive scientists to postulate hardwired mental modules. This book examines how such discoveries have changed the way we think about the structure of the mind. It contends that the mind is more supple than prevailing theories in cognitive science and artificial intelligence acknowledge. The book uses language as a test case. The claim that language is cognitively special has often been understood as the claim that it is underpinned by dedicated-and innate-cognitive mechanisms. Zerilli offers a fresh take on how our linguistic abilities could be domain-general: enabled by a composite of very small and redundant cognitive subsystems, few if any of which are likely to be specialized for language. In arguing for this position, however, the book takes seriously various cases suggesting that language dissociates from other cognitive faculties. Accessibly written, The Adaptable Mind is a fascinating account of neuroplasticity, neural reuse, the modularity of mind, the evolution of language, and faculty psychology.

Integrative Pancreatic Intervention Therapy: A Holistic Approach summarizes, in a systematic manner, the diagnosis and treatment of late, critical pancreatic diseases. The book gives insights into each interventional technique, with an ultimate goal of improving survival rates for late stage pancreatic cancer patients. Six sections cover basic and transformation research on pancreatic diseases, interventional therapy for benign pancreatic disease, interventional therapy for malignant pancreatic diseases, interventional therapy for pancreative cancer-related lesions, stem cell and targeted molecular therapy for pancreative carcinoma, and combined interventional therapy for pancreative carcinoma. This book will be useful for those looking to understand how best to apply interventional therapy for the improvement of late state pancreatic cancer treatment.

This book provides a guided approach to the geostatistical modelling of compositional spatial data. These data are data in proportions, percentages or concentrations distributed in space which exhibit spatial correlation. The book can be divided into four blocks. The first block sets the framework and provides some background on compositional data analysis. Block two introduces compositional exploratory tools for both non-spatial and spatial aspects. Block three covers all necessary facets of multivariate spatial prediction for compositional data: variogram modelling, cokriging and validation. Finally, block four details strategies for simulation of compositional data, including transformations to multivariate normality, Gaussian cosimulation, multipoint simulation of compositional data, and common postprocessing techniques, valid for both Gaussian and multipoint methods. All methods are illustrated via applications to two types of data sets: one a large-scale geochemical survey, comprised of a full suite of geochemical variables, and the other from a mining context, where only the elements of greatest importance are considered. R codes are included for all aspects of the methodology, encapsulated in the R package "gmGeostats", available in CRAN.

Biological invasions - the introduction of living organisms beyond their original range - are one of the main drivers of biodiversity loss. They are a major threat to human health and a source of pests and pathogens in the world's farms, forests and fisheries. The growth of international trade and travel means that more species are being introduced to more places than ever before. This book represents the first concerted effort to understand the economic causes and consequences of biological invasions. The volume discusses the theoretical and methodological issues raised by invasion, including control strategies, modelling options, and a study of the economic, institutional and policy conditions that predispose countries to biological invasions. Also included are case studies of fisheries, agricultural systems, tropical forests and protected areas affected by invasive species in locations such as the Black Sea, Australia and Africa, and an evaluation of control programmes. The Economics of Biological Invasions provides an important first step towards codification of the advice needed to develop decision rules, tools and protocols for the effective management of invasive biological species. This volume will be a fascinating read for researchers, academics and students in ecology, economics and environmental science with an interest in the biodiversity problem. The book will also prove to be essential reading for policymakers responsible for health, agriculture, forestry, fisheries and the environment in both developed and developing countries.

Information is a core concept in animal communication: individuals routinely produce, acquire, process and store information, which provides the basis for their social life. This book focuses on how animal acoustic signals code information and how this coding can be shaped by various environmental and social constraints. Taking birds and mammals, including humans, as models, the authors explore such topics as communication strategies for "public" and "private" signaling, static and dynamic signaling, the diversity of coded information and the way information is decoded by the receiver. The book appeals to a wide audience, ranging from bioacousticians, ethologists and ecologists to evolutionary biologists. Intended for students and researchers alike, it promotes the idea that Shannon and Weaver's Mathematical Theory of Communication still represents a strong framework for understanding all aspects of the communication process, including its dynamic dimensions.

This volume presents articles from the leading experts in the field in nanobiotechnology, providing students and researchers with a comprehensive review of the newly emerging area of neuroscience.

All aspects of nanomaterials induced alteration in brain function are considered. Basic chapters on methods and ways to enhance nano-drug delivery into the brain are presented as well as chapters on functional and structural changes in the CNS, including gene expression and related issues. Particular attention is given to possible therapeutic advancement regarding nano-drug formulation and their role in neuroprotection.

This book reviews the evolution of Biosemiotics and gives an outlook on the future of this interdisciplinary new discipline. In this volume, the foundations of symbolism are transformed into a phenomenological, technological, philosophical and psychological discussion enriching the readers' knowledge of these foundations. It offers the opportunity to rethink the impact that evolution theory and the confirmations about evolution as a historical and natural fact, has had and continues to have today. The book is divided into three parts: Part I Life, Meaning, and Information Part II Semiosis and Evolution Part III Physics, medicine, and bioenergetics It starts by laying out a general historical, philosophical, and scientific framework for the collection of studies that will follow. In the following some of the main reference models of evolutionary theories are revisited: Extended Synthesis, Formal Darwinism and Biosemiotics. The authors shed new light on how to rethink the processes underlying the origins and evolution of knowledge, the boundary between teleonomic and teleological paradigms of evolution and their possible integration, the relationship between linguistics and biological sciences, especially with reference to the concept of causality, biological information and the mechanisms of its transmission, the difference between physical and biosemiotic intentionality, as well as an examination of the results offered or deriving from the application in the economics and the engineering of design, of biosemiotic models for the transmission of culture, digitalization and proto-design. This volume is of fundamental scientific and philosophical interest, and seen as a possibility for a dialogue based on theoretical and methodological pluralism. The international nature of the publication, with contributions from all over the world, will allow a further development of academic relations, at the service of the international scientific and humanistic heritage.

It's a Jungle in There pursues the hypothesis that the overarching theory of biology, Darwin's theory, should be the overarching theory of cognitive psychology. Taking this approach, David Rosenbaum, a cognitive psychologist and former editor of the Journal of Experimental Psychology: Human Perception and Performance, proposes that the phenomena of cognitive psychology can be understood as emergent interactions among dumb neural elements all competing and cooperating in a kind of inner jungle. Rosenbaum suggests that this perspective allows for the presentation of cognitive psychology in a new way, both for students (for whom the book is mainly intended) and for seasoned investigators (who may be looking for a fresh way to approach and understand their material). Rather than offering cognitive psychology as a rag-tag collection of miscellaneous facts, as has generally been the case in cognitive-psychology textbooks, this volume presents cognitive psychology under a single rubric: "It's a jungle in there." Written in a light-hearted way with continual reference to hypothetical neural creatures eking out their livings in a tough environment, this text is meant to provide an over-arching principle that can motivate more in-depth study of the mind and brain.

This book summarizes various tools and techniques used to provide insights into the cellular and molecular pathophysiology of stroke. It also presents rodent animal models to help shed light on the pathophysiology of ischemic stroke. Presenting the latest information on the different types of stroke, including embolic, filament, photothrombotic, and bilateral common carotid artery, the book also describes techniques that are used for confirmation of stroke surgery, such as laser speckle imaging (LSI) and laser Doppler flowmetry (LDF), and discusses the non-human primates that are used in stroke surgery, cerebral venous sinuous thrombosis, and neurobehavioral assessment. Lastly, it analyzes various neuroprotective agents to treat and prevent ischemic stroke, and examines the challenges and advances in treating and preventing acute ischemic stroke.

This book explores the potential applications of animal stem cells in veterinary medicine. It begins with an overview of stem cells and their application in treating various animal diseases, including mastitis. In turn, the book discusses the challenges of using stem cells in regenerative medicine and emphasizes the importance of understanding the action of stem cells and preclinical evidence for ensuring safety and therapeutic efficacy. It also presents methods for the identification, characterization, and quantification of stem cells. Further, it discusses the therapeutic applications of different stem cells, including milk-derived, testicular, and mesenchymal stem cells in veterinary medicine. Lastly, it discusses strategies for and therapeutic applications of genome editing by CRISPER/Cas9 in mammary stem cells. As such, the book offers a valuable resource for students and scientists working in the veterinary sciences and veterinarians.