In this "Tropical Peatland Eco-management" book, eco-management is new terminology as an abbreviation of "ecology-based management for natural capital enhancement". Key concept on this eco-management is derived from previous book: "Tropical Peatland Ecosystem"(Springer, 2015, eds. by M. Osaki and N. Tsuji). Based on this new concept, this book thoroughly examines tropical peatland eco-management for scientists, political decision makers, governmental officials, land managers, students, and NGO/NPOs who are interested in 1) what the impact of peatland on climate change and ecosystem function, 2) how the management of disturbed peatland, and 3) drawing global scale restoration mechanisms of peatland and wetland. In tropical peatland, a large amount of GHGs (carbon dioxide, methane, and nitrous oxide) is emitted due to the unappropriate development and inadequate management of peatland. The peatland ecosystems consist of the carbon-water complex, which is affected easily by the impact of human and climate change. Throughout much research of tropical peatland, the problems that result from development of tropical peatland are found to stem mainly from a lack of understanding of the complexities of this ecosystem and the fragility of the relationship between peat and forest and also between carbon and water. In past, almost all peatland development and management system have been generally designed on "water drainage system". On the contrast of old system, an innovated eco- management is, here, proposed as "water irrigation system", including water cycling and natural capital enhancement. Through this book readers will learn the advanced peatland eco-management, with more practical methods and procedure based on ecosystem knowledge.

This edited volume discusses the application of very diverse human organotypic models in major areas of biomedical research. The authors lay a main focus on infectious diseases, cancer, allergies, as well as drug/vaccine discovery and toxicology studies. Representing a valid alternative to laboratory animals, these models are relevant for most areas of translational research. As the contemporary research shows, many human tissues can today be cultivated in vitro and used for several research objectives. This book provides an unprecedented overview of recent developments in an exciting field of research methodology. It is a reference guide for scientists in both academia and industry. Readers can update their knowledge and get hands-on recommendations on how to set up an organotypic model in their lab. Chapters 'Progress on Reconstructed Human Skin Models for Allergy Research and Identifying Contact Sensitizers' and 'Human Organotypic Models for Anti-infective Research' of this book are available open access under a CC BY 4.0 license at link.springer.com.

Few people have had as great an impact on the modern environmental movement as has the great writer and scientist Rachel Carson. This readable and up-to-date biography traces the famous environmentalist's development as a writer from earliest childhood through the publication of her best-known work Silent Spring (1962). Although Carson is now remembered almost exclusively for Silent Spring, which exposed the dangers of pesticides, this book was preceded by three best-sellers about the ocean environment: Under the Sea-Wind (1941), The Edge of the Sea (1955), and The Sea Around Us (1951) which catapulted her to fame. In Rachel Carson: A Biography, Carson emerges as a talented scientist and exceptional writer who was able to share her sense of wonder about nature with both scientists and the general public. Carson's great love of both writing and nature emerged at a young age and enabled her to overcome numerous obstacles in her life. She made a critical decision to switch her major in college from English to biology, she suffered financial problems during the Depression, and family and work responsibilities left her little time to write. She struggled for years to become a writer, working in relative obscurity for 15 years at the U.S. Fish and Wildlife Service writing pamphlets and brochures. She also endured harsh criticism of Silent Spring toward the end of her life while terribly ill. This biography shows how Carson overcame these difficulties and persevered to become one of the most influential writers of the last half of the 20th century. Her legacy as a champion of nature continues 50 years after her death.

This book provides essential insights into designing a localized DNA circuit to promote the rate of desired hybridization reactions over undesired leak reactions in the bulk solution. The area of dynamic DNA nanotechnology, or DNA circuits, holds great promise as a highly programmable toolbox that can be used in various applications, including molecular computing and biomolecular detection. However, a key bottleneck is the recurring issue of circuit leakage. The assembly of the localized circuit is dynamically driven by the recognition of biomolecules - a different approach from most methods, which are based on a static DNA origami assembly. The design guidelines for individual reaction modules presented here, which focus on minimizing circuit leakage, are established through NUPACK simulation and tested experimentally - which will be useful for researchers interested in adapting the concepts for other contexts. In the closing section, the design concepts are successfully applied to the biomolecular sensing of a broad range of targets including the single nucleotide mutations, proteins, and cell surface receptors.

What should the average person know about science? Because science is so central to life in the 21st century, science educators and other leaders of the scientific community believe that it is essential that everyone understand the basic concepts of the most vital and far-reaching disciplines. Genetics 101 does exactly that. This accessible volume provides readers - whether students new to the field or just interested members of the lay public - with the essential ideas of genetics using a minimum of jargon and mathematics. Concepts are introduced in a progressive order so that more complicated ideas build on simpler ones, and each is discussed in small, bite-sized segments so that they can be more easily understood. Genetics 101 provides readers of all levels a brief introduction for understanding a science that is so essential to the advancement of science today. It covers: Genetics as a science, The applications of genetics, including developmental genetics and behavioral genetics, Genetics counseling, and other ways in which genetics impacts our lives. The future of the science of genetics, including genetically modified organisms, cloning, and transgenics A glossary and sources for further research complete this handy resource.

Environmental and specific diversity in the Chihuahuan desert in general, and in the Cuatro Cienegas Basin in particular, has long been recognized as outstanding. This book provides a global ecological overview, together with in-depth studies of specific processes. The Chihuahuan desert is the warmest in North America, and has a complex geologic, climatic and biogeographical history, which affects today's distribution of vegetation and plants and generates complex phylogeographic patterns. The high number of endemic species reflects this complex set of traits. The modern distribution of environments, including aquatic and subaquatic systems, riparian environments, gypsum dunes and gypsum-rich soils, low levels of phosphorous and organic matter, and high salinity combined with an extreme climate call for a range of adaptations. Plants are distributed in a patchy pattern based on punctual variations, and many of them respond to different resources and conditions with considerable morphological plasticity. In terms of physiological, morphological and ecological variability, cacti were identified as the most important group in specific environments like bajadas, characterized by high diversity values, while gypsophytes and gypsovagues of different phylogenies, including species with restricted distribution and endemics.

Professor Linda M. Fedigan, Member of the Order of Canada and a Fellow of the Royal Society of Canada, has made major contributions to our understanding of the behavioural ecology of primates. Furthermore, Linda Fedigan pioneered and continues to advance scholarship on the role of women in science, as well as actively promoting the inclusion of women in the academy. A symposium in honour of her career was held in Banff (Alberta, Canada) in December 2016, during which former and current students and collaborators, as well as scientists with similar research interests, presented and discussed their work and their connections to Linda Fedigan. These presentations and discussions are here presented as chapters in this festschrift. The original works presented in this book are organized around four major research areas that have been greatly advanced and influenced by Linda Fedigan: Primate life histories Sex roles, gender, and science Primate-environment interactions Primate adaptation to changing environments

Birds catch the public imagination like no other group of animals; in addition, birders are perhaps the largest non-professional naturalist community. Genomics and associated bioinformatics have revolutionised daily life in just a few decades. At the same time, this development has facilitated the application of genomics technology to ecological and evolutionary studies, including biodiversity and conservation at all levels. This book reveals how the exciting toolbox of genomics offers new opportunities in all areas of avian biology. It presents contributions from prominent experts at the intersection of avian biology and genomics, and offers an ideal introduction to the world of genomics for students, biologists and bird enthusiasts alike. The book begins with a historical perspective on how genomic technology was adopted by bird ecology and evolution research groups. This led, as the book explains, to a revised understanding of avian evolution, with exciting consequences for biodiversity research as a whole. Lastly, these impacts are illustrated using seminal examples and the latest discoveries from avian biology laboratories around the world.

This book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically. The book first introduces the latest studies on the neural and cellular mechanisms of hypothalamic neurons, hypothalamic glial cells, neural circuitries, cellular signaling pathways, and synaptic plasticity in the control of appetite, body weight, feeding-related behaviors and metabolic disorders. It then summarizes the humoral mechanisms by which critical adipocyte-derived hormones and lipoprotein lipase regulate lipid and glucose metabolism, and examines the role of the hypothalamus-sympathetic nerve, a critical nerve pathway from CNS to peripheral nervous system (PNS), in the regulation of metabolism in multiple tissues/organs. Furthermore, the book discusses the functions of adipose tissue in energy metabolism. Lastly, it explores dietary interventions to treat neural diseases and some of the emerging technologies used to study the neural regulation of metabolism. Presenting cutting-edge developments in the neural regulation of metabolism, the book is a valuable reference resource for graduate students and researchers in the field of neuroscience and metabolism.

What makes an engaging presentation or a useful meeting? How can companies motivate and inspire people to do their best at work? Who are the most effective leaders? Bestselling author and scientist Dr John Medina uses peer-reviewed research to answer the most important questions about the workplace today, providing answers that will help you get ahead. The author of international bestseller Brain Rules, Medina here turns his expertise to the professional world, guiding the reader through what brain science and evolutionary biology have to say on topics ranging from office space and work-life balance to power dynamics and work interactions. He examines why taking breaks in nature during the workday improves productivity; how planning a meeting beforehand makes it more effective; why open plan isn't a good office plan; how a more diverse team is a better team; why allowing for failure is vital to a company's success; and much more. Breaking down the science to practical applications that every reader can understand and benefit from, Brain Rules for Work is the essential guide to modern office life.

Describes the lives of three generations of the first family of palaeoanthropology, and their quest for fossil evidence of human origins Three generations of Leakeys have dug in East Africa for fossil evidence that answers questions about human origins. Louise and Mary, husband and wife, began what would turn into decades of research and fieldwork, often disproving common theories and beliefs of the time. Son Richard would follow in his father's footsteps, along with his wife Meave, and would make spectacular finds as well. Louise, oldest daughter of Richard and Meave, continues the family tradition today with fieldwork in northern Kenya. The Leakey family's achievements have had an enormous impact on our knowledge of human origins and evolution. This biography describes their life in detail, including their discoveries, publications, controversies, and legacy.

Medicine, Power, and the Law demonstrates that criminal and civil justice interact with medicine and public health more than is presently understood. The book focuses on the role of healthcare practitioners and an array of other professionals across industries in identifying wrongdoers, reporting behavior, and testifying on behalf of the state or government agencies. It also covers circumstances in which law enforcement relies on medicine for evidence or support in ways that compromise medical ethics. By reporting or testifying as experts, a range of people, from specialist pediatricians to flight attendants, can have a life-changing impact on individuals in the name of public health or medicine. People who work in hospitals, social work settings, and even airlines, often contribute to wrongful and aggressive criminal and civil actions against society's most vulnerable people, including parents, older adults, and people living with poverty. The book explores a number of examples, including police use of medicine as a restraint or the collection of blood as evidence and the risks of opting out of certain scientific discoveries, such as pharmaceuticals. It describes the harms that may come to those who engage in suboptimal but generally heretofore legal child-raising behaviors, and people opting to live independently as older adults. These can lead to civil and criminal charges when noticed by those in a position of power. Medicine, Power, and the Law is an important contribution for researchers and practitioners in medicine, the law, and the expanding field of bioethics.

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologically active novel molecular entities. It presents a clear concept of the molecular mechanism of different drug targets and explores methods to help understand drug resistance. In addition, it includes chapters dedicated to natural-product- derived medicines, combinatorial drug discovery, the CryoEM technique for structure-based drug design and big data in drug discovery. The book offers an invaluable resource for graduate and postgraduate students, as well as for researchers in academic and industrial laboratories working in the areas of chemoinformatics, medicinal and pharmaceutical chemistry and pharmacoinformatics.

As part of its efforts to improve fertilizer use and efficiency in West Africa, and following the recent adoption of the West African fertilizer recommendation action plan (RAP) by ECOWAS, this volume focuses on IFDC's technical lead with key partner institutions and experts to build on previous and current fertilizer recommendations for various crops and countries in West Africa for wider uptake by public policy makers and fertilizer industry actors.

This monograph sketches out a broad spectrum of problems (from evolution and metabolism to morphogenesis and biogeographical dynamics) whose solution has been impacted by mathematical models. Each of the selected examples has led to the recognition-and set direction to further study-of certain fundamental but unintuitive properties of biological systems, such as the making and breaking of specific symmetries that underlie morphogenesis. Whether they are long-established or only recently accepted, these models are selected for being thought-provoking and illuminating both the achievements and the gaps in our current understanding of the given area of biology. The selection of models is also meant to bring to the fore the existing degree of unity in the quantitative approach to diverse general-biological questions and in the systems-level properties that are discovered across the levels of biological organization. It is the thesis of this book that further cultivation of such unity is a way forward as we progress toward a general theory of living matter. This is an ideal book for students (in the broadest sense) of biology who wish to learn from this attempt to present the exemplary models, their methodological lessons, and the outline of a unified theory of living matter that is now beginning to emerge. In addition to a doctoral student preparing for quantitative biology research, this reader could also be an interdisciplinary scientist transitioning to biology. The latter-for example, a physicist or an engineer-may be comfortable with the mathematical apparatus and prepared to quickly enter the intended area of work, but desires a broader foundation in biology from the quantitative perspective.

White biotechnology, or industrial biotechnology as it is also known, refers to the use of living cells and/or their enzymes to create industrial products that are more easily degradable, require less energy, create less waste during production and sometimes perform better than products created using traditional chemical processes. Over the last decade considerable progress has been made in white biotechnology research, and further major scientific and technological breakthroughs are expected in the future. Fungi are ubiquitous in nature and have been sorted out from different habitats, including extreme environments (high temperature, low temperature, salinity and pH), and may be associated with plants (epiphytic, endophytic and rhizospheric). The fungal strains are beneficial as well as harmful for human beings. The beneficial fungal strains may play important roles in the agricultural, industrial, and medical sectors. The fungal strains and their products (enzymes, bioactive compounds, and secondary metabolites) are very useful for industry (e.g., the discovery of penicillin from Penicillium chrysogenum). This discovery was a milestone in the development of white biotechnology as the industrial production of penicillin and antibiotics using fungi moved industrial biotechnology into the modern era, transforming it into a global industrial technology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors, providing both high value nutraceutical and pharmaceutical products. The fungal strains and bioactive compounds also play an important role in environmental cleaning. This volume covers the latest developments and research in white biotechnology with a focus on diversity and enzymes.